This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of s... See more...

Aliases for TACR1 Gene

Aliases for TACR1 Gene

  • Tachykinin Receptor 1 2 3 4 5
  • NK1R 2 3 4
  • SPR 2 3 4
  • Substance-P Receptor 3 4
  • NK-1 Receptor 3 4
  • TAC1R 3 4
  • NK-1R 3 4
  • NKIR 2 3
  • Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor) 3
  • TACR1 5

External Ids for TACR1 Gene

Previous HGNC Symbols for TACR1 Gene

  • TAC1R

Previous GeneCards Identifiers for TACR1 Gene

  • GC02M075413
  • GC02M075233
  • GC02M075250
  • GC02M075187
  • GC02M075129

Summaries for TACR1 Gene

Entrez Gene Summary for TACR1 Gene

  • This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

GeneCards Summary for TACR1 Gene

TACR1 (Tachykinin Receptor 1) is a Protein Coding gene. Diseases associated with TACR1 include Cystitis and Causalgia. Among its related pathways are Clathrin-mediated endocytosis and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and substance P receptor activity. An important paralog of this gene is TACR3.

UniProtKB/Swiss-Prot Summary for TACR1 Gene

  • This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Tocris Summary for TACR1 Gene

  • The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum and amygdala) and peripheral tissues.

Gene Wiki entry for TACR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TACR1 Gene

Genomics for TACR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TACR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J075199 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 253.2 -0.6 -581 2.2 ZNF600 ZIC2 ZEB1 CTCF ZNF217 SIN3A KLF9 CTBP1 SMC3 TEAD3 TACR1 HSALNG0016127 ENSG00000270571 LOC105374811 EVA1A
GH02J075416 Promoter/Enhancer 1 EPDnew ENCODE 250.1 -217.4 -217354 1.6 ELF1 IKZF1 RB1 MTA3 POLR2A NKRF PKNOX1 KLF5 HNF1A TARDBP HSALNG0016131 lnc-EVA1A-4 TACR1 piR-50357-071 EVA1A
GH02J075604 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.5 -407.5 -407511 5.5 ZNF654 SSRP1 JUND ZMYM3 ZIC2 CHD4 CTCF REST SIN3A TRIM22 EVA1A ENSG00000221638 MRPL19 TACR1 GCFC2 ENSG00000230477 HSALNG0016149-001
GH02J075162 Enhancer 0.5 Ensembl 29.9 +36.6 36619 1.4 MAFF ZNF316 MAFK BACH1 EMSY TACR1 EVA1A ENSG00000270571 LOC105374811 POLE4
GH02J075153 Enhancer 1.1 Ensembl ENCODE 11.6 +45.2 45227 2.2 SSRP1 CEBPA POLR2A ZIC2 CHD4 MXD4 FOXA1 KLF11 HOMEZ ZNF217 ENSG00000270571 LOC105374811 WBP1 INO80B TACR1 POLE4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TACR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TACR1

Top Transcription factor binding sites by QIAGEN in the TACR1 gene promoter:
  • AP-1
  • GR
  • GR-alpha
  • GR-beta
  • Nkx2-5

Genomic Locations for TACR1 Gene

Latest Assembly
chr2:75,046,463-75,199,520
(GRCh38/hg38)
Size:
153,058 bases
Orientation:
Minus strand

Previous Assembly
chr2:75,273,590-75,426,646
(GRCh37/hg19 by Entrez Gene)
Size:
153,057 bases
Orientation:
Minus strand

chr2:75,273,590-75,426,826
(GRCh37/hg19 by Ensembl)
Size:
153,237 bases
Orientation:
Minus strand

Genomic View for TACR1 Gene

Genes around TACR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR1 Gene

Proteins for TACR1 Gene

  • Protein details for TACR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25103-NK1R_HUMAN
    Recommended name:
    Substance-P receptor
    Protein Accession:
    P25103
    Secondary Accessions:
    • A8K150

    Protein attributes for TACR1 Gene

    Size:
    407 amino acids
    Molecular mass:
    46251 Da
    Quaternary structure:
    • Interacts with ARRB1.
    Miscellaneous:
    • [Isoform 2]: In contrast to Fong et al. data (PubMed:1310144), isoform 2 is not detected by PCR in any of 24 human tissues examined including the placenta (PubMed:11864635).

