Aliases for TAF11 Gene
- TATA-Box Binding Protein Associated Factor 11 2 3 5
- TAFII28 2 3 4
- TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 28kDa 2 3
- TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, I, 28kD 2 3
- Transcription Initiation Factor TFIID 28 KDa Subunit 3 4
- Transcription Initiation Factor TFIID Subunit 11 3 4
- TFIID Subunit P30-Beta 3 4
External Ids for TAF11 Gene
Previous HGNC Symbols for TAF11 Gene
Previous GeneCards Identifiers for TAF11 Gene
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for TAF11 Gene
TAF11 (TATA-Box Binding Protein Associated Factor 11) is a Protein Coding gene. Diseases associated with TAF11 include Facioscapulohumeral Muscular Dystrophy 1 and Epidermodysplasia Verruciformis 1. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAF11L2.
UniProtKB/Swiss-Prot Summary for TAF11 Gene
Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).