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This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a Protein Coding gene. Diseases associated with TACC3 include Gliosarcoma and Giant Cell Glioblastoma. Among its related pathways are Notch Signaling Pathway (WikiPathways) and Aurora A signaling. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 20360068 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000922 | spindle pole | IEA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005815 | microtubule organizing center | IEA | -- |
GO:0005819 | spindle | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | DNA Damage | ||
2 | RNA transport | ||
3 | Notch Signaling Pathway (WikiPathways) | ||
4 | Aurora A signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | IBA | 21873635 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007052 | mitotic spindle organization | IEA | -- |
GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | IMP | 23532825 |
GO:0008283 | cell proliferation | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TACC3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tacc3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tacc3 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TACC3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TACC3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TACC3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TACC3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TACC3 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tacc3 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | masking 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tacc3 30 31 |
|
OneToOne | |
sbcb500 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5601 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | tacc 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
729672 | Benign: not provided | 1,744,729(+) | C/A | MISSENSE_VARIANT | |
745572 | Likely Benign: not provided | 1,737,272(+) | C/T | MISSENSE_VARIANT | |
752322 | Likely Benign: not provided | 1,737,277(+) | G/A | SYNONYMOUS_VARIANT | |
774612 | Benign: not provided | 1,728,037(+) | ACAAAGCGGAGACTCC | INFRAME_DELETION | |
775209 | Benign: not provided | 1,728,184(+) | G/A | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv8901n54 | CNV | loss | 21841781 |
esv2759218 | CNV | gain | 17122850 |
esv3563250 | CNV | deletion | 23714750 |
nsv1161027 | CNV | deletion | 26073780 |
nsv290066 | CNV | insertion | 16902084 |
nsv428434 | CNV | gain | 18775914 |
nsv470000 | CNV | loss | 18288195 |
nsv508989 | CNV | insertion | 20534489 |
nsv593316 | CNV | gain | 21841781 |
nsv949756 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gliosarcoma |
|
|
giant cell glioblastoma |
|
|
thymus lymphoma |
|
|
epileptic encephalopathy, early infantile, 23 |
|
|
wolf-hirschhorn syndrome |
|
|