Aliases for TACC2 Gene
External Ids for TACC2 Gene
Previous GeneCards Identifiers for TACC2 Gene
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TACC2 Gene
TACC2 (Transforming Acidic Coiled-Coil Containing Protein 2) is a Protein Coding gene. Diseases associated with TACC2 include Breast Cancer. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and nuclear hormone receptor binding. An important paralog of this gene is TACC1.
UniProtKB/Swiss-Prot Summary for TACC2 Gene
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.