This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secr... See more...

Aliases for TAC1 Gene

Aliases for TAC1 Gene

  • Tachykinin Precursor 1 2 3 5
  • Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma) 2 3
  • Neuropeptide Gamma 2 3
  • Neurokinin Alpha 2 3
  • Preprotachykinin 2 3
  • Protachykinin-1 3 4
  • Neuropeptide K 2 3
  • Protachykinin 2 3
  • Neurokinin 1 2 3
  • Neurokinin 2 2 3
  • Neuromedin L 2 3
  • Substance K 2 3
  • Substance P 2 3
  • NKNA 3 4
  • TAC2 3 4
  • NPK 2 3
  • PPT 3 4
  • Neurokinin A 3
  • Tachykinin 2 3
  • Hs.2563 3
  • TAC1 5
  • NK2 3
  • NKA 4

External Ids for TAC1 Gene

Previous HGNC Symbols for TAC1 Gene

  • TAC2
  • NKNA

Previous GeneCards Identifiers for TAC1 Gene

  • GC07P095896
  • GC07P096959
  • GC07P096973
  • GC07P097006
  • GC07P097199
  • GC07P097361
  • GC07P091962

Summaries for TAC1 Gene

Entrez Gene Summary for TAC1 Gene

  • This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for TAC1 Gene

TAC1 (Tachykinin Precursor 1) is a Protein Coding gene. Diseases associated with TAC1 include Complex Regional Pain Syndrome and Vasomotor Rhinitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include substance P receptor binding.

UniProtKB/Swiss-Prot Summary for TAC1 Gene

  • Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Tocris Summary for TAC1 Gene

  • The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAC1 Gene

Genomics for TAC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TAC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J097731 Promoter 1.3 EPDnew Ensembl 250.7 -0.3 -283 0.4 ATF2 POLR2A ZNF639 ZNF610 ZNF843 ZNF2 ZNF189 INSM2 RAD51 ZFP37 HSALNG0059768 NONHSAG048276.2 TAC1 piR-31937-227 SDHAF3
GH07J097732 Promoter 0.9 EPDnew 250.7 0.0 -17 0.1 ATF2 ZNF223 POLR2A ZNF639 ZNF610 ZNF843 ZNF2 ZNF189 INSM2 RAD51 HSALNG0059768 NONHSAG048276.2 TAC1 piR-31937-227 SDHAF3
GH07J097734 Promoter 0.8 Ensembl 250.7 +0.6 617 1 ZNF223 POLR2A ZNF341 ZNF610 ZNF189 ZFP37 ZNF24 TAF1 SP7 ZSCAN21 HSALNG0059768 NONHSAG048276.2 TAC1 OR7E38P OR7E7P ASNS
GH07J097733 Enhancer 0.5 ENCODE 250.7 +1.4 1410 0 ZNF341 SP2 ZNF202 GLIS2 EZH2 ZNF335 ZBTB26 HSALNG0059768 NONHSAG048276.2 TAC1 RPS3AP26 ASNS
GH07J097269 Enhancer 0.5 Ensembl 13.8 -462.2 -462183 1.4 BATF JUNB IKZF1 NANOG IKZF2 RUNX3 RELB NR2F2 TAC1 piR-45012-477 piR-31292-186 SDHAF3 HSALNG0059752
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAC1

Top Transcription factor binding sites by QIAGEN in the TAC1 gene promoter:
  • GATA-1
  • Nkx2-5

Genomic Locations for TAC1 Gene

Latest Assembly
chr7:97,732,084-97,740,472
(GRCh38/hg38)
Size:
8,389 bases
Orientation:
Plus strand

Previous Assembly
chr7:97,361,398-97,369,784
(GRCh37/hg19 by Entrez Gene)
Size:
8,387 bases
Orientation:
Plus strand

chr7:97,361,220-97,369,784
(GRCh37/hg19 by Ensembl)
Size:
8,565 bases
Orientation:
Plus strand

