Aliases for SLC25A21 Gene
External Ids for SLC25A21 Gene
Previous GeneCards Identifiers for SLC25A21 Gene
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
GeneCards Summary for SLC25A21 Gene
SLC25A21 (Solute Carrier Family 25 Member 21) is a Protein Coding gene. Diseases associated with SLC25A21 include Bronchus Adenoma and Synpolydactyly. Among its related pathways are Metabolism and Viral mRNA Translation. An important paralog of this gene is SLC25A16.
UniProtKB/Swiss-Prot Summary for SLC25A21 Gene
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.