Aliases for TAB1 Gene
Aliases for TAB1 Gene
- TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1 2 3 5
- TAK1-Binding Protein 1 2 3 4
- Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 2 2
- Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1 3 4
- MAP3K7IP1 3 4
- Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1 3
External Ids for TAB1 Gene
- HGNC: 18157
- Entrez Gene: 10454
- Ensembl: ENSG00000100324
- OMIM: 602615
- UniProtKB: Q15750
Previous HGNC Symbols for TAB1 Gene
- MAP3K7IP1
Previous GeneCards Identifiers for TAB1 Gene
- GC22P039796
- GC22P022760
Summaries for TAB1 Gene
-
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAB1 Gene
TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1) is a Protein Coding gene. Among its related pathways are RANK Signaling in Osteoclasts and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include protein complex binding and kinase activator activity.
UniProtKB/Swiss-Prot for TAB1 Gene
-
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Additional gene information for TAB1 Gene
- Monarch Initiative
- Search for TAB1 at DataMed
- Search for TAB1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAB1 Gene
Genomics for TAB1 Gene
GeneHancer (GH) Regulatory Elements for TAB1 Gene
Promoters and enhancers for TAB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TAB1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TAB1 Gene
Genomic Locations for TAB1 Gene
- chr22:39,399,741-39,437,127
- (GRCh38/hg38)
- Size:
- 37,387 bases
- Orientation:
- Plus strand
- chr22:39,795,746-39,833,132
- (GRCh37/hg19)
Genomic View for TAB1 Gene
Genes around TAB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by Ensembl
- 22q13.1 by Entrez Gene
- 22q13.1 by HGNC
TAB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAB1 Gene
Proteins for TAB1 Gene
-
Protein details for TAB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15750-TAB1_HUMAN
- Recommended name:
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Protein Accession:
- Q15750
- Q2PP09
- Q8IZW2
Protein attributes for TAB1 Gene
- Size:
- 504 amino acids
- Molecular mass:
- 54644 Da
- Quaternary structure:
-
- Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).
Three dimensional structures from OCA and Proteopedia for TAB1 Gene
Protein Expression for TAB1 Gene
Post-translational modifications for TAB1 Gene
- Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
- Ubiquitination at isoforms=2150 and posLast=264264
Other Protein References for TAB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TAB1 (TAB1)
- Cell Signaling Technology (CST) Antibodies for TAB1 (TAB1)
-
Custom Antibody ServicesOriGene Antibodies for TAB1
- Novus Biologicals Antibodies for TAB1
-
Abcam antibodies for TAB1
-
Cloud-Clone Corp. Antibodies for TAB1
- Invitrogen Antibodies for TAB1
- GeneTex TAB1 antibody for TAB1
-
Custom Antibody ServicesProSci Antibodies for TAB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TAB1
Protein Products
-
OriGene Purified Proteins for TAB1
- Search Origene for MassSpec and Protein Over-expression Lysates for TAB1
- Origene Custom Protein Services for TAB1
-
Cloud-Clone Corp. Proteins for TAB1
- Search GeneTex for Proteins for TAB1
-
Abcam proteins for TAB1
Assay Products
No data available for DME Specific Peptides for TAB1 Gene
Domains & Families for TAB1 Gene
Gene Families for TAB1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TAB1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAB1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92811, Homo sapiens mitogen-activated protein kinase kinase kinase 7interacting protein 1 (MAP3K7IP1), mRNA (A8K6K3_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB94_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB95_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ23_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ24_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TAB1 Gene
Function for TAB1 Gene
Molecular function for TAB1 Gene
- GENATLAS Biochemistry:
- transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signaling through binding with API3 (XIAP)
- UniProtKB/Swiss-Prot Function:
- May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Phenotypes From GWAS Catalog for TAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 10094049 |
| GO:0008047 | enzyme activator activity | TAS | 8638164 |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for TAB1 Gene
- MGI mutant phenotypes for TAB1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TAB1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TAB1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TAB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TAB1 gene
- Search ViGene Biosciences for TAB1
CRISPR Products
-
OriGene CRISPR knockouts for TAB1
- genomics-online: gRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- Applied Biological Materials CRISPR for TAB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
- GenScript: Design CRISPR guide RNA sequences for TAB1
miRNA for TAB1 Gene
- miRTarBase miRNAs that target TAB1
-
- hsa-mir-30d-5p (MIRT047792)
- hsa-mir-26b-5p (MIRT054555)
- hsa-mir-6836-3p (MIRT532640)
- hsa-mir-4633-5p (MIRT532641)
- hsa-mir-4693-5p (MIRT532642)
- hsa-mir-4711-3p (MIRT532643)
- hsa-mir-6829-3p (MIRT532644)
- hsa-mir-6791-3p (MIRT532645)
- hsa-mir-6778-3p (MIRT532646)
- hsa-mir-4726-3p (MIRT532647)
- hsa-mir-6764-5p (MIRT532648)
- hsa-mir-1915-3p (MIRT532649)
- hsa-mir-6840-3p (MIRT532650)
- hsa-mir-532-5p (MIRT532651)
- hsa-mir-6841-5p (MIRT532652)
- hsa-mir-892a (MIRT532653)
- hsa-mir-4318 (MIRT532654)
- hsa-mir-6818-3p (MIRT621902)
- hsa-mir-7150 (MIRT621903)
- hsa-mir-6873-3p (MIRT621904)
- hsa-mir-593-3p (MIRT621905)
- hsa-mir-6895-3p (MIRT621906)
- hsa-mir-4736 (MIRT621907)
- hsa-mir-4763-3p (MIRT621908)
- hsa-mir-1207-5p (MIRT621909)
- hsa-mir-6817-3p (MIRT621910)
- hsa-mir-7110-3p (MIRT621911)
- hsa-mir-3615 (MIRT621912)
- hsa-mir-8057 (MIRT652858)
- hsa-mir-4279 (MIRT652859)
- hsa-mir-24-3p (MIRT652860)
- hsa-mir-4284 (MIRT652861)
- hsa-mir-2276-3p (MIRT652862)
- hsa-mir-26a-2-3p (MIRT652863)
- hsa-mir-26a-1-3p (MIRT652864)
- hsa-mir-1281 (MIRT652865)
- hsa-mir-4485-5p (MIRT652866)
- hsa-mir-6890-3p (MIRT652867)
- hsa-mir-6511b-3p (MIRT652868)
- hsa-mir-6511a-3p (MIRT652869)
- hsa-mir-935 (MIRT652870)
- hsa-mir-3680-5p (MIRT652871)
- hsa-mir-4798-3p (MIRT652872)
- hsa-mir-3692-3p (MIRT652873)
- hsa-mir-6881-3p (MIRT652874)
- hsa-mir-4436b-5p (MIRT652875)
- hsa-mir-6509-3p (MIRT652876)
- hsa-mir-1250-3p (MIRT652877)
- hsa-mir-483-3p (MIRT652878)
- hsa-mir-29a-5p (MIRT734746)
miRNA Products
- Search ViGene Biosciences for TAB1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- genomics-online: shRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TAB1 gene
Clone Products
- Sino Biological Human cDNA Clone for TAB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TAB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TAB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TAB1
-
ViGene Biosciences adenoviral particle packaged cDNA for TAB1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TAB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TAB1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAB1 Gene
Localization for TAB1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endosome | 4 |
| extracellular | 2 |
| mitochondrion | 1 |
- Cytosol (4)
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0010008 | endosome membrane | TAS | -- |
| GO:0016607 | nuclear speck | IDA | -- |
| GO:0043234 | protein complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAB1 Gene
Pathways & Interactions for TAB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Toll-like receptor signaling pathway | ||
| 3 | IL-1 signaling pathway | ||
| 4 | Bacterial infections in CF airways | ||
| 5 | IL-1 Family Signaling Pathways | ||
Pathways by source for TAB1 Gene
1 Sino Biological pathway for TAB1 Gene
3 GeneTex pathways for TAB1 Gene
3 Cell Signaling Technology pathways for TAB1 Gene
15 BioSystems pathways for TAB1 Gene
10 KEGG pathways for TAB1 Gene
10 GeneGo (Thomson Reuters) pathways for TAB1 Gene
2 R&D Systems pathways for TAB1 Gene
12 Qiagen pathways for TAB1 Gene
Interacting Proteins for TAB1 Gene
Selected Interacting proteins:
Q15750-TAB1_HUMAN
ENSP00000216160
for TAB1 Gene via
MINT
STRING
IID
UniProtKB
SIGNOR curated interactions for TAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000185 | activation of MAPKKK activity | IEA | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
Drugs & Compounds for TAB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | Target | 37 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for TAB1 Gene
mRNA/cDNA for TAB1 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (230) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TAB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TAB1
- genomics-online: gRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- Applied Biological Materials CRISPR for TAB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
- GenScript: Design CRISPR guide RNA sequences for TAB1
miRNA Products
- Search ViGene Biosciences for TAB1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- genomics-online: shRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TAB1 gene
Clone Products
- Sino Biological Human cDNA Clone for TAB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TAB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TAB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TAB1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Fetal Brain (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAB1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TAB1 Gene:
TAB1SOURCE GeneReport for Unigene cluster for TAB1 Gene:
Hs.507681mRNA Expression by UniProt/SwissProt for TAB1 Gene:
Q15750-TAB1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for TAB1 Gene
- Nervous system(4.8)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for TAB1
-
OriGene qPCR primer pairs and template standards for TAB1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAB1 Gene
Orthologs for TAB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TAB1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TAB1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tab1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tab1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | MAP3K7IP1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TAB1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TAB1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TAB1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TAB1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tab1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398025 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tab1 33 34 |
|
||
| Dr.16754 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002953 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | tap-1 34 |
|
OneToOne |
- Species where no ortholog for TAB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TAB1 Gene
(1) SIMAP similar genes for TAB1 Gene using alignment to 1 proteins:
No data available for Paralogs for TAB1 Gene
Variants for TAB1 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049465 | -- | 39,433,917(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000105901 | -- | 39,425,909(+) | G/A | intron_variant | |
| rs1000162606 | -- | 39,434,053(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000322641 | -- | 39,433,737(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000337588 | -- | 39,423,216(+) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv834199 | CNV | loss | 17160897 |
| nsv834198 | CNV | loss | 17160897 |
| nsv471200 | CNV | loss | 18288195 |
| nsv3628 | CNV | insertion | 18451855 |
| esv3647764 | CNV | loss | 21293372 |
| esv3568393 | CNV | loss | 25503493 |
| esv2724255 | CNV | deletion | 23290073 |
| esv2724254 | CNV | deletion | 23290073 |
Residual Variation Intolerance Score:
10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.72;
57.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TAB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAB1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB1 Gene
Disorders for TAB1 Gene
Additional Disease Information for TAB1
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TAB1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAB1 Gene
Publications for TAB1 Gene
- TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PMID: 8638164) Shibuya H … Matsumoto K (Science (New York, N.Y.) 1996) 2 3 4 22 58
- The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PMID: 16845370) Thiefes A … Kracht M (EMBO reports 2006) 3 4 22 58
- TAK1-binding protein 1 is a pseudophosphatase. (PMID: 16879102) Conner SH … Van Aalten DM (The Biochemical journal 2006) 3 4 22 58
- TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PMID: 12429732) Ge B … Han J (The Journal of biological chemistry 2003) 3 4 22 58
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PMID: 11460167) Wang C … Chen ZJ (Nature 2001) 3 4 22 58
Products for TAB1 Gene
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- Cloud-Clone Corp. Proteins for TAB1
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TAB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TAB1
- VectorBuilder custom plasmid, inducible vectors for TAB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 186 available TAB1 Antibodies ranked by validation data
- Compare Top TAB1 Antibodies
- antibodies-online: Search results for 6 available TAB1 Elisa Kits ranked by validation data
- Compare Top TAB1 Elisa Kits
- Recommended
- antibodies-online: Search results for 7 available TAB1 Proteins ranked by validation data
- Compare Top TAB1 Proteins
- GeneTex TAB1 antibody for TAB1
- Search GeneTex for Proteins for TAB1
- ViGene Biosciences adenoviral particle packaged cDNA for TAB1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TAB1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TAB1 gene
- Search ViGene Biosciences for TAB1
- Santa Cruz Biotechnology (SCBT) Antibodies for TAB1
- Search Santa Cruz Biotechnology (SCBT) for TAB1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
- Custom Antibody ServicesProSci Antibodies for TAB1
- Search for TAB1 Proteins at ProSci
- Horizon Cell Lines for TAB1
- genomics-online: cdna clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- orf clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- genomics-online: gRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- genomics-online: primer clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
- genomics-online: shRNA clones - Search results for 105 available TAB1 gene related products
- Overview of 105 available TAB1 gene related products
Sources for TAB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew