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This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants tha... See more...
Aliases for SYVN1 Gene
Aliases for SYVN1 Gene
External Ids for SYVN1 Gene
- HGNC: 20738
- NCBI Entrez Gene: 84447
- Ensembl: ENSG00000162298
- OMIM®: 608046
- UniProtKB/Swiss-Prot: Q86TM6
Previous GeneCards Identifiers for SYVN1 Gene
- GC11M064651
- GC11M064894
- GC11M061221
- GC11M065122
Summaries for SYVN1 Gene
-
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]
GeneCards Summary for SYVN1 Gene
SYVN1 (Synoviolin 1) is a Protein Coding gene. Diseases associated with SYVN1 include Wolfram Syndrome 1 and Wolfram Syndrome. Among its related pathways are Signaling by GPCR and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase activity and acid-amino acid ligase activity. An important paralog of this gene is AMFR.
UniProtKB/Swiss-Prot Summary for SYVN1 Gene
-
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity).
Additional gene information for SYVN1 Gene
- HGNC (20738)
- NCBI Entrez Gene (84447)
- Ensembl (ENSG00000162298)
- OMIM® (608046)
- UniProtKB/Swiss-Prot (Q86TM6)
- Open Targets Platform(ENSG00000162298)
- Search for SYVN1 at DataMed
- Search for SYVN1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYVN1 Gene
Genomics for SYVN1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SYVN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SYVN1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYVN1
- Top Transcription factor binding sites by QIAGEN in the SYVN1 gene promoter:
-
- AP-1
- ATF-2
- ATF6
- c-Jun
- FOXO4
- GR
- GR-alpha
- GR-beta
Genomic Locations for SYVN1 Gene
Latest Assembly
- chr11:65,121,780-65,135,178
- (GRCh38/hg38)
- Size:
- 13,399 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:64,894,751-64,901,990
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 7,240 bases
- Orientation:
- Minus strand
- chr11:64,889,252-64,902,004
- (GRCh37/hg19 by Ensembl)
- Size:
- 12,753 bases
- Orientation:
- Minus strand
Genomic View for SYVN1 Gene
Genes around SYVN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
SYVN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SYVN1 Gene
Proteins for SYVN1 Gene
-
Protein details for SYVN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86TM6-SYVN1_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase synoviolin
- Protein Accession:
- Q86TM6
- Q8N3K3
- Q8N6E8
- Q96JL5
- Q96PK3
Protein attributes for SYVN1 Gene
- Size:
- 617 amino acids
- Molecular mass:
- 67685 Da
- Quaternary structure:
-
- Homodimer (PubMed:16289116). Interacts with p53/TP53 (PubMed:17170702). Interacts with HTT (PubMed:17141218). Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1 (PubMed:16289116, PubMed:16186509, PubMed:18264092, PubMed:26471130, PubMed:28827405). FAM8A1 is stabilized by interaction with SYNV1, which prevents its proteasomal degradation. OS9 and UBE2J1 recruitment to the complex may be mediated by SEL1L (PubMed:28827405). SYNV1 assembles with SEL1L and FAM8A1 through its transmembrane domains, but interaction with its cytoplasmic domain is required to confer stability to FAM8A1 and enhance recruitment of HERPUD1 (PubMed:28827405). The HRD1 complex also associates with VIMP and may transfer misfolded proteins from the endoplasmic reticulum to VCP (PubMed:16289116). May form a complex with ERLEC1; HSPA5; OS9 AND SEL1L (PubMed:18502753, PubMed:18264092). Interacts with VCP (PubMed:16289116, PubMed:16186510). Interacts with UBXN6 (PubMed:18656546). Interacts with BAG6 (PubMed:21636303). Interacts with NFE2L1 (By similarity). Interacts (via N-terminus) with components of the pre-B cell receptor, including IGLL1 and VPREB1 (By similarity). Interacts with CREB3L3; this interaction leads to CREB3L3 ubiquitination and proteasomal degradation (By similarity).
- SequenceCaution:
-
- Sequence=BAB47439.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SYVN1 Gene
Selected DME Specific Peptides for SYVN1 Gene
- Q86TM6:
-
- PRFVALFT
- KCFHWLA
- CLRSWFQRQQTCPTCR
- LPPFPPGMFPLWPPMG
- KVHTFPLFAIRPMYLAMRQFKKAVTDA
- LYIQAFVLVFLLGK
- RVDFMERSP
- MSRRAIRNMNTLYPDAT
- KVFFGQLRAAEMEHL
- QFYPTVVYLTKSSPSMA
- RGASVQLVFGFEYAILMT
Post-translational modifications for SYVN1 Gene
- Not N-glycosylated.
- Auto-ubiquitinated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SYVN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SYVN1 / HRD1 Antibody (LS-B3451) and SYVN1 / HRD1 Antibody (LS-B13873)
- G Biosciences Immunotag™ SYVN1 Antibody
- NSJ Bioreagents SYVN1 Antibody (HRD1)
- Novus Biologicals Antibodies for SYVN1
-
Abcam antibodies for SYVN1
- Invitrogen Antibodies for SYVN1 (AFLGC-SYVN1)
- antibodies-online: Show 22 available SYVN1 Antibodies ranked by validation data
- Compare Top SYVN1 Antibodies
-
Recommended
- 88 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 42 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 20 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Biorbyt antibodies for SYVN1
-
Boster Bio Antibodies for SYVN1
-
Custom Antibody ServicesProSci Antibodies for SYVN1
- synovial apoptosis inhibitor 1, synoviolin [43-661]
- synovial apoptosis inhibitor 1, synoviolin [29-859]
- synovial apoptosis inhibitor 1, synoviolin [29-860]
- synovial apoptosis inhibitor 1, synoviolin [43-402]
- E3 ubiquitin-protein ligase synoviolin [61-136]
- E3 ubiquitin-protein ligase synoviolin [61-137]
- E3 ubiquitin-protein ligase synoviolin [61-139]
-
Santa Cruz Biotechnology (SCBT) Antibodies for SYVN1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for SYVN1
- Origene Custom Protein Services for SYVN1
-
Abcam proteins for SYVN1
Assay products for research
- antibodies-online: Show 5 available SYVN1 Elisa Kits ranked by validation data
- Compare Top SYVN1 Elisa Kits
-
Quality Products:
Domains & Families for SYVN1 Gene
Gene Families for SYVN1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for SYVN1 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- ProtoNet:
Suggested Antigen Peptide Sequences for SYVN1 Gene
- GenScript: Design optimal peptide antigens:
-
- Synovial apoptosis inhibitor 1 (SYVN1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86TM6UniProtKB/Swiss-Prot:
SYVN1_HUMAN :- The RING-type zinc finger is required for E3 ligase activity.
- Belongs to the HRD1 family.
- Domain:
-
- The RING-type zinc finger is required for E3 ligase activity.
- Family:
-
- Belongs to the HRD1 family.
Function for SYVN1 Gene
Molecular function for SYVN1 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:17141218, ECO:0000269|PubMed:17170702};.
- UniProtKB/Swiss-Prot Induction:
- By endoplasmic reticulum stress-inducing agents such as thapsigargin, tunicamycin or brefeldin A, but not by heat shock.
Enzyme Numbers (IUBMB) for SYVN1 Gene
Phenotypes From GWAS Catalog for SYVN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17170702 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0051082 | unfolded protein binding | IPI | 17059562 |
| GO:0051087 | chaperone binding | IPI | 21636303 |
Phenotypes for SYVN1 Gene
- MGI mutant phenotypes for SYVN1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SYVN1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- no effect
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased NF-kappaB reporter expression
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Increased ionizing radiation sensitivity
- Increased caspase activity
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
Animal Models for SYVN1 Gene
- MGI Knock Outs for SYVN1:
-
- Syvn1 Syvn1<tm1Tn>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SYVN1 - Starting at $85 >
- * SYVN1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SYVN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SYVN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SYVN1
miRNA for SYVN1 Gene
- miRTarBase miRNAs that target SYVN1
-
- hsa-miR-335-5p (MIRT016772)
- hsa-miR-615-3p (MIRT040147)
- hsa-miR-196a-5p (MIRT048209)
- hsa-let-7a-5p (MIRT052635)
- hsa-miR-3692-3p (MIRT652879)
- hsa-miR-4436b-5p (MIRT652880)
- hsa-miR-6509-3p (MIRT652881)
- hsa-miR-8059 (MIRT652882)
- hsa-miR-4471 (MIRT652883)
- hsa-miR-1292-5p (MIRT652884)
- hsa-miR-6781-3p (MIRT652885)
- hsa-miR-2682-3p (MIRT652886)
- hsa-miR-3124-3p (MIRT652887)
- hsa-miR-130b-5p (MIRT652888)
- hsa-miR-6849-3p (MIRT652889)
- hsa-miR-6819-3p (MIRT652890)
- hsa-miR-6877-3p (MIRT652891)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SYVN1
- Browse OriGene Inhibitory RNA Products For SYVN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYVN1
Clone products for research
- Applied Biological Materials (abm): Clones for SYVN1 - Starting at $45 >
- * SYVN1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG209408
- MG219322
- MR209408
- MR209408L3
- MR209408L4
- MR219322
- MR219322L3
- MR219322L4
- RC207132
- RC207132L3
- RC207132L4
- RC220540
- RC220540L1
- RC220540L2
- RC220540L3
- RC220540L4
- RG207132
- RG220540
- RR210996
- RR210996L3
- RR210996L4
- MR209408L3V
- MR209408L4V
- MR219322L3V
- MR219322L4V
- RC207132L3V
- RC207132L4V
- RC220540L1V
- RC220540L2V
- RC220540L3V
- RC220540L4V
- RR210996L3V
- RR210996L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SYVN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SYVN1
Cell Lines for research
-
Horizon Cell Lines for SYVN1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYVN1 Gene
Localization for SYVN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SYVN1 Gene
- Endoplasmic reticulum membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| plasma membrane | 3 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
- Endoplasmic reticulum (4)
