Aliases for TACC3 Gene
Aliases for TACC3 Gene
External Ids for TACC3 Gene
- HGNC: 11524
- Entrez Gene: 10460
- Ensembl: ENSG00000013810
- OMIM: 605303
- UniProtKB: Q9Y6A5
Previous GeneCards Identifiers for TACC3 Gene
- GC04P001715
- GC04P001684
- GC04P001690
Summaries for TACC3 Gene
-
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
GeneCards Summary for TACC3 Gene
TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a Protein Coding gene. Diseases associated with TACC3 include Gliosarcoma and Giant Cell Glioblastoma. Among its related pathways are Aurora A signaling and RNA transport. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.
UniProtKB/Swiss-Prot for TACC3 Gene
-
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).
Additional gene information for TACC3 Gene
- Monarch Initiative
- Search for TACC3 at DataMed
- Search for TACC3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACC3 Gene
Genomics for TACC3 Gene
GeneHancer (GH) Regulatory Elements for TACC3 Gene
Promoters and enhancers for TACC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TACC3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TACC3 Gene
Genomic Locations for TACC3 Gene
- chr4:1,721,490-1,745,178
- (GRCh38/hg38)
- Size:
- 23,689 bases
- Orientation:
- Plus strand
- chr4:1,723,227-1,746,898
- (GRCh37/hg19)
Genomic View for TACC3 Gene
Genes around TACC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.3 by Ensembl
- 4p16.3 by Entrez Gene
- 4p16.3 by HGNC
TACC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TACC3 Gene
Proteins for TACC3 Gene
-
Protein details for TACC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6A5-TACC3_HUMAN
- Recommended name:
- Transforming acidic coiled-coil-containing protein 3
- Protein Accession:
- Q9Y6A5
- Q2NKK4
- Q3KQS5
- Q9UMQ1
Protein attributes for TACC3 Gene
- Size:
- 838 amino acids
- Molecular mass:
- 90360 Da
- Quaternary structure:
-
- Interacts with microtubules. Interacts with CKAP5 independently of clathrin. Interacts with CKAP5 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; TACC3 (phosphorylated at Ser-558 by AURKA) and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582, PubMed:23918938, PubMed:25596274). Interacts with CCDC100/CEP120. The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF (PubMed:14767476).
Protein Expression for TACC3 Gene
Post-translational modifications for TACC3 Gene
Other Protein References for TACC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TACC3 (TACC3)
- Novus Biologicals Antibodies for TACC3
-
Abcam antibodies for TACC3
- Invitrogen Antibodies for TACC3
- Search GeneTex for Antibodies for TACC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for TACC3
- Sino Biological Antibodies for TACC3
Protein Products
-
OriGene Purified Proteins for TACC3
- Search Origene for MassSpec and Protein Over-expression Lysates for TACC3
- Origene Custom Protein Services for TACC3
- Search GeneTex for Proteins for TACC3
-
Abcam proteins for TACC3
Assay Products
No data available for DME Specific Peptides for TACC3 Gene
Domains & Families for TACC3 Gene
Gene Families for TACC3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TACC3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TACC3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6A5- Family:
-
- Belongs to the TACC family.
Function for TACC3 Gene
Molecular function for TACC3 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in various cancer cell lines.
Phenotypes From GWAS Catalog for TACC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20360068 |
Phenotypes for TACC3 Gene
- MGI mutant phenotypes for TACC3:
-
inferred from 4 alleles
- normal phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for TACC3:
-
- Mitotic spindle defects
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Dynamic nuclei (hole, folded or small irregular)
- FOXO1 nuclear localization
- Decreased viability with paclitaxel
- Effect on mitosis
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Decreased viability of wild-type and TP53 knockout cells
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TACC3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TACC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TACC3 gene
- Search ViGene Biosciences for TACC3
CRISPR Products
-
OriGene CRISPR knockouts for TACC3
- genomics-online: gRNA clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
- Applied Biological Materials CRISPR for TACC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TACC3
- GenScript: Design CRISPR guide RNA sequences for TACC3
miRNA for TACC3 Gene
- miRTarBase miRNAs that target TACC3
-
- hsa-mir-193b-3p (MIRT016566)
- hsa-mir-744-5p (MIRT037681)
- hsa-mir-769-3p (MIRT039103)
- hsa-mir-18a-3p (MIRT040904)
- hsa-mir-324-3p (MIRT042910)
- hsa-mir-324-5p (MIRT043259)
- hsa-mir-149-5p (MIRT045607)
- hsa-mir-24-3p (MIRT438421)
- hsa-mir-152-3p (MIRT438422)
- hsa-mir-425-5p (MIRT438423)
- hsa-mir-6885-5p (MIRT489742)
- hsa-mir-328-5p (MIRT489743)
- hsa-mir-4697-5p (MIRT489744)
- hsa-mir-4488 (MIRT489745)
- hsa-mir-1237-5p (MIRT489746)
- hsa-mir-6816-5p (MIRT489747)
- hsa-mir-3196 (MIRT489748)
- hsa-mir-3180-3p (MIRT489749)
- hsa-mir-6787-5p (MIRT489750)
- hsa-mir-3180 (MIRT489751)
- hsa-mir-663a (MIRT489752)
- hsa-mir-1908-5p (MIRT489753)
- hsa-mir-4749-5p (MIRT489754)
- hsa-mir-4706 (MIRT489755)
- hsa-mir-6798-5p (MIRT489756)
miRNA Products
- Search ViGene Biosciences for TACC3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TACC3
- Browse OriGene Inhibitory RNA Products For TACC3
- genomics-online: shRNA clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TACC3 gene
Clone Products
- Sino Biological Human cDNA Clone for TACC3
- VectorBuilder custom plasmid, inducible vectors for TACC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TACC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TACC3
- Applied Biological Materials Clones for TACC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TACC3
-
ViGene Biosciences adenoviral particle packaged cDNA for TACC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TACC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TACC3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACC3 Gene
Localization for TACC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TACC3 Gene
- Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. {ECO:0000269 PubMed:25596274}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 4 |
| nucleus | 3 |
- Mitotic spindle (4)
- Centrosome (3)
- Cytosol (3)
- Microtubule organizing center (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005815 | microtubule organizing center | IDA,IEA | -- |
| GO:0005819 | spindle | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for TACC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RNA transport | ||
| 2 | DNA Damage | ||
| 3 | Notch signaling pathway (KEGG) | ||
| 4 | Aurora A signaling | ||
Pathways by source for TACC3 Gene
1 BioSystems pathway for TACC3 Gene
1 KEGG pathway for TACC3 Gene
1 R&D Systems pathway for TACC3 Gene
1 Cell Signaling Technology pathway for TACC3 Gene
Interacting Proteins for TACC3 Gene
Selected Interacting proteins:
Q9Y6A5-TACC3_HUMAN
ENSP00000326550
for TACC3 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | IMP | 23532825 |
| GO:0008283 | cell proliferation | IBA | -- |
| GO:0021987 | cerebral cortex development | IBA | -- |
| GO:0051301 | cell division | IEA | -- |
No data available for SIGNOR curated interactions for TACC3 Gene
Transcripts for TACC3 Gene
mRNA/cDNA for TACC3 Gene
- (5) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (258) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TACC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TACC3
- genomics-online: gRNA clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
- Applied Biological Materials CRISPR for TACC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TACC3
- GenScript: Design CRISPR guide RNA sequences for TACC3
miRNA Products
- Search ViGene Biosciences for TACC3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TACC3
- Browse OriGene Inhibitory RNA Products For TACC3
- genomics-online: shRNA clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TACC3 gene
Clone Products
- Sino Biological Human cDNA Clone for TACC3
- VectorBuilder custom plasmid, inducible vectors for TACC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TACC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TACC3
- Applied Biological Materials Clones for TACC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for TACC3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Blood (Hematopoietic System)
- Bone (Muscoskeletal System)
- Intestine (Gastrointestinal Tract)
-
Gonad
- Primary Oocyte Primary Follicle
-
Ovary (Reproductive System)
- Primary Oocyte Primary Follicle
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TACC3 Gene
This gene is overexpressed in Whole Blood (x17.5) and Testis (x5.4).