    Three dimensional structures from OCA and Proteopedia for TACR1 Gene

    Alternative splice isoforms for TACR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TACR1 Gene

Post-translational modifications for TACR1 Gene

  • Glycosylation at Asn14 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR1 Gene

No data available for DME Specific Peptides for TACR1 Gene

Domains & Families for TACR1 Gene

Gene Families for TACR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TACR1 Gene

InterPro:
Blocks:
  • Neurokinin receptor signature
  • Neurokinin NK1 receptor signature

Suggested Antigen Peptide Sequences for TACR1 Gene

GenScript: Design optimal peptide antigens:
  • Tachykinin receptor 1 (NK1R_HUMAN)
  • TACR1 protein (Q4VBL8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25103

UniProtKB/Swiss-Prot:

NK1R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR1: view

Function for TACR1 Gene

Molecular function for TACR1 Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
GENATLAS Biochemistry:
tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor superfamily,expressed in mucosal but non peripheral mononuclear cells,involved in mucosal immunomodulation

Phenotypes From GWAS Catalog for TACR1 Gene

Gene Ontology (GO) - Molecular Function for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004995 tachykinin receptor activity TAS,IBA 21873635
GO:0005515 protein binding IPI 12716968
GO:0016496 substance P receptor activity IBA,IMP 12716968
genes like me logo Genes that share ontologies with TACR1: view
genes like me logo Genes that share phenotypes with TACR1: view

Animal Models for TACR1 Gene

MGI Knock Outs for TACR1:

Animal Models for research

  • Taconic Biosciences Mouse Models for TACR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TACR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACR1 Gene

Localization for TACR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
endosome 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 1657150
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0036126 sperm flagellum IDA 17437961
genes like me logo Genes that share ontologies with TACR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TACR1 Gene

Pathways & Interactions for TACR1 Gene

genes like me logo Genes that share pathways with TACR1: view

Pathways by source for TACR1 Gene

SIGNOR curated interactions for TACR1 Gene

Gene Ontology (GO) - Biological Process for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10854844
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway TAS 1657150
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 12716968
genes like me logo Genes that share ontologies with TACR1: view

Drugs & Compounds for TACR1 Gene

(132) Drugs for TACR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprepitant Approved, Investigational Pharma Antagonist, Target Substance P (SP) inhibitor 192
Rolapitant Approved, Investigational Pharma Antagonist, Target Orally active neurokinin NK1 receptor antagonist. 0
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 150
netupitant Approved, Investigational Pharma Antagonist, Target 0
Fosnetupitant Approved Pharma Target, antagonist 0

(41) Additional Compounds for TACR1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LY303870
Antagonist
GR 73632
133156-06-6
[<sup>3</sup>H]BH-[Sar<sup>9</sup>,Met(O<sub>2</sub>)<sup>11</sup>]SP
[Pro<sup>9</sup>]SP
Agonist, Full agonist
neuropeptide-&alpha;
Agonist, Full agonist

(5) Tocris Compounds for TACR1 Gene

Compound Action Cas Number
[Sar9,Met(O2)11]-Substance P Potent, selective NK1 agonist 110880-55-2
C14TKL-1 Endogenous NK1 agonist
GR 73632 Potent, selective NK1 agonist 133156-06-6
Hemokinin 1 (human) Endogenous, selective NK1 agonist 491851-53-7
Hemokinin 1 (mouse) Endogenous, high affinity, selective NK1 agonist 208041-90-1

(19) ApexBio Compounds for TACR1 Gene

Compound Action Cas Number
[Sar9,Met(O2)11]-Substance P 110880-55-2
Aprepitant Substance P (SP) inhibitor 170729-80-3
C14TKL-1
CP 96345 132746-60-2
CP 99994 dihydrochloride 145148-39-6
FK 888 138449-07-7
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
GR 82334 129623-01-4
Hemokinin 1 (human) 491851-53-7
Hemokinin 1 (mouse) 208041-90-1
L 760735 188923-01-5
L-732,138 148451-96-1
L-733,060 hydrochloride 148687-76-7
Rolapitant Orally active neurokinin NK1 receptor antagonist. 552292-08-7
RP 67580 135911-02-3
SDZ NKT 343 180046-99-5
Spantide I 91224-37-2
SR 140333 153050-21-6
genes like me logo Genes that share compounds with TACR1: view

Drug products for research

Transcripts for TACR1 Gene

mRNA/cDNA for TACR1 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TACR1

Alternative Splicing Database (ASD) splice patterns (SP) for TACR1 Gene

No ASD Table

Relevant External Links for TACR1 Gene

GeneLoc Exon Structure for
TACR1

Expression for TACR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TACR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.5) and Cervix - Endocervix (x4.5).

Protein differential expression in normal tissues from HIPED for TACR1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TACR1 Gene



Protein tissue co-expression partners for TACR1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TACR1

SOURCE GeneReport for Unigene cluster for TACR1 Gene:

Hs.633301

Evidence on tissue expression from TISSUES for TACR1 Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Kidney(2.4)
  • Blood(2.3)
  • Skin(2.2)
  • Muscle(2.2)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with TACR1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACR1 Gene

Orthologs for TACR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TACR1 29 30
  • 99.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NK1R 30
  • 94 (a)
OneToOne
TACR1 29
  • 89.76 (n)
Dog
(Canis familiaris)
Mammalia TACR1 29 30
  • 92.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tacr1 29 16 30
  • 89.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tacr1 29
  • 89.35 (n)
Oppossum
(Monodelphis domestica)
Mammalia TACR1 30
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 21 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ASPR 30
  • 79 (a)
OneToOne
TACR1 29
  • 78.21 (n)
Lizard
(Anolis carolinensis)
Reptilia TACR1 30
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tacr1 29
  • 71.7 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20126 29
Zebrafish
(Danio rerio)
Actinopterygii tacr1a 29 30
  • 70.82 (n)
OneToMany
tacr1b 30
  • 70 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG10626 31
  • 32 (a)
NepYr 31
  • 32 (a)
Takr99D 30 31
  • 30 (a)
ManyToMany
Takr86C 30 31
  • 24 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea C49A9.7 31
  • 36 (a)
tkr-2 30
  • 30 (a)
ManyToMany
tkr-1 30 31
  • 29 (a)
ManyToMany
Y59H11AL.1 31
  • 29 (a)
C50F7.1 31
  • 28 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 40 (a)
OneToMany
Species where no ortholog for TACR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TACR1 Gene

ENSEMBL:
Gene Tree for TACR1 (if available)
TreeFam:
Gene Tree for TACR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TACR1: view image
Alliance of Genome Resources:
Additional Orthologs for TACR1

Paralogs for TACR1 Gene

(15) SIMAP similar genes for TACR1 Gene using alignment to 4 proteins:

  • NK1R_HUMAN
  • Q4VBL8_HUMAN
  • Q53TQ2_HUMAN
  • Q53TR1_HUMAN
genes like me logo Genes that share paralogs with TACR1: view

Variants for TACR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TACR1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs199842504 Likely Benign: not provided 75,120,594(-) C/T
NM_001058.4(TACR1):c.564G>A (p.Pro188=)
SYNONYMOUS
rs200685841 -- p.Tyr192His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TACR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TACR1 Gene

Variant ID Type Subtype PubMed ID
dgv32n64 CNV loss 17921354
esv1335930 CNV insertion 17803354
esv2489063 CNV insertion 19546169
esv2664298 CNV deletion 23128226
esv2759062 CNV loss 17122850
esv28202 CNV loss 19812545
esv3583870 CNV loss 25503493
esv3591293 CNV loss 21293372
nsv1001495 CNV gain 25217958
nsv10035 CNV gain 18304495
nsv1142958 CNV tandem duplication 24896259
nsv438354 CNV loss 16468122
nsv520917 CNV gain 19592680
nsv525695 CNV loss 19592680
nsv527009 CNV gain 19592680
nsv582218 CNV loss 21841781
nsv834262 CNV gain 17160897
nsv963624 CNV duplication 23825009
nsv998145 CNV loss 25217958

Variation tolerance for TACR1 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACR1
Leiden Open Variation Database (LOVD)
TACR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR1 Gene

Disorders for TACR1 Gene

MalaCards: The human disease database

(47) MalaCards diseases for TACR1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cystitis
  • infective cystitis
causalgia
  • complex regional pain syndrome, type ii
fibromyalgia
  • diffuse myofascial pain syndrome
complex regional pain syndrome
  • complex regional pain syndromes
social phobia
  • phobia social
- elite association - COSMIC cancer census association via MalaCards
Search TACR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TACR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TACR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACR1 Gene

Publications for TACR1 Gene

  1. Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. (PMID: 1657150) Gerard NP … Gerard C (Biochemistry 1991) 2 3 4 22
  2. Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. (PMID: 20074437) Ablin JN … Orr-Urtreger A (Clinical and experimental rheumatology 2009) 3 22 40
  3. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PMID: 18452185) Hodges LM … Hamilton SP (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 40
  4. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PMID: 16893949) Park HK … Kim YY (Thorax 2006) 3 22 40
  5. Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. (PMID: 8384323) Fong TM … Strader CD (Nature 1993) 3 4 22

Products for TACR1 Gene

  • Addgene plasmids for TACR1

Sources for TACR1 Gene