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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]
TAF13 (TATA-Box Binding Protein Associated Factor 13) is a Protein Coding gene. Diseases associated with TAF13 include Mental Retardation, Autosomal Recessive 60 and Primary Autosomal Recessive Microcephaly. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein C-terminus binding. An important paralog of this gene is SUPT3H.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 7729427 |
GO:0008022 | protein C-terminus binding | IPI | 7729427 |
GO:0016251 | RNA polymerase II general transcription initiation factor activity | IC | 29111974 |
GO:0017025 | TBP-class protein binding | IPI | 29111974 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005669 | transcription factor TFIID complex | NAS | 9695952 |
GO:0005730 | nucleolus | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Assembly of RNA Polymerase-II Initiation Complex
.91
Transcription of mRNA
.91
|
Protein Acetylation and Deacetylation
.51
Crosstalk Between CARM1 and ESRs
.39
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.32
|
2 | HIV Life Cycle |
.91
.64
|
.45
|
3 | Formation of HIV-1 elongation complex containing HIV-1 Tat | ||
4 | Regulation of TP53 Activity | ||
5 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006352 | DNA-templated transcription, initiation | NAS | 9695952 |
GO:0006366 | transcription by RNA polymerase II | IBA,TAS | -- |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0042795 | snRNA transcription by RNA polymerase II | TAS | -- |
GO:1901796 | regulation of signal transduction by p53 class mediator | TAS | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TAF13 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TAF13 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TAF13 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TAF13 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Taf13 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TAF13 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TAF13 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | taf13 30 |
|
||
Str.6597 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4615 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | taf13 30 31 |
|
OneToOne | |
wufc20d03 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1879 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Taf13 30 31 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008045 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | taf-13 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TAF13 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | TAF13 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5080 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4198 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
986182 | Uncertain Significance: Inborn genetic diseases | 109,066,214(-) |
C/T NM_005645.4(TAF13):c.125G>A (p.Gly42Asp) |
MISSENSE | |
rs1060505029 | Pathogenic: Mental retardation, autosomal recessive 60; not provided. Mental retardation, autosomal recessive 60 (MRT60) [MIM:617432] | 109,066,220(-) |
A/Tp.Met40Lys NM_005645.4(TAF13):c.119T>A (p.Met40Lys) |
MISSENSE | |
rs1060505030 | Pathogenic: Mental retardation, autosomal recessive 60; not provided. Mental retardation, autosomal recessive 60 (MRT60) [MIM:617432] | 109,075,001(-) |
A/Tp.Leu31His NM_005645.4(TAF13):c.92T>A (p.Leu31His) |
MISSENSE | |
rs749360940 | Likely Benign: not provided | 109,066,189(-) |
A/G NM_005645.4(TAF13):c.150T>C (p.Tyr50=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2669667 | CNV | deletion | 23128226 |
esv2715973 | CNV | deletion | 23290073 |
esv2715984 | CNV | deletion | 23290073 |
esv3587147 | CNV | loss | 21293372 |
esv3894001 | CNV | gain | 25118596 |
nsv1078062 | CNV | deletion | 25765185 |
nsv1119707 | CNV | deletion | 24896259 |
nsv831026 | CNV | loss | 17160897 |
nsv954947 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mental retardation, autosomal recessive 60 |
|
|
primary autosomal recessive microcephaly |
|
|
schizophrenia |
|
|
dystonia 3, torsion, x-linked |
|
|
microcephaly |
|
|