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The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding ... See more...
Aliases for TAB1 Gene
Aliases for TAB1 Gene
External Ids for TAB1 Gene
- HGNC: 18157
- Entrez Gene: 10454
- Ensembl: ENSG00000100324
- OMIM: 602615
- UniProtKB: Q15750
Previous HGNC Symbols for TAB1 Gene
- MAP3K7IP1
Previous GeneCards Identifiers for TAB1 Gene
- GC22P039796
- GC22P022760
Summaries for TAB1 Gene
-
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAB1 Gene
TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and IL-1 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include kinase activator activity. An important paralog of this gene is PPM1E.
UniProtKB/Swiss-Prot Summary for TAB1 Gene
-
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Additional gene information for TAB1 Gene
- Monarch Initiative
- Search for TAB1 at DataMed
- Search for TAB1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAB1 Gene
Genomics for TAB1 Gene
GeneHancer (GH) Regulatory Elements for TAB1 Gene
Promoters and enhancers for TAB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TAB1 on UCSC Golden Path with GeneCards custom track
Genomic Locations for TAB1 Gene
Genomic Locations for TAB1 Gene
- chr22:39,399,754-39,437,127
- (GRCh38/hg38)
- Size:
- 37,374 bases
- Orientation:
- Plus strand
- chr22:39,795,746-39,833,132
- (GRCh37/hg19)
- Size:
- 37,387 bases
- Orientation:
- Plus strand
Genomic View for TAB1 Gene
Genes around TAB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by HGNC
- 22q13.1 by Entrez Gene
- 22q13.1 by Ensembl
TAB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAB1 Gene
Proteins for TAB1 Gene
-
Protein details for TAB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15750-TAB1_HUMAN
- Recommended name:
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Protein Accession:
- Q15750
- Q2PP09
- Q8IZW2
Protein attributes for TAB1 Gene
- Size:
- 504 amino acids
- Molecular mass:
- 54644 Da
- Quaternary structure:
-
- Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).
Three dimensional structures from OCA and Proteopedia for TAB1 Gene
Protein Expression for TAB1 Gene
Post-translational modifications for TAB1 Gene
- Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
-
Ubiquitination at Lys150 and Lys264
- NX_Q15750 (NX_Q15750-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TAB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MAP3K7IP1 Antibody and Immunotag™ TAB1 Antibody
- Atlas Antibodies Anti-TAB1 Antibody (HPA057104) and Anti-TAB1 Antibody (HPA039988)
-
Creative Diagnostics
- BioLegend TAB1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for TAB1
- Novus Biologicals Antibodies for TAB1
-
Abcam antibodies for TAB1
- Invitrogen Antibodies for TAB1 (AFLGC-TAB1)
- antibodies-online: Show 53 available TAB1 Antibodies ranked by validation data
- Compare Top TAB1 Antibodies
-
Recommended
- 135 WB Antibodies (anti-human)
- 15 IF (p) Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 51 WB Antibodies (anti-mouse)
- 15 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 34 WB Antibodies (anti-rat)
- 15 IF (p) Antibodies (anti-rat)
-
Biorbyt antibodies for TAB1
-
Custom Antibody ServicesProSci Antibodies for TAB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TAB1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TAB1
- Origene Custom Protein Services for TAB1
-
Abcam proteins for TAB1
Assay Products
- Aviva Systems Biology TAB1 ELISA Kit (Human) : 96 Wells (OKEH01679)
- antibodies-online: Show 7 available TAB1 Elisa Kits ranked by validation data
- Compare Top TAB1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TAB1 Gene
Domains & Families for TAB1 Gene
Gene Families for TAB1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TAB1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAB1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92811, Homo sapiens mitogen-activated protein kinase kinase kinase 7interacting protein 1 (MAP3K7IP1), mRNA (A8K6K3_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB94_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B7ZB95_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ23_HUMAN)
- Mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (B8ZZ24_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TAB1 Gene
Function for TAB1 Gene
Molecular function for TAB1 Gene
- UniProtKB/Swiss-Prot Function:
- May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
- GENATLAS Biochemistry:
- transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signaling through binding with API3 (XIAP)
Phenotypes From GWAS Catalog for TAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IBA | 21873635 |
| GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 10094049 |
| GO:0008047 | enzyme activator activity | TAS | 8638164 |
Phenotypes for TAB1 Gene
- MGI mutant phenotypes for TAB1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TAB1:
-
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for TAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAB1
- genomics-online: gRNA clones - Search for available TAB1 gRNA products
