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Aliases for TAF4B Gene

Aliases for TAF4B Gene

  • TATA-Box Binding Protein Associated Factor 4b 2 3 5
  • TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 105kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2, 105kD 2 3
  • Transcription Initiation Factor TFIID 105 KDa Subunit 3 4
  • TATA Box Binding Protein (TBP)-Associated Factor 4B 2 3
  • TAF(II)105 3 4
  • TAFII105 3 4
  • TAF2C2 3 4
  • Transcription Initiation Factor TFIID Subunit 4B 3
  • TAFII-105 4
  • SPGF13 3

External Ids for TAF4B Gene

Previous HGNC Symbols for TAF4B Gene

  • TAF2C2

Previous GeneCards Identifiers for TAF4B Gene

  • GC18P023722
  • GC18P023538
  • GC18P022037
  • GC18P022039
  • GC18P023806
  • GC18P020657

Summaries for TAF4B Gene

Entrez Gene Summary for TAF4B Gene

  • TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

GeneCards Summary for TAF4B Gene

TAF4B (TATA-Box Binding Protein Associated Factor 4b) is a Protein Coding gene. Diseases associated with TAF4B include Spermatogenic Failure 13. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and NF-kappaB binding. An important paralog of this gene is TAF4.

UniProtKB/Swiss-Prot for TAF4B Gene

  • Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

Gene Wiki entry for TAF4B Gene

Additional gene information for TAF4B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF4B Gene

Genomics for TAF4B Gene

GeneHancer (GH) Regulatory Elements for TAF4B Gene

Promoters and enhancers for TAF4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I026224 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557.5 +0.7 655 3.9 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B TAF4B GC18M026382 SS18 KCTD1 PIR33021
GH18I026088 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7 -135.9 -135899 3.8 HDGF PKNOX1 SMAD1 MLX ARNT SIN3A DMAP1 ZBTB7B YY1 SLC30A9 SS18 TAF4B GC18M026383
GH18I026133 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 6 -92.2 -92174 1 POLR2A GABPB1 ZBTB33 PSMA8 TAF4B GC18P026127
GH18I026255 Enhancer 0.9 Ensembl ENCODE 7.2 +30.1 30055 0.8 HDAC1 PKNOX1 ATF1 TEAD4 TAL1 FEZF1 ZNF335 TCF12 CTBP1 FOXK2 FAM60BP TAF4B GC18M026379
GH18I026385 Enhancer 0.8 Ensembl ENCODE 5.8 +160.3 160340 1.6 SOX5 SOX13 USF1 TFE3 FOXA2 RXRA RAD21 NR2F2 RARA YY1 TAF4B RNU6-1289P GC18M026369 GC18M026408
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAF4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAF4B gene promoter:

Genomic Locations for TAF4B Gene

Genomic Locations for TAF4B Gene
chr18:26,225,936-26,391,685
(GRCh38/hg38)
Size:
165,750 bases
Orientation:
Plus strand
chr18:23,805,900-23,971,649
(GRCh37/hg19)

Genomic View for TAF4B Gene

Genes around TAF4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF4B Gene

Proteins for TAF4B Gene

  • Protein details for TAF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92750-TAF4B_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 4B
    Protein Accession:
    Q92750
    Secondary Accessions:
    • Q29YA4
    • Q29YA5

    Protein attributes for TAF4B Gene

    Size:
    862 amino acids
    Molecular mass:
    91091 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for octamer-dependent transcription.

    Alternative splice isoforms for TAF4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF4B Gene

Post-translational modifications for TAF4B Gene

  • Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF4B Gene

No data available for DME Specific Peptides for TAF4B Gene

Domains & Families for TAF4B Gene

Gene Families for TAF4B Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TAF4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92750

UniProtKB/Swiss-Prot:

TAF4B_HUMAN :
  • Belongs to the TAF4 family.
Family:
  • Belongs to the TAF4 family.
genes like me logo Genes that share domains with TAF4B: view

Function for TAF4B Gene

Molecular function for TAF4B Gene

UniProtKB/Swiss-Prot Function:
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

Phenotypes From GWAS Catalog for TAF4B Gene

Gene Ontology (GO) - Molecular Function for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001075 contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA --
GO:0003677 DNA binding IDA,IEA 15601843
GO:0003700 DNA binding transcription factor activity IEA --
GO:0003713 transcription coactivator activity IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF4B: view
genes like me logo Genes that share phenotypes with TAF4B: view

Human Phenotype Ontology for TAF4B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAF4B Gene

MGI Knock Outs for TAF4B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TAF4B Gene

Localization for TAF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF4B Gene

Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. {ECO:0000269 PubMed:11567023}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF4B gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAF4B: view

