TAC3 Gene (Protein Coding)

Tachykinin Precursor 3

GC12M057009
GIFtS:
46
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer ... See more...

Aliases for TAC3 Gene

Aliases for TAC3 Gene

  • Tachykinin Precursor 3 2 3 5
  • ZNEUROK1 2 3 4
  • LncZBTB39-1:2 2 3
  • Neuromedin K 2 3
  • Tachykinin 3 2 3
  • Tachykinin-3 3 4
  • LncZBTB39 2 3
  • NKNB 3 4
  • NK3 2 3
  • NKB 2 3
  • Preprotachykinin-B 2
  • Gamma Tachykinin 3 3
  • Preprotachykinin B 3
  • Neurokinin Beta 2
  • Neurokinin B 3
  • PRO1155 3
  • HH10 3
  • TAC3 5

External Ids for TAC3 Gene

Previous HGNC Symbols for TAC3 Gene

  • NKNB

Previous GeneCards Identifiers for TAC3 Gene

  • GC12M057378
  • GC12M057628
  • GC12M057120
  • GC12M055690
  • GC12M057403
  • GC12M054443

Summaries for TAC3 Gene

Entrez Gene Summary for TAC3 Gene

  • This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for TAC3 Gene

TAC3 (Tachykinin Precursor 3) is a Protein Coding gene. Diseases associated with TAC3 include Hypogonadotropic Hypogonadism 10 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

UniProtKB/Swiss-Prot Summary for TAC3 Gene

  • Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.

Tocris Summary for TAC3 Gene

  • The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC3 Gene

Additional gene information for TAC3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAC3 Gene

Genomics for TAC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TAC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAC3

Top Transcription factor binding sites by QIAGEN in the TAC3 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • HNF-4alpha1
  • HSF1 (long)
  • HSF1short
  • Meis-1
  • Meis-1a
  • Meis-1b
  • SEF-1 (1)
  • TGIF

Genomic Locations for TAC3 Gene

Latest Assembly
chr12:57,010,000-57,028,883
(GRCh38/hg38)
Size:
18,884 bases
Orientation:
Minus strand

Previous Assembly
chr12:57,403,784-57,410,313
(GRCh37/hg19 by Entrez Gene)
Size:
6,530 bases
Orientation:
Minus strand

chr12:57,403,784-57,422,667
(GRCh37/hg19 by Ensembl)
Size:
18,884 bases
Orientation:
Minus strand

Genomic View for TAC3 Gene

Genes around TAC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAC3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TAC3 Gene

Proteins for TAC3 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for TAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHF0-TKNK_HUMAN
    Recommended name:
    Tachykinin-3
    Protein Accession:
    Q9UHF0
    Secondary Accessions:
    • Q6IAG2
    • Q71BC6
    • Q71BC9

    Protein attributes for TAC3 Gene

    Size:
    121 amino acids
    Molecular mass:
    13438 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TAC3 Gene

    Alternative splice isoforms for TAC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAC3 Gene

Protein Expression for TAC3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TAC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAC3 Gene

Domains & Families for TAC3 Gene

Gene Families for TAC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for TAC3 Gene

InterPro:
Blocks:
  • Tachykinin/Neurokinin
ProtoNet:

Suggested Antigen Peptide Sequences for TAC3 Gene

GenScript: Design optimal peptide antigens:
  • Neurokinin-B protein (Q2UVB8_HUMAN)
  • Neurokinin B (Q334E7_HUMAN)
  • ZNEUROK1 (TKNK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHF0

UniProtKB/Swiss-Prot:

TKNK_HUMAN :
  • Belongs to the tachykinin family.
Family:
  • Belongs to the tachykinin family.
genes like me logo Genes that share domains with TAC3: view

Function for TAC3 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for TAC3 Gene

UniProtKB/Swiss-Prot Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.
GENATLAS Biochemistry:
tachykinin 3,neurokinin B (neuromedin K)

Phenotypes From GWAS Catalog for TAC3 Gene

Gene Ontology (GO) - Molecular Function for TAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 10866201
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TAC3: view
genes like me logo Genes that share phenotypes with TAC3: view

Human Phenotype Ontology for TAC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAC3 Gene

MGI Knock Outs for TAC3:

Animal Models for research

miRNA for TAC3 Gene

miRTarBase miRNAs that target TAC3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAC3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TAC3 Gene

Localization for TAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAC3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAC3 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 10866201
genes like me logo Genes that share ontologies with TAC3: view

Pathways & Interactions for TAC3 Gene

genes like me logo Genes that share pathways with TAC3: view

Gene Ontology (GO) - Biological Process for TAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007217 tachykinin receptor signaling pathway TAS,IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007565 female pregnancy TAS 10866201
GO:0045777 positive regulation of blood pressure IBA 21873635
genes like me logo Genes that share ontologies with TAC3: view

No data available for SIGNOR curated interactions for TAC3 Gene

Drugs & Compounds for TAC3 Gene

Products:

  1. Drug products for research

(34) Drugs for TAC3 Gene - From: DrugBank, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 271
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 150
Senktide Pharma Tachykinin NK3 agonist 0
Antagonist G Pharma 0
Eledoisin-Related Peptide Pharma 0

(4) Additional Compounds for TAC3 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SB 223412
174636-32-9

(5) Tocris Compounds for TAC3 Gene

Compound Action Cas Number
SB 218795 Potent, selective non-peptide NK3 antagonist 174635-53-1
SB 222200 Potent, selective non-peptide NK3 antagonist. Brain penetrant 174635-69-9
SB 223412 Potent, selective non-peptide NK3 antagonist. Brain penetrant 174636-32-9
Senktide Tachykinin NK3 agonist 106128-89-6
SSR 146977 hydrochloride Potent and selective NK3 antagonist 264618-38-4

(8) ApexBio Compounds for TAC3 Gene

Compound Action Cas Number
Antagonist G 115150-59-9
Eledoisin-Related Peptide 2990-43-4
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
Locustatachykinin I 126985-97-5
Neurokinin A (porcine) 86933-74-6
Neurokinin B (human, porcine) 86933-75-7
Substance P 33507-63-0
genes like me logo Genes that share compounds with TAC3: view

Drug products for research

Transcripts for TAC3 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for TAC3 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAC3

Alternative Splicing Database (ASD) splice patterns (SP) for TAC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - -
SP10:

Relevant External Links for TAC3 Gene

GeneLoc Exon Structure for
TAC3

Expression for TAC3 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAC3 Gene

mRNA expression in normal human tissues for TAC3 Gene
mRNA expression by BioGPS for TAC3 GenemRNA expression by GTEx for TAC3 Gene

mRNA differential expression in normal tissues according to GTEx for TAC3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.4), Brain - Caudate (basal ganglia) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Hypothalamus (x4.8), Stomach (x4.4), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for TAC3 Gene

This gene is overexpressed in Placenta (45.5), Vitreous humor (15.6), and Platelet (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAC3 Gene



Protein tissue co-expression partners for TAC3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAC3

SOURCE GeneReport for Unigene cluster for TAC3 Gene:

Hs.9730

Evidence on tissue expression from TISSUES for TAC3 Gene

  • Nervous system(4.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TAC3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • head
  • hypothalamus
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • olfactory bulb
  • pharynx
  • pituitary gland
  • skull
Thorax:
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
Pelvis:
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with TAC3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt for TAC3 Gene

Orthologs for TAC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TAC3 30 31
  • 99.72 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TAC3 30 31
  • 81.67 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TAC3 30 31
  • 79.61 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tac2 30 17 31
  • 76.58 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tac3 30
  • 75.38 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia TAC3 31
  • 46 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TAC3 31
  • 41 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TAC3 31
  • 37 (a)
 OneToOne
Species where no ortholog for TAC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TAC3 Gene

ENSEMBL:
Gene Tree for TAC3 (if available)
TreeFam:
Gene Tree for TAC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAC3: view image

Paralogs for TAC3 Gene

No data available for Paralogs for TAC3 Gene

Variants for TAC3 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAC3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1057521962 Likely Benign: not specified 57,010,288(-) A/G
NM_013251.4(TAC3):c.*2T>C 		NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
rs121918123 Pathogenic: Hypogonadotropic hypogonadism 10 without anosmia; not provided. Hypogonadotropic hypogonadism 10 with or without anosmia (HH10) [MIM:614839] 57,012,845(-) A/Gp.Met90Thr
NM_013251.4(TAC3):c.269T>C (p.Met90Thr) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs141908560 Likely Benign: not provided 57,012,424(-) G/A
NM_013251.4(TAC3):c.321C>T (p.Asn107=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs143862988 Likely Pathogenic: Delayed puberty 57,012,866(-) T/C
NM_013251.4(TAC3):c.248A>G (p.His83Arg) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs17119330 Benign: not provided 57,015,455(-) G/A
NM_013251.4(TAC3):c.114+229C>T 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAC3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TAC3 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789
nsv559022 CNV loss 21841781
nsv820171 CNV loss 19587683
nsv832428 CNV gain 17160897

Variation tolerance for TAC3 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAC3 Gene

Human Gene Mutation Database (HGMD)
TAC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAC3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAC3 Gene

Disorders for TAC3 Gene

MalaCards: The human disease database

(17) MalaCards diseases for TAC3 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 10 with or without anosmia
  • hh10
normosmic congenital hypogonadotropic hypogonadism
  • normosmic idiopathic hypogonadotropic hypogonadism
eclampsia
  • eclampsia in puerperium
hypogonadotropic hypogonadism
  • congenital idiopathic hypogonadotropic hypogonadism
hypogonadism
- elite association - COSMIC cancer census association via MalaCards
Search TAC3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TKNK_HUMAN
  • Hypogonadotropic hypogonadism 10 with or without anosmia (HH10) [MIM:614839]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:19079066, ECO:0000269 PubMed:23643382}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for TAC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TAC3: view

No data available for Genatlas for TAC3 Gene

Publications for TAC3 Gene

  1. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. (PMID: 19079066) Topaloglu AK … Semple RK (Nature genetics 2009) 3 4 23 74
  2. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. (PMID: 10866201) Page NM … Lowry PJ (Nature 2000) 2 3 4 23
  3. The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PMID: 17175032) Cunningham S … Vandenbroeck K (Journal of neuroimmunology 2007) 3 23 41
  4. Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. (PMID: 20580442) Klassert TE … Hernández M (Journal of neuroimmunology 2010) 3 41
  5. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. (PMID: 20332248) Gianetti E … Seminara SB (The Journal of clinical endocrinology and metabolism 2010) 3 74

ExternalLinks

View latest publications for TAC3 gene in Mastermind

Products for TAC3 Gene

  • Addgene plasmids for TAC3

Sources for TAC3 Gene