Aliases for TAF4B Gene
- TATA-Box Binding Protein Associated Factor 4b 2 3 5
- TAFII105 2 3 4
- TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 105kDa 2 3
- TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2, 105kD 2 3
- Transcription Initiation Factor TFIID 105 KDa Subunit 3 4
- TATA Box Binding Protein (TBP)-Associated Factor 4B 2 3
External Ids for TAF4B Gene
Previous HGNC Symbols for TAF4B Gene
Previous GeneCards Identifiers for TAF4B Gene
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
GeneCards Summary for TAF4B Gene
TAF4B (TATA-Box Binding Protein Associated Factor 4b) is a Protein Coding gene. Diseases associated with TAF4B include Spermatogenic Failure 13 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Among its related pathways are Regulation of TP53 Activity and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and NF-kappaB binding. An important paralog of this gene is TAF4.
UniProtKB/Swiss-Prot Summary for TAF4B Gene
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.