Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, w... See more...

Aliases for TAF12 Gene

Aliases for TAF12 Gene

  • TATA-Box Binding Protein Associated Factor 12 2 3 5
  • TAFII20 2 3 4
  • TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, J, 20kD 2 3
  • Transcription Initiation Factor TFIID 20/15 KDa Subunits 3 4
  • Transcription Initiation Factor TFIID Subunit 12 3 4
  • TAFII-20/TAFII-15 3 4
  • TAFII20/TAFII15 3 4
  • TAF2J 3 4
  • TAF12 5
  • TAF15 4

External Ids for TAF12 Gene

Previous HGNC Symbols for TAF12 Gene

  • TAF2J

Previous GeneCards Identifiers for TAF12 Gene

  • GC01P028822
  • GC01M027888
  • GC01M028434
  • GC01M028617
  • GC01M028750
  • GC01M028801
  • GC01M028915
  • GC01M027182
  • GC01M028645
  • GC01M028647
  • GC01M028640
  • GC01M028649
  • GC01M028622
  • GC01M028627
  • GC01M028632
  • GC01M028637
  • GC01M028659

Summaries for TAF12 Gene

Entrez Gene Summary for TAF12 Gene

  • Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for TAF12 Gene

TAF12 (TATA-Box Binding Protein Associated Factor 12) is a Protein Coding gene. Diseases associated with TAF12 include Choroid Plexus Cancer and Atypical Choroid Plexus Papilloma. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Chromatin organization. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot Summary for TAF12 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

Gene Wiki entry for TAF12 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF12 Gene

Genomics for TAF12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAF12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF12

Top Transcription factor binding sites by QIAGEN in the TAF12 gene promoter:
  • AP-4
  • CUTL1
  • E47
  • GR-alpha
  • Lmo2
  • MyoD
  • Pbx1a
  • POU6F1 (c2)
  • Tal-1
  • TBP

Genomic Locations for TAF12 Gene

Latest Assembly
chr1:28,589,323-28,648,707
(GRCh38/hg38)
Size:
59,385 bases
Orientation:
Minus strand

Previous Assembly
chr1:28,929,362-28,969,579
(GRCh37/hg19 by Entrez Gene)
Size:
40,218 bases
Orientation:
Minus strand

chr1:28,915,835-28,969,597
(GRCh37/hg19 by Ensembl)
Size:
53,763 bases
Orientation:
Minus strand

Genomic View for TAF12 Gene

Genes around TAF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF12 Gene

Proteins for TAF12 Gene

  • Protein details for TAF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16514-TAF12_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 12
    Protein Accession:
    Q16514
    Secondary Accessions:
    • D3DPM5
    • Q15775
    • Q5T077

    Protein attributes for TAF12 Gene

    Size:
    161 amino acids
    Molecular mass:
    17924 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/KIAA0764, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts (isoform TAFII15 and isoform TAFII20) with ATF7 (via the transactivation domain); the interaction is prevented by sumoylation of ATF7 and promotes (isoform TAFII20 only) the transactivation of ATF7.

    Three dimensional structures from OCA and Proteopedia for TAF12 Gene

    Alternative splice isoforms for TAF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF12 Gene

Post-translational modifications for TAF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF12 Gene

Antibodies for research

  • Boster Bio Antibodies for TAF12

No data available for DME Specific Peptides for TAF12 Gene

Domains & Families for TAF12 Gene

Gene Families for TAF12 Gene

Protein Domains for TAF12 Gene

InterPro:
Blocks:
  • Transcription initiation factor TFIID

Suggested Antigen Peptide Sequences for TAF12 Gene

GenScript: Design optimal peptide antigens:
  • Transcription initiation factor TFIID 20/15 kDa subunits (TAF12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16514

UniProtKB/Swiss-Prot:

TAF12_HUMAN :
  • Belongs to the TAF12 family.
Family:
  • Belongs to the TAF12 family.
genes like me logo Genes that share domains with TAF12: view

Function for TAF12 Gene

Molecular function for TAF12 Gene

UniProtKB/Swiss-Prot Function:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

Phenotypes From GWAS Catalog for TAF12 Gene

Gene Ontology (GO) - Molecular Function for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA,IDA 15601843
GO:0003713 transcription coactivator activity IDA 11564863
GO:0005515 protein binding IPI 7667268
GO:0008134 transcription factor binding IDA 17264123
GO:0016251 contributes_to RNA polymerase II general transcription initiation factor activity IDA 9603525
genes like me logo Genes that share ontologies with TAF12: view
genes like me logo Genes that share phenotypes with TAF12: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF12 Gene

