TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two differen... See more...

Aliases for TAF4B Gene

Aliases for TAF4B Gene

  • TATA-Box Binding Protein Associated Factor 4b 2 3 5
  • TAFII105 2 3 4
  • TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 105kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2, 105kD 2 3
  • Transcription Initiation Factor TFIID 105 KDa Subunit 3 4
  • TATA Box Binding Protein (TBP)-Associated Factor 4B 2 3
  • Transcription Initiation Factor TFIID Subunit 4B 3 4
  • TAF(II)105 3 4
  • TAF2C2 3 4
  • TAFII-105 4
  • SPGF13 3
  • TAF4B 5

External Ids for TAF4B Gene

Previous HGNC Symbols for TAF4B Gene

  • TAF2C2

Previous GeneCards Identifiers for TAF4B Gene

  • GC18P023722
  • GC18P023538
  • GC18P022037
  • GC18P022039
  • GC18P023806
  • GC18P020657

Summaries for TAF4B Gene

Entrez Gene Summary for TAF4B Gene

  • TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

GeneCards Summary for TAF4B Gene

TAF4B (TATA-Box Binding Protein Associated Factor 4b) is a Protein Coding gene. Diseases associated with TAF4B include Spermatogenic Failure 13 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Among its related pathways are Regulation of TP53 Activity and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and NF-kappaB binding. An important paralog of this gene is TAF4.

UniProtKB/Swiss-Prot Summary for TAF4B Gene

  • Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

Gene Wiki entry for TAF4B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF4B Gene

Genomics for TAF4B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAF4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J026224 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 607.4 +0.6 566 4.8 RNF2 SP1 CREB1 HNRNPL ATF7 PRDM10 ZNF629 ZNF512 IKZF1 KDM1A TAF4B KCTD1 piR-32022
GH18J026088 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 7 -136.6 -136644 4.4 SP1 ATF7 TEAD4 ZNF629 PRDM10 REST ZNF512 SIX5 LEF1 IKZF1 SS18 lnc-KCTD1-3 TAF4B lnc-KCTD1-5 ZNF521
GH18J026255 Promoter/Enhancer 1 Ensembl ENCODE 7.3 +29.6 29624 0.7 IKZF1 PKNOX1 DPF2 ZNF239 HDAC1 ZNF600 SOX6 TCF12 HMBOX1 CTBP1 SINHCAFP1 lnc-SS18-3 piR-39904-009 piR-61945-232 TAF4B KCTD1
GH18J026133 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 6 -92.4 -92406 1.5 POLR2A YY1 ZBTB33 TAF1 TBP GABPB1 EGR1 PSMA8 piR-57460-303 SS18 TAF4B
GH18J026385 Enhancer 0.8 Ensembl ENCODE 5.8 +159.8 159785 1.7 CREB1 TFE3 SOX13 SP1 CTBP1 FOXA2 USF1 YY1 NR2F2 RAD21 TAF4B piR-50437-301 RF00026-476 RNU6-1289P KCTD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF4B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF4B

Top Transcription factor binding sites by QIAGEN in the TAF4B gene promoter:
  • AREB6
  • c-Myc
  • Elk-1
  • HNF-1
  • HNF-1A
  • HNF-4alpha1
  • HNF-4alpha2
  • IRF-1
  • Max
  • Pax-5

Genomic Locations for TAF4B Gene

Genomic Locations for TAF4B Gene
chr18:26,226,445-26,391,685
(GRCh38/hg38)
Size:
165,241 bases
Orientation:
Plus strand
chr18:23,805,900-23,971,649
(GRCh37/hg19)
Size:
165,750 bases
Orientation:
Plus strand

Genomic View for TAF4B Gene

Genes around TAF4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF4B Gene

Proteins for TAF4B Gene

  • Protein details for TAF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92750-TAF4B_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 4B
    Protein Accession:
    Q92750
    Secondary Accessions:
    • Q29YA4
    • Q29YA5

    Protein attributes for TAF4B Gene

    Size:
    862 amino acids
    Molecular mass:
    91091 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for octamer-dependent transcription.
    Miscellaneous:
    • [Isoform 2]: May be due to exon inclusion. Unphosphorylated form.

    Alternative splice isoforms for TAF4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF4B Gene

Post-translational modifications for TAF4B Gene

  • Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAF4B Gene

Domains & Families for TAF4B Gene

Gene Families for TAF4B Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TAF4B Gene

InterPro:
Blocks:
  • TAF-like region
  • Transcription initiation factor TFIID component TAF4
ProtoNet:

Suggested Antigen Peptide Sequences for TAF4B Gene

GenScript: Design optimal peptide antigens:
  • TATA box binding protein (TBP)-associated factor 4B (A4PBF7_HUMAN)
  • TATA box binding protein (TBP)-associated factor 4B (A4PBF8_HUMAN)
  • Transcription initiation factor TFIID 105 kDa subunit (TAF4B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92750

UniProtKB/Swiss-Prot:

TAF4B_HUMAN :
  • Belongs to the TAF4 family.
Family:
  • Belongs to the TAF4 family.
genes like me logo Genes that share domains with TAF4B: view

Function for TAF4B Gene

Molecular function for TAF4B Gene

UniProtKB/Swiss-Prot Function:
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

