Aliases for TAF4B Gene
- TATA-Box Binding Protein Associated Factor 4b 2 3 5
- TAFII105 2 3 4
- TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 105kDa 2 3
- TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2, 105kD 2 3
- Transcription Initiation Factor TFIID 105 KDa Subunit 3 4
- TATA Box Binding Protein (TBP)-Associated Factor 4B 2 3
External Ids for TAF4B Gene
Previous HGNC Symbols for TAF4B Gene
Previous GeneCards Identifiers for TAF4B Gene
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
GeneCards Summary for TAF4B Gene
TAF4B (TATA-Box Binding Protein Associated Factor 4b) is a Protein Coding gene. Diseases associated with TAF4B include Spermatogenic Failure 13 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and NF-kappaB binding. An important paralog of this gene is TAF4.
UniProtKB/Swiss-Prot Summary for TAF4B Gene
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.