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Aliases for TAF10 Gene

Aliases for TAF10 Gene

  • TATA-Box Binding Protein Associated Factor 10 2 3 5
  • TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 30kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, H, 30kD 2 3
  • Transcription Initiation Factor TFIID 30 KDa Subunit 3 4
  • TAF(II)30 3 4
  • TAFII-30 3 4
  • TAFII30 3 4
  • STAF28 3 4
  • TAF2A 3 4
  • TAF2H 3 4
  • Transcription Initiation Factor TFIID 30 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 10 3

External Ids for TAF10 Gene

Previous HGNC Symbols for TAF10 Gene

  • TAF2H
  • TAF2A

Previous GeneCards Identifiers for TAF10 Gene

  • GC11M007375
  • GC11M007092
  • GC11M006586
  • GC11M006596
  • GC11M006588
  • GC11M006291
  • GC11M006627

Summaries for TAF10 Gene

Entrez Gene Summary for TAF10 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF10 Gene

TAF10 (TATA-Box Binding Protein Associated Factor 10) is a Protein Coding gene. Diseases associated with TAF10 include Neuronal Ceroid Lipofuscinosis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity.

UniProtKB/Swiss-Prot for TAF10 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

Gene Wiki entry for TAF10 Gene

Additional gene information for TAF10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF10 Gene

Genomics for TAF10 Gene

GeneHancer (GH) Regulatory Elements for TAF10 Gene

Promoters and enhancers for TAF10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006601 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.4 +5.2 5171 12.4 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 SSRP1 ZNF610 RRP8 ILK TAF10 DNHD1 FAM160A2 ENSG00000254641 DCHS1 CAVIN3 ENSG00000254400 PIR55036
GH11J006742 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -132.6 -132565 6.5 HDAC1 PKNOX1 SMAD1 RB1 NFRKB YBX1 BATF KLF5 TCF12 ZNF766 GVINP1 MRPL17 OR2AG2 ILK RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1
GH11J006693 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 -82.3 -82332 3.3 HDAC1 PKNOX1 TAF9B TCF12 ZNF121 ATF7 PHF21A RXRA CAVIN1 ZBTB11 GC11P006693 GC11P006694 RRP8 OLFML1 GVINP2 OR2AG2 ILK LOC644169 ENSG00000254400 TIMM10B
GH11J006317 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 5.2 +291.8 291763 7 PKNOX1 BATF RFX5 RCOR1 FOS ETV6 IKZF2 RUNX3 CREM SMARCC1 CAVIN3 FAM160A2 RRP8 OR56A1 TAF10 LOC101927825 GC11M006313
GH11J006667 Enhancer 0.9 Ensembl ENCODE 10.8 -55.4 -55362 1.1 CTCF CEBPG EBF1 E4F1 RAD21 RELA ZNF143 SMC3 PRDM10 IKZF2 ENSG00000254641 TAF10 ILK RRP8 GC11P006673 DCHS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAF10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAF10 gene promoter:
  • STAT3
  • ATF-2
  • CRE-BP1
  • ATF

Genomic Locations for TAF10 Gene

Genomic Locations for TAF10 Gene
chr11:6,606,296-6,612,667
(GRCh38/hg38)
Size:
6,372 bases
Orientation:
Minus strand
chr11:6,627,526-6,633,898
(GRCh37/hg19)
Size:
6,373 bases
Orientation:
Minus strand

Genomic View for TAF10 Gene

Genes around TAF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF10 Gene

Proteins for TAF10 Gene

  • Protein details for TAF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12962-TAF10_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 10
    Protein Accession:
    Q12962
    Secondary Accessions:
    • O00703
    • Q13175
    • Q6FH13

    Protein attributes for TAF10 Gene

    Size:
    218 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP (PubMed:9885574). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP (PubMed:10373431, PubMed:12601814). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:11564863, PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with TAF3 (PubMed:11438666). Interacts with LOXL2 (PubMed:25959397).

    Three dimensional structures from OCA and Proteopedia for TAF10 Gene

neXtProt entry for TAF10 Gene

Post-translational modifications for TAF10 Gene

  • Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II.
  • Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription.
  • Ubiquitination at isoforms=161
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF10 Gene

Domains & Families for TAF10 Gene

Gene Families for TAF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF10 Gene

Suggested Antigen Peptide Sequences for TAF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12962

UniProtKB/Swiss-Prot:

TAF10_HUMAN :
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
  • Belongs to the TAF10 family.
Domain:
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
Family:
  • Belongs to the TAF10 family.
genes like me logo Genes that share domains with TAF10: view

Function for TAF10 Gene

Molecular function for TAF10 Gene

UniProtKB/Swiss-Prot Function:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