Pathways & Interactions for TAF4B Gene

genes like me logo Genes that share pathways with TAF4B: view

Pathways by source for TAF4B Gene

Gene Ontology (GO) - Biological Process for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF4B: view

No data available for SIGNOR curated interactions for TAF4B Gene

Drugs & Compounds for TAF4B Gene

No Compound Related Data Available

Transcripts for TAF4B Gene

mRNA/cDNA for TAF4B Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF4B Gene

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF4B Gene

No ASD Table

Relevant External Links for TAF4B Gene

GeneLoc Exon Structure for
TAF4B
ECgene alternative splicing isoforms for
TAF4B

Expression for TAF4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF4B Gene

This gene is overexpressed in Colon muscle (30.7) and Peripheral blood mononuclear cells (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAF4B Gene



NURSA nuclear receptor signaling pathways regulating expression of TAF4B Gene:

TAF4B

SOURCE GeneReport for Unigene cluster for TAF4B Gene:

Hs.369519

mRNA Expression by UniProt/SwissProt for TAF4B Gene:

Q92750-TAF4B_HUMAN
Tissue specificity: Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells.

Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF4B Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Regions:
Pelvis:
  • ovary
  • testicle
genes like me logo Genes that share expression patterns with TAF4B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for TAF4B Gene

Orthologs for TAF4B Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF4B 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia TAF4B 33 34
  • 90.16 (n)
cow
(Bos Taurus)
Mammalia TAF4B 33 34
  • 87.5 (n)
mouse
(Mus musculus)
Mammalia Taf4b 33 16 34
  • 85.02 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562997 33
  • 84.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF4B 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF4B 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF4B 33 34
  • 67.68 (n)
lizard
(Anolis carolinensis)
Reptilia TAF4B 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii taf4b 33 34
  • 55.44 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5624 33
fruit fly
(Drosophila melanogaster)
Insecta Taf4 35 34
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-4 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8870 34
  • 37 (a)
OneToMany
Species where no ortholog for TAF4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TAF4B Gene

ENSEMBL:
Gene Tree for TAF4B (if available)
TreeFam:
Gene Tree for TAF4B (if available)

Paralogs for TAF4B Gene

Paralogs for TAF4B Gene

(2) SIMAP similar genes for TAF4B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TAF4B Gene

genes like me logo Genes that share paralogs with TAF4B: view

Variants for TAF4B Gene

Sequence variations from dbSNP and Humsavar for TAF4B Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs587777427 pathogenic, Spermatogenic failure 13 26,293,530(+) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant, stop_gained, synonymous_variant
rs1000004948 -- 26,251,177(+) C/T intron_variant
rs1000010973 -- 26,296,251(+) A/G intron_variant
rs1000038124 -- 26,281,758(+) A/G intron_variant
rs1000084163 -- 26,296,560(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAF4B Gene

Variant ID Type Subtype PubMed ID
dgv1568n106 CNV deletion 24896259
esv1519371 CNV insertion 17803354
esv2459954 CNV deletion 19546169
nsv1070872 CNV deletion 25765185
nsv1109138 CNV deletion 24896259
nsv477391 CNV novel sequence insertion 20440878
nsv512522 CNV loss 21212237
nsv576576 CNV gain 21841781
nsv952693 CNV duplication 24416366
nsv961038 CNV duplication 23825009

Variation tolerance for TAF4B Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF4B Gene

Human Gene Mutation Database (HGMD)
TAF4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF4B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF4B Gene

Disorders for TAF4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF4B Gene - From: HGMD, OMIM, ClinVar, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 13
  • spgf13
- elite association - COSMIC cancer census association via MalaCards
Search TAF4B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAF4B_HUMAN
  • Spermatogenic failure 13 (SPGF13) [MIM:615841]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:24431330}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TAF4B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TAF4B: view

No data available for Genatlas for TAF4B Gene

Publications for TAF4B Gene

  1. Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line. (PMID: 16088961) Wu Y … Li R (Journal of cellular biochemistry 2005) 3 4 22 58
  2. A composite nuclear export signal in the TBP-associated factor TAFII105. (PMID: 11567023) Rashevsky-Finkel A … Dikstein R (The Journal of biological chemistry 2001) 3 4 22 58
  3. Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. (PMID: 10849440) Yamit-Hezi A … Dikstein R (The Journal of biological chemistry 2000) 2 3 4 58
  4. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PMID: 10828057) Wolstein O … Dikstein R (The Journal of biological chemistry 2000) 3 4 22 58
  5. Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130. (PMID: 8858156) Dikstein R … Tjian R (Cell 1996) 2 3 4 58

Products for TAF4B Gene

  • Addgene plasmids for TAF4B

Sources for TAF4B Gene

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