The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009] See more...

Aliases for TAF3 Gene

Aliases for TAF3 Gene

  • TATA-Box Binding Protein Associated Factor 3 2 3 5
  • TAF3 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 140kDa 2 3
  • Transcription Initiation Factor TFIID 140 KDa Subunit 3 4
  • 140 KDa TATA Box-Binding Protein-Associated Factor 3 4
  • Transcription Initiation Factor TFIID Subunit 3 3 4
  • TBP-Associated Factor 3 3 4
  • TAF(II)140 3 4
  • TAFII-140 3 4
  • TAFII140 3 4
  • TAF140 3 4
  • TAF3 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 140 KD 2
  • RNA Polymerase II Transcription Factor TAFII140 3

External Ids for TAF3 Gene

Previous GeneCards Identifiers for TAF3 Gene

  • GC10P007805
  • GC10M007824
  • GC10P008010
  • GC10P007864
  • GC10P007898

Summaries for TAF3 Gene

Entrez Gene Summary for TAF3 Gene

  • The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]

GeneCards Summary for TAF3 Gene

TAF3 (TATA-Box Binding Protein Associated Factor 3) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Gene Expression. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and p53 binding. An important paralog of this gene is CXXC1.

UniProtKB/Swiss-Prot Summary for TAF3 Gene

  • Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

Gene Wiki entry for TAF3 Gene

Additional gene information for TAF3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF3 Gene

Genomics for TAF3 Gene

GeneHancer (GH) Regulatory Elements for TAF3 Gene

Promoters and enhancers for TAF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF3

Top Transcription factor binding sites by QIAGEN in the TAF3 gene promoter:
  • ATF-2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP
  • TFIID

Genomic Locations for TAF3 Gene

Genomic Locations for TAF3 Gene
chr10:7,818,477-8,016,631
(GRCh38/hg38)
Size:
198,155 bases
Orientation:
Plus strand
chr10:7,860,467-8,058,590
(GRCh37/hg19)
Size:
198,124 bases
Orientation:
Plus strand

Genomic View for TAF3 Gene

Genes around TAF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF3 Gene

Proteins for TAF3 Gene

  • Protein details for TAF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWG9-TAF3_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 3
    Protein Accession:
    Q5VWG9
    Secondary Accessions:
    • Q05DA0
    • Q6GMS5
    • Q6P6B5
    • Q86VY6
    • Q9BQS9
    • Q9UFI8

    Protein attributes for TAF3 Gene

    Size:
    929 amino acids
    Molecular mass:
    103582 Da
    Quaternary structure:
    • Belongs to the TFIID complex which is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF10 via the histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2. Interacts with TBPL2.
    SequenceCaution:
    • Sequence=AAH45106.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62352.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH73884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF3 Gene

neXtProt entry for TAF3 Gene

Post-translational modifications for TAF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF3 Gene

Domains & Families for TAF3 Gene

Protein Domains for TAF3 Gene

Blocks:
  • Zn-finger-like, PHD finger
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAF3 Gene

GenScript: Design optimal peptide antigens:
  • TAF3 protein (Q05DA0_HUMAN)
  • TAF3 protein (Q0VGM1_HUMAN)
  • Transcription initiation factor TFIID 140 kDa subunit (TAF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VWG9

UniProtKB/Swiss-Prot:

TAF3_HUMAN :
  • The PHD-type zinc finger mediates binding to histone H3 methyllysine at position 4 (H3K4me3).
  • Belongs to the TAF3 family.
Domain:
  • The PHD-type zinc finger mediates binding to histone H3 methyllysine at position 4 (H3K4me3).
Family:
  • Belongs to the TAF3 family.
genes like me logo Genes that share domains with TAF3: view

Function for TAF3 Gene

Molecular function for TAF3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

Phenotypes From GWAS Catalog for TAF3 Gene

Gene Ontology (GO) - Molecular Function for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0005515 protein binding IPI 11438666
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF3: view
genes like me logo Genes that share phenotypes with TAF3: view

Animal Model Products

CRISPR Products

miRNA for TAF3 Gene

miRTarBase miRNAs that target TAF3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF3 Gene

Localization for TAF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF3 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15870280
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 11438666
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with TAF3: view

