Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one ... See more...

Aliases for TAF1B Gene

Aliases for TAF1B Gene

  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B 2 3 5
  • TAFI63 2 3 4
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kD 2 3
  • TATA Box-Binding Protein-Associated Factor RNA Polymerase I Subunit B 3 4
  • RNA Polymerase I-Specific TBP-Associated Factor 63 KDa 3 4
  • Transcription Initiation Factor SL1/TIF-IB Subunit B 3 4
  • TATA Box-Binding Protein-Associated Factor 1B 3 4
  • TBP-Associated Factor 1B 3 4
  • RAFI63 2 3
  • RAF1B 2 3
  • SL1 2 3
  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I, B 3
  • SL1, 63kD Subunit 3
  • MGC:9349 3
  • TAF1B 5

External Ids for TAF1B Gene

Previous GeneCards Identifiers for TAF1B Gene

  • GC02P009767
  • GC02P010034
  • GC02P010006
  • GC02P010007
  • GC02P009934
  • GC02P009983

Summaries for TAF1B Gene

Entrez Gene Summary for TAF1B Gene

  • Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for TAF1B Gene

TAF1B (TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase I CORE element sequence-specific DNA binding.

UniProtKB/Swiss-Prot Summary for TAF1B Gene

  • Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.

Gene Wiki entry for TAF1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF1B Gene

Genomics for TAF1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAF1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF1B

Top Transcription factor binding sites by QIAGEN in the TAF1B gene promoter:
  • c-Ets-1
  • CUTL1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • NRF-2
  • Zic1
  • ZIC2

Genomic Locations for TAF1B Gene

Latest Assembly
chr2:9,843,442-9,934,416
(GRCh38/hg38)
Size:
90,975 bases
Orientation:
Plus strand

Previous Assembly
chr2:9,983,571-10,074,545
(GRCh37/hg19 by Entrez Gene)
Size:
90,975 bases
Orientation:
Plus strand

chr2:9,983,483-10,074,545
(GRCh37/hg19 by Ensembl)
Size:
91,063 bases
Orientation:
Plus strand

Genomic View for TAF1B Gene

Genes around TAF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF1B Gene

Proteins for TAF1B Gene

  • Protein details for TAF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53T94-TAF1B_HUMAN
    Recommended name:
    TATA box-binding protein-associated factor RNA polymerase I subunit B
    Protein Accession:
    Q53T94
    Secondary Accessions:
    • B4DI42
    • F8WD72
    • Q15574
    • Q8WVC3

    Protein attributes for TAF1B Gene

    Size:
    588 amino acids
    Molecular mass:
    68832 Da
    Quaternary structure:
    • Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3.
    SequenceCaution:
    • Sequence=AAA62863.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TAF1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF1B Gene

Post-translational modifications for TAF1B Gene

  • Ubiquitination at Lys56, Lys431, and Lys508
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TAF1B Gene

Domains & Families for TAF1B Gene

Gene Families for TAF1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TAF1B Gene

Suggested Antigen Peptide Sequences for TAF1B Gene

GenScript: Design optimal peptide antigens:
  • Transcription initiation factor SL1/TIF-IB subunit B (TAF1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q53T94

UniProtKB/Swiss-Prot:

TAF1B_HUMAN :
  • Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (PubMed:21921198 and PubMed:21921199).
  • Belongs to the RRN7/TAF1B family.
Domain:
  • Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (PubMed:21921198 and PubMed:21921199).
Family:
  • Belongs to the RRN7/TAF1B family.
genes like me logo Genes that share domains with TAF1B: view

Function for TAF1B Gene

Molecular function for TAF1B Gene

UniProtKB/Swiss-Prot Function:
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
GENATLAS Biochemistry:
template activating factor I,specifically interactin with mitotic cyclin B

Phenotypes From GWAS Catalog for TAF1B Gene

Gene Ontology (GO) - Molecular Function for TAF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001164 RNA polymerase I CORE element sequence-specific DNA binding IEA,IDA 21921198
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17318177
GO:0017025 TBP-class protein binding TAS 21921199
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TAF1B: view
genes like me logo Genes that share phenotypes with TAF1B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF1B Gene

