Aliases for TACC1 Gene
External Ids for TACC1 Gene
Previous GeneCards Identifiers for TACC1 Gene
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
GeneCards Summary for TACC1 Gene
TACC1 (Transforming Acidic Coiled-Coil Containing Protein 1) is a Protein Coding gene. Diseases associated with TACC1 include Gliosarcoma and Giant Cell Glioblastoma. Among its related pathways are Aurora B signaling and Aurora A signaling. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.
UniProtKB/Swiss-Prot Summary for TACC1 Gene
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.