Pathways & Interactions for TAF3 Gene

genes like me logo Genes that share pathways with TAF3: view

Pathways by source for TAF3 Gene

1 KEGG pathway for TAF3 Gene
1 GeneGo (Thomson Reuters) pathway for TAF3 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes

Gene Ontology (GO) - Biological Process for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 18549481
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0043433 negative regulation of DNA-binding transcription factor activity IEA,IDA 18549481
GO:0051457 maintenance of protein location in nucleus IDA 15870280
genes like me logo Genes that share ontologies with TAF3: view

No data available for SIGNOR curated interactions for TAF3 Gene

Drugs & Compounds for TAF3 Gene

No Compound Related Data Available

Transcripts for TAF3 Gene

mRNA/cDNA for TAF3 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF3

Alternative Splicing Database (ASD) splice patterns (SP) for TAF3 Gene

No ASD Table

Relevant External Links for TAF3 Gene

GeneLoc Exon Structure for
TAF3

Expression for TAF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF3 Gene

This gene is overexpressed in Testis (10.3), Lung (10.2), Tlymphocyte (8.8), Fetal Liver (8.3), Pancreas (8.1), and Stomach (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF3

SOURCE GeneReport for Unigene cluster for TAF3 Gene:

Hs.527688

Evidence on tissue expression from TISSUES for TAF3 Gene

  • Liver(4.2)
  • Skin(4.1)
  • Bone(4)
genes like me logo Genes that share expression patterns with TAF3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF3 Gene

Orthologs for TAF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF3 31 30
  • 99.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TAF3 31
  • 89 (a)
OneToOne
LOC506674 30
  • 82.49 (n)
dog
(Canis familiaris)
Mammalia TAF3 31 30
  • 85.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf3 30
  • 83.57 (n)
mouse
(Mus musculus)
Mammalia Taf3 17 31 30
  • 83.39 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF3 31
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF3 31
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF3 31 30
  • 75.59 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF3 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf3 30
  • 67.29 (n)
Str.8912 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.13976 30
zebrafish
(Danio rerio)
Actinopterygii taf3 31
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6361 30
fruit fly
(Drosophila melanogaster)
Insecta bip2 31
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-3 31
  • 20 (a)
OneToOne
Species where no ortholog for TAF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF3 Gene

ENSEMBL:
Gene Tree for TAF3 (if available)
TreeFam:
Gene Tree for TAF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF3: view image

Paralogs for TAF3 Gene

Paralogs for TAF3 Gene

genes like me logo Genes that share paralogs with TAF3: view

Variants for TAF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
778458 Benign: not provided 7,964,581(+) C/T SYNONYMOUS_VARIANT
784157 Benign: not provided 8,009,249(+) C/T SYNONYMOUS_VARIANT
785305 Benign: not provided 7,964,498(+) A/T MISSENSE_VARIANT
rs10795583 - p.Val696Leu
rs1244229 - p.Val696Ala

Additional dbSNP identifiers (rs#s) for TAF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAF3 Gene

Variant ID Type Subtype PubMed ID
dgv91e201 CNV deletion 23290073
dgv92e201 CNV deletion 23290073
dgv953n54 CNV loss 21841781
esv1001263 CNV insertion 20482838
esv24837 CNV loss 19812545
esv26156 CNV gain 19812545
esv2732428 CNV deletion 23290073
esv3545867 CNV deletion 23714750
esv3545868 CNV deletion 23714750
esv3578606 CNV loss 25503493
esv3622278 CNV loss 21293372
nsv1041904 CNV loss 25217958
nsv1145425 CNV deletion 24896259
nsv526356 CNV gain 19592680
nsv526540 CNV loss 19592680
nsv549933 CNV gain 21841781
nsv549945 CNV loss 21841781
nsv549948 CNV loss 21841781

Variation tolerance for TAF3 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF3 Gene

Human Gene Mutation Database (HGMD)
TAF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF3 Gene

Disorders for TAF3 Gene

Additional Disease Information for TAF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TAF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF3 Gene

Publications for TAF3 Gene

  1. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. (PMID: 11438666) Gangloff YG … Davidson I (Molecular and cellular biology 2001) 2 3 4 54
  2. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X … Kong X (PloS one 2010) 3 41 54
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41 54
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 41 54

Products for TAF3 Gene

Sources for TAF3 Gene