Genomic View for TAC1 Gene

Genes around TAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAC1 Gene

Proteins for TAC1 Gene

  • Protein details for TAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20366-TKN1_HUMAN
    Recommended name:
    Protachykinin-1
    Protein Accession:
    P20366
    Secondary Accessions:
    • O60600
    • O60601
    • Q00072
    • Q53GH4
    • Q549V0
    • Q549V1
    • Q549V2
    • Q6FHM1

    Protein attributes for TAC1 Gene

    Size:
    129 amino acids
    Molecular mass:
    15003 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TAC1 Gene

    Alternative splice isoforms for TAC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAC1 Gene

Post-translational modifications for TAC1 Gene

  • The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAC1 Gene

No data available for DME Specific Peptides for TAC1 Gene

Domains & Families for TAC1 Gene

Gene Families for TAC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TAC1 Gene

InterPro:
Blocks:
  • Tachykinin/Neurokinin

Suggested Antigen Peptide Sequences for TAC1 Gene

GenScript: Design optimal peptide antigens:
  • PPT (TKN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20366

UniProtKB/Swiss-Prot:

TKN1_HUMAN :
  • Belongs to the tachykinin family.
Family:
  • Belongs to the tachykinin family.
genes like me logo Genes that share domains with TAC1: view

Function for TAC1 Gene

Molecular function for TAC1 Gene

UniProtKB/Swiss-Prot Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
GENATLAS Biochemistry:
tachykinin 1,neurokinin A (substance K) and substance P precursor gene

Phenotypes From GWAS Catalog for TAC1 Gene

Gene Ontology (GO) - Molecular Function for TAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031835 substance P receptor binding IBA 21873635
genes like me logo Genes that share ontologies with TAC1: view
genes like me logo Genes that share phenotypes with TAC1: view

Animal Models for TAC1 Gene

MGI Knock Outs for TAC1:

Animal Models for research

  • Taconic Biosciences Mouse Models for TAC1

miRNA for TAC1 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAC1

Clone products for research

  • Addgene plasmids for TAC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAC1 Gene

Localization for TAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAC1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 3
nucleus 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0030424 axon IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TAC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAC1 Gene

Pathways & Interactions for TAC1 Gene

genes like me logo Genes that share pathways with TAC1: view

Pathways by source for TAC1 Gene

1 KEGG pathway for TAC1 Gene
2 Qiagen pathways for TAC1 Gene
  • Neuropathic Pain-Signaling in Dorsal Horn Neurons
  • NK1R-mediated Non-Apoptotic PCD

SIGNOR curated interactions for TAC1 Gene

Activates:

Gene Ontology (GO) - Biological Process for TAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IEA --
GO:0006954 inflammatory response IBA 21873635
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 8957234
GO:0007217 tachykinin receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with TAC1: view

Drugs & Compounds for TAC1 Gene

(111) Drugs for TAC1 Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 150
Antagonist G Pharma 0
Eledoisin-Related Peptide Pharma 0
Fosaprepitant dimeglumine salt Pharma Neurokinin-1 antagonist 0
Locustatachykinin I Pharma 0

(49) Additional Compounds for TAC1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GR 159897
158848-32-9

(5) Tocris Compounds for TAC1 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) NK2 agonist 122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10) Selective NK2 agonist 137565-28-7
GR 159897 Non-peptide, potent NK2 antagonist 158848-32-9
GR 64349 Potent, selective NK2 agonist 137593-52-3
MDL 29,913 Selective NK2 antagonist 135721-56-1

(8) ApexBio Compounds for TAC1 Gene

Compound Action Cas Number
Antagonist G 115150-59-9
Eledoisin-Related Peptide 2990-43-4
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
Locustatachykinin I 126985-97-5
Neurokinin A (porcine) 86933-74-6
Neurokinin B (human, porcine) 86933-75-7
Substance P 33507-63-0
genes like me logo Genes that share compounds with TAC1: view

Drug products for research

Transcripts for TAC1 Gene

mRNA/cDNA for TAC1 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAC1

Clone products for research

  • Addgene plasmids for TAC1

Alternative Splicing Database (ASD) splice patterns (SP) for TAC1 Gene

No ASD Table

Relevant External Links for TAC1 Gene

GeneLoc Exon Structure for
TAC1

Expression for TAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAC1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x12.5), Brain - Putamen (basal ganglia) (x11.9), and Brain - Nucleus accumbens (basal ganglia) (x8.5).