Localization for TAF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF1B Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF1B gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 7801123
GO:0005654 nucleoplasm TAS --
GO:0005668 RNA polymerase transcription factor SL1 complex IBA 21873635
GO:0005730 nucleolus IEA,IDA --
GO:0070860 RNA polymerase I core factor complex IEA,IDA 21921198
genes like me logo Genes that share ontologies with TAF1B: view

Pathways & Interactions for TAF1B Gene

genes like me logo Genes that share pathways with TAF1B: view

Pathways by source for TAF1B Gene

6 Qiagen pathways for TAF1B Gene
  • Assembly of RNA Polymerase-I Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

Gene Ontology (GO) - Biological Process for TAF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001188 RNA polymerase I preinitiation complex assembly IEA,IDA 21921199
GO:0006351 transcription, DNA-templated NAS 7801123
GO:0006360 transcription by RNA polymerase I IEA --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with TAF1B: view

No data available for SIGNOR curated interactions for TAF1B Gene

Drugs & Compounds for TAF1B Gene

No Compound Related Data Available

Transcripts for TAF1B Gene

mRNA/cDNA for TAF1B Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF1B

Alternative Splicing Database (ASD) splice patterns (SP) for TAF1B Gene

No ASD Table

Relevant External Links for TAF1B Gene

GeneLoc Exon Structure for
TAF1B

Expression for TAF1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF1B Gene

This gene is overexpressed in Lung (51.7) and Platelet (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF1B Gene



Protein tissue co-expression partners for TAF1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF1B

SOURCE GeneReport for Unigene cluster for TAF1B Gene:

Hs.584833

Evidence on tissue expression from TISSUES for TAF1B Gene

  • Intestine(4.3)
  • Nervous system(4.3)
  • Blood(2.9)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with TAF1B: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF1B Gene

Orthologs for TAF1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAF1B 29 30
  • 99.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TAF1B 29 30
  • 87.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TAF1B 29 30
  • 85.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Taf1b 29 16 30
  • 80.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Taf1b 29
  • 79.39 (n)
Oppossum
(Monodelphis domestica)
Mammalia TAF1B 30
  • 69 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 64 (a)
OneToMany
-- 30
  • 63 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TAF1B 29 30
  • 64.84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TAF1B 30
  • 44 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia taf1b 29
  • 58.93 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52843 29
Zebrafish
(Danio rerio)
Actinopterygii taf1b 29 30
  • 50.49 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 23 (a)
OneToOne
Species where no ortholog for TAF1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TAF1B Gene

ENSEMBL:
Gene Tree for TAF1B (if available)
TreeFam:
Gene Tree for TAF1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF1B: view image
Alliance of Genome Resources:
Additional Orthologs for TAF1B

Paralogs for TAF1B Gene

No data available for Paralogs for TAF1B Gene

Variants for TAF1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF1B Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1054565 -- p.Thr351Ala
rs16867223 -- p.Arg292His
rs16867245 -- p.Thr487Met
rs1820965 -- p.Glu462Asp
rs2303914 -- p.Ala6Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAF1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TAF1B Gene

Variant ID Type Subtype PubMed ID
dgv1100e212 CNV loss 25503493
dgv3714n100 CNV loss 25217958
nsv1003026 CNV gain 25217958
nsv1003855 CNV loss 25217958
nsv1005938 CNV loss 25217958
nsv1009210 CNV loss 25217958
nsv580960 CNV gain 21841781

Variation tolerance for TAF1B Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.20; 90.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF1B
Leiden Open Variation Database (LOVD)
TAF1B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF1B Gene

Disorders for TAF1B Gene

Additional Disease Information for TAF1B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TAF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF1B Gene

Publications for TAF1B Gene

  1. Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. (PMID: 10894955) Di Pietro C … Purrello M (Cytogenetics and cell genetics 2000) 3 4 22
  2. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PMID: 7801123) Comai L … Tjian R (Science (New York, N.Y.) 1994) 2 3 4
  3. Yeast Rrn7 and human TAF1B are TFIIB-related RNA polymerase I general transcription factors. (PMID: 21921198) Knutson BA … Hahn S (Science (New York, N.Y.) 2011) 3 4
  4. TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I. (PMID: 21921199) Naidu S … Zomerdijk JC (Science (New York, N.Y.) 2011) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40

Products for TAF1B Gene

Sources for TAF1B Gene