Aliases for TAB1 Gene
Aliases for TAB1 Gene
- TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1 2 3 5
- TAK1-Binding Protein 1 2 3 4
- Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1 3 4
- Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 2 2
- MAP3K7IP1 3 4
- Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1 3
External Ids for TAB1 Gene
- HGNC: 18157
- Entrez Gene: 10454
- Ensembl: ENSG00000100324
- OMIM: 602615
- UniProtKB: Q15750
Previous HGNC Symbols for TAB1 Gene
- MAP3K7IP1
Previous GeneCards Identifiers for TAB1 Gene
- GC22P039796
- GC22P022760
Summaries for TAB1 Gene
-
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAB1 Gene
TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include kinase activator activity.
UniProtKB/Swiss-Prot for TAB1 Gene
-
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Additional gene information for TAB1 Gene
- Monarch Initiative
- Search for TAB1 at DataMed
- Search for TAB1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAB1 Gene
Genomics for TAB1 Gene
GeneHancer (GH) Regulatory Elements for TAB1 Gene
Promoters and enhancers for TAB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around TAB1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TAB1 Gene
Genomic Locations for TAB1 Gene
- chr22:39,399,741-39,437,127
- (GRCh38/hg38)
- Size:
- 37,387 bases
- Orientation:
- Plus strand
- chr22:39,795,746-39,833,132
- (GRCh37/hg19)
- Size:
- 37,387 bases
- Orientation:
- Plus strand
Genomic View for TAB1 Gene
Genes around TAB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by Entrez Gene
- 22q13.1 by HGNC
- 22q13.1 by Ensembl
TAB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAB1 Gene
Proteins for TAB1 Gene
-
Protein details for TAB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15750-TAB1_HUMAN
- Recommended name:
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Protein Accession:
- Q15750
- Q2PP09
- Q8IZW2
Protein attributes for TAB1 Gene
- Size:
- 504 amino acids
- Molecular mass:
- 54644 Da
- Quaternary structure:
-
- Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).
Three dimensional structures from OCA and Proteopedia for TAB1 Gene
Protein Expression for TAB1 Gene
Post-translational modifications for TAB1 Gene
- Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
- Ubiquitination at isoforms=2264 and isoforms=2150
- Modification sites at PhosphoSitePlus
Other Protein References for TAB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TAB1 (TAB1)
-
Custom Antibody ServicesOriGene Antibodies for TAB1
- Novus Biologicals Antibodies for TAB1
-
Abcam antibodies for TAB1
- Invitrogen Antibodies for TAB1
- GeneTex TAB1 Antibody for TAB1
-
Custom Antibody ServicesProSci Antibodies for TAB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TAB1
Protein Products
-
OriGene Purified Proteins for TAB1
- Search Origene for MassSpec and Protein Over-expression Lysates for TAB1
- Origene Custom Protein Services for TAB1
- Search GeneTex for Proteins for TAB1
-
Abcam proteins for TAB1
Assay Products
No data available for DME Specific Peptides for TAB1 Gene
Domains & Families for TAB1 Gene
Gene Families for TAB1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TAB1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAB1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92811, Homo sapiens mitogen-activated protein kinase kinase kinase 7interacting protein 1 (MAP3K7IP1), mRNA (A8K6K3_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB94_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB95_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ23_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ24_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TAB1 Gene
Function for TAB1 Gene
Molecular function for TAB1 Gene
- UniProtKB/Swiss-Prot Function:
- May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
- GENATLAS Biochemistry:
- transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signaling through binding with API3 (XIAP)
Phenotypes From GWAS Catalog for TAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 10094049 |
| GO:0008047 | enzyme activator activity | TAS | 8638164 |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for TAB1 Gene
- MGI mutant phenotypes for TAB1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TAB1:
-
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TAB1
-
CRISPR Products
-
OriGene CRISPR knockouts for TAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAB1
- genomics-online: gRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- Applied Biological Materials CRISPR for TAB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
- GenScript: Design CRISPR guide RNA sequences for TAB1
miRNA for TAB1 Gene
- miRTarBase miRNAs that target TAB1
-
- hsa-mir-30d-5p (MIRT047792)
- hsa-mir-26b-5p (MIRT054555)
- hsa-mir-6836-3p (MIRT532640)
- hsa-mir-4633-5p (MIRT532641)
- hsa-mir-4693-5p (MIRT532642)
- hsa-mir-4711-3p (MIRT532643)
- hsa-mir-6829-3p (MIRT532644)
- hsa-mir-6791-3p (MIRT532645)
- hsa-mir-6778-3p (MIRT532646)
- hsa-mir-4726-3p (MIRT532647)
- hsa-mir-6764-5p (MIRT532648)
- hsa-mir-1915-3p (MIRT532649)
- hsa-mir-6840-3p (MIRT532650)
- hsa-mir-532-5p (MIRT532651)
- hsa-mir-6841-5p (MIRT532652)
- hsa-mir-892a (MIRT532653)
- hsa-mir-4318 (MIRT532654)
- hsa-mir-6818-3p (MIRT621902)
- hsa-mir-7150 (MIRT621903)
- hsa-mir-6873-3p (MIRT621904)
- hsa-mir-593-3p (MIRT621905)
- hsa-mir-6895-3p (MIRT621906)
- hsa-mir-4736 (MIRT621907)
- hsa-mir-4763-3p (MIRT621908)
- hsa-mir-1207-5p (MIRT621909)
- hsa-mir-6817-3p (MIRT621910)
- hsa-mir-7110-3p (MIRT621911)
- hsa-mir-3615 (MIRT621912)
- hsa-mir-8057 (MIRT652858)
- hsa-mir-4279 (MIRT652859)
- hsa-mir-24-3p (MIRT652860)
- hsa-mir-4284 (MIRT652861)
- hsa-mir-2276-3p (MIRT652862)
- hsa-mir-26a-2-3p (MIRT652863)
- hsa-mir-26a-1-3p (MIRT652864)
- hsa-mir-1281 (MIRT652865)
- hsa-mir-4485-5p (MIRT652866)
- hsa-mir-6890-3p (MIRT652867)
- hsa-mir-6511b-3p (MIRT652868)
- hsa-mir-6511a-3p (MIRT652869)
- hsa-mir-935 (MIRT652870)
- hsa-mir-3680-5p (MIRT652871)
- hsa-mir-4798-3p (MIRT652872)
- hsa-mir-3692-3p (MIRT652873)
- hsa-mir-6881-3p (MIRT652874)
- hsa-mir-4436b-5p (MIRT652875)
- hsa-mir-6509-3p (MIRT652876)
- hsa-mir-1250-3p (MIRT652877)
- hsa-mir-483-3p (MIRT652878)
- hsa-mir-29a-5p (MIRT734746)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAB1
- genomics-online: shRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TAB1
- VectorBuilder custom plasmid, inducible vectors for TAB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAB1
- Applied Biological Materials Clones for TAB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TAB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAB1 Gene
Localization for TAB1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endosome | 4 |
| extracellular | 2 |
| mitochondrion | 1 |
- Cytosol (4)
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0010008 | endosome membrane | TAS | -- |
| GO:0016607 | nuclear speck | IDA | -- |
| GO:0032991 | protein-containing complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAB1 Gene
Pathways & Interactions for TAB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Toll-like Receptor Signaling Pathway | ||
| 3 | IL-1 signaling pathway | ||
| 4 | Bacterial infections in CF airways | ||
| 5 | IL-1 Family Signaling Pathways | ||
Pathways by source for TAB1 Gene
1 Sino Biological pathway for TAB1 Gene
3 GeneTex pathways for TAB1 Gene
16 BioSystems pathways for TAB1 Gene
43 Reactome pathways for TAB1 Gene
10 KEGG pathways for TAB1 Gene
10 GeneGo (Thomson Reuters) pathways for TAB1 Gene
2 R&D Systems pathways for TAB1 Gene
12 Qiagen pathways for TAB1 Gene
3 Cell Signaling Technology pathways for TAB1 Gene
Interacting Proteins for TAB1 Gene
Selected Interacting proteins:
Q15750-TAB1_HUMAN
ENSP00000216160
for TAB1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TAB1
SIGNOR curated interactions for TAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000185 | activation of MAPKKK activity | IEA | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
Drugs & Compounds for TAB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | Target | 37 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for TAB1 Gene
mRNA/cDNA for TAB1 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (230) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000216160 3237 bps (uc003axt.4)
- ENST00000473613 534 bps (uc062elc.1)
- ENST00000331454 1660 bps (uc003axu.2)
- ENST00000461775 573 bps (uc062eld.1)
- ENST00000490819 240 bps (uc062ele.1)
Unigene Clusters for TAB1 Gene
- TGF-beta activated kinase 1/MAP3K7 binding protein 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAB1
- genomics-online: gRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- Applied Biological Materials CRISPR for TAB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
- GenScript: Design CRISPR guide RNA sequences for TAB1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAB1
- genomics-online: shRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TAB1
- VectorBuilder custom plasmid, inducible vectors for TAB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAB1
- Applied Biological Materials Clones for TAB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TAB1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Fetal Brain (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAB1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TAB1 Gene:
TAB1SOURCE GeneReport for Unigene cluster for TAB1 Gene:
Hs.507681mRNA Expression by UniProt/SwissProt for TAB1 Gene:
Q15750-TAB1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for TAB1 Gene
- Nervous system(4.8)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for TAB1
-
OriGene qPCR primer pairs for TAB1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAB1 Gene
Orthologs for TAB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TAB1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TAB1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tab1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tab1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | MAP3K7IP1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TAB1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TAB1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TAB1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TAB1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tab1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398025 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tab1 34 33 |
|
OneToOne | |
| Dr.16754 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002953 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | tap-1 34 |
|
OneToOne |
- Species where no ortholog for TAB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for TAB1 Gene
- ENSEMBL:
- Gene Tree for TAB1 (if available)
- TreeFam:
- Gene Tree for TAB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TAB1: view image
Paralogs for TAB1 Gene
(1) SIMAP similar genes for TAB1 Gene using alignment to 1 proteins:
- TAB1_HUMAN
No data available for Paralogs for TAB1 Gene
Variants for TAB1 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049465 | -- | 39,433,917(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000105901 | -- | 39,425,909(+) | G/A | intron_variant | |
| rs1000162606 | -- | 39,434,053(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000322641 | -- | 39,433,737(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000337588 | -- | 39,423,216(+) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2724254 | CNV | deletion | 23290073 |
| esv2724255 | CNV | deletion | 23290073 |
| esv3568393 | CNV | loss | 25503493 |
| esv3647764 | CNV | loss | 21293372 |
| nsv3628 | CNV | insertion | 18451855 |
| nsv471200 | CNV | loss | 18288195 |
| nsv834198 | CNV | loss | 17160897 |
| nsv834199 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.72;
57.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TAB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAB1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB1 Gene
Disorders for TAB1 Gene
Additional Disease Information for TAB1
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TAB1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAB1 Gene
Publications for TAB1 Gene
- TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PMID: 8638164) Shibuya H … Matsumoto K (Science (New York, N.Y.) 1996) 2 3 4 22 58
- The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PMID: 16845370) Thiefes A … Kracht M (EMBO reports 2006) 3 4 22 58
- TAK1-binding protein 1 is a pseudophosphatase. (PMID: 16879102) Conner SH … Van Aalten DM (The Biochemical journal 2006) 3 4 22 58
- TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PMID: 12429732) Ge B … Han J (The Journal of biological chemistry 2003) 3 4 22 58
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PMID: 11460167) Wang C … Chen ZJ (Nature 2001) 3 4 22 58
Products for TAB1 Gene
- R&D Systems Antibodies for TAB1 (TAB1)
- Browse R&D Systems for Human Recombinant Proteins
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- Custom Antibody ServicesOriGene Antibodies for TAB1
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- OriGene Purified Proteins for TAB1
- Search Origene for MassSpec and Protein Over-expression Lysates for TAB1
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- Origene sirna, shrna, and RNAi products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- OriGene qPCR primer pairs and template standards for TAB1
- OriGene qPCR primer pairs for TAB1
- OriGene CRISPR knockouts for TAB1
- OriGene ORF clones in human for TAB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for TAB1 in any vector
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- GenScript: Design CRISPR guide RNA sequences for TAB1
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TAB1
- Novus Biologicals proteins and lysates for TAB1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TAB1
- Abcam proteins for TAB1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for TAB1
- VectorBuilder custom plasmid, inducible vectors for TAB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 186 available TAB1 Antibodies ranked by validation data
- Compare Top TAB1 Antibodies
- antibodies-online: Search results for 6 available TAB1 Elisa Kits ranked by validation data
- Compare Top TAB1 Elisa Kits
- Recommended
- antibodies-online: Search results for 7 available TAB1 Proteins ranked by validation data
- Compare Top TAB1 Proteins
- GeneTex TAB1 Antibody for TAB1
- Search GeneTex for Proteins for TAB1
- Santa Cruz Biotechnology (SCBT) Antibodies for TAB1
- Search Santa Cruz Biotechnology (SCBT) for TAB1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
- Custom Antibody ServicesProSci Antibodies for TAB1
- Search for TAB1 Proteins at ProSci
- Horizon Cell Lines for TAB1
- genomics-online: cdna clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- orf clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- genomics-online: gRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- genomics-online: primer clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- genomics-online: shRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAB1
- GeneCopoeia miRNA 3'UTR Target clone products for TAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAB1
Sources for TAB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard