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The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding ... See more...
Aliases for TAB1 Gene
Aliases for TAB1 Gene
External Ids for TAB1 Gene
- HGNC: 18157
- NCBI Entrez Gene: 10454
- Ensembl: ENSG00000100324
- OMIM®: 602615
- UniProtKB/Swiss-Prot: Q15750
Previous HGNC Symbols for TAB1 Gene
- MAP3K7IP1
Previous GeneCards Identifiers for TAB1 Gene
- GC22P039796
- GC22P022760
Summaries for TAB1 Gene
-
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAB1 Gene
TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1) is a Protein Coding gene. Diseases associated with TAB1 include Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant and Frontometaphyseal Dysplasia. Among its related pathways are Toll-Like receptor Signaling Pathways and RANK Signaling in Osteoclasts. Gene Ontology (GO) annotations related to this gene include kinase activator activity. An important paralog of this gene is PPM1E.
UniProtKB/Swiss-Prot Summary for TAB1 Gene
-
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Additional gene information for TAB1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAB1 Gene
Genomics for TAB1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TAB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TAB1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAB1
Genomic Locations for TAB1 Gene
Latest Assembly
- chr22:39,399,778-39,437,132
- (GRCh38/hg38)
- Size:
- 37,355 bases
- Orientation:
- Plus strand
Previous Assembly
- chr22:39,795,785-39,833,137
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 37,353 bases
- Orientation:
- Plus strand
Genomic View for TAB1 Gene
Genes around TAB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by HGNC
- 22q13.1 by Entrez Gene
- 22q13.1 by Ensembl
TAB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAB1 Gene
Proteins for TAB1 Gene
-
Protein details for TAB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15750-TAB1_HUMAN
- Recommended name:
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Protein Accession:
- Q15750
- Q2PP09
- Q8IZW2
Protein attributes for TAB1 Gene
- Size:
- 504 amino acids
- Molecular mass:
- 54644 Da
- Quaternary structure:
-
- Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).
- Miscellaneous:
-
- [Isoform 2]: Does not bind nor activate MAP3K7/TAK1.
Three dimensional structures from OCA and Proteopedia for TAB1 Gene
Protein Expression for TAB1 Gene
Post-translational modifications for TAB1 Gene
- Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
-
Ubiquitination at Lys150 and Lys264
- NX_Q15750 (NX_Q15750-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TAB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences TAB1 Antibody
- G Biosciences Immunotag™ MAP3K7IP1 Antibody and Immunotag™ TAB1 Antibody
- BioLegend TAB1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for TAB1
- Novus Biologicals Antibodies for TAB1
-
Abcam antibodies for TAB1
- Invitrogen Antibodies for TAB1 (AFLGC-TAB1)
- antibodies-online: Show 53 available TAB1 Antibodies ranked by validation data
- Compare Top TAB1 Antibodies
-
Recommended
- 135 WB Antibodies (anti-human)
- 15 IF (p) Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 51 WB Antibodies (anti-mouse)
- 15 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 34 WB Antibodies (anti-rat)
- 15 IF (p) Antibodies (anti-rat)
-
Biorbyt antibodies for TAB1
-
Custom Antibody ServicesProSci Antibodies for TAB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TAB1
- Sino Biological Antibodies for TAB1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for TAB1
- Origene Custom Protein Services for TAB1
-
Abcam proteins for TAB1
Assay products for research
- antibodies-online: Show 7 available TAB1 Elisa Kits ranked by validation data
- Compare Top TAB1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TAB1 Gene
Domains & Families for TAB1 Gene
Gene Families for TAB1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TAB1 Gene
- InterPro:
Suggested Antigen Peptide Sequences for TAB1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92811, Homo sapiens mitogen-activated protein kinase kinase kinase 7interacting protein 1 (MAP3K7IP1), mRNA (A8K6K3_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB94_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB95_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ23_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ24_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TAB1 Gene
Function for TAB1 Gene
Molecular function for TAB1 Gene
- UniProtKB/Swiss-Prot Function:
- May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
- GENATLAS Biochemistry:
- transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signaling through binding with API3 (XIAP)
Phenotypes From GWAS Catalog for TAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA | -- |
| GO:0004724 | NOT magnesium-dependent protein serine/threonine phosphatase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 10094049 |
