TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010] See more...

Aliases for TADA2B Gene

Aliases for TADA2B Gene

  • Transcriptional Adaptor 2B 2 3 5
  • Transcriptional Adapter 2-Beta 3 4
  • ADA2-Like Protein Beta 3 4
  • ADA2-Beta 3 4
  • ADA2B 3 4
  • Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Beta 3
  • ADA2(Beta) 3
  • MGC21874 2
  • TADA2B 5

External Ids for TADA2B Gene

Previous GeneCards Identifiers for TADA2B Gene

  • GC04P007096
  • GC04P006972
  • GC04P007043
  • GC04P007045

Summaries for TADA2B Gene

Entrez Gene Summary for TADA2B Gene

  • TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TADA2B Gene

TADA2B (Transcriptional Adaptor 2B) is a Protein Coding gene. Diseases associated with TADA2B include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Chromatin organization and Deubiquitination. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is TADA2A.

UniProtKB/Swiss-Prot Summary for TADA2B Gene

  • Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TADA2B Gene

Genomics for TADA2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TADA2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J007041 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 260.6 +1.8 1802 4.2 SP1 ZNF207 MYC ZNF600 POLR2A ZIC2 YY1 MXD4 CTCF REST TADA2B CCDC96 GRPEL1 LOC100129931
GH04J007042 Promoter 0.4 Ensembl 250.7 -0.6 -598 0.2 ZBTB33 CCDC96 TADA2B piR-42138 LOC100129931 TBC1D14
GH04J006914 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.2 -125.3 -125260 5.1 NCOR1 MYC IKZF1 ZNF600 JUND ZNF580 ZNF592 CEBPA ZNF10 ZIC2 KIAA0232 TBC1D14 GRPEL1 TADA2B MAN2B2 S100P HSALNG0032664 piR-57133-443
GH04J006781 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.2 -258.9 -258898 4 SP1 MYC ZNF207 IKZF1 JUND ZNF592 POLR2A CEBPA ZIC2 ZBTB10 KIAA0232 lnc-KIAA0232-2 TADA2B TBC1D14 HSALNG0032657
GH04J007045 Enhancer 0.6 ENCODE 13.5 +4.7 4658 1.3 RXRA IRF4 EBF1 BHLHE40 IKZF1 NR2F1 TBL1XR1 EED RUNX3 SCRT2 LOC100129931 TADA2B CCDC96 piR-48759-221 GRPEL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TADA2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TADA2B

Top Transcription factor binding sites by QIAGEN in the TADA2B gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • E47
  • Elk-1
  • ER-alpha
  • Evi-1
  • GATA-1
  • NCX
  • Nkx2-5

Genomic Locations for TADA2B Gene

Latest Assembly
chr4:7,041,899-7,057,952
(GRCh38/hg38)
Size:
16,054 bases
Orientation:
Plus strand

Previous Assembly
chr4:7,045,099-7,059,679
(GRCh37/hg19 by Entrez Gene)
Size:
14,581 bases
Orientation:
Plus strand

chr4:7,043,626-7,059,679
(GRCh37/hg19 by Ensembl)
Size:
16,054 bases
Orientation:
Plus strand

Genomic View for TADA2B Gene

Genes around TADA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TADA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TADA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA2B Gene

Proteins for TADA2B Gene

  • Protein details for TADA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TJ2-TAD2B_HUMAN
    Recommended name:
    Transcriptional adapter 2-beta
    Protein Accession:
    Q86TJ2
    Secondary Accessions:
    • A0AUJ8
    • A4QMR7
    • B3KSN0
    • B3KU86
    • Q6MZG9

    Protein attributes for TADA2B Gene

    Size:
    420 amino acids
    Molecular mass:
    48470 Da
    Quaternary structure:
    • Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex.
    SequenceCaution:
    • Sequence=AAH47794.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI01338.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TADA2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TADA2B Gene

Post-translational modifications for TADA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TADA2B Gene

No data available for DME Specific Peptides for TADA2B Gene

Domains & Families for TADA2B Gene

Gene Families for TADA2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TADA2B Gene

Suggested Antigen Peptide Sequences for TADA2B Gene

GenScript: Design optimal peptide antigens:
  • ADA2-like protein beta (TAD2B_HUMAN)
genes like me logo Genes that share domains with TADA2B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TADA2B Gene

Function for TADA2B Gene

Molecular function for TADA2B Gene

UniProtKB/Swiss-Prot Function:
Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.

