Aliases for SLC25A5 Gene
External Ids for SLC25A5 Gene
Previous HGNC Symbols for SLC25A5 Gene
Previous GeneCards Identifiers for SLC25A5 Gene
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]
GeneCards Summary for SLC25A5 Gene
SLC25A5 (Solute Carrier Family 25 Member 5) is a Protein Coding gene. Diseases associated with SLC25A5 include Oncocytoma and Non-Syndromic Intellectual Disability. Among its related pathways are Pathways of neurodegeneration - multiple diseases and cGMP-PKG signaling pathway. Gene Ontology (GO) annotations related to this gene include adenine transmembrane transporter activity. An important paralog of this gene is SLC25A6.
UniProtKB/Swiss-Prot Summary for SLC25A5 Gene
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.