Phenotypes From GWAS Catalog for TAF10 Gene

Gene Ontology (GO) - Molecular Function for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 contributes_to DNA binding transcription factor activity IDA 9603525
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 9674425
GO:0005515 contributes_to protein binding IPI 15870280
genes like me logo Genes that share ontologies with TAF10: view
genes like me logo Genes that share phenotypes with TAF10: view

Animal Models for TAF10 Gene

MGI Knock Outs for TAF10:

Animal Model Products

miRNA for TAF10 Gene

miRTarBase miRNAs that target TAF10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF10 Gene

Localization for TAF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF10 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex IDA 9674425
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 7729427
GO:0005737 cytoplasm IDA 15870280
genes like me logo Genes that share ontologies with TAF10: view

Pathways & Interactions for TAF10 Gene

genes like me logo Genes that share pathways with TAF10: view

Gene Ontology (GO) - Biological Process for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001889 liver development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IEA,IDA 9212049
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TAF10: view

No data available for SIGNOR curated interactions for TAF10 Gene

Drugs & Compounds for TAF10 Gene

No Compound Related Data Available

Transcripts for TAF10 Gene

mRNA/cDNA for TAF10 Gene

Unigene Clusters for TAF10 Gene

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for TAF10 Gene

GeneLoc Exon Structure for
TAF10
ECgene alternative splicing isoforms for
TAF10

Expression for TAF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF10 Gene

mRNA differential expression in normal tissues according to GTEx for TAF10 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for TAF10 Gene

This gene is overexpressed in Liver (26.2) and Breast (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF10 Gene



Protein tissue co-expression partners for TAF10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF10 Gene:

TAF10

SOURCE GeneReport for Unigene cluster for TAF10 Gene:

Hs.5158

Evidence on tissue expression from TISSUES for TAF10 Gene

  • Kidney(4.5)
  • Liver(4.5)
  • Muscle(3)
  • Nervous system(2.8)
  • Heart(2.6)
  • Intestine(2.5)
  • Stomach(2.5)
genes like me logo Genes that share expression patterns with TAF10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF10 Gene

Orthologs for TAF10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF10 34 33
  • 97.86 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF10 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF10 34 33
  • 94.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TAF10 34 33
  • 93.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Taf10 16 34 33
  • 90.67 (n)
Gm4799 34
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Taf10 33
  • 90.06 (n)
lizard
(Anolis carolinensis)
Reptilia TAF10 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf10 33
  • 76.55 (n)
Str.6326 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23803 33
zebrafish
(Danio rerio)
Actinopterygii taf10 34 33
  • 69.84 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10113 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008612 33
  • 67.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta Taf10 33
  • 63.64 (n)
Taf10b 34 35
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-10 34
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF10 36 34
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TAFII15 33
  • 52.61 (n)
rice
(Oryza sativa)
Liliopsida Os09g0431500 33
  • 54.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7978 34
  • 52 (a)
OneToOne
Species where no ortholog for TAF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF10 Gene

ENSEMBL:
Gene Tree for TAF10 (if available)
TreeFam:
Gene Tree for TAF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAF10: view image

Paralogs for TAF10 Gene

Pseudogenes.org Pseudogenes for TAF10 Gene

genes like me logo Genes that share paralogs with TAF10: view

No data available for Paralogs for TAF10 Gene

Variants for TAF10 Gene

Sequence variations from dbSNP and Humsavar for TAF10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1044739961 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 6,612,772(-) C/T upstream_transcript_variant
rs1045450 benign, Neuronal Ceroid-Lipofuscinosis, Recessive 6,613,428(-) C/G upstream_transcript_variant
rs1048574242 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 6,613,134(-) A/C upstream_transcript_variant
rs188148381 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 6,613,560(-) G/C upstream_transcript_variant
rs188544089 uncertain-significance, Neuronal Ceroid-Lipofuscinosis, Recessive 6,613,118(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TAF10 Gene

Variant ID Type Subtype PubMed ID
esv996362 CNV deletion 20482838
nsv1035138 CNV gain 25217958
nsv553373 CNV loss 21841781
nsv825755 CNV gain 20364138

Variation tolerance for TAF10 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF10 Gene

Disorders for TAF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuronal ceroid lipofuscinosis
  • batten disease
- elite association - COSMIC cancer census association via MalaCards
Search TAF10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAF10

genes like me logo Genes that share disorders with TAF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF10 Gene

Publications for TAF10 Gene

  1. Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30). (PMID: 8530084) Scheer E … Tora L (Genomics 1995) 3 4 22 58
  2. Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. (PMID: 7923369) Jacq X … Tora L (Cell 1994) 2 3 4 58
  3. LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation. (PMID: 25959397) Iturbide A … Peiró S (Molecular cell 2015) 3 4 58
  4. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PMID: 18206972) Zhao Y … Devys D (Molecular cell 2008) 3 4 58
  5. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. (PMID: 17375202) Demény MA … Tora L (PloS one 2007) 3 22 58

Products for TAF10 Gene

Sources for TAF10 Gene

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