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Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
TADA2A (Transcriptional Adaptor 2A) is a Protein Coding gene. Diseases associated with TADA2A include Chromosome 17Q12 Deletion Syndrome. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coregulator activity. An important paralog of this gene is TADA2B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IBA | 21873635 |
GO:0003713 | transcription coactivator activity | IEA,IBA | 21873635 |
GO:0004402 | contributes_to histone acetyltransferase activity | IDA | 9674425 |
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000125 | PCAF complex | IDA | 9674425 |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IEA | -- |
GO:0005694 | chromosome | IEA | -- |
GO:0070461 | SAGA-type complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chromatin organization | ||
2 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IEA | -- |
GO:0001932 | regulation of protein phosphorylation | IEA | -- |
GO:0006338 | chromatin remodeling | IBA | 21873635 |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,TAS | 8552087 |
GO:0031063 | regulation of histone deacetylation | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TADA2A 30 |
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Dog (Canis familiaris) |
Mammalia | TADA2A 30 |
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Cow (Bos Taurus) |
Mammalia | TADA2A 30 |
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Mouse (Mus musculus) |
Mammalia | Tada2a 30 17 |
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Rat (Rattus norvegicus) |
Mammalia | Tada2a 30 |
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Chicken (Gallus gallus) |
Aves | TADA2A 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tada2a 30 |
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Str.10606 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | tada2a 30 |
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Dr.12657 30 |
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Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1143 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | Ada2a 30 |
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||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ADA2 30 |
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||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B01496g 30 |
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||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER318C 30 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ADA2B 30 |
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Rice (Oryza sativa) |
Liliopsida | Os03g0750800 30 |
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Bread mold (Neurospora crassa) |
Ascomycetes | NCU04459 30 |
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Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ada2 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1462n106 | CNV | deletion | 24896259 |
dgv3157n100 | CNV | gain | 25217958 |
dgv524n67 | CNV | loss | 20364138 |
dgv549e199 | CNV | deletion | 23128226 |
dgv550e199 | CNV | deletion | 23128226 |
esv1010097 | CNV | gain | 20482838 |
esv2661747 | CNV | deletion | 23128226 |
esv2715889 | CNV | deletion | 23290073 |
esv2758687 | CNV | gain | 17122850 |
esv2763164 | CNV | loss | 21179565 |
esv3554385 | CNV | deletion | 23714750 |
esv3640493 | CNV | gain | 21293372 |
esv3640494 | CNV | gain | 21293372 |
esv3640495 | OTHER | inversion | 21293372 |
esv3640496 | CNV | loss | 21293372 |
esv3640497 | CNV | loss | 21293372 |
nsv1061860 | CNV | gain | 25217958 |
nsv1136234 | CNV | deletion | 24896259 |
nsv435684 | CNV | deletion | 17901297 |
nsv476793 | CNV | novel sequence insertion | 20440878 |
nsv9543 | CNV | loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chromosome 17q12 deletion syndrome |
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