Aliases for TAAR1 Gene
External Ids for TAAR1 Gene
Previous HGNC Symbols for TAAR1 Gene
Previous GeneCards Identifiers for TAAR1 Gene
The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]
GeneCards Summary for TAAR1 Gene
TAAR1 (Trace Amine Associated Receptor 1) is a Protein Coding gene. Diseases associated with TAAR1 include Multiple Personality Disorder and Hypoparathyroidism, Sensorineural Deafness, And Renal Disease. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR2.
UniProtKB/Swiss-Prot Summary for TAAR1 Gene
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
The trace amine 1 (TA1) receptor (also known as the trace amine-associated receptor 1, TAAR1) is a class A GPCR that is activated by endogenous trace amines. To date, the TA1 receptor is the only trace amine-associated receptor that has been de-orphaned.