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Aliases for TACR2 Gene

Aliases for TACR2 Gene

  • Tachykinin Receptor 2 2 3 4 5
  • Neurokinin A Receptor 3 4
  • NK-2 Receptor 3 4
  • NKNAR 3 4
  • TAC2R 3 4
  • NK-2R 3 4
  • NK2R 3 4
  • SKR 3 4
  • Seven Transmembrane Helix Receptor 3
  • Neurokinin 2 Receptor 3
  • Substance-K Receptor 3

External Ids for TACR2 Gene

Previous HGNC Symbols for TACR2 Gene

  • TAC2R
  • NKNAR

Previous GeneCards Identifiers for TACR2 Gene

  • GC10M069975
  • GC10M070250
  • GC10M071056
  • GC10M070509
  • GC10M070834
  • GC10M071163
  • GC10M065163

Summaries for TACR2 Gene

Entrez Gene Summary for TACR2 Gene

  • This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACR2 Gene

TACR2 (Tachykinin Receptor 2) is a Protein Coding gene. Diseases associated with TACR2 include Retinitis Pigmentosa 68 and Asthma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and substance K receptor activity. An important paralog of this gene is TACR3.

UniProtKB/Swiss-Prot for TACR2 Gene

  • This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Tocris Summary for TACR2 Gene

  • The neurokinin 2 (NK2) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery (including inflammatory cells and bronchial smooth muscle).

Gene Wiki entry for TACR2 Gene

Additional gene information for TACR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR2 Gene

Genomics for TACR2 Gene

GeneHancer (GH) Regulatory Elements for TACR2 Gene

Promoters and enhancers for TACR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I069417 Enhancer 1 ENCODE dbSUPER 550.8 -1.2 -1184 1.5 ELF3 DMAP1 RAD21 ZNF48 ZSCAN9 RARA KAT8 NFIL3 MIER3 RCOR2 TACR2 TSPAN15
GH10I069416 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.8 0.0 -20 0.1 ZIC2 TACR2 TSPAN15
GH10I069407 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +7.4 7373 3.8 PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 POLR2B ZNF766 ZNF213 E2F8 CCAR1 DDX50 TACR2 HK1 SAR1A HKDC1 ENSG00000231748 RPL26P27 TSPAN15 SRGN
GH10I069445 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 5.2 -32.7 -32675 9 PKNOX1 FOXA2 NEUROD1 SIN3A ZNF213 ZNF143 FOS SP3 CEBPZ NFYC TSPAN15 DDX50 CCAR1 DDX21 TYSND1 FAM241B VPS26A TACR2 AIFM2 GC10M069447
GH10I069085 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 +326.9 326900 8.7 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 IRF4 YY1 POLR2B ZNF766 SRGN GC10P069089 GC10P069090 DDX50 DDX21 SUPV3L1 HKDC1 PBLD LOC101928994 TACR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TACR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TACR2 gene promoter:

Genomic Locations for TACR2 Gene

Genomic Locations for TACR2 Gene
chr10:69,403,903-69,416,918
(GRCh38/hg38)
Size:
13,016 bases
Orientation:
Minus strand
chr10:71,163,659-71,176,674
(GRCh37/hg19)

Genomic View for TACR2 Gene

Genes around TACR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR2 Gene

Proteins for TACR2 Gene

  • Protein details for TACR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21452-NK2R_HUMAN
    Recommended name:
    Substance-K receptor
    Protein Accession:
    P21452
    Secondary Accessions:
    • A8K7I1
    • Q4QRI5
    • Q8NGQ8
    • Q9UDE6
    • Q9UDE7

    Protein attributes for TACR2 Gene

    Size:
    398 amino acids
    Molecular mass:
    44442 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TACR2 Gene

Post-translational modifications for TACR2 Gene

  • Glycosylation at posLast=1111 and posLast=1919
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TACR2 Gene

Domains & Families for TACR2 Gene

Gene Families for TACR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TACR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21452

UniProtKB/Swiss-Prot:

NK2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR2: view

Function for TACR2 Gene

Molecular function for TACR2 Gene

GENATLAS Biochemistry:
tachykinin 2 receptor,neurokinin A receptor (substance K), G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

Phenotypes From GWAS Catalog for TACR2 Gene

Gene Ontology (GO) - Molecular Function for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004995 tachykinin receptor activity TAS,IEA 8307161
GO:0005515 protein binding IPI 12716968
GO:0016497 substance K receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with TACR2: view
genes like me logo Genes that share phenotypes with TACR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TACR2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TACR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TACR2 Gene

Localization for TACR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACR2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 2173708
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0036126 sperm flagellum IDA 17437961
genes like me logo Genes that share ontologies with TACR2: view

Pathways & Interactions for TACR2 Gene

genes like me logo Genes that share pathways with TACR2: view

SIGNOR curated interactions for TACR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TACR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2173708
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007217 tachykinin receptor signaling pathway TAS,IEA 8307161
GO:0007268 chemical synaptic transmission IBA --
genes like me logo Genes that share ontologies with TACR2: view

Drugs & Compounds for TACR2 Gene

(81) Drugs for TACR2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 160
Substance P Investigational Pharma Full agonist, Agonist 256
Nepadutant Investigational Pharma Antagonist, antagonist 0
Osanetant Investigational Pharma Antagonist, antagonist 0

(21) Additional Compounds for TACR2 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[betaAla<sup>8</sup>]neurokinin A-(4-10)
Full agonist, Agonist
MEN 15596
Antagonist

(5) Tocris Compounds for TACR2 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) NK2 agonist 122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10) Selective NK2 agonist 137565-28-7
GR 159897 Non-peptide, potent NK2 antagonist 158848-32-9
GR 64349 Potent, selective NK2 agonist 137593-52-3
MDL 29,913 Selective NK2 antagonist 135721-56-1

(15) ApexBio Compounds for TACR2 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) 122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10) 137565-28-7
Antagonist G 115150-59-9
Eledoisin-Related Peptide 2990-43-4
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
GR 159897 158848-32-9
GR 64349 137593-52-3
GR 94800 141636-65-9
Locustatachykinin I 126985-97-5
MDL 29,913 135721-56-1
MEN 10376 135306-85-3
Neurokinin A (porcine) 86933-74-6
Neurokinin B (human, porcine) 86933-75-7
Substance P 33507-63-0
genes like me logo Genes that share compounds with TACR2: view

Drug Products

Transcripts for TACR2 Gene

mRNA/cDNA for TACR2 Gene

Unigene Clusters for TACR2 Gene

Tachykinin receptor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TACR2

Alternative Splicing Database (ASD) splice patterns (SP) for TACR2 Gene

No ASD Table

Relevant External Links for TACR2 Gene

GeneLoc Exon Structure for
TACR2
ECgene alternative splicing isoforms for
TACR2

Expression for TACR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TACR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR2 Gene

This gene is overexpressed in Colon - Sigmoid (x15.3), Esophagus - Gastroesophageal Junction (x9.6), and Esophagus - Muscularis (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of TACR2 Gene:

TACR2

SOURCE GeneReport for Unigene cluster for TACR2 Gene:

Hs.88372

Evidence on tissue expression from TISSUES for TACR2 Gene

  • Intestine(4.5)
  • Lung(4.4)
  • Stomach(4.4)
  • Muscle(2.9)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with TACR2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACR2 Gene

Orthologs for TACR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACR2 33 34
  • 98.83 (n)
cow
(Bos Taurus)
Mammalia TACR2 33 34
  • 88.74 (n)
dog
(Canis familiaris)
Mammalia TACR2 33 34
  • 87.6 (n)
rat
(Rattus norvegicus)
Mammalia Tacr2 33
  • 86.23 (n)
mouse
(Mus musculus)
Mammalia Tacr2 33 16 34
  • 85.09 (n)
oppossum
(Monodelphis domestica)
Mammalia TACR2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACR2 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACR2 33 34
  • 67.82 (n)
lizard
(Anolis carolinensis)
Reptilia TACR2 34
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tacr2 33 34
  • 61.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRTAK1 33
  • 54.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta Takr86C 35 33 34
  • 50.67 (n)
Takr99D 35 34
  • 37 (a)
NepYr 35
  • 34 (a)
CG10626 35
  • 31 (a)
Lkr 34
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tkr-1 35 34
  • 33 (a)
Y59H11AL.1 35
  • 33 (a)
C49A9.7 35
  • 31 (a)
tkr-2 34
  • 29 (a)
ManyToMany
tkr-3 34
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for TACR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TACR2 Gene

ENSEMBL:
Gene Tree for TACR2 (if available)
TreeFam:
Gene Tree for TACR2 (if available)

Paralogs for TACR2 Gene

Paralogs for TACR2 Gene

(6) SIMAP similar genes for TACR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TACR2: view

Variants for TACR2 Gene

Sequence variations from dbSNP and Humsavar for TACR2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000123551 -- 69,415,616(-) C/A/T intron_variant
rs1000550904 -- 69,417,917(-) C/T upstream_transcript_variant
rs1000978439 -- 69,411,756(-) A/G intron_variant
rs1001118367 -- 69,416,559(-) C/G 5_prime_UTR_variant
rs1001279450 -- 69,406,159(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TACR2 Gene

Variant ID Type Subtype PubMed ID
esv3546472 CNV deletion 23714750
nsv1145467 CNV deletion 24896259
nsv551453 CNV loss 21841781

Variation tolerance for TACR2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.10; 87.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR2 Gene

Disorders for TACR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TACR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 68
  • rp68
asthma
  • asthma, susceptibility to
retinitis pigmentosa
  • rp
- elite association - COSMIC cancer census association via MalaCards
Search TACR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TACR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TACR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACR2 Gene

Publications for TACR2 Gene

  1. Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough. (PMID: 19583679) Kim TB … Kim YY (Journal of clinical pharmacy and therapeutics 2009) 3 22 44 58
  2. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PMID: 16893949) Park HK … Kim YY (Thorax 2006) 3 22 44 58
  3. Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. (PMID: 1848773) Kris RM … Schlessinger J (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991) 3 4 22 58
  4. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. (PMID: 2173708) Gerard NP … Gerard C (The Journal of biological chemistry 1990) 3 4 22 58
  5. No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease. (PMID: 19375820) Friedrich P … Riemenschneider M (Neurobiology of aging 2011) 3 44 58

Products for TACR2 Gene

  • Addgene plasmids for TACR2

Sources for TACR2 Gene

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