Phenotypes From GWAS Catalog for TADA2B Gene

Gene Ontology (GO) - Molecular Function for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0003713 transcription coactivator activity IBA 21873635
GO:0005515 protein binding IPI 29232376
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TADA2B: view
genes like me logo Genes that share phenotypes with TADA2B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TADA2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TADA2B Gene

Localization for TADA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TADA2B gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0030914 STAGA complex IEA --
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with TADA2B: view

Pathways & Interactions for TADA2B Gene

genes like me logo Genes that share pathways with TADA2B: view

Pathways by source for TADA2B Gene

Gene Ontology (GO) - Biological Process for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0016579 protein deubiquitination TAS --
GO:0035065 regulation of histone acetylation IEA --
GO:0035066 positive regulation of histone acetylation IBA 21873635
genes like me logo Genes that share ontologies with TADA2B: view

No data available for SIGNOR curated interactions for TADA2B Gene

Drugs & Compounds for TADA2B Gene

No Compound Related Data Available

Transcripts for TADA2B Gene

mRNA/cDNA for TADA2B Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TADA2B

Alternative Splicing Database (ASD) splice patterns (SP) for TADA2B Gene

No ASD Table

Relevant External Links for TADA2B Gene

GeneLoc Exon Structure for
TADA2B

Expression for TADA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TADA2B Gene

mRNA differential expression in normal tissues according to GTEx for TADA2B Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for TADA2B Gene

This gene is overexpressed in Lung (15.7), Cerebrospinal fluid (6.7), and Urinary Bladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TADA2B Gene



Protein tissue co-expression partners for TADA2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TADA2B

SOURCE GeneReport for Unigene cluster for TADA2B Gene:

Hs.518614

Evidence on tissue expression from TISSUES for TADA2B Gene

  • Nervous system(4.4)
  • Intestine(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TADA2B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TADA2B Gene

Orthologs for TADA2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TADA2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TADA2B 29 30
  • 99.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 94 (a)
OneToMany
TADA2B 29 30
  • 88.65 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Tada2b 29 16 30
  • 88.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tada2b 29
  • 88.1 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 88 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
-- 30
  • 21 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia TADA2B 29 30
  • 85.57 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TADA2B 30
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TADA2B 29 30
  • 84.6 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TADA2B 30
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tada2b 29
  • 77.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18623 29
Zebrafish
(Danio rerio)
Actinopterygii tada2b 29 30
  • 76.83 (n)
OneToOne
wufb72h11 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003109 29
  • 54.68 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Ada2b 29 30
  • 54.17 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADA2 30
  • 26 (a)
OneToMany
Species where no ortholog for TADA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TADA2B Gene

ENSEMBL:
Gene Tree for TADA2B (if available)
TreeFam:
Gene Tree for TADA2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TADA2B: view image
Alliance of Genome Resources:
Additional Orthologs for TADA2B

Paralogs for TADA2B Gene

Paralogs for TADA2B Gene

(1) SIMAP similar genes for TADA2B Gene using alignment to 3 proteins:

  • TAD2B_HUMAN
  • D6RC20_HUMAN
  • D6RJ05_HUMAN
genes like me logo Genes that share paralogs with TADA2B: view

Variants for TADA2B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TADA2B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TADA2B Gene

Variant ID Type Subtype PubMed ID
dgv8941n54 CNV gain 21841781
esv26516 CNV loss 19812545
esv2759221 CNV gain 17122850
esv34033 CNV loss 18971310
esv34196 OTHER inversion 12058347
nsv4217 CNV deletion 18451855
nsv428436 CNV gain 18775914
nsv469847 CNV gain 16826518
nsv593548 CNV loss 21841781
nsv593549 CNV gain+loss 21841781
nsv593550 CNV gain 21841781
nsv593556 CNV gain 21841781

Variation tolerance for TADA2B Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TADA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TADA2B
Leiden Open Variation Database (LOVD)
TADA2B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TADA2B Gene

Disorders for TADA2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TADA2B Gene - From: COP

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TADA2B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TADA2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TADA2B Gene

Publications for TADA2B Gene

  1. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PMID: 12972612) Barlev NA … Berger SL (Molecular and cellular biology 2003) 2 3 4 22
  2. The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. (PMID: 18936164) Gamper AM … Roeder RG (Molecular and cellular biology 2009) 2 3 22
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3

Products for TADA2B Gene

Sources for TADA2B Gene