Aliases for TAB1 Gene
- TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1 2 3 5
- TAK1-Binding Protein 1 2 3 4
- Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 2 2
- Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1 3 4
- MAP3K7IP1 3 4
- Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1 3
External Ids for TAB1 Gene
Previous HGNC Symbols for TAB1 Gene
Previous GeneCards Identifiers for TAB1 Gene
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAB1 Gene
TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1) is a Protein Coding gene. Among its related pathways are RANK Signaling in Osteoclasts and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include protein complex binding and kinase activator activity.
UniProtKB/Swiss-Prot for TAB1 Gene
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.