Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory sign... See more...

Aliases for TAF11 Gene

Aliases for TAF11 Gene

  • TATA-Box Binding Protein Associated Factor 11 2 3 5
  • TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 28kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, I, 28kD 2 3
  • Transcription Initiation Factor TFIID 28 KDa Subunit 3 4
  • Transcription Initiation Factor TFIID Subunit 11 3 4
  • TFIID Subunit P30-Beta 3 4
  • TAF(II)28 3 4
  • TAFII-28 3 4
  • TAFII28 3 4
  • TAF2I 3 4
  • Transcription Initiation Factor TFIID 28 KD Subunit 3
  • MGC:15243 3
  • PRO2134 3

External Ids for TAF11 Gene

Previous HGNC Symbols for TAF11 Gene

  • TAF2I

Previous GeneCards Identifiers for TAF11 Gene

  • GC06M034847
  • GC06M034892
  • GC06M034953
  • GC06M034568
  • GC06M034974
  • GC06M035239
  • GC06M035734
  • GC06M035589
  • GC06M035592
  • GC06M038951
  • GC06M039643
  • GC06M039947
  • GC06M036292
  • GC06M036661
  • GC06M037014
  • GC06M037364
  • GC06M037720
  • GC06M038066
  • GC06M038456
  • GC06M038801

Summaries for TAF11 Gene

Entrez Gene Summary for TAF11 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for TAF11 Gene

TAF11 (TATA-Box Binding Protein Associated Factor 11) is a Protein Coding gene. Diseases associated with TAF11 include Facioscapulohumeral Muscular Dystrophy 1 and Epidermodysplasia Verruciformis 1. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAF11L2.

UniProtKB/Swiss-Prot Summary for TAF11 Gene

  • Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Gene Wiki entry for TAF11 Gene

Additional gene information for TAF11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF11 Gene

Genomics for TAF11 Gene

GeneHancer (GH) Regulatory Elements for TAF11 Gene

Promoters and enhancers for TAF11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF11

Top Transcription factor binding sites by QIAGEN in the TAF11 gene promoter:
  • AML1a
  • AP-4
  • CREB
  • deltaCREB
  • HEN1
  • HOXA5
  • LCR-F1
  • POU3F1
  • STAT3

Genomic Locations for TAF11 Gene

Genomic Locations for TAF11 Gene
chr6:34,877,462-34,888,071
(GRCh38/hg38)
Size:
10,610 bases
Orientation:
Minus strand
chr6:34,845,555-34,855,866
(GRCh37/hg19)
Size:
10,312 bases
Orientation:
Minus strand

Genomic View for TAF11 Gene

Genes around TAF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF11 Gene

Proteins for TAF11 Gene

  • Protein details for TAF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15544-TAF11_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 11
    Protein Accession:
    Q15544
    Secondary Accessions:
    • B2R8R3
    • B4DY18
    • Q9UHS0

    Protein attributes for TAF11 Gene

    Size:
    211 amino acids
    Molecular mass:
    23307 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF13 both in vitro and intracellularly; also interacts directly with TBP.
    SequenceCaution:
    • Sequence=AAF22038.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF11 Gene

    Alternative splice isoforms for TAF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF11 Gene

Post-translational modifications for TAF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF11 Gene

No data available for DME Specific Peptides for TAF11 Gene

Domains & Families for TAF11 Gene

Gene Families for TAF11 Gene

Protein Domains for TAF11 Gene

Blocks:
  • TAFII28-like protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAF11 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50289, highly similar to Transcription initiation factor TFIID subunit 11 (B4DY18_HUMAN)
  • Transcription initiation factor TFIID 28 kDa subunit (TAF11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15544

UniProtKB/Swiss-Prot:

TAF11_HUMAN :
  • TBP and TAFII18 bind to distinct domains of TAFII28.
  • Belongs to the TAF11 family.
Domain:
  • TBP and TAFII18 bind to distinct domains of TAFII28.
Family:
  • Belongs to the TAF11 family.
genes like me logo Genes that share domains with TAF11: view

Function for TAF11 Gene

Molecular function for TAF11 Gene

UniProtKB/Swiss-Prot Function:
Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Phenotypes From GWAS Catalog for TAF11 Gene

Gene Ontology (GO) - Molecular Function for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 8670810
GO:0005515 protein binding IPI 7729427
GO:0008134 transcription factor binding IBA 21873635
GO:0042809 vitamin D receptor binding IPI 10744685
GO:0046966 thyroid hormone receptor binding IPI 10744685
genes like me logo Genes that share ontologies with TAF11: view
genes like me logo Genes that share phenotypes with TAF11: view

Animal Models for TAF11 Gene

MGI Knock Outs for TAF11:
  • Taf11 Taf11<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF11 Gene

Localization for TAF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF11 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 7729427
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TAF11: view

Pathways & Interactions for TAF11 Gene

genes like me logo Genes that share pathways with TAF11: view

Pathways by source for TAF11 Gene

1 KEGG pathway for TAF11 Gene
1 GeneGo (Thomson Reuters) pathway for TAF11 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
7 Qiagen pathways for TAF11 Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

SIGNOR curated interactions for TAF11 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0042795 snRNA transcription by RNA polymerase II TAS --
GO:0043923 positive regulation by host of viral transcription IDA 9108034
GO:0051123 RNA polymerase II preinitiation complex assembly IBA 21873635
genes like me logo Genes that share ontologies with TAF11: view

Drugs & Compounds for TAF11 Gene

No Compound Related Data Available

Transcripts for TAF11 Gene

mRNA/cDNA for TAF11 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF11 Gene

No ASD Table

Relevant External Links for TAF11 Gene

GeneLoc Exon Structure for
TAF11

Expression for TAF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF11 Gene

This gene is overexpressed in Stomach (62.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF11 Gene



Protein tissue co-expression partners for TAF11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF11

SOURCE GeneReport for Unigene cluster for TAF11 Gene:

Hs.112444

Evidence on tissue expression from TISSUES for TAF11 Gene

  • Nervous system(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TAF11: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF11 Gene

Orthologs for TAF11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF11 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAF11 31 30
  • 89.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TAF11 31 30
  • 89.37 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF11 31
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf11 17 31 30
  • 84.68 (n)
rat
(Rattus norvegicus)
Mammalia Taf11 30
  • 84.04 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 75 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves TAF11 31 30
  • 69.6 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF11 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf11 30
  • 74.4 (n)
Str.1018 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8264 30
zebrafish
(Danio rerio)
Actinopterygii taf11 31 30
  • 74.88 (n)
OneToOne
Dr.15759 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5100 30
fruit fly
(Drosophila melanogaster)
Insecta Taf11 31 32 30
  • 63.44 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-11.1 31
  • 23 (a)
OneToMany
taf-11.3 31
  • 22 (a)
OneToMany
taf-11.2 31
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF11 33 31
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2026 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2026 30
Species where no ortholog for TAF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF11 Gene

ENSEMBL:
Gene Tree for TAF11 (if available)
TreeFam:
Gene Tree for TAF11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF11: view image

Paralogs for TAF11 Gene

Variants for TAF11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF11 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs11537996 - p.Ser155Phe
rs15922 - p.Thr68Arg

Additional dbSNP identifiers (rs#s) for TAF11 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAF11 Gene

Variant ID Type Subtype PubMed ID
dgv5955n100 CNV gain 25217958
esv2763967 CNV gain 21179565
nsv1026121 CNV gain 25217958
nsv462905 CNV gain 19166990
nsv508402 CNV deletion 20534489
nsv602906 CNV gain 21841781

Variation tolerance for TAF11 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF11 Gene

Disorders for TAF11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TAF11 Gene - From: DISEASES