Aliases for TACR2 Gene
External Ids for TACR2 Gene
Previous HGNC Symbols for TACR2 Gene
Previous GeneCards Identifiers for TACR2 Gene
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
GeneCards Summary for TACR2 Gene
TACR2 (Tachykinin Receptor 2) is a Protein Coding gene. Diseases associated with TACR2 include Retinitis Pigmentosa 67 and Baritosis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and substance K receptor activity. An important paralog of this gene is TACR3.
UniProtKB/Swiss-Prot Summary for TACR2 Gene
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
The neurokinin 2 (NK2) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (including inflammatory cells and bronchial smooth muscle).