- Overview of 116 available TAB1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for TAB1 - Select products 50% OFF >
- * TAB1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TAB1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
miRNA for TAB1 Gene
- miRTarBase miRNAs that target TAB1
-
- hsa-mir-30d-5p (MIRT047792)
- hsa-mir-26b-5p (MIRT054555)
- hsa-mir-6836-3p (MIRT532640)
- hsa-mir-4633-5p (MIRT532641)
- hsa-mir-4693-5p (MIRT532642)
- hsa-mir-4711-3p (MIRT532643)
- hsa-mir-6829-3p (MIRT532644)
- hsa-mir-6791-3p (MIRT532645)
- hsa-mir-6778-3p (MIRT532646)
- hsa-mir-4726-3p (MIRT532647)
- hsa-mir-6764-5p (MIRT532648)
- hsa-mir-1915-3p (MIRT532649)
- hsa-mir-6840-3p (MIRT532650)
- hsa-mir-532-5p (MIRT532651)
- hsa-mir-6841-5p (MIRT532652)
- hsa-mir-892a (MIRT532653)
- hsa-mir-4318 (MIRT532654)
- hsa-mir-6818-3p (MIRT621902)
- hsa-mir-7150 (MIRT621903)
- hsa-mir-6873-3p (MIRT621904)
- hsa-mir-593-3p (MIRT621905)
- hsa-mir-6895-3p (MIRT621906)
- hsa-mir-4736 (MIRT621907)
- hsa-mir-4763-3p (MIRT621908)
- hsa-mir-1207-5p (MIRT621909)
- hsa-mir-6817-3p (MIRT621910)
- hsa-mir-7110-3p (MIRT621911)
- hsa-mir-3615 (MIRT621912)
- hsa-mir-8057 (MIRT652858)
- hsa-mir-4279 (MIRT652859)
- hsa-mir-24-3p (MIRT652860)
- hsa-mir-4284 (MIRT652861)
- hsa-mir-2276-3p (MIRT652862)
- hsa-mir-26a-2-3p (MIRT652863)
- hsa-mir-26a-1-3p (MIRT652864)
- hsa-mir-1281 (MIRT652865)
- hsa-mir-4485-5p (MIRT652866)
- hsa-mir-6890-3p (MIRT652867)
- hsa-mir-6511b-3p (MIRT652868)
- hsa-mir-6511a-3p (MIRT652869)
- hsa-mir-935 (MIRT652870)
- hsa-mir-3680-5p (MIRT652871)
- hsa-mir-4798-3p (MIRT652872)
- hsa-mir-3692-3p (MIRT652873)
- hsa-mir-6881-3p (MIRT652874)
- hsa-mir-4436b-5p (MIRT652875)
- hsa-mir-6509-3p (MIRT652876)
- hsa-mir-1250-3p (MIRT652877)
- hsa-mir-483-3p (MIRT652878)
- hsa-mir-29a-5p (MIRT734746)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAB1
- genomics-online: shRNA clones - Search for available TAB1 shRNA products
- Overview of 116 available TAB1 gene related products
Clone Products
-
- MG208071
- MR208071
- MR208071L3
- MR208071L3V
- MR208071L4
- MR208071L4V
- RC208522
- RC208522L1
- RC208522L1V
- RC208522L2
- RC208522L2V
- RC208522L3
- RC208522L3V
- RC208522L4
- RC208522L4V
- RC217213
- RC217213L3
- RC217213L3V
- RC217213L4
- RC217213L4V
- RG208522
- RG217213
- RR212135
- RR212135L1
- RR212135L1V
- RR212135L2
- RR212135L2V
- RR212135L3
- RR212135L3V
- RR212135L4
- RR212135L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAB1
- genomics-online: cdna clones - Search for available TAB1 CDNA products
- Overview of 116 available TAB1 gene related products
- orf clones - Search for available TAB1 ORF products
- Overview of 116 available TAB1 gene related products
- Applied Biological Materials (abm): Clones for TAB1 - Select products 50% OFF >
- * TAB1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TAB1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for TAB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAB1 Gene
Localization for TAB1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endosome | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 0 |
- Cytosol (4)
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0010008 | endosome membrane | TAS | -- |
| GO:0016607 | nuclear speck | IDA | -- |
| GO:0032991 | protein-containing complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAB1 Gene
Pathways & Interactions for TAB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Toll-like Receptor Signaling Pathway |
.37
|
|
| 3 | IL-1 signaling pathway | ||
| 4 | Bacterial infections in CF airways | ||
| 5 | IL-1 Family Signaling Pathways | ||
Pathways by source for TAB1 Gene
1 Sino Biological pathway for TAB1 Gene
16 BioSystems pathways for TAB1 Gene
43 Reactome pathways for TAB1 Gene
14 KEGG pathways for TAB1 Gene
10 GeneGo (Thomson Reuters) pathways for TAB1 Gene
2 R&D Systems pathways for TAB1 Gene
12 Qiagen pathways for TAB1 Gene
- APRIL Pathway
- BAFF in B-Cell Signaling
- BMP Pathway
- IL-1 Pathway
- iNOS Signaling
3 Cell Signaling Technology pathways for TAB1 Gene
3 GeneTex pathways for TAB1 Gene
Interacting Proteins for TAB1 Gene
Selected Interacting proteins:
Q15750-TAB1_HUMAN
ENSP00000216160
for TAB1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TAB1
SIGNOR curated interactions for TAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000185 | activation of MAPKKK activity | IEA | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
Drugs & Compounds for TAB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Manganese | Approved | Nutra | Target | 48 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for TAB1 Gene
mRNA/cDNA for TAB1 Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (230) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000216160 3198 bps (ENST00000216160.10)
- ENST00000331454 1660 bps (ENST00000331454.3)
- ENST00000461775 573 bps (ENST00000461775.1)
- ENST00000473491 574 bps (ENST00000473491.1)
- ENST00000473613 534 bps (ENST00000473613.5)
CRISPR Products
-
OriGene CRISPR knockouts for TAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TAB1
- genomics-online: gRNA clones - Search for available TAB1 gRNA products
