Aliases for TAF13 Gene
- TATA-Box Binding Protein Associated Factor 13 2 3 5
- Transcription Initiation Factor TFIID Subunit 13 2 3 4
- TAFII18 2 3 4
- TAF13 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 18kDa 2 3
- TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, K, 18kD 2 3
- Transcription Initiation Factor TFIID 18 KDa Subunit 3 4
External Ids for TAF13 Gene
Previous HGNC Symbols for TAF13 Gene
Previous GeneCards Identifiers for TAF13 Gene
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAF13 Gene
TAF13 (TATA-Box Binding Protein Associated Factor 13) is a Protein Coding gene. Diseases associated with TAF13 include Mental Retardation, Autosomal Recessive 60 and Primary Autosomal Recessive Microcephaly. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein C-terminus binding. An important paralog of this gene is SUPT3H.
UniProtKB/Swiss-Prot Summary for TAF13 Gene
Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells.