TAAR1 Gene (Protein Coding)

Trace Amine Associated Receptor 1

GC06M132644
GIFtS:
39
The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in bloo... See more...

Aliases for TAAR1 Gene

Aliases for TAAR1 Gene

  • Trace Amine Associated Receptor 1 2 3 5
  • Trace Amine Receptor 1 2 3 4
  • TAR1 2 3 4
  • TA1 2 3 4
  • Trace Amine-Associated Receptor 1 3 4
  • TRAR1 3 4
  • TAAR1 5
  • TaR-1 4

External Ids for TAAR1 Gene

Previous HGNC Symbols for TAAR1 Gene

  • TRAR1

Previous GeneCards Identifiers for TAAR1 Gene

  • GC06M133008
  • GC06M130541
  • GC06M132966

Summaries for TAAR1 Gene

Entrez Gene Summary for TAAR1 Gene

  • The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

GeneCards Summary for TAAR1 Gene

TAAR1 (Trace Amine Associated Receptor 1) is a Protein Coding gene. Diseases associated with TAAR1 include Multiple Personality Disorder and Hypoparathyroidism, Sensorineural Deafness, And Renal Disease. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR2.

UniProtKB/Swiss-Prot Summary for TAAR1 Gene

  • Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Tocris Summary for TAAR1 Gene

  • The trace amine 1 (TA1) receptor (also known as the trace amine-associated receptor 1, TAAR1) is a class A GPCR that is activated by endogenous trace amines. To date, the TA1 receptor is the only trace amine-associated receptor that has been de-orphaned.

Gene Wiki entry for TAAR1 Gene

Additional gene information for TAAR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TAAR1 Gene

Genomics for TAAR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TAAR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J132669 Enhancer 0.9 Ensembl ENCODE 0.4 -14.2 -14219 7.6 CTCF BHLHE40 RAD51 FOXA2 SMC3 RAD21 BCL6 USF2 SPI1 HNF4A HLFP1 lnc-TAAR6-1 VNN1 ENSG00000234484 VNN2 VNN3 RPS12 SNORA33 SNORD100 SNORD101
GH06J132711 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 0.2 -54.3 -54282 3 CEBPA FOXA2 RXRA RARA ZBTB33 JUND SPI1 MAX HNF4A RAD21 VNN1 lnc-RPS12-5 TAAR1
GH06J132648 Enhancer 0.6 Ensembl 0.4 +10.5 10482 1 FEZF1 ZNF843 CBFB BATF FOXA1 ATF2 JUNB BCL6B ZSCAN26 RUNX3 VNN1 TAAR1 TAAR2
GH06J132650 Enhancer 0.5 Ensembl 0.4 +8.2 8181 1.2 ATF2 ATF4 CEBPB ATF3 ZNF7 ATF7 CEBPG VNN2 TAAR1 TAAR2
GH06J132665 Enhancer 0.5 Ensembl 0.4 -7.3 -7319 0.2 ZNF316 NFE2 NFE2L2 MAFG SP1 VNN1 TAAR1 lnc-TAAR6-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAAR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TAAR1

Top Transcription factor binding sites by QIAGEN in the TAAR1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CUTL1
  • FOXD3
  • HNF-3beta
  • Pax-4a
  • RSRFC4
  • TBP
  • TFIID

Genomic Locations for TAAR1 Gene

Latest Assembly
chr6:132,643,312-132,659,182
(GRCh38/hg38)
Size:
15,871 bases
Orientation:
Minus strand

Previous Assembly
chr6:132,964,451-132,980,321
(GRCh37/hg19 by Entrez Gene)
Size:
15,871 bases
Orientation:
Minus strand

chr6:132,966,123-132,967,142
(GRCh37/hg19 by Ensembl)
Size:
1,020 bases
Orientation:
Minus strand

Genomic View for TAAR1 Gene

Genes around TAAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAAR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TAAR1 Gene

Proteins for TAAR1 Gene

Products:

  1. Antibodies for research
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  3. Assay products for research

  • Protein details for TAAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RJ0-TAAR1_HUMAN
    Recommended name:
    Trace amine-associated receptor 1
    Protein Accession:
    Q96RJ0
    Secondary Accessions:
    • Q2M1W5
    • Q3MIH8
    • Q5VUQ1