- Nucleoplasm (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000836 | Hrd1p ubiquitin ligase complex | IEA,TAS | 21454652 |
| GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex | IMP | 26471130 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005783 | endoplasmic reticulum | TAS | 23710284 |
Pathways & Interactions for SYVN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Calnexin/calreticulin cycle | ||
| 2 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 3 | Unfolded Protein Response (UPR) | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Metabolism of proteins | ||
Pathways by source for SYVN1 Gene
16 Reactome pathways for SYVN1 Gene
2 KEGG pathways for SYVN1 Gene
1 GeneTex pathway for SYVN1 Gene
UniProtKB/Swiss-Prot Q86TM6-SYVN1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for SYVN1 Gene
Selected Interacting proteins:
Q86TM6-SYVN1_HUMAN
ENSP00000366395
for SYVN1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SYVN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002327 | immature B cell differentiation | ISS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | 23710284 |
| GO:0016567 | protein ubiquitination | IEA,TAS | 23710284 |
| GO:0030433 | ubiquitin-dependent ERAD pathway | IEA,TAS | 22013210 |
| GO:0030970 | retrograde protein transport, ER to cytosol | IMP | 25660456 |
Drugs & Compounds for SYVN1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for SYVN1 Gene
mRNA/cDNA for SYVN1 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000294256 3048 nts (view in UCSC)
- ENST00000307289 2841 nts (view in UCSC)
- ENST00000377190 3038 nts (view in UCSC)
- ENST00000449943 4547 nts (view in UCSC)
- ENST00000525874 475 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SYVN1 - Starting at $85 >
- * SYVN1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SYVN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SYVN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SYVN1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SYVN1
- Browse OriGene Inhibitory RNA Products For SYVN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYVN1
Clone products for research
- Applied Biological Materials (abm): Clones for SYVN1 - Starting at $45 >
- * SYVN1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG209408
- MG219322
- MR209408
- MR209408L3
- MR209408L4
- MR219322
- MR219322L3
- MR219322L4
- RC207132
- RC207132L3
- RC207132L4
- RC220540
- RC220540L1
- RC220540L2
- RC220540L3
- RC220540L4
- RG207132
- RG220540
- RR210996
- RR210996L3
- RR210996L4
- MR209408L3V
- MR209408L4V
- MR219322L3V
- MR219322L4V
- RC207132L3V
- RC207132L4V
- RC220540L1V
- RC220540L2V
- RC220540L3V
- RC220540L4V
- RR210996L3V
- RR210996L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SYVN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SYVN1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 15a | · | 15b | · | 15c | · | 15d | · | 15e | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | - | ||||||||||
| SP9: | - | - | |||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | - | ||||||||||
| SP13: |
Relevant External Links for SYVN1 Gene
- GeneLoc Exon Structure for
- SYVN1
Expression for SYVN1 Gene
This gene is overexpressed in Nasal epithelium (44.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SYVN1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYVN1
SOURCE GeneReport for Unigene cluster for SYVN1 Gene:
Hs.75859mRNA Expression by UniProt/SwissProt for SYVN1 Gene:
Q86TM6-SYVN1_HUMAN
Tissue specificity:
Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level).
Evidence on tissue expression from TISSUES for SYVN1 Gene
- Liver(4.6)
- Nervous system(4.5)
- Blood(4.4)
- Skin(3.6)
- Intestine(3)
- Muscle(2.9)
- Kidney(2.8)
- Heart(2.7)
- Stomach(2.6)
- Lymph node(2.2)
- Pancreas(2.2)
- Spleen(2.1)
- Lung(2)
Primer products for research
-
OriGene qPCR primer pairs for SYVN1
-
OriGene qPCR primer pairs and template standards for SYVN1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYVN1 Gene
Orthologs for SYVN1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SYVN1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SYVN1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SYVN1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Syvn1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Syvn1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | SYVN1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SYVN1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SYVN1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SYVN1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | syvn1 30 |
|
||
| Str.10714 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | syvn1 30 31 |
|
OneToOne | |
| Dr.3405 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10009 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | sip3 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | sel-11 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRD1 31 33 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G16090 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os06g0301000 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for SYVN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SYVN1 Gene
- ENSEMBL:
- Gene Tree for SYVN1 (if available)
- TreeFam:
- Gene Tree for SYVN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SYVN1: view image