TACC3 Gene (Protein Coding)

Transforming Acidic Coiled-Coil Containing Protein 3

GC04P001723
GIFtS:
43
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011] See more...

Aliases for TACC3 Gene

Aliases for TACC3 Gene

  • Transforming Acidic Coiled-Coil Containing Protein 3 2 3 5
  • Transforming Acidic Coiled-Coil-Containing Protein 3 3 4
  • ERIC-1 3 4
  • ERIC1 3 4
  • Transforming, Acidic Coiled-Coil Containing Protein 3 2
  • Maskin 3
  • Tacc4 3

External Ids for TACC3 Gene

Previous GeneCards Identifiers for TACC3 Gene

  • GC04P001715
  • GC04P001684
  • GC04P001690

Summaries for TACC3 Gene

Entrez Gene Summary for TACC3 Gene

  • This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]

GeneCards Summary for TACC3 Gene

TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a Protein Coding gene. Diseases associated with TACC3 include Giant Cell Glioblastoma and Gliosarcoma. Among its related pathways are Notch Signaling Pathway (WikiPathways) and DNA Damage. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.

UniProtKB/Swiss-Prot Summary for TACC3 Gene

  • Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).

Gene Wiki entry for TACC3 Gene

Additional gene information for TACC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TACC3 Gene

Genomics for TACC3 Gene

GeneHancer (GH) Regulatory Elements for TACC3 Gene

Promoters and enhancers for TACC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TACC3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TACC3

Top Transcription factor binding sites by QIAGEN in the TACC3 gene promoter:
  • GATA-1
  • HTF
  • NF-E2
  • NF-E2 p45
  • Nkx2-5
  • p53

Genomic Locations for TACC3 Gene

Genomic Locations for TACC3 Gene
chr4:1,712,891-1,745,178
(GRCh38/hg38)
Size:
32,288 bases
Orientation:
Plus strand
chr4:1,723,227-1,746,898
(GRCh37/hg19)
Size:
23,672 bases
Orientation:
Plus strand

Genomic View for TACC3 Gene

Genes around TACC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACC3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TACC3 Gene

Proteins for TACC3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TACC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6A5-TACC3_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 3
    Protein Accession:
    Q9Y6A5
    Secondary Accessions:
    • Q2NKK4
    • Q3KQS5
    • Q9UMQ1

    Protein attributes for TACC3 Gene

    Size:
    838 amino acids
    Molecular mass:
    90360 Da
    Quaternary structure:
    • Interacts with microtubules. Interacts with CKAP5 independently of clathrin. Interacts with CKAP5 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; TACC3 (phosphorylated at Ser-558 by AURKA) and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582, PubMed:23918938, PubMed:25596274). Interacts with CCDC100/CEP120. The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF (PubMed:14767476).

    Three dimensional structures from OCA and Proteopedia for TACC3 Gene

neXtProt entry for TACC3 Gene

Protein Expression for TACC3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TACC3 Gene

  • Ubiquitination at Lys562 and Lys674
  • Modification sites at PhosphoSitePlus

Other Protein References for TACC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TACC3

No data available for DME Specific Peptides for TACC3 Gene

Domains & Families for TACC3 Gene

Gene Families for TACC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TACC3 Gene

Blocks:
  • Transforming acidic coiled-coil-containing
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TACC3 Gene

GenScript: Design optimal peptide antigens:
  • Transforming, acidic coiled-coil containing protein 3 (Q2NKK4_HUMAN)
  • ERIC-1 (TACC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6A5

UniProtKB/Swiss-Prot:

TACC3_HUMAN :
  • Belongs to the TACC family.
Family:
  • Belongs to the TACC family.
genes like me logo Genes that share domains with TACC3: view

Function for TACC3 Gene

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Molecular function for TACC3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).
UniProtKB/Swiss-Prot Induction:
Up-regulated in various cancer cell lines.

Phenotypes From GWAS Catalog for TACC3 Gene

Gene Ontology (GO) - Molecular Function for TACC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with TACC3: view
genes like me logo Genes that share phenotypes with TACC3: view

Animal Models for TACC3 Gene

MGI Knock Outs for TACC3:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for TACC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACC3 Gene

Localization for TACC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC3 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. {ECO:0000269 PubMed:25596274}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACC3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Mitotic spindle (4)
  • Centriolar satellite (3)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TACC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TACC3: view

Pathways & Interactions for TACC3 Gene

genes like me logo Genes that share pathways with TACC3: view

Pathways by source for TACC3 Gene

1 BioSystems pathway for TACC3 Gene
1 KEGG pathway for TACC3 Gene
1 R&D Systems pathway for TACC3 Gene
1 Cell Signaling Technology pathway for TACC3 Gene