    Protein attributes for TAAR1 Gene

    Size:
    339 amino acids
    Molecular mass:
    39092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAAR1 Gene

Protein Expression for TAAR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TAAR1 Gene

  • Glycosylation at Asn10 and Asn17
  • Modification sites at PhosphoSitePlus

Other Protein References for TAAR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAAR1 Gene

Domains & Families for TAAR1 Gene

Gene Families for TAAR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAAR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAAR1 Gene

GenScript: Design optimal peptide antigens:
  • Trace amine-associated receptor 1 (TAAR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RJ0

UniProtKB/Swiss-Prot:

TAAR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TAAR1: view

Function for TAAR1 Gene

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  1. Animal Models for research
  2. CRISPR products for research
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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for TAAR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Phenotypes From GWAS Catalog for TAAR1 Gene

Gene Ontology (GO) - Molecular Function for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IDA 11723224
GO:0008227 G protein-coupled amine receptor activity IEA --
genes like me logo Genes that share ontologies with TAAR1: view
genes like me logo Genes that share phenotypes with TAAR1: view

Animal Models for TAAR1 Gene

MGI Knock Outs for TAAR1:

Animal Models for research

  • Taconic Biosciences Mouse Models for TAAR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAAR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAAR1 Gene

Localization for TAAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAAR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TAAR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAAR1 Gene

Pathways & Interactions for TAAR1 Gene

genes like me logo Genes that share pathways with TAAR1: view

Interacting Proteins for TAAR1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000275216 Q96RJ0-TAAR1_HUMAN for TAAR1 Gene via STRING IID

GPS-Prot Interaction Network for TAAR1

Gene Ontology (GO) - Biological Process for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TAAR1: view

No data available for SIGNOR curated interactions for TAAR1 Gene

Drugs & Compounds for TAAR1 Gene

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  1. Drug products for research

(17) Drugs for TAAR1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amphetamine Approved, Illicit, Investigational Pharma Target, agonist, antagonist 158
Methamphetamine Approved, Illicit Pharma Target, agonist, antagonist 258
Dextroamphetamine Approved, Illicit Pharma Agonist, Full agonist, Target 91
Propylhexedrine Approved Pharma Target, agonist 0
Lisdexamfetamine Approved, Investigational Pharma Target, agonist 0

(3) Additional Compounds for TAAR1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ractopamine hydrochloride
90274-24-1

(2) Tocris Compounds for TAAR1 Gene

Compound Action Cas Number
EPPTB Trace amine 1 (TA1) receptor antagonist/inverse agonist 1110781-88-8
Ractopamine hydrochloride Trace amine 1 (TA1) receptor agonist 90274-24-1
genes like me logo Genes that share compounds with TAAR1: view

Transcripts for TAAR1 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for TAAR1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAAR1

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR1 Gene

No ASD Table

Relevant External Links for TAAR1 Gene

GeneLoc Exon Structure for
TAAR1

Expression for TAAR1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAAR1 Gene

mRNA expression in normal human tissues for TAAR1 Gene
mRNA expression by BioGPS for TAAR1 GenemRNA expression by GTEx for TAAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for TAAR1 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TAAR1 Gene



Protein tissue co-expression partners for TAAR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TAAR1

SOURCE GeneReport for Unigene cluster for TAAR1 Gene:

Hs.375030

mRNA Expression by UniProt/SwissProt for TAAR1 Gene:

Q96RJ0-TAAR1_HUMAN
Tissue specificity: Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.

Evidence on tissue expression from TISSUES for TAAR1 Gene

  • Lung(4.3)
  • Thyroid gland(2.5)
  • Kidney(2.3)
  • Nervous system(2.3)
  • Heart(2.2)
  • Muscle(2.2)
  • Intestine(2.1)
  • Stomach(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with TAAR1: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAAR1 Gene

