This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017] See more...

Aliases for TACC1 Gene

Aliases for TACC1 Gene

  • Transforming Acidic Coiled-Coil Containing Protein 1 2 3 5
  • Transforming Acidic Coiled-Coil-Containing Protein 1 3 4
  • Gastric Cancer Antigen Ga55 3 4
  • Taxin-1 3 4
  • Transforming, Acidic Coiled-Coil Containing Protein 1 2
  • KIAA1103 4
  • Ga55 3

External Ids for TACC1 Gene

Previous GeneCards Identifiers for TACC1 Gene

  • GC08P038196
  • GC08P038859
  • GC08P038326
  • GC08P038603
  • GC08P038733
  • GC08P038586
  • GC08P037121

Summaries for TACC1 Gene

Entrez Gene Summary for TACC1 Gene

  • This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

GeneCards Summary for TACC1 Gene

TACC1 (Transforming Acidic Coiled-Coil Containing Protein 1) is a Protein Coding gene. Diseases associated with TACC1 include Gliosarcoma and Giant Cell Glioblastoma. Among its related pathways are Aurora B signaling and Aurora A signaling. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.

UniProtKB/Swiss-Prot Summary for TACC1 Gene

  • Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Gene Wiki entry for TACC1 Gene

Additional gene information for TACC1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TACC1 Gene

Genomics for TACC1 Gene

GeneHancer (GH) Regulatory Elements for TACC1 Gene

Promoters and enhancers for TACC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TACC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TACC1

Top Transcription factor binding sites by QIAGEN in the TACC1 gene promoter:
  • Arnt
  • E47
  • Evi-1
  • FOXO1
  • FOXO1a
  • Gfi-1
  • HSF1 (long)
  • HSF1short
  • Sox9
  • Tal-1beta

Genomic Locations for TACC1 Gene

Genomic Locations for TACC1 Gene
chr8:38,728,186-38,853,028
(GRCh38/hg38)
Size:
124,843 bases
Orientation:
Plus strand
chr8:38,585,704-38,710,546
(GRCh37/hg19)
Size:
124,843 bases
Orientation:
Plus strand

Genomic View for TACC1 Gene

Genes around TACC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC1 Gene

Proteins for TACC1 Gene

  • Protein details for TACC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75410-TACC1_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 1
    Protein Accession:
    O75410
    Secondary Accessions:
    • B2RBD9
    • B4E302
    • D3DSX6
    • Q6Y687
    • Q86YG7
    • Q8IUJ2
    • Q8IUJ3
    • Q8IUJ4
    • Q8IZG2
    • Q8NEY7
    • Q9UPP9

    Protein attributes for TACC1 Gene

    Size:
    805 amino acids
    Molecular mass:
    87794 Da
    Quaternary structure:
    • Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF. Interacts with the thyroid hormone receptors THRB and THRA, predominantly with isoform alpha-2. The interaction with THRA isoform alpha-1 and THRB is decreased in the presence of thyroid hormone T3 (PubMed:20078863). Also interacts with other nuclear receptors, including ESR1, NR3C1, PPARG, RARA and RXRA, preferentially in the absence of their hormonal ligands (PubMed:20078863).
    SequenceCaution:
    • Sequence=BAG65314.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TACC1 Gene

neXtProt entry for TACC1 Gene

Post-translational modifications for TACC1 Gene

  • Isoform 1 is heavily phosphorylated; isoform 6 is not.
  • Ubiquitination at Lys169
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TACC1 Gene

Domains & Families for TACC1 Gene

Gene Families for TACC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TACC1 Gene

Blocks:
  • Transforming acidic coiled-coil-containing
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TACC1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52297, highly similar to Transforming acidic coiled-coil-containing protein 1 (B4E3H6_HUMAN)
  • Transforming, acidic coiled-coil containing protein 1 variant TACC1-B (Q8IUJ5_HUMAN)
  • Taxin-1 (TACC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75410

UniProtKB/Swiss-Prot:

TACC1_HUMAN :
  • Belongs to the TACC family.
Family:
  • Belongs to the TACC family.
genes like me logo Genes that share domains with TACC1: view

Function for TACC1 Gene

Molecular function for TACC1 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
GENATLAS Biochemistry:
transforming acidic coiled-coil gene 1,highly expressed during early embryogenesis,potentially promoting tumorigenicity in breast cancers with amplification of the 8p11 region

Phenotypes From GWAS Catalog for TACC1 Gene

Gene Ontology (GO) - Molecular Function for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11903063
GO:0016922 nuclear receptor binding IDA 20078863
GO:0030331 estrogen receptor binding IDA 20078863
GO:0035259 glucocorticoid receptor binding IDA 20078863
GO:0042974 retinoic acid receptor binding IDA 20078863
genes like me logo Genes that share ontologies with TACC1: view
genes like me logo Genes that share phenotypes with TACC1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TACC1 Gene

Localization for TACC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. {ECO:0000269 PubMed:21531210}.
[Isoform 5]: Membrane; Lipid-anchor.
[Isoform 10]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACC1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TACC1: view