Protein differential expression in normal tissues from HIPED for TAC1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAC1 Gene



Protein tissue co-expression partners for TAC1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAC1

SOURCE GeneReport for Unigene cluster for TAC1 Gene:

Hs.2563

Evidence on tissue expression from TISSUES for TAC1 Gene

  • Nervous system(4.8)
  • Intestine(4.6)
  • Blood(4.6)
  • Adrenal gland(4.5)
  • Muscle(2.9)
  • Spleen(2.6)
  • Heart(2.5)
  • Skin(2.5)
  • Stomach(2.5)
  • Lung(2.4)
  • Eye(2.3)
  • Kidney(2.2)
  • Bone(2.2)
  • Gall bladder(2.2)
  • Pancreas(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with TAC1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAC1 Gene

Orthologs for TAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAC1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TAC1 29 30
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TAC1 29 30
  • 96.12 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tac1 29 16 30
  • 93.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TAC1 29 30
  • 93.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tac1 29
  • 93.02 (n)
Oppossum
(Monodelphis domestica)
Mammalia TAC1 30
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TAC1 30
  • 42 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TAC1 29 30
  • 74.63 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TAC1 30
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tac1 29
  • 71.07 (n)
Zebrafish
(Danio rerio)
Actinopterygii tac1 29 30
  • 62.76 (n)
OneToOne
Species where no ortholog for TAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TAC1 Gene

ENSEMBL:
Gene Tree for TAC1 (if available)
TreeFam:
Gene Tree for TAC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAC1: view image
Alliance of Genome Resources:
Additional Orthologs for TAC1

Paralogs for TAC1 Gene

No data available for Paralogs for TAC1 Gene

Variants for TAC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAC1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs142031557 Likely Benign: not provided 97,736,303(+) T/C
NM_003182.3(TAC1):c.294T>C (p.His98=)
SYNONYMOUS_VARIANT,INTRON
rs201382322 Benign: not provided 97,732,624(+) C/G
NM_003182.3(TAC1):c.12C>G (p.Leu4=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAC1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TAC1 Gene

Variant ID Type Subtype PubMed ID
nsv437559 CNV loss 16327808

Variation tolerance for TAC1 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAC1 Gene

Human Gene Mutation Database (HGMD)
TAC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAC1
Leiden Open Variation Database (LOVD)
TAC1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAC1 Gene

Disorders for TAC1 Gene

MalaCards: The human disease database

(125) MalaCards diseases for TAC1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
complex regional pain syndrome
  • complex regional pain syndromes
vasomotor rhinitis
  • rhinitis vasomotor
cystitis
  • infective cystitis
keratopathy
interstitial cystitis
  • ulcerative cystitis
- elite association - COSMIC cancer census association via MalaCards
Search TAC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAC1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAC1 Gene

Publications for TAC1 Gene

  1. Do motor control genes contribute to interindividual variability in decreased movement in patients with pain? (PMID: 17655760) Mishra BK … Max MB (Molecular pain 2007) 3 22 40
  2. Three-dimensional structure of neuropeptide k bound to dodecylphosphocholine micelles. (PMID: 16503654) Dike A … Cowsik SM (Biochemistry 2006) 3 4 22
  3. Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. (PMID: 1708336) Chiwakata C … Ivell R (Endocrinology 1991) 2 3 4
  4. Characterization of the C-terminal flanking peptide of human beta-preprotachykinin. (PMID: 2284201) McGregor GP … Conlon JM (Peptides 1990) 3 4 22
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 40

Products for TAC1 Gene

  • Addgene plasmids for TAC1

Sources for TAC1 Gene