Orthologs for TAAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TAAR1 30 31
  • 99.21 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TAAR1 31
  • 84 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Taar1 30
  • 79.12 (n)
Mouse
(Mus musculus)
 Mammalia Taar1 30 17 31
  • 78.92 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TAAR1 31
  • 76 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TAAR1 31
  • 68 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TAAR1 30 31
  • 70.18 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TAAR1 31
  • 64 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia taar1 30
  • 67.97 (n)
Zebrafish
(Danio rerio)
 Actinopterygii taar1b 30 31
  • 56.9 (n)
 OneToMany
taar10b 31
  • 49 (a)
 OneToMany
taar10d 31
  • 48 (a)
 OneToMany
taar10c 31
  • 47 (a)
 OneToMany
taar10a 31
  • 47 (a)
 OneToMany
TAAR1 (22 of 92) 31
  • 46 (a)
 OneToMany
taar10 31
  • 46 (a)
 OneToMany
taar11 31
  • 45 (a)
 OneToMany
TAAR1 (33 of 92) 31
  • 44 (a)
 OneToMany
taar16b 31
  • 37 (a)
 OneToMany
taar20x 31
  • 36 (a)
 OneToMany
taar20t 31
  • 36 (a)
 OneToMany
taar19i 31
  • 36 (a)
 OneToMany
taar19p 31
  • 35 (a)
 OneToMany
TAAR1 (73 of 92) 31
  • 35 (a)
 OneToMany
taar32 31
  • 35 (a)
 OneToMany
taar19e 31
  • 35 (a)
 OneToMany
TAAR1 (17 of 92) 31
  • 35 (a)
 OneToMany
taar19o 31
  • 35 (a)
 OneToMany
taar19s 31
  • 35 (a)
 OneToMany
taar20d1 31
  • 35 (a)
 OneToMany
taar19h 31
  • 35 (a)
 OneToMany
TAAR1 (64 of 92) 31
  • 35 (a)
 OneToMany
taar19n 31
  • 35 (a)
 OneToMany
taar20b 31
  • 35 (a)
 OneToMany
TAAR1 (62 of 92) 31
  • 35 (a)
 OneToMany
TAAR1 (44 of 92) 31
  • 35 (a)
 OneToMany
taar20l 31
  • 35 (a)
 OneToMany
taar19t 31
  • 35 (a)
 OneToMany
taar19c 31
  • 35 (a)
 OneToMany
taar20w 31
  • 35 (a)
 OneToMany
taar19g 31
  • 35 (a)
 OneToMany
taar20n 31
  • 34 (a)
 OneToMany
taar19a 31
  • 34 (a)
 OneToMany
taar20q 31
  • 34 (a)
 OneToMany
TAAR1 (75 of 92) 31
  • 34 (a)
 OneToMany
taar20a1 31
  • 34 (a)
 OneToMany
taar14l 31
  • 34 (a)
 OneToMany
TAAR1 (19 of 92) 31
  • 34 (a)
 OneToMany
taar20z 31
  • 34 (a)
 OneToMany
taar20c1 31
  • 34 (a)
 OneToMany
taar20p 31
  • 34 (a)
 OneToMany
taar20j 31
  • 34 (a)
 OneToMany
taar19d 31
  • 34 (a)
 OneToMany
taar19f 31
  • 34 (a)
 OneToMany
taar18h 31
  • 34 (a)
 OneToMany
taar19q 31
  • 34 (a)
 OneToMany
taar18a 31
  • 34 (a)
 OneToMany
taar20a 31
  • 34 (a)
 OneToMany
taar14i 31
  • 34 (a)
 OneToMany
taar20b1 31
  • 34 (a)
 OneToMany
TAAR1 (21 of 92) 31
  • 34 (a)
 OneToMany
taar16a 31
  • 34 (a)
 OneToMany
taar19m 31
  • 34 (a)
 OneToMany
taar15 31
  • 34 (a)
 OneToMany
taar18b 31
  • 34 (a)
 OneToMany
taar20o 31
  • 34 (a)
 OneToMany
taar20g 31
  • 34 (a)
 OneToMany
taar19k 31
  • 34 (a)
 OneToMany
taar20r 31
  • 33 (a)
 OneToMany
TAAR1 (74 of 92) 31
  • 33 (a)
 OneToMany
taar18e 31
  • 33 (a)
 OneToMany
taar18i 31
  • 33 (a)
 OneToMany
taar20f 31
  • 33 (a)
 OneToMany
taar14f 31
  • 33 (a)
 OneToMany
taar19j 31
  • 33 (a)
 OneToMany
taar18j 31
  • 33 (a)
 OneToMany
taar20c 31
  • 33 (a)
 OneToMany
TAAR1 (42 of 92) 31
  • 33 (a)
 OneToMany
taar20u 31
  • 33 (a)
 OneToMany
taar19b 31
  • 33 (a)
 OneToMany
taar14h 31
  • 33 (a)
 OneToMany
TAAR1 (55 of 92) 31
  • 33 (a)
 OneToMany
TAAR1 (32 of 92) 31
  • 33 (a)
 OneToMany
taar18g 31
  • 33 (a)
 OneToMany
taar14e 31
  • 33 (a)
 OneToMany
taar14d 31
  • 33 (a)
 OneToMany
taar14a 31
  • 33 (a)
 OneToMany
taar19u 31
  • 33 (a)
 OneToMany
taar18d 31
  • 32 (a)
 OneToMany
taar14g 31
  • 32 (a)
 OneToMany
taar18f 31
  • 32 (a)
 OneToMany
taar17a 31
  • 32 (a)
 OneToMany
taar20m 31
  • 32 (a)
 OneToMany
taar16f 31
  • 32 (a)
 OneToMany
taar16g 31
  • 32 (a)
 OneToMany
taar20i 31
  • 32 (a)
 OneToMany
taar19l 31
  • 32 (a)
 OneToMany
taar20h 31
  • 32 (a)
 OneToMany
TAAR1 (7 of 92) 31
  • 32 (a)
 OneToMany
taar14j 31
  • 30 (a)
 OneToMany
taar18c 31
  • 23 (a)
 OneToMany
Species where no ortholog for TAAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TAAR1 Gene

