DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase ... See more...

Aliases for TADA3 Gene

Aliases for TADA3 Gene

  • Transcriptional Adaptor 3 2 3 5
  • HADA3 2 3 4
  • ADA3 2 3 4
  • Alteration/Deficiency In Activation 3 2 3
  • Transcriptional Adapter 3 3 4
  • ADA3-Like Protein 3 4
  • ADA3 Homolog 3 4
  • STAF54 3 4
  • TADA3L 3 4
  • NGG1 2 3
  • Transcriptional Adaptor 3 (NGG1 Homolog, Yeast)-Like 2
  • Epididymis Secretory Sperm Binding Protein 3
  • Transcriptional Adapter 3-Like 4
  • FLJ20221 2
  • FLJ21329 2
  • TADA3 5

External Ids for TADA3 Gene

Previous HGNC Symbols for TADA3 Gene

  • TADA3L

Previous GeneCards Identifiers for TADA3 Gene

  • GC03M009797
  • GC03M009822

Summaries for TADA3 Gene

Entrez Gene Summary for TADA3 Gene

  • DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for TADA3 Gene

TADA3 (Transcriptional Adaptor 3) is a Protein Coding gene. Diseases associated with TADA3 include Tolosa-Hunt Syndrome. Among its related pathways are Chromatin organization and Deubiquitination. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein domain specific binding.

UniProtKB/Swiss-Prot Summary for TADA3 Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for TADA3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TADA3 Gene

Genomics for TADA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TADA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TADA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TADA3

Genomic Locations for TADA3 Gene

Latest Assembly
chr3:9,779,860-9,793,011
(GRCh38/hg38)
Size:
13,152 bases
Orientation:
Minus strand

Previous Assembly
chr3:9,821,648-9,834,695
(GRCh37/hg19 by Entrez Gene)
Size:
13,048 bases
Orientation:
Minus strand

chr3:9,821,544-9,834,695
(GRCh37/hg19 by Ensembl)
Size:
13,152 bases
Orientation:
Minus strand

Genomic View for TADA3 Gene

Genes around TADA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TADA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TADA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA3 Gene

Proteins for TADA3 Gene

  • Protein details for TADA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75528-TADA3_HUMAN
    Recommended name:
    Transcriptional adapter 3
    Protein Accession:
    O75528
    Secondary Accessions:
    • Q6FI83
    • Q9UFS2

    Protein attributes for TADA3 Gene

    Size:
    432 amino acids
    Molecular mass:
    48902 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Alternative splice isoforms for TADA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TADA3 Gene

Post-translational modifications for TADA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TADA3 Gene

No data available for DME Specific Peptides for TADA3 Gene

Domains & Families for TADA3 Gene

Gene Families for TADA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TADA3 Gene

Suggested Antigen Peptide Sequences for TADA3 Gene

GenScript: Design optimal peptide antigens:
  • Transcriptional adapter 3-like (TADA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75528

UniProtKB/Swiss-Prot:

TADA3_HUMAN :
  • Belongs to the NGG1 family.
Family:
  • Belongs to the NGG1 family.
genes like me logo Genes that share domains with TADA3: view

Function for TADA3 Gene

Molecular function for TADA3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Phenotypes From GWAS Catalog for TADA3 Gene

Gene Ontology (GO) - Molecular Function for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IBA,IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IBA 21873635
GO:0005515 protein binding IPI 15383276
GO:0016922 nuclear receptor binding IPI 20413580
GO:0019904 protein domain specific binding IPI 20413580
genes like me logo Genes that share ontologies with TADA3: view
genes like me logo Genes that share phenotypes with TADA3: view

Animal Models for TADA3 Gene

MGI Knock Outs for TADA3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TADA3

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TADA3 Gene

Localization for TADA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TADA3 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA 21873635
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IBA,IDA 18838386
GO:0030914 STAGA complex IDA 11564863
genes like me logo Genes that share ontologies with TADA3: view

