This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also refe... See more...

Aliases for TACR2 Gene

Aliases for TACR2 Gene

  • Tachykinin Receptor 2 2 3 4 5
  • NK2R 2 3 4
  • SKR 2 3 4
  • Neurokinin A Receptor 3 4
  • Substance-K Receptor 3 4
  • NK-2 Receptor 3 4
  • NKNAR 3 4
  • TAC2R 3 4
  • NK-2R 3 4
  • Seven Transmembrane Helix Receptor 3
  • Neurokinin 2 Receptor 3
  • TACR2 5

External Ids for TACR2 Gene

Previous HGNC Symbols for TACR2 Gene

  • TAC2R
  • NKNAR

Previous GeneCards Identifiers for TACR2 Gene

  • GC10M069975
  • GC10M070250
  • GC10M071056
  • GC10M070509
  • GC10M070834
  • GC10M071163
  • GC10M065163

Summaries for TACR2 Gene

Entrez Gene Summary for TACR2 Gene

  • This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACR2 Gene

TACR2 (Tachykinin Receptor 2) is a Protein Coding gene. Diseases associated with TACR2 include Retinitis Pigmentosa 67 and Baritosis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and substance K receptor activity. An important paralog of this gene is TACR3.

UniProtKB/Swiss-Prot Summary for TACR2 Gene

  • This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Tocris Summary for TACR2 Gene

  • The neurokinin 2 (NK2) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (including inflammatory cells and bronchial smooth muscle).

Gene Wiki entry for TACR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TACR2 Gene

Genomics for TACR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TACR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J069417 Enhancer 1.1 Ensembl ENCODE dbSUPER 250.7 -1.2 -1184 1.5 CEBPA CHD4 KDM6A SMAD4 SAP130 ETV4 MIER3 RARA DMAP1 GABPB1 HSALNG0078575 TACR2 TSPAN15 lnc-TACR2-3
GH10J069415 Promoter/Enhancer 0.7 Ensembl dbSUPER 255.4 +1.0 1017 1.8 ZIC2 HNRNPL KDM1A TACR2 HSALNG0078575 TSPAN15 lnc-HK1-3 HK1
GH10J069416 Promoter/Enhancer 0.6 EPDnew dbSUPER 250.7 0.0 -20 0.1 ZIC2 HSALNG0078575 TACR2 TSPAN15
GH10J069407 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 +7.4 7373 3.8 BCLAF1 SP1 NCOR1 MYC SSRP1 ZNF580 ZNF592 ZNF10 NFIC ZIC2 CCAR1 DDX50 TACR2 HK1 SAR1A HKDC1 ENSG00000231748 RPL26P27 TSPAN15 SRGN
GH10J069445 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 5.3 -32.7 -32675 9 SP1 JUND ZIC2 ZBTB10 CEBPB FOXA1 HES1 MBD2 ZEB1 CTCF TSPAN15 HSALNG0078579 DDX50 CCAR1 DDX21 FAM241B VPS26A TACR2 AIFM2 piR-31199-034
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TACR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TACR2

Top Transcription factor binding sites by QIAGEN in the TACR2 gene promoter:
  • AREB6
  • c-Myb
  • CUTL1
  • E47
  • GATA-1
  • Hand1
  • HNF-4alpha1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for TACR2 Gene

Latest Assembly
chr10:69,403,903-69,416,918
(GRCh38/hg38)
Size:
13,016 bases
Orientation:
Minus strand

Previous Assembly
chr10:71,163,659-71,176,674
(GRCh37/hg19 by Entrez Gene)
Size:
13,016 bases
Orientation:
Minus strand

chr10:71,163,659-71,176,623
(GRCh37/hg19 by Ensembl)
Size:
12,965 bases
Orientation:
Minus strand

Genomic View for TACR2 Gene

Genes around TACR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR2 Gene

Proteins for TACR2 Gene

  • Protein details for TACR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21452-NK2R_HUMAN
    Recommended name:
    Substance-K receptor
    Protein Accession:
    P21452
    Secondary Accessions:
    • A8K7I1
    • Q4QRI5
    • Q8NGQ8
    • Q9UDE6
    • Q9UDE7