ENSEMBL:
Gene Tree for TAAR1 (if available)
TreeFam:
Gene Tree for TAAR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TAAR1: view image

Paralogs for TAAR1 Gene

Paralogs for TAAR1 Gene

(16) SIMAP similar genes for TAAR1 Gene using alignment to 1 proteins:

  • TAAR1_HUMAN

Pseudogenes.org Pseudogenes for TAAR1 Gene

genes like me logo Genes that share paralogs with TAAR1: view

Variants for TAAR1 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TAAR1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1358747980 Likely Benign: not provided 132,645,542(-) A/G
NM_138327.3(TAAR1):c.462T>C (p.Phe154=) 		SYNONYMOUS
rs140105605 Likely Benign: not provided 132,645,383(-) T/C
NM_138327.3(TAAR1):c.621A>G (p.Leu207=) 		SYNONYMOUS
rs6926857 Benign: not provided. - 132,645,250(-) T/Cp.Thr252Ala
NM_138327.3(TAAR1):c.754A>G (p.Thr252Ala) 		MISSENSE
rs73775159 Benign: not provided 132,645,893(-) T/G
NM_138327.3(TAAR1):c.111A>C (p.Thr37=) 		SYNONYMOUS
rs8192618 Benign: not provided. - 132,645,937(-) G/Ap.Arg23Cys
NM_138327.3(TAAR1):c.67C>T (p.Arg23Cys) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TAAR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for TAAR1 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAAR1 Gene

Human Gene Mutation Database (HGMD)
TAAR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAAR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAAR1 Gene

Disorders for TAAR1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TAAR1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search TAAR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAAR1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
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No data available for UniProtKB/Swiss-Prot and Genatlas for TAAR1 Gene

Publications for TAAR1 Gene

  1. Trace amines: identification of a family of mammalian G protein-coupled receptors. (PMID: 11459929) Borowsky B … Gerald C (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 26
  2. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PMID: 15718104) Lindemann L … Hoener MC (Genomics 2005) 2 3 4
  3. Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1. (PMID: 18602830) Lewin AH … Mascarella SW (Bioorganic & medicinal chemistry 2008) 3 23
  4. Trace amine-associated receptor 1-Family archetype or iconoclast? (PMID: 17888514) Grandy DK (Pharmacology & therapeutics 2007) 23 26
  5. Trace amine-associated receptor 1 is a modulator of the dopamine transporter. (PMID: 17234899) Xie Z … Miller GM (The Journal of pharmacology and experimental therapeutics 2007) 23 26

ExternalLinks

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