TADA2A Gene (Protein Coding)

Transcriptional Adaptor 2A

GC17P037406
GIFtS:
38
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at ... See more...

Aliases for TADA2A Gene

Aliases for TADA2A Gene

  • Transcriptional Adaptor 2A 2 3 5
  • Transcriptional Adapter 2-Alpha 3 4
  • ADA2-Like Protein 3 4
  • TADA2L 3 4
  • Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Like 2
  • Transcriptional Adaptor 2 Alpha 3
  • Transcriptional Adapter 2-Like 4
  • ADA2A 3
  • KL04P 3
  • HADA2 3
  • ADA2 3

External Ids for TADA2A Gene

Previous HGNC Symbols for TADA2A Gene

  • TADA2L

Previous GeneCards Identifiers for TADA2A Gene

  • GC17P032842
  • GC17P035767
  • GC17P031705

Summaries for TADA2A Gene

Entrez Gene Summary for TADA2A Gene

  • Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]

GeneCards Summary for TADA2A Gene

TADA2A (Transcriptional Adaptor 2A) is a Protein Coding gene. Diseases associated with TADA2A include Chromosome 17Q12 Deletion Syndrome. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coregulator activity. An important paralog of this gene is TADA2B.

UniProtKB/Swiss-Prot Summary for TADA2A Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).

Gene Wiki entry for TADA2A Gene

Additional gene information for TADA2A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TADA2A Gene

Genomics for TADA2A Gene

GeneHancer (GH) Regulatory Elements for TADA2A Gene

Promoters and enhancers for TADA2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TADA2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for TADA2A Gene

Genomic Locations for TADA2A Gene
chr17:37,406,877-37,479,725
(GRCh38/hg38)
Size:
72,849 bases
Orientation:
Plus strand
chr17:35,766,965-35,839,835
(GRCh37/hg19)
Size:
72,871 bases
Orientation:
Plus strand

Genomic View for TADA2A Gene

Genes around TADA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TADA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TADA2A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TADA2A Gene

Proteins for TADA2A Gene

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  • Protein details for TADA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75478-TAD2A_HUMAN
    Recommended name:
    Transcriptional adapter 2-alpha
    Protein Accession:
    O75478
    Secondary Accessions:
    • A8MVD0
    • B3KMU9
    • Q9BVJ0
    • Q9UCW2
    • Q9UP49

    Protein attributes for TADA2A Gene

    Size:
    443 amino acids
    Molecular mass:
    51506 Da
    Quaternary structure:
    • Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Interacts with CCDC134 (PubMed:22644376).

    Three dimensional structures from OCA and Proteopedia for TADA2A Gene

    Alternative splice isoforms for TADA2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TADA2A Gene

Protein Expression for TADA2A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TADA2A Gene

  • Ubiquitination at Lys132, Lys398, and Lys407
  • Modification sites at PhosphoSitePlus

Other Protein References for TADA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TADA2A Gene

Domains & Families for TADA2A Gene

Gene Families for TADA2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TADA2A Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TADA2A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ39052 fis, clone NT2RP7011721, highly similar to Transcriptional adapter 2 (B3KU13_HUMAN)
  • Transcriptional adapter 2-like (TAD2A_HUMAN)
genes like me logo Genes that share domains with TADA2A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TADA2A Gene

Function for TADA2A Gene

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Molecular function for TADA2A Gene

UniProtKB/Swiss-Prot Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).

Phenotypes From GWAS Catalog for TADA2A Gene

Gene Ontology (GO) - Molecular Function for TADA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA 21873635
GO:0003713 transcription coactivator activity IEA,IBA 21873635
GO:0004402 contributes_to histone acetyltransferase activity IDA 9674425
genes like me logo Genes that share ontologies with TADA2A: view
genes like me logo Genes that share phenotypes with TADA2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TADA2A Gene

Localization for TADA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA2A Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TADA2A gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TADA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex IDA 9674425
GO:0005634 nucleus IBA,IEA 21873635
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA --
GO:0005694 chromosome IEA --
GO:0070461 SAGA-type complex IBA 21873635
genes like me logo Genes that share ontologies with TADA2A: view

Pathways & Interactions for TADA2A Gene

genes like me logo Genes that share pathways with TADA2A: view

Pathways by source for TADA2A Gene

1 GeneGo (Thomson Reuters) pathway for TADA2A Gene

Gene Ontology (GO) - Biological Process for TADA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006338 chromatin remodeling IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IEA,TAS 8552087
GO:0031063 regulation of histone deacetylation IEA --
GO:0031647 regulation of protein stability IEA --
genes like me logo Genes that share ontologies with TADA2A: view

No data available for SIGNOR curated interactions for TADA2A Gene

Drugs & Compounds for TADA2A Gene

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No Compound Related Data Available

Transcripts for TADA2A Gene

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mRNA/cDNA for TADA2A Gene

(4) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(112) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TADA2A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TADA2A Gene

No ASD Table

Relevant External Links for TADA2A Gene

GeneLoc Exon Structure for
TADA2A
ECgene alternative splicing isoforms for
TADA2A

Expression for TADA2A Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TADA2A Gene

mRNA expression in normal human tissues for TADA2A Gene
mRNA expression by BioGPS for TADA2A GenemRNA expression by GTEx for TADA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TADA2A Gene



Protein tissue co-expression partners for TADA2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TADA2A Gene:

TADA2A

SOURCE GeneReport for Unigene cluster for TADA2A Gene:

Hs.500066

mRNA Expression by UniProt/SwissProt for TADA2A Gene:

O75478-TAD2A_HUMAN
Tissue specificity: Expressed in all tissues, but most abundantly in testis.

Evidence on tissue expression from TISSUES for TADA2A Gene

  • Lymph node(4.2)
  • Muscle(4.2)
  • Spleen(4.2)
  • Eye(4.1)
  • Blood(4)
genes like me logo Genes that share expression patterns with TADA2A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TADA2A Gene

Orthologs for TADA2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TADA2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TADA2A 32
  • 99.85 (n)
dog
(Canis familiaris)
 Mammalia TADA2A 32
  • 95.33 (n)
cow
(Bos Taurus)
 Mammalia TADA2A 32
  • 94.28 (n)
mouse
(Mus musculus)
 Mammalia Tada2a 17 32
  • 90.67 (n)
rat
(Rattus norvegicus)
 Mammalia Tada2a 32
  • 90.52 (n)
chicken
(Gallus gallus)
 Aves TADA2A 32
  • 81.04 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia tada2a 32
  • 76.47 (n)
Str.10606 32
zebrafish
(Danio rerio)
 Actinopterygii tada2a 32
  • 71.6 (n)
Dr.12657 32
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.1143 32
fruit fly
(Drosophila melanogaster)
 Insecta Ada2a 32
  • 44.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes ADA2 32
  • 44.18 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0B01496g 32
  • 43.86 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AER318C 32
  • 43.15 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons ADA2B 32
  • 46.25 (n)
rice
(Oryza sativa)
 Liliopsida Os03g0750800 32
  • 46.07 (n)
bread mold
(Neurospora crassa)
 Ascomycetes NCU04459 32
  • 44.2 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ada2 32
  • 42.9 (n)
Species where no ortholog for TADA2A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA2A Gene

ENSEMBL:
Gene Tree for TADA2A (if available)
TreeFam:
Gene Tree for TADA2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TADA2A: view image

Paralogs for TADA2A Gene

Paralogs for TADA2A Gene

(1) SIMAP similar genes for TADA2A Gene using alignment to 6 proteins:

  • TAD2A_HUMAN
  • K7EJX2_HUMAN
  • K7EK94_HUMAN
  • K7EKE3_HUMAN
  • K7EME2_HUMAN
  • K7ER71_HUMAN
genes like me logo Genes that share paralogs with TADA2A: view

Variants for TADA2A Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TADA2A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000020853 -- 37,450,160(+) A/G intron_variant
rs1000068877 -- 37,472,627(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000084007 -- 37,473,112(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000085442 -- 37,466,549(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000134995 -- 37,425,493(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TADA2A Gene

Variant ID Type Subtype PubMed ID
dgv1462n106 CNV deletion 24896259
dgv3157n100 CNV gain 25217958
dgv524n67 CNV loss 20364138
dgv549e199 CNV deletion 23128226
dgv550e199 CNV deletion 23128226
esv1010097 CNV gain 20482838
esv2661747 CNV deletion 23128226
esv2715889 CNV deletion 23290073
esv2758687 CNV gain 17122850
esv2763164 CNV loss 21179565
esv3554385 CNV deletion 23714750
esv3640493 CNV gain 21293372
esv3640494 CNV gain 21293372
esv3640495 OTHER inversion 21293372
esv3640496 CNV loss 21293372
esv3640497 CNV loss 21293372
nsv1061860 CNV gain 25217958
nsv1136234 CNV deletion 24896259
nsv435684 CNV deletion 17901297
nsv476793 CNV novel sequence insertion 20440878
nsv9543 CNV loss 18304495

Variation tolerance for TADA2A Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TADA2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TADA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TADA2A Gene

Disorders for TADA2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for TADA2A Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q12 deletion syndrome
  • 17q12 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TADA2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TADA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TADA2A Gene

Publications for TADA2A Gene

  1. Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor. (PMID: 9154805) Henriksson A … Wright AP (Molecular and cellular biology 1997) 3 4 23 56
  2. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PMID: 8552087) Candau R … Berger SL (Molecular and cellular biology 1996) 2 3 4 56
  3. CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest. (PMID: 22644376) Huang J … Qiu X (Histochemistry and cell biology 2012) 3 4 56
  4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 43 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

ExternalLinks

View latest publications for TADA2A gene in Mastermind

Products for TADA2A Gene

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Sources for TADA2A Gene