Pathways & Interactions for TACC1 Gene

PathCards logo

SuperPathways for TACC1 Gene

genes like me logo Genes that share pathways with TACC1: view

Pathways by source for TACC1 Gene

2 BioSystems pathways for TACC1 Gene

Gene Ontology (GO) - Biological Process for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA 21873635
GO:0007049 cell cycle IEA --
GO:0007052 mitotic spindle organization IEA --
GO:0008283 cell proliferation IBA 21873635
GO:0021987 cerebral cortex development IBA 21873635
genes like me logo Genes that share ontologies with TACC1: view

No data available for SIGNOR curated interactions for TACC1 Gene

Drugs & Compounds for TACC1 Gene

No Compound Related Data Available

Transcripts for TACC1 Gene

mRNA/cDNA for TACC1 Gene

31 REFSEQ mRNAs :
28 NCBI additional mRNA sequence :
29 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - -
SP5: - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - -
SP12: - - -
SP13: - -
SP14:
SP15:
SP16:

ExUns: 16c ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TACC1 Gene

GeneLoc Exon Structure for
TACC1

Expression for TACC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TACC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TACC1 Gene

This gene is overexpressed in Liver (20.7) and Peripheral blood mononuclear cells (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TACC1 Gene



Protein tissue co-expression partners for TACC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TACC1

SOURCE GeneReport for Unigene cluster for TACC1 Gene:

Hs.279245

mRNA Expression by UniProt/SwissProt for TACC1 Gene:

O75410-TACC1_HUMAN
Tissue specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.

Evidence on tissue expression from TISSUES for TACC1 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Muscle(4.3)
  • Lung(2.7)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with TACC1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACC1 Gene

Orthologs for TACC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACC1 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TACC1 31 30
  • 87.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacc1 30
  • 80.34 (n)
mouse
(Mus musculus)
Mammalia Tacc1 17 31 30
  • 80.16 (n)
cow
(Bos Taurus)
Mammalia TACC1 31 30
  • 79.96 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACC1 31
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACC1 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACC1 31 30
  • 69.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACC1 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tacc1 30
  • 65.44 (n)
Str.5836 30
zebrafish
(Danio rerio)
Actinopterygii tacc1 31 30
  • 57.17 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tacc 31
  • 10 (a)
OneToMany
Species where no ortholog for TACC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC1 Gene

ENSEMBL:
Gene Tree for TACC1 (if available)
TreeFam:
Gene Tree for TACC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TACC1: view image

Paralogs for TACC1 Gene

Paralogs for TACC1 Gene

(2) SIMAP similar genes for TACC1 Gene using alignment to 14 proteins:

  • TACC1_HUMAN
  • B4E3H6_HUMAN
  • E5RFM9_HUMAN
  • E5RI10_HUMAN
  • E5RIP3_HUMAN
  • E5RJG6_HUMAN
  • E5RJU4_HUMAN
  • E7ET87_HUMAN
  • E7EVI4_HUMAN
  • G8JLK4_HUMAN
  • H0YAY0_HUMAN
  • H0YBT8_HUMAN
  • Q8IUJ5_HUMAN
  • R4GMT7_HUMAN

Pseudogenes.org Pseudogenes for TACC1 Gene

genes like me logo Genes that share paralogs with TACC1: view

Variants for TACC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TACC1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
712917 Benign: not provided 38,820,389(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
778393 Benign: not provided 38,819,724(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs10107016 - p.Glu255Gly
rs34235313 - p.Pro187Leu
rs6980553 - p.Ile243Thr

Additional dbSNP identifiers (rs#s) for TACC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TACC1 Gene

Variant ID Type Subtype PubMed ID
esv25816 CNV loss 19812545
esv3433731 CNV duplication 20981092
esv3449093 CNV insertion 20981092
esv3616933 CNV loss 21293372
nsv396891 CNV insertion 16902084
nsv528721 CNV loss 19592680
nsv831296 CNV gain 17160897

Variation tolerance for TACC1 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC1 Gene

Disorders for TACC1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TACC1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
giant cell glioblastoma
  • monstrocellular sarcoma
breast cancer
  • breast cancer, familial
gastric cancer
  • gastric cancer, somatic
acute apical periodontitis
  • acute apical periodontitis of pulpal origin
- elite association - COSMIC cancer census association via MalaCards
Search TACC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TACC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TACC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACC1 Gene

Publications for TACC1 Gene

  1. Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. (PMID: 10435627) Still IH … Cowell JK (Oncogene 1999) 2 3 4 23 54
  2. Aurora B -TACC1 protein complex in cytokinesis. (PMID: 15064709) Delaval B … Birnbaum D (Oncogene 2004) 3 4 23 54
  3. TACC1-chTOG-Aurora A protein complex in breast cancer. (PMID: 14603251) Conte N … Birnbaum D (Oncogene 2003) 3 4 23 54
  4. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PMID: 11903063) Lauffart B … Still IH (The Biochemical journal 2002) 3 4 23 54
  5. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N … Birnbaum D (Oncogene 2002) 3 4 23 54

Products for TACC1 Gene

  • Boster Bio Antibodies for TACC1
  • Boster Bio ELISA Kits for TACC1

Sources for TACC1 Gene