Localization for TAF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF12 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
plasma membrane 0

Gene Ontology (GO) - Cellular Components for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IEA --
GO:0000125 PCAF complex IDA --
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex TAS,IDA 14580349
genes like me logo Genes that share ontologies with TAF12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAF12 Gene

Pathways & Interactions for TAF12 Gene

genes like me logo Genes that share pathways with TAF12: view

Pathways by source for TAF12 Gene

1 GeneGo (Thomson Reuters) pathway for TAF12 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
7 Qiagen pathways for TAF12 Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

SIGNOR curated interactions for TAF12 Gene

Activates:

Gene Ontology (GO) - Biological Process for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006352 DNA-templated transcription, initiation IDA 9603525
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0043966 histone H3 acetylation IDA 11564863
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TAF12: view

Drugs & Compounds for TAF12 Gene

No Compound Related Data Available

Transcripts for TAF12 Gene

mRNA/cDNA for TAF12 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF12

Alternative Splicing Database (ASD) splice patterns (SP) for TAF12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TAF12 Gene

GeneLoc Exon Structure for
TAF12

Expression for TAF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF12 Gene

Protein differential expression in normal tissues from HIPED for TAF12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAF12 Gene



Protein tissue co-expression partners for TAF12 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF12

SOURCE GeneReport for Unigene cluster for TAF12 Gene:

Hs.530251

mRNA Expression by UniProt/SwissProt for TAF12 Gene:

Q16514-TAF12_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TAF12 Gene

  • Liver(4.3)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with TAF12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF12 Gene

Orthologs for TAF12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF12 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAF12 29 30
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 99 (a)
OneToMany
TAF12 29
  • 96.48 (n)
-- 30
  • 76 (a)
OneToMany
-- 30
  • 50 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TAF12 29 30
  • 95.24 (n)
OneToMany
-- 30
  • 91 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia TAF12 30
  • 94 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Taf12 29
  • 91.72 (n)
Mouse
(Mus musculus)
Mammalia Taf12 29 16 30
  • 91.1 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TAF12 30
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TAF12 29 30
  • 84.06 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TAF12 30
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia taf12 29
  • 73.5 (n)
Str.7323 29
African clawed frog
(Xenopus laevis)
Amphibia taf12-A-prov 29
Zebrafish
(Danio rerio)
Actinopterygii taf12 29 30
  • 73.79 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003135 29
  • 64.06 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Taf12 29 30
  • 54.82 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea taf-12 30
  • 14 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF12 30 32 32
  • 12 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4626 30
  • 36 (a)
OneToOne
Species where no ortholog for TAF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TAF12 Gene

ENSEMBL:
Gene Tree for TAF12 (if available)
TreeFam:
Gene Tree for TAF12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF12: view image
Alliance of Genome Resources:
Additional Orthologs for TAF12

Paralogs for TAF12 Gene

No data available for Paralogs for TAF12 Gene

Variants for TAF12 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAF12 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TAF12 Gene

Variant ID Type Subtype PubMed ID
esv2660216 CNV deletion 23128226
esv2665007 CNV deletion 23128226
esv3585589 CNV loss 21293372
nsv475854 CNV novel sequence insertion 20440878
nsv476520 CNV novel sequence insertion 20440878
nsv506924 OTHER sequence alteration 20534489
nsv545916 CNV gain 21841781
nsv819244 CNV loss 19587683
nsv822209 CNV loss 20364138

Variation tolerance for TAF12 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF12
Leiden Open Variation Database (LOVD)
TAF12

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF12 Gene

Disorders for TAF12 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TAF12 Gene - From: COP

Disorder Aliases PubMed IDs
choroid plexus cancer
  • choroid plexus neoplasm
atypical choroid plexus papilloma
  • atypical papilloma of choroid plexus
splenic manifestation of leukemia
  • splenic leukemia
cerebrovascular benign neoplasm
cerebral ventricle cancer
  • cerebral ventricle neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search TAF12 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAF12

genes like me logo Genes that share disorders with TAF12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF12 Gene

Publications for TAF12 Gene

  1. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PMID: 15735663) Hamard PJ … Chatton B (Oncogene 2005) 3 4 22
  2. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PMID: 10594036) Gangloff YG … Davidson I (Molecular and cellular biology 2000) 3 4 22
  3. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G … Davidson I (The EMBO journal 1995) 2 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TAF12 Gene

Sources for TAF12 Gene