Gene Ontology (GO) - Biological Process for TACC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0007049 cell cycle IEA --
GO:0007052 mitotic spindle organization IEA --
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IMP 23532825
GO:0008283 cell proliferation IBA 21873635
genes like me logo Genes that share ontologies with TACC3: view

No data available for SIGNOR curated interactions for TACC3 Gene

Drugs & Compounds for TACC3 Gene

Products:

  1. Drug

(1) Drugs for TACC3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TACC3: view

Transcripts for TACC3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TACC3 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for TACC3

Alternative Splicing Database (ASD) splice patterns (SP) for TACC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for TACC3 Gene

GeneLoc Exon Structure for
TACC3

Expression for TACC3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TACC3 Gene

mRNA expression in normal human tissues for TACC3 Gene
mRNA expression by BioGPS for TACC3 GenemRNA expression by GTEx for TACC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACC3 Gene

This gene is overexpressed in Whole Blood (x17.5) and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for TACC3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9), Monocytes (11.2), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TACC3 Gene



Protein tissue co-expression partners for TACC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TACC3

SOURCE GeneReport for Unigene cluster for TACC3 Gene:

Hs.104019

Evidence on tissue expression from TISSUES for TACC3 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with TACC3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACC3 Gene

Orthologs for TACC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TACC3 31 30
  • 95.98 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Tacc3 17 31 30
  • 74.34 (n)
rat
(Rattus norvegicus)
 Mammalia Tacc3 30
  • 73.58 (n)
cow
(Bos Taurus)
 Mammalia TACC3 31 30
  • 69.15 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TACC3 31
  • 54 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia TACC3 31
  • 53 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia TACC3 31
  • 33 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TACC3 31 30
  • 54.61 (n)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tacc3 30
  • 57.74 (n)
African clawed frog
(Xenopus laevis)
 Amphibia masking 30
zebrafish
(Danio rerio)
 Actinopterygii tacc3 31 30
  • 50.98 (n)
 OneToOne
sbcb500 30
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.5601 30
fruit fly
(Drosophila melanogaster)
 Insecta tacc 31
  • 9 (a)
 OneToMany
Species where no ortholog for TACC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC3 Gene

ENSEMBL:
Gene Tree for TACC3 (if available)
TreeFam:
Gene Tree for TACC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TACC3: view image

Paralogs for TACC3 Gene

Paralogs for TACC3 Gene

(2) SIMAP similar genes for TACC3 Gene using alignment to 7 proteins:

  • TACC3_HUMAN
  • C9JA91_HUMAN
  • C9JWI7_HUMAN
  • E7EMT0_HUMAN
  • F8WC55_HUMAN
  • H0Y8F2_HUMAN
  • Q2NKK4_HUMAN

Pseudogenes.org Pseudogenes for TACC3 Gene

genes like me logo Genes that share paralogs with TACC3: view

Variants for TACC3 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TACC3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs1063743 - p.Gly287Ser
rs17132047 - p.Cys275Tyr
rs17680881 - p.Gly514Glu
rs34205238 - p.Glu143Lys

Additional dbSNP identifiers (rs#s) for TACC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TACC3 Gene

Variant ID Type Subtype PubMed ID
dgv8901n54 CNV loss 21841781
esv2759218 CNV gain 17122850
esv3563250 CNV deletion 23714750
nsv1161027 CNV deletion 26073780
nsv290066 CNV insertion 16902084
nsv428434 CNV gain 18775914
nsv470000 CNV loss 18288195
nsv508989 CNV insertion 20534489
nsv593316 CNV gain 21841781
nsv949756 CNV deletion 24416366

Variation tolerance for TACC3 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC3 Gene

Disorders for TACC3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TACC3 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
giant cell glioblastoma
  • monstrocellular sarcoma
gliosarcoma
  • glioblastoma with sarcomatous component
thymus lymphoma
  • thymic lymphoma
wolf-hirschhorn syndrome
  • whs
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TACC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TACC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TACC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACC3 Gene

Publications for TACC3 Gene

  1. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. (PMID: 10366448) Still IH … Cowell JK (Genomics 1999) 2 3 4 23 54
  2. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. (PMID: 17675670) Schneider L … Piekorz RP (The Journal of biological chemistry 2007) 2 3 23 54
  3. Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. (PMID: 23532825) Cheeseman LP … Royle SJ (Journal of cell science 2013) 3 4 54
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41 54
  5. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. (PMID: 21297582) Booth DG … Royle SJ (The EMBO journal 2011) 3 4 54

ExternalLinks

View latest publications for TACC3 gene in Mastermind

Products for TACC3 Gene

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Sources for TACC3 Gene