- Overview of 116 available TAB1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for TAB1 - Select products 50% OFF >
- * TAB1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TAB1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAB1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TAB1
- Browse OriGene Inhibitory RNA Products For TAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAB1
- genomics-online: shRNA clones - Search for available TAB1 shRNA products
- Overview of 116 available TAB1 gene related products
Clone Products
-
- MG208071
- MR208071
- MR208071L3
- MR208071L3V
- MR208071L4
- MR208071L4V
- RC208522
- RC208522L1
- RC208522L1V
- RC208522L2
- RC208522L2V
- RC208522L3
- RC208522L3V
- RC208522L4
- RC208522L4V
- RC217213
- RC217213L3
- RC217213L3V
- RC217213L4
- RC217213L4V
- RG208522
- RG217213
- RR212135
- RR212135L1
- RR212135L1V
- RR212135L2
- RR212135L2V
- RR212135L3
- RR212135L3V
- RR212135L4
- RR212135L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TAB1
- genomics-online: cdna clones - Search for available TAB1 CDNA products
- Overview of 116 available TAB1 gene related products
- orf clones - Search for available TAB1 ORF products
- Overview of 116 available TAB1 gene related products
- Applied Biological Materials (abm): Clones for TAB1 - Select products 50% OFF >
- * TAB1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TAB1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for TAB1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Fetal Brain (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAB1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TAB1 Gene:
TAB1SOURCE GeneReport for Unigene cluster for TAB1 Gene:
Hs.507681mRNA Expression by UniProt/SwissProt for TAB1 Gene:
Q15750-TAB1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for TAB1 Gene
- Nervous system(4.8)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for TAB1
-
OriGene qPCR primer pairs and template standards for TAB1
- genomics-online: primer clones - Search for available TAB1 Primer products
- Overview of 116 available TAB1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAB1 Gene
Orthologs for TAB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TAB1 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TAB1 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tab1 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tab1 32 |
|
||
| cow (Bos Taurus) |
Mammalia | MAP3K7IP1 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TAB1 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TAB1 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TAB1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TAB1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tab1 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398025 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tab1 33 32 |
|
OneToOne | |
| Dr.16754 32 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002953 32 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | tap-1 33 |
|
OneToOne |
- Species where no ortholog for TAB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for TAB1 Gene
- ENSEMBL:
- Gene Tree for TAB1 (if available)
- TreeFam:
- Gene Tree for TAB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TAB1: view image
Paralogs for TAB1 Gene
Variants for TAB1 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049465 | -- | 39,433,917(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000105901 | -- | 39,425,909(+) | G/A | intron_variant | |
| rs1000162606 | -- | 39,434,053(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000322641 | -- | 39,433,737(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000337588 | -- | 39,423,216(+) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2724254 | CNV | deletion | 23290073 |
| esv2724255 | CNV | deletion | 23290073 |
| esv3568393 | CNV | loss | 25503493 |
| esv3647764 | CNV | loss | 21293372 |
| nsv3628 | CNV | insertion | 18451855 |
| nsv471200 | CNV | loss | 18288195 |
| nsv834198 | CNV | loss | 17160897 |
| nsv834199 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.72;
57.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TAB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAB1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB1 Gene
Disorders for TAB1 Gene
Additional Disease Information for TAB1
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TAB1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAB1 Gene
Publications for TAB1 Gene
- TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PMID: 8638164) Shibuya H … Matsumoto K (Science (New York, N.Y.) 1996) 2 3 4 23 56
- TAK1-binding protein 1 is a pseudophosphatase. (PMID: 16879102) Conner SH … Van Aalten DM (The Biochemical journal 2006) 3 4 23 56
- The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PMID: 16845370) Thiefes A … Kracht M (EMBO reports 2006) 3 4 23 56
- TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PMID: 12429732) Ge B … Han J (The Journal of biological chemistry 2003) 3 4 23 56
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PMID: 11460167) Wang C … Chen ZJ (Nature 2001) 3 4 23 56
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