This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011] See more...

Aliases for TAF1A Gene

Aliases for TAF1A Gene

  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A 2 3 5
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kD 2 3
  • TATA Box-Binding Protein-Associated Factor RNA Polymerase I Subunit A 3 4
  • RNA Polymerase I-Specific TBP-Associated Factor 48 KDa 3 4
  • Transcription Initiation Factor SL1/TIF-IB Subunit A 3 4
  • TATA Box-Binding Protein-Associated Factor 1A 3 4
  • Transcription Factor SL1 3 4
  • TBP-Associated Factor 1A 3 4
  • TAFI48 3 4
  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I, A 3
  • SL1, 48kD Subunit 3
  • MGC:17061 3
  • RAFI48 3
  • SL1 3

External Ids for TAF1A Gene

Previous GeneCards Identifiers for TAF1A Gene

  • GC01M221325
  • GC01M218646
  • GC01M219263
  • GC01M219787
  • GC01M219119
  • GC01M220797
  • GC01M222731
  • GC01M193405

Summaries for TAF1A Gene

Entrez Gene Summary for TAF1A Gene

  • This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

GeneCards Summary for TAF1A Gene

TAF1A (TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A) is a Protein Coding gene. Diseases associated with TAF1A include Familial Isolated Dilated Cardiomyopathy. Among its related pathways are RNA Polymerase I Promoter Escape and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot Summary for TAF1A Gene

  • Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

Gene Wiki entry for TAF1A Gene

Additional gene information for TAF1A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF1A Gene

Genomics for TAF1A Gene

GeneHancer (GH) Regulatory Elements for TAF1A Gene

Promoters and enhancers for TAF1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF1A on UCSC Golden Path with GeneCards custom track

Genomic Locations for TAF1A Gene

Genomic Locations for TAF1A Gene
chr1:222,557,902-222,590,096
(GRCh38/hg38)
Size:
32,195 bases
Orientation:
Minus strand
chr1:222,731,244-222,763,275
(GRCh37/hg19)
Size:
32,032 bases
Orientation:
Minus strand

Genomic View for TAF1A Gene

Genes around TAF1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF1A Gene

Proteins for TAF1A Gene

  • Protein details for TAF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15573-TAF1A_HUMAN
    Recommended name:
    TATA box-binding protein-associated factor RNA polymerase I subunit A
    Protein Accession:
    Q15573
    Secondary Accessions:
    • B2RDZ8
    • D3DTB7
    • Q9NWA1

    Protein attributes for TAF1A Gene

    Size:
    450 amino acids
    Molecular mass:
    52676 Da
    Quaternary structure:
    • Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT. Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868).

    Alternative splice isoforms for TAF1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF1A Gene

Post-translational modifications for TAF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAF1A Gene

Domains & Families for TAF1A Gene

Gene Families for TAF1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF1A Gene

Suggested Antigen Peptide Sequences for TAF1A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57856, highly similar to TATA box-binding protein-associated factor RNA polymerase I subunit A (B4DS21_HUMAN)
  • Transcription initiation factor SL1/TIF-IB subunit A (TAF1A_HUMAN)
genes like me logo Genes that share domains with TAF1A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TAF1A Gene

Function for TAF1A Gene

Molecular function for TAF1A Gene

UniProtKB/Swiss-Prot Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

Phenotypes From GWAS Catalog for TAF1A Gene

Gene Ontology (GO) - Molecular Function for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17318177
genes like me logo Genes that share ontologies with TAF1A: view
genes like me logo Genes that share phenotypes with TAF1A: view

Human Phenotype Ontology for TAF1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for TAF1A Gene

miRTarBase miRNAs that target TAF1A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF1A Gene

Localization for TAF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF1A gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000120 RNA polymerase I transcription factor complex IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with TAF1A: view

Pathways & Interactions for TAF1A Gene

genes like me logo Genes that share pathways with TAF1A: view

Pathways by source for TAF1A Gene

6 Qiagen pathways for TAF1A Gene
  • Assembly of RNA Polymerase-I Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

Gene Ontology (GO) - Biological Process for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006360 transcription by RNA polymerase I TAS 7801123
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
GO:0006363 termination of RNA polymerase I transcription TAS --
GO:0006366 transcription by RNA polymerase II TAS 7801123
genes like me logo Genes that share ontologies with TAF1A: view

No data available for SIGNOR curated interactions for TAF1A Gene

Drugs & Compounds for TAF1A Gene

(1) Additional Compounds for TAF1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAF1A: view

Transcripts for TAF1A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:

Relevant External Links for TAF1A Gene

GeneLoc Exon Structure for
TAF1A
ECgene alternative splicing isoforms for
TAF1A

Expression for TAF1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF1A Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF1A Gene



Protein tissue co-expression partners for TAF1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF1A Gene:

TAF1A

SOURCE GeneReport for Unigene cluster for TAF1A Gene:

Hs.153088

Evidence on tissue expression from TISSUES for TAF1A Gene

  • Skin(4.2)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with TAF1A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF1A Gene

Orthologs for TAF1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF1A 33 32
  • 99.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAF1A 33 32
  • 87.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TAF1A 33 32
  • 85.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Taf1a 17 33 32
  • 81.03 (n)
rat
(Rattus norvegicus)
Mammalia Taf1a 32
  • 80.8 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF1A 33
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF1A 33
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF1A 33 32
  • 59.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF1A 33
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf1a 32
  • 55.05 (n)
zebrafish
(Danio rerio)
Actinopterygii taf1a 33 32
  • 50.79 (n)
OneToOne
Species where no ortholog for TAF1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF1A Gene

ENSEMBL:
Gene Tree for TAF1A (if available)
TreeFam:
Gene Tree for TAF1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF1A: view image

Paralogs for TAF1A Gene

No data available for Paralogs for TAF1A Gene

Variants for TAF1A Gene

Sequence variations from dbSNP and Humsavar for TAF1A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000049603 -- 222,577,081(-) C/T intron_variant
rs1000154705 -- 222,565,190(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000271475 -- 222,570,316(-) C/G intron_variant
rs1000276793 -- 222,558,770(-) A/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000307880 -- 222,558,379(-) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TAF1A Gene

Variant ID Type Subtype PubMed ID
esv2762168 CNV loss 21179565

Variation tolerance for TAF1A Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF1A Gene

Human Gene Mutation Database (HGMD)
TAF1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF1A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF1A Gene

Disorders for TAF1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF1A Gene - From: Orphanet

Disorder Aliases PubMed IDs
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
- elite association - COSMIC cancer census association via MalaCards
Search TAF1A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAF1A

genes like me logo Genes that share disorders with TAF1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF1A Gene

Publications for TAF1A Gene

  1. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PMID: 7801123) Comai L … Tjian R (Science (New York, N.Y.) 1994) 2 3 4 23 56
  2. Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. (PMID: 20075868) Müller C … Calkhoven CF (The EMBO journal 2010) 3 4 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for TAF1A Gene

Sources for TAF1A Gene