This gene is overexpressed in Peripheral blood mononuclear cells (23.9), Monocytes (11.2), and Lymph node (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TACC3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TACC3 Gene:
TACC3SOURCE GeneReport for Unigene cluster for TACC3 Gene:
Hs.104019Evidence on tissue expression from TISSUES for TACC3 Gene
- Skin(4.1)
Primer Products
-
OriGene qPCR primer pairs for TACC3
-
OriGene qPCR primer pairs and template standards for TACC3
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACC3 Gene
Orthologs for TACC3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TACC3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tacc3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tacc3 33 |
|
||
| cow (Bos Taurus) |
Mammalia | TACC3 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TACC3 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TACC3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TACC3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TACC3 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tacc3 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | masking 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tacc3 33 34 |
|
||
| sbcb500 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5601 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | tacc 34 |
|
OneToMany |
- Species where no ortholog for TACC3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TACC3 Gene
(2) SIMAP similar genes for TACC3 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for TACC3 Gene
Variants for TACC3 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033570 | -- | 1,734,266(+) | C/G/T | intron_variant | |
| rs1000120885 | -- | 1,725,223(+) | C/T | intron_variant | |
| rs1000156188 | -- | 1,729,719(+) | A/G | intron_variant | |
| rs1000616773 | -- | 1,721,296(+) | C/G | upstream_transcript_variant | |
| rs1000790565 | -- | 1,722,759(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv8901n54 | CNV | loss | 21841781 |
| esv2759218 | CNV | gain | 17122850 |
| esv3563250 | CNV | deletion | 23714750 |
| nsv1161027 | CNV | deletion | 26073780 |
| nsv290066 | CNV | insertion | 16902084 |
| nsv428434 | CNV | gain | 18775914 |
| nsv470000 | CNV | loss | 18288195 |
| nsv508989 | CNV | insertion | 20534489 |
| nsv593316 | CNV | gain | 21841781 |
| nsv949756 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.35;
85.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TACC3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TACC3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC3 Gene
Disorders for TACC3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gliosarcoma |
|
|
| giant cell glioblastoma |
|
|
Search TACC3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TACC3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TACC3 Gene
Publications for TACC3 Gene
- The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. (PMID: 17675670) Schneider L … Piekorz RP (The Journal of biological chemistry 2007) 2 3 22 58
- The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. (PMID: 10366448) Still IH … Cowell JK (Genomics 1999) 3 4 22 58
- Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. (PMID: 23532825) Cheeseman LP … Royle SJ (Journal of cell science 2013) 3 4 58
- A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. (PMID: 21297582) Booth DG … Royle SJ (The EMBO journal 2011) 3 4 58
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
Products for TACC3 Gene
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- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TACC3
- Novus Biologicals lysates and proteins for TACC3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TACC3
- Abcam proteins for TACC3
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for TACC3
- VectorBuilder custom plasmid, inducible vectors for TACC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TACC3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TACC3
- antibodies-online: Search results for 63 available TACC3 Antibodies ranked by validation data
- Compare Top TACC3 Antibodies
- antibodies-online: Search results for available TACC3 related products ranked by validation data
- antibodies-online: Search results for 4 available TACC3 Proteins ranked by validation data
- Compare Top TACC3 Proteins
- Search GeneTex for Antibodies for TACC3
- Search GeneTex for Proteins for TACC3
- ViGene Biosciences adenoviral particle packaged cDNA for TACC3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TACC3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TACC3 gene
- Search ViGene Biosciences for TACC3
- Santa Cruz Biotechnology (SCBT) Antibodies for TACC3
- Search Santa Cruz Biotechnology (SCBT) for TACC3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TACC3
- Horizon Cell Lines for TACC3
- genomics-online: cdna clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
- orf clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
- genomics-online: gRNA clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
- genomics-online: primer clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
- genomics-online: shRNA clones - Search results for 111 available TACC3 gene related products
- Overview of 111 available TACC3 gene related products
Sources for TACC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems