TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009] See more...

Aliases for TADA1 Gene

Aliases for TADA1 Gene

  • Transcriptional Adaptor 1 2 3 5
  • STAF42 2 3 4
  • Transcriptional Adaptor 1 (HFI1 Homolog, Yeast) 2 3
  • Transcriptional Adapter 1-Like Protein 3 4
  • Transcriptional Adapter 1 3 4
  • TADA1L 3 4
  • HADA1 2 3
  • ADA1 2 3
  • HFI1 2 3
  • Transcriptional Adaptor 1 (HFI1 Homolog, Yeast)-Like 2
  • SPT3-Associated Factor 42 (STAF42) 3
  • SPT3-Associated Factor 42 4
  • TADA1 5

External Ids for TADA1 Gene

Previous HGNC Symbols for TADA1 Gene

  • TADA1L

Previous GeneCards Identifiers for TADA1 Gene

  • GC01M165093
  • GC01M138072

Summaries for TADA1 Gene

Entrez Gene Summary for TADA1 Gene

  • TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]

GeneCards Summary for TADA1 Gene

TADA1 (Transcriptional Adaptor 1) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity.

UniProtKB/Swiss-Prot Summary for TADA1 Gene

Additional gene information for TADA1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TADA1 Gene

Genomics for TADA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TADA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TADA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TADA1

Genomic Locations for TADA1 Gene

Genomic Locations for TADA1 Gene
chr1:166,856,510-166,876,264
(GRCh38/hg38)
Size:
19,755 bases
Orientation:
Minus strand
chr1:166,825,747-166,845,654
(GRCh37/hg19)
Size:
19,908 bases
Orientation:
Minus strand

Genomic View for TADA1 Gene

Genes around TADA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TADA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TADA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA1 Gene

Proteins for TADA1 Gene

  • Protein details for TADA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BN2-TADA1_HUMAN
    Recommended name:
    Transcriptional adapter 1
    Protein Accession:
    Q96BN2
    Secondary Accessions:
    • A8K4J9

    Protein attributes for TADA1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37382 Da
    Quaternary structure:
    • Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

neXtProt entry for TADA1 Gene

Post-translational modifications for TADA1 Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for TADA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TADA1 Gene

Domains & Families for TADA1 Gene

Gene Families for TADA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TADA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TADA1 Gene

GenScript: Design optimal peptide antigens:
  • Transcriptional adapter 1-like protein (TADA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96BN2

UniProtKB/Swiss-Prot:

TADA1_HUMAN :
  • Belongs to the TADA1 family.
Family:
  • Belongs to the TADA1 family.
genes like me logo Genes that share domains with TADA1: view

Function for TADA1 Gene

Molecular function for TADA1 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in transcriptional regulation.

Phenotypes From GWAS Catalog for TADA1 Gene

Gene Ontology (GO) - Molecular Function for TADA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IBA,IDA 11564863
GO:0004402 histone acetyltransferase activity IBA --
genes like me logo Genes that share ontologies with TADA1: view
genes like me logo Genes that share phenotypes with TADA1: view

Animal Models for TADA1 Gene

MGI Knock Outs for TADA1:
  • Tada1 Tada1<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TADA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TADA1 Gene

Localization for TADA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TADA1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TADA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA 21873635
GO:0005634 nucleus IEA,IDA 11564863
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with TADA1: view

Pathways & Interactions for TADA1 Gene

PathCards logo

SuperPathways for TADA1 Gene

genes like me logo Genes that share pathways with TADA1: view

Pathways by source for TADA1 Gene

Gene Ontology (GO) - Biological Process for TADA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0043966 histone H3 acetylation IBA,IDA 11564863
GO:1903508 positive regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with TADA1: view

No data available for SIGNOR curated interactions for TADA1 Gene

Drugs & Compounds for TADA1 Gene

No Compound Related Data Available

Transcripts for TADA1 Gene

mRNA/cDNA for TADA1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TADA1

Alternative Splicing Database (ASD) splice patterns (SP) for TADA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for TADA1 Gene

GeneLoc Exon Structure for
TADA1

Expression for TADA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TADA1 Gene

Protein differential expression in normal tissues from HIPED for TADA1 Gene

This gene is overexpressed in CD8 Tcells (20.3), CD4 Tcells (17.2), Retina (12.2), and Monocytes (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TADA1 Gene



Protein tissue co-expression partners for TADA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TADA1

SOURCE GeneReport for Unigene cluster for TADA1 Gene:

Hs.435967

Evidence on tissue expression from TISSUES for TADA1 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with TADA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TADA1 Gene

Orthologs for TADA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TADA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TADA1 30 31
  • 99.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TADA1 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TADA1 30 31
  • 92.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TADA1 30 31
  • 92.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tada1 30
  • 89.75 (n)
Mouse
(Mus musculus)
Mammalia Tada1 30 17 31
  • 89.15 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TADA1L 30 31
  • 80.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TADA1 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tada1 30
  • 72.61 (n)
Str.8277 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18350 30
Zebrafish
(Danio rerio)
Actinopterygii tada1 30
  • 64.93 (n)
CABZ01085888.1 31
  • 61 (a)
OneToOne
Dr.26909 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004085 30
  • 45.96 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Ada1-2 30 31
  • 44.52 (n)
OneToMany
Ada1-1 31
  • 26 (a)
OneToMany
Species where no ortholog for TADA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TADA1 Gene

ENSEMBL:
Gene Tree for TADA1 (if available)
TreeFam:
Gene Tree for TADA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TADA1: view image

Paralogs for TADA1 Gene

Pseudogenes.org Pseudogenes for TADA1 Gene

genes like me logo Genes that share paralogs with TADA1: view

No data available for Paralogs for TADA1 Gene

Variants for TADA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TADA1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
715435 Benign: not provided 166,863,911(-) T/A SYNONYMOUS_VARIANT
rs2272792 - p.Arg198Gln

Additional dbSNP identifiers (rs#s) for TADA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TADA1 Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185

Variation tolerance for TADA1 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TADA1 Gene

Human Gene Mutation Database (HGMD)
TADA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TADA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TADA1 Gene

Disorders for TADA1 Gene

Additional Disease Information for TADA1

No disorders were found for TADA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TADA1 Gene

Publications for TADA1 Gene

  1. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. (PMID: 11564863) Martinez E … Roeder RG (Molecular and cellular biology 2001) 2 3 4
  2. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. (PMID: 29656893) Gupta R … Choudhary C (Cell 2018) 3
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  4. MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. (PMID: 30415952) Kalkat M … Penn LZ (Molecular cell 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for TADA1 Gene

Sources for TADA1 Gene