Aliases for TADA3 Gene
External Ids for TADA3 Gene
Previous HGNC Symbols for TADA3 Gene
Previous GeneCards Identifiers for TADA3 Gene
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
GeneCards Summary for TADA3 Gene
TADA3 (Transcriptional Adaptor 3) is a Protein Coding gene. Diseases associated with TADA3 include Tolosa-Hunt Syndrome. Among its related pathways are Chromatin organization and Deubiquitination. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein domain specific binding.
UniProtKB/Swiss-Prot Summary for TADA3 Gene
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.