Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to ... See more...

Aliases for TACC2 Gene

Aliases for TACC2 Gene

  • Transforming Acidic Coiled-Coil Containing Protein 2 2 3 5
  • Transforming Acidic Coiled-Coil-Containing Protein 2 3 4
  • AZU-1 3 4
  • Transforming, Acidic Coiled-Coil Containing Protein 2 2
  • Anti Zuai-1 3
  • Anti-Zuai-1 4
  • EC 2.4.2.10 52
  • EC 4.3.2.1 52
  • EC 6.3.5.2 52
  • ECTACC 3

External Ids for TACC2 Gene

Previous GeneCards Identifiers for TACC2 Gene

  • GC10P122942
  • GC10P123166
  • GC10P123879
  • GC10P123446
  • GC10P123474
  • GC10P123738
  • GC10P117379

Summaries for TACC2 Gene

Entrez Gene Summary for TACC2 Gene

  • Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACC2 Gene

TACC2 (Transforming Acidic Coiled-Coil Containing Protein 2) is a Protein Coding gene. Diseases associated with TACC2 include Breast Cancer. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and nuclear hormone receptor binding. An important paralog of this gene is TACC1.

UniProtKB/Swiss-Prot Summary for TACC2 Gene

  • Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Gene Wiki entry for TACC2 Gene

Additional gene information for TACC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TACC2 Gene

Genomics for TACC2 Gene

GeneHancer (GH) Regulatory Elements for TACC2 Gene

Promoters and enhancers for TACC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J122162 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.1 +175.1 175098 4 EP300 JUND ZBTB10 ZBTB26 ATF2 MXI1 HDAC2 ZNF341 FOXA2 POLR2A lnc-NSMCE4A-5 TACC2 HTRA1 ENSG00000285973
GH10J121993 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 500.4 +6.0 5992 3.3 CTBP1 ESRRA CTCF GATA3 FOXA1 PKNOX1 DPF2 MAZ RXRA GLIS1 TACC2 ATE1-AS1 NSMCE4A piR-38580-047
GH10J121987 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 500.7 -0.6 -556 2 USF1 ZNF639 RFX1 KLF7 RAD51 SIN3A ZNF263 TRIM28 KLF13 FOSL1 TACC2 NSMCE4A ATE1 ATE1-AS1 piR-53063-028
GH10J121990 Enhancer 0.6 ENCODE dbSUPER 500.7 +1.5 1450 0.9 NFIC IRF1 NFIB NFIA SP1 TACC2 ATE1-AS1 NSMCE4A piR-38580-047
GH10J122101 Enhancer 1.2 Ensembl ENCODE dbSUPER 26.6 +113.3 113250 2 TCF12 ZNF639 ZNF10 ZIC2 NR3C1 TEAD1 ZEB1 ATF2 OSR2 BCL11A TACC2 lnc-BTBD16-2 ENSG00000285973
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TACC2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TACC2

Top Transcription factor binding sites by QIAGEN in the TACC2 gene promoter:
  • AP-4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXD1
  • Pax-6
  • PPAR-alpha

Genomic Locations for TACC2 Gene

Genomic Locations for TACC2 Gene
chr10:121,989,163-122,254,545
(GRCh38/hg38)
Size:
265,383 bases
Orientation:
Plus strand
chr10:123,748,689-124,014,060
(GRCh37/hg19)
Size:
265,372 bases
Orientation:
Plus strand

Genomic View for TACC2 Gene

Genes around TACC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC2 Gene

Proteins for TACC2 Gene

  • Protein details for TACC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95359-TACC2_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 2
    Protein Accession:
    O95359
    Secondary Accessions:
    • Q4VXL0
    • Q4VXL3
    • Q4VXL6
    • Q4VXL7
    • Q5U5T7
    • Q86WG6
    • Q86WG7
    • Q8TCK9
    • Q9BVQ1
    • Q9NZ41
    • Q9NZR5

    Protein attributes for TACC2 Gene

    Size:
    2948 amino acids
    Molecular mass:
    309427 Da
    Quaternary structure:
    • Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF.
    SequenceCaution:
    • Sequence=AAF29537.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAF63433.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TACC2 Gene

neXtProt entry for TACC2 Gene

Selected DME Specific Peptides for TACC2 Gene

O95359:
  • DAYSTGSS
  • LASGLPSP
  • ASTPSCP

Post-translational modifications for TACC2 Gene

  • Phosphorylated by TTK; which is required for localization in centrosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TACC2 Gene

Gene Families for TACC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TACC2 Gene

Blocks:
  • Transforming acidic coiled-coil-containing
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TACC2 Gene

GenScript: Design optimal peptide antigens:
  • TACC2 protein (B2RWP4_HUMAN)
  • TACC2 protein (B7ZMJ9_HUMAN)
  • Transforming, acidic coiled-coil containing protein 2 (Q4VXL2_HUMAN)
  • Transforming, acidic coiled-coil containing protein 2 (Q4VXL5_HUMAN)
  • Anti-Zuai-1 (TACC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95359

UniProtKB/Swiss-Prot:

TACC2_HUMAN :
  • Belongs to the TACC family.
Family:
  • Belongs to the TACC family.
genes like me logo Genes that share domains with TACC2: view

Function for TACC2 Gene

Molecular function for TACC2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Enzyme Numbers (IUBMB) for TACC2 Gene

Phenotypes From GWAS Catalog for TACC2 Gene

Gene Ontology (GO) - Molecular Function for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035257 nuclear hormone receptor binding IDA 15207008
genes like me logo Genes that share ontologies with TACC2: view
genes like me logo Genes that share phenotypes with TACC2: view

Animal Models for TACC2 Gene

MGI Knock Outs for TACC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TACC2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACC2 Gene

Localization for TACC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC2 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACC2 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytoskeleton 4
cytosol 4
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TACC2: view

Pathways & Interactions for TACC2 Gene

PathCards logo

SuperPathways for TACC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0007052 mitotic spindle organization IEA --
GO:0008283 cell proliferation IBA 21873635
GO:0021987 cerebral cortex development IBA 21873635
genes like me logo Genes that share ontologies with TACC2: view

No data available for Pathways by source and SIGNOR curated interactions for TACC2 Gene

Drugs & Compounds for TACC2 Gene

No Compound Related Data Available

Transcripts for TACC2 Gene

mRNA/cDNA for TACC2 Gene

8 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
30 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TACC2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - -
SP16:
SP17: - - - - - - - - - - - -
SP18: - - - - - - - -

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:

Relevant External Links for TACC2 Gene

GeneLoc Exon Structure for
TACC2

Expression for TACC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TACC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACC2 Gene

This gene is overexpressed in Muscle - Skeletal (x9.9) and Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for TACC2 Gene

This gene is overexpressed in Urine (13.4), Cervix (12.8), and Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TACC2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TACC2

SOURCE GeneReport for Unigene cluster for TACC2 Gene:

Hs.501252

mRNA Expression by UniProt/SwissProt for TACC2 Gene:

O95359-TACC2_HUMAN
Tissue specificity: Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.

Evidence on tissue expression from TISSUES for TACC2 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Muscle(4.7)
  • Lung(4.5)
  • Heart(4.4)
  • Intestine(4.2)
  • Pancreas(4)
  • Skin(3.8)
  • Eye(3.4)
  • Kidney(3.4)
  • Stomach(3.1)
  • Thyroid gland(2.8)
  • Blood(2.3)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with TACC2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACC2 Gene

Orthologs for TACC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACC2 31 30
  • 99.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TACC2 31 30
  • 78.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TACC2 31 30
  • 78.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tacc2 17 31 30
  • 74.58 (n)
rat
(Rattus norvegicus)
Mammalia Tacc2 30
  • 73.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TACC2 31
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACC2 31
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACC2 31
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACC2 31
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tacc2 30
  • 60.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9694 30
zebrafish
(Danio rerio)
Actinopterygii TACC2 31
  • 34 (a)
OneToOne
-- 30
fruit fly
(Drosophila melanogaster)
Insecta tacc 31
  • 12 (a)
OneToMany
Species where no ortholog for TACC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC2 Gene

ENSEMBL:
Gene Tree for TACC2 (if available)
TreeFam:
Gene Tree for TACC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TACC2: view image

Paralogs for TACC2 Gene

Paralogs for TACC2 Gene

(2) SIMAP similar genes for TACC2 Gene using alignment to 15 proteins:

  • TACC2_HUMAN
  • B2RWP4_HUMAN
  • B7ZMJ9_HUMAN
  • D6RAA5_HUMAN
  • E7EMZ9_HUMAN
  • E9PBC6_HUMAN
  • E9PGB3_HUMAN
  • H0Y8P9_HUMAN
  • H0Y911_HUMAN
  • H0Y954_HUMAN
  • H0Y9C3_HUMAN
  • H0Y9Y7_HUMAN
  • H0YA73_HUMAN
  • Q4VXL4_HUMAN
  • Q4VXL8_HUMAN
genes like me logo Genes that share paralogs with TACC2: view

Variants for TACC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TACC2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
VAR_036381 A breast cancer sample p.Leu798Val
VAR_036382 A breast cancer sample p.Ala1347Ser
rs1063627 - p.Gln2900Lys
rs10887063 - p.Leu830Phe
rs11200385 - p.Val170Ile

Additional dbSNP identifiers (rs#s) for TACC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TACC2 Gene

Variant ID Type Subtype PubMed ID
dgv1407n54 CNV gain 21841781
dgv1408n54 CNV loss 21841781
esv1958270 CNV deletion 18987734
esv2666599 CNV deletion 23128226
esv275180 CNV gain+loss 21479260
esv34167 CNV loss 18971310
esv3624764 CNV loss 21293372
esv3624765 CNV loss 21293372
esv3624766 CNV loss 21293372
esv3624767 CNV loss 21293372
esv3624769 CNV loss 21293372
esv3624771 CNV loss 21293372
nsv1045815 CNV loss 25217958
nsv1051882 CNV loss 25217958
nsv467468 CNV loss 19166990
nsv519434 CNV loss 19592680
nsv521165 CNV loss 19592680
nsv526940 CNV loss 19592680
nsv552247 CNV loss 21841781
nsv552248 CNV loss 21841781
nsv825593 CNV gain 20364138
nsv832009 CNV loss 17160897
nsv951864 CNV deletion 24416366

Variation tolerance for TACC2 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.94; 94.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACC2 Gene

Human Gene Mutation Database (HGMD)
TACC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC2 Gene

Disorders for TACC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TACC2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search TACC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TACC2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TACC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACC2 Gene

Publications for TACC2 Gene

  1. TTK kinase is essential for the centrosomal localization of TACC2. (PMID: 15304323) Dou Z … Yao X (FEBS letters 2004) 3 4 23 54
  2. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PMID: 14767476) Gangisetty O … Still IH (Oncogene 2004) 2 3 4 54
  3. Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. (PMID: 11161455) Pu JJ … Banerjee D (Cytokine 2001) 2 3 4 54
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for TACC2 Gene

Sources for TACC2 Gene