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Aliases for SZRD1 Gene

Aliases for SZRD1 Gene

  • SUZ RNA Binding Domain Containing 1 2 3 5
  • Putative MAPK-Activating Protein PM18/PM20/PM22 3 4
  • C1orf144 3 4
  • Putative MAPK Activating Protein PM20,PM21 3
  • Chromosome 1 Open Reading Frame 144 2
  • SUZ Domain-Containing Protein 1 3
  • UPF0485 Protein C1orf144 3

External Ids for SZRD1 Gene

Previous HGNC Symbols for SZRD1 Gene

  • C1orf144

Previous GeneCards Identifiers for SZRD1 Gene

  • GC01P016681

Summaries for SZRD1 Gene

GeneCards Summary for SZRD1 Gene

SZRD1 (SUZ RNA Binding Domain Containing 1) is a Protein Coding gene.

Additional gene information for SZRD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SZRD1 Gene

Genomics for SZRD1 Gene

GeneHancer (GH) Regulatory Elements for SZRD1 Gene

Promoters and enhancers for SZRD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I016348 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 550.8 -1.6 -1604 5.5 SMAD1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 CBX5 ZNF213 FBXO42 SZRD1 ENSG00000237938 RPL22P3 SPEN ARHGEF19 CROCC RPS16P1 MFAP2 ZBTB17
GH01I016902 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 20.8 +552.5 552475 4.9 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000272426 CROCC ZBTB17 CROCCP3 LINC01772 RPL22P3 ARHGEF19 MFAP2 NBPF1 NECAP2
GH01I016729 Enhancer 1.2 ENCODE dbSUPER 22.6 +375.0 374966 0.2 HNRNPUL1 ARNT FEZF1 GLI4 ZNF2 ETS1 GTF3C2 ZNF121 ZNF213 ZNF548 GC01P016729 TRG-CCC5-1 TRV-CAC13-1 SPEN ENSG00000237938 CROCC CROCCP3 RPS16P1 ZBTB17 RPL22P3
GH01I016440 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +90.1 90064 5.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC NECAP2 ENSG00000237938 SPEN LOC100421279 ZBTB17 SZRD1 RPS16P1 RPL22P3 MFAP2 LINC01783
GH01I015829 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -518.6 -518574 9.6 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000237938 ZBTB17 SPEN ARHGEF19 CLCNKA NECAP2 FLJ37453 HSPB7 RPS16P1 RPL22P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SZRD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SZRD1 Gene

Genomic Locations for SZRD1 Gene
chr1:16,352,575-16,398,148
(GRCh38/hg38)
Size:
45,574 bases
Orientation:
Plus strand
chr1:16,679,070-16,724,640
(GRCh37/hg19)

Genomic View for SZRD1 Gene

Genes around SZRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SZRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SZRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SZRD1 Gene

Proteins for SZRD1 Gene

  • Protein details for SZRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z422-SZRD1_HUMAN
    Recommended name:
    SUZ domain-containing protein 1
    Protein Accession:
    Q7Z422
    Secondary Accessions:
    • A8MXJ2
    • C9K0U0
    • Q7Z424
    • Q8IVM2
    • Q8TBV3
    • Q9Y403

    Protein attributes for SZRD1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16997 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB43245.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82500.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SZRD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SZRD1 Gene

Post-translational modifications for SZRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SZRD1 Gene

No data available for DME Specific Peptides for SZRD1 Gene

Domains & Families for SZRD1 Gene

Gene Families for SZRD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SZRD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SZRD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z422

UniProtKB/Swiss-Prot:

SZRD1_HUMAN :
  • Belongs to the SZRD1 family.
Family:
  • Belongs to the SZRD1 family.
genes like me logo Genes that share domains with SZRD1: view

Function for SZRD1 Gene

Phenotypes for SZRD1 Gene

genes like me logo Genes that share phenotypes with SZRD1: view

Animal Model Products

CRISPR Products

miRNA for SZRD1 Gene

miRTarBase miRNAs that target SZRD1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SZRD1 Gene

Localization for SZRD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SZRD1 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SZRD1 Gene

Pathways & Interactions for SZRD1 Gene

SuperPathways for SZRD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SZRD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SZRD1 Gene

Drugs & Compounds for SZRD1 Gene

No Compound Related Data Available

Transcripts for SZRD1 Gene

Unigene Clusters for SZRD1 Gene

SUZ RNA binding domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SZRD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -

Relevant External Links for SZRD1 Gene

GeneLoc Exon Structure for
SZRD1
ECgene alternative splicing isoforms for
SZRD1

Expression for SZRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SZRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SZRD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.0), Heart (11.1), and Bone (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SZRD1 Gene



Protein tissue co-expression partners for SZRD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SZRD1 Gene:

SZRD1

SOURCE GeneReport for Unigene cluster for SZRD1 Gene:

Hs.252967

Evidence on tissue expression from TISSUES for SZRD1 Gene

  • Nervous system(4.5)
  • Skin(3.7)
  • Lung(3.6)
  • Kidney(3)
  • Eye(2.6)
  • Pancreas(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SZRD1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SZRD1 Gene

Orthologs for SZRD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SZRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SZRD1 33
  • 100 (n)
C1ORF144 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SZRD1 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SZRD1 33 34
  • 96.05 (n)
rat
(Rattus norvegicus)
Mammalia Szrd1 33
  • 95.39 (n)
cow
(Bos Taurus)
Mammalia SZRD1 33 34
  • 94.96 (n)
mouse
(Mus musculus)
Mammalia Szrd1 33 16 34
  • 94.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SZRD1 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SZRD1 34
  • 93 (a)
OneToOne
C21H1ORF144 33
  • 85.96 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia szrd1 33
  • 76.32 (n)
MGC76116 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3649 33
zebrafish
(Danio rerio)
Actinopterygii szrd1 33 34
  • 64.25 (n)
wufb15h05 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9729 33
Species where no ortholog for SZRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SZRD1 Gene

ENSEMBL:
Gene Tree for SZRD1 (if available)
TreeFam:
Gene Tree for SZRD1 (if available)

Paralogs for SZRD1 Gene

Pseudogenes.org Pseudogenes for SZRD1 Gene

genes like me logo Genes that share paralogs with SZRD1: view

No data available for Paralogs for SZRD1 Gene

Variants for SZRD1 Gene

Sequence variations from dbSNP and Humsavar for SZRD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000070632 -- 16,386,291(+) T/TT intron_variant
rs1000098392 -- 16,375,118(+) C/T intron_variant
rs1000144057 -- 16,374,938(+) C/T intron_variant
rs1000157345 -- 16,371,051(+) C/G intron_variant
rs1000298752 -- 16,380,701(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SZRD1 Gene

Variant ID Type Subtype PubMed ID
esv3585337 CNV gain 21293372
nsv945790 CNV duplication 23825009

Variation tolerance for SZRD1 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SZRD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SZRD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SZRD1 Gene

Disorders for SZRD1 Gene

Additional Disease Information for SZRD1

No disorders were found for SZRD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SZRD1 Gene

Publications for SZRD1 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for SZRD1 Gene

Sources for SZRD1 Gene

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