Aliases for TACR3 Gene
External Ids for TACR3 Gene
Previous GeneCards Identifiers for TACR3 Gene
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
GeneCards Summary for TACR3 Gene
TACR3 (Tachykinin Receptor 3) is a Protein Coding gene. Diseases associated with TACR3 include Hypogonadotropic Hypogonadism 11 With Or Without Anosmia and Kallmann Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and tachykinin receptor activity. An important paralog of this gene is TACR1.
UniProtKB/Swiss-Prot Summary for TACR3 Gene
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (including the hippocampus, hypothalamus and substantia nigra).