Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory sign... See more...

Aliases for TAF10 Gene

Aliases for TAF10 Gene

  • TATA-Box Binding Protein Associated Factor 10 2 3 5
  • TAFII30 2 3 4
  • TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 30kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, H, 30kD 2 3
  • Transcription Initiation Factor TFIID 30 KDa Subunit 3 4
  • Transcription Initiation Factor TFIID Subunit 10 3 4
  • TAF(II)30 3 4
  • TAFII-30 3 4
  • STAF28 3 4
  • TAF2A 3 4
  • TAF2H 3 4
  • Transcription Initiation Factor TFIID 30 KD Subunit 3
  • TAF10 5

External Ids for TAF10 Gene

Previous HGNC Symbols for TAF10 Gene

  • TAF2H
  • TAF2A

Previous GeneCards Identifiers for TAF10 Gene

  • GC11M007375
  • GC11M007092
  • GC11M006586
  • GC11M006596
  • GC11M006588
  • GC11M006291
  • GC11M006627

Summaries for TAF10 Gene

Entrez Gene Summary for TAF10 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF10 Gene

TAF10 (TATA-Box Binding Protein Associated Factor 10) is a Protein Coding gene. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Chromatin organization. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity.

UniProtKB/Swiss-Prot Summary for TAF10 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

Gene Wiki entry for TAF10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAF10 Gene

Genomics for TAF10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAF10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006601 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.4 +5.0 5043 12.4 BCLAF1 SP1 ZNF207 NCOR1 IKZF1 MYC ZNF600 SSRP1 JUND ZNF592 RRP8 ILK HSALNG0082453 NONHSAG007540.2 TAF10 FHIP1B CAVIN3 OLFML1 DNHD1 ENSG00000254641
GH11J006614 Promoter/Enhancer 0.5 Ensembl dbSUPER 250.7 -1.6 -1562 0.2 lnc-ILK-9 TAF10 ENSG00000285338 lnc-TPP1-2 TPP1
GH11J006654 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.5 -42.2 -42231 5.2 ZNF600 IKZF1 SIN3A FOXA2 ZNF521 SMAD4 NKRF RARA BCL6 HLTF DCHS1 RRP8 ENSG00000254641 ILK FHIP1B MRPL17 RPL21P94 ENSG00000254400 LOC100506258 TAF10
GH11J006742 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -132.6 -132593 6.7 ZNF207 MYC NCOR1 IKZF1 ZNF592 POLR2A SIN3A TRIM22 TAL1 ZNF316 GVINP1 MRPL17 lnc-OR2AG2-1 ILK OR2AG2 CAVIN3 RRP8 ENSG00000254641 TAF10 OR10A4
GH11J006693 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.2 -82.5 -82459 4 NCOR1 ZNF592 ATF2 NFIC ZNF341 TAF9B RXRA JUND RELA ZNF318 HSALNG0082471 RRP8 OLFML1 GVINP2 OR2AG2 ILK ENSG00000254595 ENSG00000254400 TIMM10B TAF10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAF10

Top Transcription factor binding sites by QIAGEN in the TAF10 gene promoter:
  • ATF
  • ATF-2
  • CRE-BP1
  • STAT3

Genomic Locations for TAF10 Gene

Latest Assembly
chr11:6,606,294-6,612,539
(GRCh38/hg38)
Size:
6,246 bases
Orientation:
Minus strand

Previous Assembly
chr11:6,627,524-6,633,447
(GRCh37/hg19 by Entrez Gene)
Size:
5,924 bases
Orientation:
Minus strand

chr11:6,627,526-6,633,898
(GRCh37/hg19 by Ensembl)
Size:
6,373 bases
Orientation:
Minus strand

Genomic View for TAF10 Gene

Genes around TAF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF10 Gene

Proteins for TAF10 Gene

  • Protein details for TAF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12962-TAF10_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 10
    Protein Accession:
    Q12962
    Secondary Accessions:
    • O00703
    • Q13175
    • Q6FH13

    Protein attributes for TAF10 Gene

    Size:
    218 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP (PubMed:9885574). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP (PubMed:10373431, PubMed:12601814). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:11564863, PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with TAF3 (PubMed:11438666). Interacts with LOXL2 (PubMed:25959397).

    Three dimensional structures from OCA and Proteopedia for TAF10 Gene

neXtProt entry for TAF10 Gene

Post-translational modifications for TAF10 Gene

  • Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II.
  • Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription.
  • Ubiquitination at Lys161
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF10 Gene

Domains & Families for TAF10 Gene

Gene Families for TAF10 Gene

Protein Domains for TAF10 Gene

InterPro:
Blocks:
  • Transcription initiation factor TFIID 23-30kDa subunit signature

Suggested Antigen Peptide Sequences for TAF10 Gene

GenScript: Design optimal peptide antigens:
  • Transcription initiation factor TFIID 30 kDa subunit (TAF10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q12962

UniProtKB/Swiss-Prot:

TAF10_HUMAN :
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
  • Belongs to the TAF10 family.
Domain:
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
Family:
  • Belongs to the TAF10 family.
genes like me logo Genes that share domains with TAF10: view

Function for TAF10 Gene

Molecular function for TAF10 Gene

UniProtKB/Swiss-Prot Function:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

Phenotypes From GWAS Catalog for TAF10 Gene

Gene Ontology (GO) - Molecular Function for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004402 contributes_to histone acetyltransferase activity IDA 9674425
GO:0005515 contributes_to protein binding IPI 15870280
GO:0016251 contributes_to RNA polymerase II general transcription initiation factor activity IDA 9603525
GO:0019899 enzyme binding IPI 16415881
genes like me logo Genes that share ontologies with TAF10: view
genes like me logo Genes that share phenotypes with TAF10: view

Animal Models for TAF10 Gene

MGI Knock Outs for TAF10:

miRNA for TAF10 Gene

miRTarBase miRNAs that target TAF10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF10 Gene

Localization for TAF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF10 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex IDA 9674425
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 7729427
GO:0005737 cytoplasm IDA 15870280
genes like me logo Genes that share ontologies with TAF10: view

Pathways & Interactions for TAF10 Gene

genes like me logo Genes that share pathways with TAF10: view

Pathways by source for TAF10 Gene

1 GeneGo (Thomson Reuters) pathway for TAF10 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
7 Qiagen pathways for TAF10 Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

Gene Ontology (GO) - Biological Process for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001889 liver development IEA --
GO:0006352 DNA-templated transcription, initiation IEA,IDA 9212049
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF10: view

No data available for SIGNOR curated interactions for TAF10 Gene

Drugs & Compounds for TAF10 Gene

No Compound Related Data Available

Transcripts for TAF10 Gene

mRNA/cDNA for TAF10 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAF10

Alternative Splicing Database (ASD) splice patterns (SP) for TAF10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for TAF10 Gene

GeneLoc Exon Structure for
TAF10

Expression for TAF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF10 Gene

mRNA differential expression in normal tissues according to GTEx for TAF10 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for TAF10 Gene

This gene is overexpressed in Liver (26.2) and Breast (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF10 Gene



Protein tissue co-expression partners for TAF10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAF10

SOURCE GeneReport for Unigene cluster for TAF10 Gene:

Hs.5158

Evidence on tissue expression from TISSUES for TAF10 Gene

  • Liver(4.6)
  • Kidney(4.6)
  • Muscle(3.3)
  • Nervous system(3.2)
  • Heart(2.9)
  • Intestine(2.9)
  • Stomach(2.5)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with TAF10: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF10 Gene

Orthologs for TAF10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAF10 29 30
  • 97.86 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TAF10 30
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TAF10 29 30
  • 94.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TAF10 29 30
  • 93.73 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Taf10 29 16 30
  • 90.67 (n)
OneToMany
Gm4799 30
  • 90 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Taf10 29
  • 90.06 (n)
Lizard
(Anolis carolinensis)
Reptilia TAF10 30
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia taf10 29
  • 76.55 (n)
Str.6326 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.23803 29
Zebrafish
(Danio rerio)
Actinopterygii taf10 29 30
  • 69.84 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10113 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008612 29
  • 67.97 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Taf10 29
  • 63.64 (n)
Taf10b 30 31
  • 52 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea taf-10 30
  • 38 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF10 30 32
  • 25 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons TAFII15 29
  • 52.61 (n)
Rice
(Oryza sativa)
Liliopsida Os09g0431500 29
  • 54.58 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7978 30
  • 52 (a)
OneToOne
Species where no ortholog for TAF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TAF10 Gene

ENSEMBL:
Gene Tree for TAF10 (if available)
TreeFam:
Gene Tree for TAF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF10: view image
Alliance of Genome Resources:
Additional Orthologs for TAF10

Paralogs for TAF10 Gene

Pseudogenes.org Pseudogenes for TAF10 Gene

genes like me logo Genes that share paralogs with TAF10: view

No data available for Paralogs for TAF10 Gene

Variants for TAF10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAF10 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
1002892 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,609,849(-) A/AGGCCACAAGCTCA
NM_004517.4(ILK):c.978+5_979-38dup
THREE_PRIME_UTR_VARIANT,INTRON
1015492 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,608,131(-) C/G
NM_004517.4(ILK):c.175C>G (p.Arg59Gly)
MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON
1015536 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,609,825(-) C/G
NM_004517.4(ILK):c.958C>G (p.Leu320Val)
MISSENSE_VARIANT,THREE_PRIME_UTR
1021993 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,609,353(-) C/T
NM_004517.4(ILK):c.673C>T (p.Arg225Ter)
NONSENSE,THREE_PRIME_UTR
1022333 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,610,559(-) G/A
NM_004517.4(ILK):c.1307G>A (p.Arg436Gln)
MISSENSE_VARIANT,THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAF10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TAF10 Gene

Variant ID Type Subtype PubMed ID
esv996362 CNV deletion 20482838
nsv1035138 CNV gain 25217958
nsv553373 CNV loss 21841781
nsv825755 CNV gain 20364138

Variation tolerance for TAF10 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF10
Leiden Open Variation Database (LOVD)
TAF10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF10 Gene

Disorders for TAF10 Gene

Additional Disease Information for TAF10

No disorders were found for TAF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF10 Gene

Publications for TAF10 Gene

  1. Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30). (PMID: 8530084) Scheer E … Tora L (Genomics 1995) 3 4 22
  2. Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. (PMID: 7923369) Jacq X … Tora L (Cell 1994) 2 3 4
  3. LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation. (PMID: 25959397) Iturbide A … Peiró S (Molecular cell 2015) 3 4
  4. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PMID: 18206972) Zhao Y … Devys D (Molecular cell 2008) 3 4
  5. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. (PMID: 17375202) Demény MA … Tora L (PloS one 2007) 3 22

Products for TAF10 Gene

Sources for TAF10 Gene