Pathways & Interactions for TADA3 Gene

genes like me logo Genes that share pathways with TADA3: view

Pathways by source for TADA3 Gene

1 GeneGo (Thomson Reuters) pathway for TADA3 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes

Gene Ontology (GO) - Biological Process for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS,IBA 21873635
GO:0010628 positive regulation of gene expression IMP 20413580
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with TADA3: view

No data available for SIGNOR curated interactions for TADA3 Gene

Drugs & Compounds for TADA3 Gene

No Compound Related Data Available

Transcripts for TADA3 Gene

mRNA/cDNA for TADA3 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TADA3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TADA3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5: - - - - -
SP6:
SP7: -
SP8: - - -

Relevant External Links for TADA3 Gene

GeneLoc Exon Structure for
TADA3

Expression for TADA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TADA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for TADA3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.9) and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TADA3 Gene



Protein tissue co-expression partners for TADA3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TADA3

SOURCE GeneReport for Unigene cluster for TADA3 Gene:

Hs.386390

mRNA Expression by UniProt/SwissProt for TADA3 Gene:

O75528-TADA3_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for TADA3 Gene

  • Muscle(4.5)
  • Intestine(4.4)
  • Liver(4.4)
  • Pancreas(4.2)
  • Nervous system(4)
  • Lung(3.1)
  • Kidney(2.3)
  • Eye(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with TADA3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TADA3 Gene

Orthologs for TADA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TADA3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TADA3 29 30
  • 99.69 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TADA3 30
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TADA3 30
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TADA3 29 30
  • 92.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TADA3 29 30
  • 92.28 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tada3 29 16 30
  • 90.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tada3 29
  • 90.05 (n)
Chicken
(Gallus gallus)
Aves TADA3 29 30
  • 83.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TADA3 30
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tada3 29
  • 77.78 (n)
Str.4150 29
African clawed frog
(Xenopus laevis)
Amphibia MGC64374 29
Zebrafish
(Danio rerio)
Actinopterygii tada3l 29 30
  • 72.54 (n)
OneToOne
wufa03f04 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010459 29
  • 49.61 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta dik 29 30
  • 47.99 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5222 30
  • 44 (a)
OneToOne
Species where no ortholog for TADA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TADA3 Gene

ENSEMBL:
Gene Tree for TADA3 (if available)
TreeFam:
Gene Tree for TADA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TADA3: view image
Alliance of Genome Resources:
Additional Orthologs for TADA3

Paralogs for TADA3 Gene

No data available for Paralogs for TADA3 Gene

Variants for TADA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TADA3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs150345911 Benign: not provided 9,789,739(-) C/T
NM_001278270.1(TADA3):c.432G>A (p.Arg144=)
SYNONYMOUS
rs61751574 Benign: not provided 9,785,375(-) C/T
NM_001278270.1(TADA3):c.861G>A (p.Gly287=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TADA3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TADA3 Gene

Variant ID Type Subtype PubMed ID
nsv1010768 CNV gain 25217958
nsv834615 CNV loss 17160897

Variation tolerance for TADA3 Gene

Residual Variation Intolerance Score: 9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TADA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TADA3
Leiden Open Variation Database (LOVD)
TADA3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TADA3 Gene

Disorders for TADA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TADA3 Gene - From: COP

Disorder Aliases PubMed IDs
tolosa-hunt syndrome
  • tolosa hunt syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TADA3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TADA3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TADA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TADA3 Gene

Publications for TADA3 Gene

  1. hADA3 is required for p53 activity. (PMID: 11707411) Wang T … Brachmann RK (The EMBO journal 2001) 2 3 4
  2. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko VV … Nakatani Y (Cell 1998) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  4. HPV16 E6-induced and E6AP-dependent inhibition of the transcriptional coactivator hADA3 in human cervical carcinoma cells. (PMID: 19194825) Hu Y … Xie X (Cancer investigation 2009) 3 22
  5. Ankyrin repeats-containing cofactors interact with ADA3 and modulate its co-activator function. (PMID: 18377363) Li CW … Chen JD (The Biochemical journal 2008) 3 22

Products for TADA3 Gene

Sources for TADA3 Gene