Aliases for TAF12 Gene
External Ids for TAF12 Gene
Previous HGNC Symbols for TAF12 Gene
Previous GeneCards Identifiers for TAF12 Gene
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for TAF12 Gene
TAF12 (TATA-Box Binding Protein Associated Factor 12) is a Protein Coding gene. Diseases associated with TAF12 include Choroid Plexus Cancer and Atypical Choroid Plexus Papilloma. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Chromatin organization. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity.
UniProtKB/Swiss-Prot Summary for TAF12 Gene
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.