The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding ... See more...

Aliases for TAB1 Gene

Aliases for TAB1 Gene

  • TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1 2 3 5
  • TAK1-Binding Protein 1 2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1 3 4
  • TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 1 3 4
  • MAP3K7IP1 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 2
  • Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1 3
  • TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1 2
  • TGF-Beta-Activated Kinase 1-Binding Protein 1 4
  • 3'-Tab1 3

External Ids for TAB1 Gene

Previous HGNC Symbols for TAB1 Gene

  • MAP3K7IP1

Previous GeneCards Identifiers for TAB1 Gene

  • GC22P039796
  • GC22P022760

Summaries for TAB1 Gene

Entrez Gene Summary for TAB1 Gene

  • The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAB1 Gene

TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1) is a Protein Coding gene. Diseases associated with TAB1 include Breast Cancer. Among its related pathways are Metabolism of proteins and MicroRNAs in cardiomyocyte hypertrophy. Gene Ontology (GO) annotations related to this gene include kinase activator activity. An important paralog of this gene is PPM1K.

UniProtKB/Swiss-Prot Summary for TAB1 Gene

  • May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Gene Wiki entry for TAB1 Gene

Additional gene information for TAB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAB1 Gene

Genomics for TAB1 Gene

GeneHancer (GH) Regulatory Elements for TAB1 Gene

Promoters and enhancers for TAB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAB1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAB1

Genomic Locations for TAB1 Gene

Genomic Locations for TAB1 Gene
chr22:39,399,754-39,437,127
(GRCh38/hg38)
Size:
37,374 bases
Orientation:
Plus strand
chr22:39,795,746-39,833,132
(GRCh37/hg19)
Size:
37,387 bases
Orientation:
Plus strand

Genomic View for TAB1 Gene

Genes around TAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAB1 Gene

Proteins for TAB1 Gene

  • Protein details for TAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15750-TAB1_HUMAN
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Protein Accession:
    Q15750
    Secondary Accessions:
    • Q2PP09
    • Q8IZW2

    Protein attributes for TAB1 Gene

    Size:
    504 amino acids
    Molecular mass:
    54644 Da
    Quaternary structure:
    • Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).
    Miscellaneous:
    • [Isoform 2]: Does not bind nor activate MAP3K7/TAK1.

    Three dimensional structures from OCA and Proteopedia for TAB1 Gene

    Alternative splice isoforms for TAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAB1 Gene

Post-translational modifications for TAB1 Gene

  • Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
  • Ubiquitination at Lys150 and Lys264
  • Modification sites at PhosphoSitePlus

Other Protein References for TAB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAB1 Gene

Domains & Families for TAB1 Gene

Gene Families for TAB1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TAB1 Gene

Suggested Antigen Peptide Sequences for TAB1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92811, Homo sapiens mitogen-activated protein kinase kinase kinase 7interacting protein 1 (MAP3K7IP1), mRNA (A8K6K3_HUMAN)
  • Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB94_HUMAN)
  • Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB95_HUMAN)
  • Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ23_HUMAN)
  • Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ24_HUMAN)
genes like me logo Genes that share domains with TAB1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TAB1 Gene

Function for TAB1 Gene

Molecular function for TAB1 Gene

UniProtKB/Swiss-Prot Function:
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
GENATLAS Biochemistry:
transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signaling through binding with API3 (XIAP)

Phenotypes From GWAS Catalog for TAB1 Gene

Gene Ontology (GO) - Molecular Function for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IBA 21873635
GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity IBA 21873635
GO:0005515 protein binding IPI 10094049
GO:0008047 enzyme activator activity TAS 8638164
genes like me logo Genes that share ontologies with TAB1: view
genes like me logo Genes that share phenotypes with TAB1: view

Animal Models for TAB1 Gene

MGI Knock Outs for TAB1:
  • Tab1 Tab1<tm1Geny>
  • Tab1 Tab1<tm1.1Mis>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAB1 Gene

Localization for TAB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAB1 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
GO:0016607 nuclear speck IDA --
GO:0032991 protein-containing complex IEA --
genes like me logo Genes that share ontologies with TAB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAB1 Gene

Pathways & Interactions for TAB1 Gene

PathCards logo

SuperPathways for TAB1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Toll-like Receptor Signaling Pathway
3 IL-1 signaling pathway
4 Bacterial infections in CF airways
.78
.78
.46
.43
5 IL-1 Family Signaling Pathways
.42
.41
genes like me logo Genes that share pathways with TAB1: view

Pathways by source for TAB1 Gene

1 Sino Biological pathway for TAB1 Gene
10 GeneGo (Thomson Reuters) pathways for TAB1 Gene
  • Bacterial infections in CF airways
  • Cell adhesion_Plasmin signaling
  • Development_TGF-beta receptor signaling
  • IL-1 beta-dependent CFTR expression
  • Immune response Bacterial infections in normal airways
12 Qiagen pathways for TAB1 Gene
  • APRIL Pathway
  • BAFF in B-Cell Signaling
  • BMP Pathway
  • IL-1 Pathway
  • iNOS Signaling
3 Cell Signaling Technology pathways for TAB1 Gene
3 GeneTex pathways for TAB1 Gene

SIGNOR curated interactions for TAB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0001701 in utero embryonic development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TAB1: view

Drugs & Compounds for TAB1 Gene

(2) Drugs for TAB1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra Target 51

(2) Additional Compounds for TAB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAB1: view

Transcripts for TAB1 Gene

mRNA/cDNA for TAB1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAB1 Gene

No ASD Table

Relevant External Links for TAB1 Gene

GeneLoc Exon Structure for
TAB1

Expression for TAB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAB1 Gene

Protein differential expression in normal tissues from HIPED for TAB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Fetal Brain (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAB1 Gene



Protein tissue co-expression partners for TAB1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAB1

SOURCE GeneReport for Unigene cluster for TAB1 Gene:

Hs.507681

mRNA Expression by UniProt/SwissProt for TAB1 Gene:

Q15750-TAB1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TAB1 Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TAB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAB1 Gene

Orthologs for TAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAB1 31 30
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAB1 31 30
  • 90.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tab1 17 31 30
  • 88.71 (n)
rat
(Rattus norvegicus)
Mammalia Tab1 30
  • 87.45 (n)
cow
(Bos Taurus)
Mammalia MAP3K7IP1 31
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAB1 31
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAB1 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAB1 31 30
  • 80.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAB1 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tab1 30
  • 71.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398025 30
zebrafish
(Danio rerio)
Actinopterygii tab1 31 30
  • 66 (n)
OneToOne
Dr.16754 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002953 30
  • 49.07 (n)
worm
(Caenorhabditis elegans)
Secernentea tap-1 31
  • 26 (a)
OneToOne
Species where no ortholog for TAB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAB1 Gene

ENSEMBL:
Gene Tree for TAB1 (if available)
TreeFam:
Gene Tree for TAB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAB1: view image

Paralogs for TAB1 Gene

(1) SIMAP similar genes for TAB1 Gene using alignment to 1 proteins:

  • TAB1_HUMAN
genes like me logo Genes that share paralogs with TAB1: view

Variants for TAB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAB1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
715987 Benign: not provided 39,416,786(+) C/T INTRON_VARIANT
777712 Benign: not provided 39,426,846(+) C/T SYNONYMOUS_VARIANT
rs17001096 - p.Asp224Glu

Additional dbSNP identifiers (rs#s) for TAB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TAB1 Gene

Variant ID Type Subtype PubMed ID
esv2724254 CNV