    Protein attributes for TACR2 Gene

    Size:
    398 amino acids
    Molecular mass:
    44442 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TACR2 Gene

Post-translational modifications for TACR2 Gene

  • Glycosylation at Asn11 and Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR2 Gene

No data available for DME Specific Peptides for TACR2 Gene

Domains & Families for TACR2 Gene

Gene Families for TACR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TACR2 Gene

InterPro:
Blocks:
  • Neurokinin NK2 receptor signature
  • Neurokinin receptor signature

Suggested Antigen Peptide Sequences for TACR2 Gene

GenScript: Design optimal peptide antigens:
  • Tachykinin receptor 2 (NK2R_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21452

UniProtKB/Swiss-Prot:

NK2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR2: view

Function for TACR2 Gene

Molecular function for TACR2 Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
GENATLAS Biochemistry:
tachykinin 2 receptor,neurokinin A receptor (substance K), G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for TACR2 Gene

Gene Ontology (GO) - Molecular Function for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004995 tachykinin receptor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 12716968
GO:0016497 substance K receptor activity IBA 21873635
genes like me logo Genes that share ontologies with TACR2: view
genes like me logo Genes that share phenotypes with TACR2: view

Animal Models for research

  • Taconic Biosciences Mouse Models for TACR2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TACR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TACR2 Gene

Localization for TACR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 2173708
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0036126 sperm flagellum IDA 17437961
genes like me logo Genes that share ontologies with TACR2: view

Pathways & Interactions for TACR2 Gene

genes like me logo Genes that share pathways with TACR2: view

SIGNOR curated interactions for TACR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2173708
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007217 tachykinin receptor signaling pathway IEA,TAS 8307161
GO:0007588 excretion TAS 10862829
genes like me logo Genes that share ontologies with TACR2: view

Drugs & Compounds for TACR2 Gene

(81) Drugs for TACR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 150
Saredutant Investigational Pharma Antagonist, Target 0
Nepadutant Investigational Pharma Antagonist 0
Osanetant Investigational Pharma Antagonist 0
Talnetant Investigational Pharma Antagonist NK3 receptor antagonist,potent and selective 0

(20) Additional Compounds for TACR2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MEN 15596
Antagonist
GR 159897
158848-32-9

(5) Tocris Compounds for TACR2 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) NK2 agonist 122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10) Selective NK2 agonist 137565-28-7
GR 159897 Non-peptide, potent NK2 antagonist 158848-32-9
GR 64349 Potent, selective NK2 agonist 137593-52-3
MDL 29,913 Selective NK2 antagonist 135721-56-1

(14) ApexBio Compounds for TACR2 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) 122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10) 137565-28-7
Antagonist G 115150-59-9
Eledoisin-Related Peptide 2990-43-4
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
GR 64349 137593-52-3
GR 94800 141636-65-9
Locustatachykinin I 126985-97-5
MDL 29,913 135721-56-1
MEN 10376 135306-85-3
Neurokinin A (porcine) 86933-74-6
Neurokinin B (human, porcine) 86933-75-7
Substance P 33507-63-0
genes like me logo Genes that share compounds with TACR2: view

Drug products for research

Transcripts for TACR2 Gene

mRNA/cDNA for TACR2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TACR2

Alternative Splicing Database (ASD) splice patterns (SP) for TACR2 Gene

No ASD Table

Relevant External Links for TACR2 Gene

GeneLoc Exon Structure for
TACR2

Expression for TACR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TACR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR2 Gene

This gene is overexpressed in Colon - Sigmoid (x15.3), Esophagus - Gastroesophageal Junction (x9.6), and Esophagus - Muscularis (x6.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TACR2

SOURCE GeneReport for Unigene cluster for TACR2 Gene:

Hs.88372

Evidence on tissue expression from TISSUES for TACR2 Gene

  • Intestine(4.5)
  • Stomach(4.4)
  • Lung(4.4)
  • Muscle(2.7)
  • Nervous system(2.5)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with TACR2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACR2 Gene

Orthologs for TACR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TACR2 29 30
  • 98.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TACR2 29 30
  • 88.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TACR2 29 30
  • 87.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tacr2 29
  • 86.23 (n)
Mouse
(Mus musculus)
Mammalia Tacr2 29 16 30
  • 85.09 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TACR2 30
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TACR2 30
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TACR2 29 30
  • 67.82 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TACR2 30
  • 50 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tacr2 29 30
  • 61.04 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRTAK1 29
  • 54.11 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Takr86C 29 30 31
  • 50.67 (n)
ManyToMany
NepYr 31
  • 34 (a)
CG10626 31
  • 31 (a)
Takr99D 30 31
  • 26 (a)
ManyToMany
Lkr 30
  • 21 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea Y59H11AL.1 31
  • 33 (a)
C49A9.7 31
  • 31 (a)
tkr-2 30
  • 29 (a)
ManyToMany
tkr-1 30 31
  • 27 (a)
ManyToMany
tkr-3 30
  • 22 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 40 (a)
OneToMany
Species where no ortholog for TACR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TACR2 Gene

ENSEMBL:
Gene Tree for TACR2 (if available)
TreeFam:
Gene Tree for TACR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TACR2: view image
Alliance of Genome Resources:
Additional Orthologs for TACR2

Paralogs for TACR2 Gene

(6) SIMAP similar genes for TACR2 Gene using alignment to 2 proteins:

  • NK2R_HUMAN
  • A6NEW7_HUMAN
genes like me logo Genes that share paralogs with TACR2: view

Variants for TACR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TACR2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs139162766 Likely Benign: not provided 69,405,000(-) C/T
NM_001057.3(TACR2):c.1023G>A (p.Thr341=)
SYNONYMOUS
rs142415572 Benign: not provided 69,407,271(-) T/C
NM_001057.3(TACR2):c.751A>G (p.Thr251Ala)
MISSENSE
rs201487567 Benign: not provided 69,415,924(-) C/T
NM_001057.3(TACR2):c.392+8G>A
INTRON
rs2229171 Benign: not provided 69,404,895(-) G/A
NM_001057.3(TACR2):c.1128C>T (p.Pro376=)
SYNONYMOUS
rs61732393 Benign: not provided 69,405,055(-) C/T
NM_001057.3(TACR2):c.968G>A (p.Arg323His)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TACR2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TACR2 Gene

Variant ID Type Subtype PubMed ID
esv3546472 CNV deletion 23714750
nsv1145467 CNV deletion 24896259
nsv551453 CNV loss 21841781

Variation tolerance for TACR2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.10; 87.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACR2
Leiden Open Variation Database (LOVD)
TACR2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR2 Gene

Disorders for TACR2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TACR2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
retinitis pigmentosa 67
  • rp67
baritosis
  • deposition of barium in the lungs
retinitis pigmentosa 68
  • rp68
constipation
major depressive disorder
  • mdd
- elite association - COSMIC cancer census association via MalaCards
Search TACR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TACR2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TACR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACR2 Gene

Publications for TACR2 Gene

  1. Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough. (PMID: 19583679) Kim TB … Kim YY (Journal of clinical pharmacy and therapeutics 2009) 3 22 40
  2. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PMID: 16893949) Park HK … Kim YY (Thorax 2006) 3 22 40
  3. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of the cDNA from tracheal and gastric tissues. (PMID: 1845990) Gerard NP … Gerard C (The Journal of biological chemistry 1991) 3 4 22
  4. Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. (PMID: 1848773) Kris RM … Schlessinger J (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991) 3 4 22
  5. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. (PMID: 2173708) Gerard NP … Gerard C (The Journal of biological chemistry 1990) 3 4 22

Products for TACR2 Gene

  • Addgene plasmids for TACR2

Sources for TACR2 Gene