Phenotypes From GWAS Catalog for TAF4B Gene

Gene Ontology (GO) - Molecular Function for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,IDA 15601843
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0008134 transcription factor binding IBA 21873635
GO:0046982 protein heterodimerization activity IEA --
GO:0051059 NF-kappaB binding IPI 10849440
genes like me logo Genes that share ontologies with TAF4B: view
genes like me logo Genes that share phenotypes with TAF4B: view

Human Phenotype Ontology for TAF4B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAF4B Gene

MGI Knock Outs for TAF4B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF4B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TAF4B Gene

Localization for TAF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF4B Gene

Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. {ECO:0000269 PubMed:11567023}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF4B gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAF4B: view

Pathways & Interactions for TAF4B Gene

genes like me logo Genes that share pathways with TAF4B: view

Pathways by source for TAF4B Gene

2 KEGG pathways for TAF4B Gene
1 GeneGo (Thomson Reuters) pathway for TAF4B Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes

Gene Ontology (GO) - Biological Process for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with TAF4B: view

No data available for SIGNOR curated interactions for TAF4B Gene

Drugs & Compounds for TAF4B Gene

No Compound Related Data Available

Transcripts for TAF4B Gene

mRNA/cDNA for TAF4B Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF4B

Alternative Splicing Database (ASD) splice patterns (SP) for TAF4B Gene

No ASD Table

Relevant External Links for TAF4B Gene

GeneLoc Exon Structure for
TAF4B

Expression for TAF4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF4B Gene

This gene is overexpressed in Colon muscle (30.7) and Peripheral blood mononuclear cells (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAF4B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF4B

SOURCE GeneReport for Unigene cluster for TAF4B Gene:

Hs.369519

mRNA Expression by UniProt/SwissProt for TAF4B Gene:

Q92750-TAF4B_HUMAN
Tissue specificity: Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells.

Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF4B Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Regions:
Pelvis:
  • ovary
  • testicle
genes like me logo Genes that share expression patterns with TAF4B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for TAF4B Gene

Orthologs for TAF4B Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF4B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAF4B 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TAF4B 30 31
  • 90.16 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TAF4B 30 31
  • 87.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Taf4b 30 17 31
  • 85.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1562997 30
  • 84.3 (n)
Oppossum
(Monodelphis domestica)
Mammalia TAF4B 31
  • 59 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TAF4B 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TAF4B 30 31
  • 67.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TAF4B 31
  • 46 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii taf4b 30 31
  • 55.44 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5624 30
Fruit Fly
(Drosophila melanogaster)
Insecta Taf4 31 32
  • 20 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea taf-4 31
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8870 31
  • 37 (a)
OneToMany
Species where no ortholog for TAF4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TAF4B Gene

ENSEMBL:
Gene Tree for TAF4B (if available)
TreeFam:
Gene Tree for TAF4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF4B: view image

Paralogs for TAF4B Gene

Paralogs for TAF4B Gene

(2) SIMAP similar genes for TAF4B Gene using alignment to 3 proteins:

  • TAF4B_HUMAN
  • J3KTH2_HUMAN
  • L0R5D1_HUMAN

Pseudogenes.org Pseudogenes for TAF4B Gene

genes like me logo Genes that share paralogs with TAF4B: view

Variants for TAF4B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF4B Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
708963 Benign: not provided 26,285,995(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
711702 Benign: not provided 26,274,810(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
712134 Benign: not provided 26,285,900(+) C/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
714746 Benign: not provided 26,265,280(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
714747 Benign: not provided 26,265,281(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for TAF4B Gene

Structural Variations from Database of Genomic Variants (DGV) for TAF4B Gene

Variant ID Type Subtype PubMed ID
dgv1568n106 CNV deletion 24896259
esv1519371 CNV insertion 17803354
esv2459954 CNV deletion 19546169
nsv1070872 CNV deletion 25765185
nsv1109138 CNV deletion 24896259
nsv477391 CNV novel sequence insertion 20440878
nsv512522 CNV loss 21212237
nsv576576 CNV gain 21841781
nsv952693 CNV duplication 24416366
nsv961038 CNV duplication 23825009

Variation tolerance for TAF4B Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF4B Gene

Human Gene Mutation Database (HGMD)
TAF4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF4B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF4B Gene

Disorders for TAF4B Gene

MalaCards: The human disease database

(5) MalaCards diseases for TAF4B Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 13
  • spgf13
male infertility with azoospermia or oligozoospermia due to single gene mutation
azoospermia
  • spermatogenic failure
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
male infertility
  • infertility male
- elite association - COSMIC cancer census association via MalaCards
Search TAF4B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAF4B_HUMAN
  • Spermatogenic failure 13 (SPGF13) [MIM:615841]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:24431330}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TAF4B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TAF4B: view

No data available for Genatlas for TAF4B Gene

Publications for TAF4B Gene

  1. Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line. (PMID: 16088961) Wu Y … Li R (Journal of cellular biochemistry 2005) 3 4 23
  2. A composite nuclear export signal in the TBP-associated factor TAFII105. (PMID: 11567023) Rashevsky-Finkel A … Dikstein R (The Journal of biological chemistry 2001) 3 4 23
  3. Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. (PMID: 10849440) Yamit-Hezi A … Dikstein R (The Journal of biological chemistry 2000) 2 3 4
  4. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PMID: 10828057) Wolstein O … Dikstein R (The Journal of biological chemistry 2000) 3 4 23
  5. Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130. (PMID: 8858156) Dikstein R … Tjian R (Cell 1996) 2 3 4

Products for TAF4B Gene

Sources for TAF4B Gene