| GO:0008047 | enzyme activator activity | TAS | 8638164 |
Phenotypes for TAB1 Gene
- MGI mutant phenotypes for TAB1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TAB1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Downregulation of NF-kappaB pathway after IL-1beta stimulation
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TAB1 - Starting at $85 >
- * TAB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
miRNA for TAB1 Gene
- miRTarBase miRNAs that target TAB1
-
- hsa-miR-30d-5p (MIRT047792)
- hsa-miR-26b-5p (MIRT054555)
- hsa-miR-6836-3p (MIRT532640)
- hsa-miR-4633-5p (MIRT532641)
- hsa-miR-4693-5p (MIRT532642)
- hsa-miR-4711-3p (MIRT532643)
- hsa-miR-6829-3p (MIRT532644)
- hsa-miR-6791-3p (MIRT532645)
- hsa-miR-6778-3p (MIRT532646)
- hsa-miR-4726-3p (MIRT532647)
- hsa-miR-6764-5p (MIRT532648)
- hsa-miR-1915-3p (MIRT532649)
- hsa-miR-6840-3p (MIRT532650)
- hsa-miR-532-5p (MIRT532651)
- hsa-miR-6841-5p (MIRT532652)
- hsa-miR-892a (MIRT532653)
- hsa-miR-4318 (MIRT532654)
- hsa-miR-6818-3p (MIRT621902)
- hsa-miR-7150 (MIRT621903)
- hsa-miR-6873-3p (MIRT621904)
- hsa-miR-593-3p (MIRT621905)
- hsa-miR-6895-3p (MIRT621906)
- hsa-miR-4736 (MIRT621907)
- hsa-miR-4763-3p (MIRT621908)
- hsa-miR-1207-5p (MIRT621909)
- hsa-miR-6817-3p (MIRT621910)
- hsa-miR-7110-3p (MIRT621911)
- hsa-miR-3615 (MIRT621912)
- hsa-miR-8057 (MIRT652858)
- hsa-miR-4279 (MIRT652859)
- hsa-miR-24-3p (MIRT652860)
- hsa-miR-4284 (MIRT652861)
- hsa-miR-2276-3p (MIRT652862)
- hsa-miR-26a-2-3p (MIRT652863)
- hsa-miR-26a-1-3p (MIRT652864)
- hsa-miR-1281 (MIRT652865)
- hsa-miR-4485-5p (MIRT652866)
- hsa-miR-6890-3p (MIRT652867)
- hsa-miR-6511b-3p (MIRT652868)
- hsa-miR-6511a-3p (MIRT652869)
- hsa-miR-935 (MIRT652870)
- hsa-miR-3680-5p (MIRT652871)
- hsa-miR-4798-3p (MIRT652872)
- hsa-miR-3692-3p (MIRT652873)
- hsa-miR-6881-3p (MIRT652874)
- hsa-miR-4436b-5p (MIRT652875)
- hsa-miR-6509-3p (MIRT652876)
- hsa-miR-1250-3p (MIRT652877)
- hsa-miR-483-3p (MIRT652878)
- hsa-miR-29a-5p (MIRT734746)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAB1
Clone products for research
- Applied Biological Materials (abm): Clones for TAB1 - Starting at $45 >
- * TAB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TAB1
- Addgene plasmids for TAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAB1
Cell Lines for research
-
Horizon Cell Lines for TAB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAB1 Gene
Localization for TAB1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endosome | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0010008 | endosome membrane | TAS | -- |
| GO:0016607 | nuclear speck | IDA | -- |
| GO:0032991 | protein-containing complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAB1 Gene
Pathways & Interactions for TAB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Toll-like Receptor Signaling Pathway |
.37
|
|
| 3 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
|
|
| 4 | IL-1 signaling pathway | ||
| 5 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
IL-1 beta-dependent CFTR expression
.43
|
Pathways by source for TAB1 Gene
3 Sino Biological pathways for TAB1 Gene
16 BioSystems pathways for TAB1 Gene
43 Reactome pathways for TAB1 Gene
17 KEGG pathways for TAB1 Gene
10 GeneGo (Thomson Reuters) pathways for TAB1 Gene
- Bacterial infections in CF airways
- Cell adhesion_Plasmin signaling
- Development_TGF-beta receptor signaling
- IL-1 beta-dependent CFTR expression
- Immune response Bacterial infections in normal airways
3 R&D Systems pathways for TAB1 Gene
12 Qiagen pathways for TAB1 Gene
- APRIL Pathway
- BAFF in B-Cell Signaling
- BMP Pathway
- IL-1 Pathway
- iNOS Signaling
3 Cell Signaling Technology pathways for TAB1 Gene
3 GeneTex pathways for TAB1 Gene
Interacting Proteins for TAB1 Gene
Selected Interacting proteins:
Q15750-TAB1_HUMAN
ENSP00000216160
for TAB1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TAB1
SIGNOR curated interactions for TAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000185 | activation of MAPKKK activity | TAS,IEA | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
Drugs & Compounds for TAB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | Target | 65 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for TAB1 Gene
mRNA/cDNA for TAB1 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000216160 3198 nts (view in UCSC)
- ENST00000331454 1660 nts (view in UCSC)
- ENST00000461775 573 nts (view in UCSC)
- ENST00000473491 574 nts (view in UCSC)
- ENST00000473613 534 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TAB1 - Starting at $85 >
- * TAB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAB1
Clone products for research
- Applied Biological Materials (abm): Clones for TAB1 - Starting at $45 >
- * TAB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TAB1
- Addgene plasmids for TAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAB1
Relevant External Links for TAB1 Gene
- GeneLoc Exon Structure for
- TAB1
Expression for TAB1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Fetal Brain (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAB1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAB1
SOURCE GeneReport for Unigene cluster for TAB1 Gene:
Hs.507681mRNA Expression by UniProt/SwissProt for TAB1 Gene:
Q15750-TAB1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for TAB1 Gene
- Nervous system(4.9)
- Liver(4.4)
- Intestine(2.3)
- Blood(2.3)
- Kidney(2.3)
- Spleen(2.3)
- Heart(2.2)
- Muscle(2.2)
- Skin(2.1)
- Lymph node(2.1)
- Lung(2)
Primer products for research
-
OriGene qPCR primer pairs for TAB1
-
OriGene qPCR primer pairs and template standards for TAB1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAB1 Gene
Orthologs for TAB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TAB1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TAB1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tab1 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tab1 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | MAP3K7IP1 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TAB1 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TAB1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TAB1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TAB1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tab1 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398025 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tab1 29 30 |
|
OneToOne | |
| Dr.16754 29 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002953 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | tap-1 30 |
|
OneToOne |
- Species where no ortholog for TAB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TAB1 Gene
- ENSEMBL:
- Gene Tree for TAB1 (if available)
- TreeFam:
- Gene Tree for TAB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TAB1: view image
- Alliance of Genome Resources:
- Additional Orthologs for TAB1
Paralogs for TAB1 Gene
Variants for TAB1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAB1 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs118131187 | Benign: not provided | 39,416,786(+) |
C/T NM_006116.3(TAB1):c.325-5C>T |
INTRON | |
| rs36044118 | Benign: not provided | 39,426,846(+) |
C/T NM_006116.3(TAB1):c.1065C>T (p.His355=) |
SYNONYMOUS | |
| rs17001096 | -- |
p.Asp224Glu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2724254 | CNV | deletion | 23290073 |
| esv2724255 | CNV | deletion | 23290073 |
| esv3568393 | CNV | loss | 25503493 |
| esv3647764 | CNV | loss | 21293372 |
| nsv3628 | CNV | insertion | 18451855 |
| nsv471200 | CNV | loss | 18288195 |
| nsv834198 | CNV | loss | 17160897 |
| nsv834199 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.72;
57.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TAB1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB1 Gene
Disorders for TAB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant |
|
|
| frontometaphyseal dysplasia |
|
|
| breast cancer |
|
|
| noonan syndrome 1 |
|
|
Search TAB1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TAB1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TAB1 Gene
Publications for TAB1 Gene
- TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PMID: 8638164) Shibuya H … Matsumoto K (Science (New York, N.Y.) 1996) 2 3 4 22
- The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PMID: 16845370) Thiefes A … Kracht M (EMBO reports 2006) 3 4 22
- TAK1-binding protein 1 is a pseudophosphatase. (PMID: 16879102) Conner SH … Van Aalten DM (The Biochemical journal 2006) 3 4 22
- TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PMID: 12429732) Ge B … Han J (The Journal of biological chemistry 2003) 3 4 22
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PMID: 11460167) Wang C … Chen ZJ (Nature 2001) 3 4 22
ExternalLinks
Products for TAB1 Gene
- Custom Antibody ServicesOriGene Antibodies for TAB1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for TAB1
- Origene Custom Protein Services for TAB1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- OriGene qPCR primer pairs for TAB1
- OriGene qPCR primer pairs and template standards for TAB1
- OriGene CRISPR knockouts for TAB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TAB1
- Sino Biological Human cDNA Clone for TAB1
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- Sino Biological Antibodies for TAB1
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TAB1
- Novus Biologicals proteins and lysates for TAB1
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- Abcam antibodies for TAB1
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- Invitrogen Antibodies for TAB1 (AFLGC-TAB1)
- VectorBuilder Custom and pre-made DNA vectors for TAB1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TAB1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TAB1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TAB1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TAB1
- Addgene plasmids for TAB1
- antibodies-online: Show 53 available TAB1 Antibodies ranked by validation data