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Aliases for SYTL5 Gene

Aliases for SYTL5 Gene

  • Synaptotagmin Like 5 2 3 5
  • Exophilin 9 2 3
  • Slp5 3 4
  • Synaptotagmin-Like Protein 5 3
  • Synaptotagmin-Like 5 2

External Ids for SYTL5 Gene

Previous GeneCards Identifiers for SYTL5 Gene

  • GC0XP035998
  • GC0XP036180
  • GC0XP036737
  • GC0XP036924
  • GC0XP036923
  • GC0XP037622
  • GC0XP037750
  • GC0XP037778
  • GC0XP037865
  • GC0XP035611
  • GC0XP038006

Summaries for SYTL5 Gene

Entrez Gene Summary for SYTL5 Gene

  • The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for SYTL5 Gene

SYTL5 (Synaptotagmin Like 5) is a Protein Coding gene. Among its related pathways are wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF) and Deregulation of Rab and Rab Effector Genes in Bladder Cancer. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYTL4.

UniProtKB/Swiss-Prot for SYTL5 Gene

  • May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

Additional gene information for SYTL5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL5 Gene

Genomics for SYTL5 Gene

GeneHancer (GH) Regulatory Elements for SYTL5 Gene

Promoters and enhancers for SYTL5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI037905 Promoter/Enhancer 1.3 Ensembl ENCODE 550.8 0.0 -14 1.1 RAD21 ZNF335 ZNF121 GLIS2 FOS ZNF398 ZEB2 ZFP69B KLF16 GLIS1 ENSG00000259977 SYTL5 RNU6-49P ENSG00000250349
GH0XI038005 Promoter/Enhancer 1.1 EPDnew ENCODE 555.7 +100.3 100337 1.3 SMARCE1 CBFA2T3 DPF2 FOXA1 ZNF217 CTBP1 ATF4 GATA3 NCOR1 TRIM28 SYTL5 ENSG00000229674 MIR548AJ2 ENSG00000250349
GH0XI037904 Enhancer 0.7 ENCODE 550.8 -0.9 -948 0.6 NCOA3 ESRRA ZKSCAN1 CTBP1 GATA3 FOSL2 FOS RXRA DPF2 ZNF592 ENSG00000259977 SYTL5 RNU6-49P ENSG00000250349
GH0XI038106 Enhancer 0.3 ENCODE 16.1 +201.2 201178 0.8 HNF4A SYTL5 GC0XM038061 SRPX ENSG00000250349
GH0XI038051 Enhancer 0.7 ENCODE 6.3 +146.2 146249 1.1 JUN CEBPG ZNF2 ZKSCAN1 FOSL1 SCRT2 FOSL2 ZNF600 FOS ZBTB20 SYTL5 GC0XM038060 MIR548AJ2 ENSG00000250349
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYTL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYTL5 gene promoter:

Genomic Locations for SYTL5 Gene

Genomic Locations for SYTL5 Gene
223,227 bases
Plus strand

Genomic View for SYTL5 Gene

Genes around SYTL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYTL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL5 Gene

Proteins for SYTL5 Gene

  • Protein details for SYTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptotagmin-like protein 5
    Protein Accession:
    Secondary Accessions:
    • A2RRF2

    Protein attributes for SYTL5 Gene

    730 amino acids
    Molecular mass:
    81523 Da
    Quaternary structure:
    • Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.

    Alternative splice isoforms for SYTL5 Gene


neXtProt entry for SYTL5 Gene

Post-translational modifications for SYTL5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SYTL5 Gene

Domains & Families for SYTL5 Gene

Gene Families for SYTL5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SYTL5 Gene

Suggested Antigen Peptide Sequences for SYTL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYTL5: view

No data available for UniProtKB/Swiss-Prot for SYTL5 Gene

Function for SYTL5 Gene

Molecular function for SYTL5 Gene

UniProtKB/Swiss-Prot Function:
May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

Phenotypes From GWAS Catalog for SYTL5 Gene

Gene Ontology (GO) - Molecular Function for SYTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 12051743
GO:0005543 phospholipid binding IEA --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0017137 Rab GTPase binding IEA --
genes like me logo Genes that share ontologies with SYTL5: view
genes like me logo Genes that share phenotypes with SYTL5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SYTL5 Gene

Localization for SYTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL5 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYTL5 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 4
cytoskeleton 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0045202 synapse IEA --
GO:0070382 exocytic vesicle IBA --
GO:0098793 presynapse IEA --
genes like me logo Genes that share ontologies with SYTL5: view

Pathways & Interactions for SYTL5 Gene

genes like me logo Genes that share pathways with SYTL5: view

Pathways by source for SYTL5 Gene

1 GeneGo (Thomson Reuters) pathway for SYTL5 Gene

Gene Ontology (GO) - Biological Process for SYTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006887 exocytosis IEA --
GO:0006906 vesicle fusion IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYTL5: view

No data available for SIGNOR curated interactions for SYTL5 Gene

Drugs & Compounds for SYTL5 Gene

(1) Drugs for SYTL5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SYTL5: view

Transcripts for SYTL5 Gene

mRNA/cDNA for SYTL5 Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYTL5 Gene

Synaptotagmin-like 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2: - -
SP3: -

Relevant External Links for SYTL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYTL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYTL5 Gene

mRNA differential expression in normal tissues according to GTEx for SYTL5 Gene

This gene is overexpressed in Brain - Hippocampus (x6.3), Brain - Nucleus accumbens (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x5.0), Brain - Amygdala (x4.6), Brain - Hypothalamus (x4.5), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for SYTL5 Gene

This gene is overexpressed in Nasal epithelium (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYTL5 Gene

Protein tissue co-expression partners for SYTL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYTL5 Gene:


SOURCE GeneReport for Unigene cluster for SYTL5 Gene:


mRNA Expression by UniProt/SwissProt for SYTL5 Gene:

Tissue specificity: Highly expressed in placenta and liver.
genes like me logo Genes that share expression patterns with SYTL5: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYTL5 Gene

Orthologs for SYTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYTL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYTL5 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia SYTL5 33 34
  • 90.2 (n)
(Bos Taurus)
Mammalia SYTL5 33 34
  • 88.3 (n)
(Mus musculus)
Mammalia Sytl5 33 16 34
  • 86.06 (n)
(Rattus norvegicus)
Mammalia Sytl5 33
  • 85.57 (n)
(Monodelphis domestica)
Mammalia SYTL5 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SYTL5 34
  • 69 (a)
(Gallus gallus)
Aves SYTL5 33 34
  • 71.05 (n)
(Anolis carolinensis)
Reptilia SYTL5 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sytl5 33
  • 59.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398672 33
(Danio rerio)
Actinopterygii sytl5 33 34
  • 58.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7343 35
  • 39 (a)
Species where no ortholog for SYTL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL5 Gene

Gene Tree for SYTL5 (if available)
Gene Tree for SYTL5 (if available)

Paralogs for SYTL5 Gene

Paralogs for SYTL5 Gene

(2) SIMAP similar genes for SYTL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SYTL5: view

Variants for SYTL5 Gene

Sequence variations from dbSNP and Humsavar for SYTL5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000034495 -- 38,064,472(+) T/C intron_variant
rs1000035457 -- 37,953,619(+) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000047907 -- 38,127,169(+) G/A 3_prime_UTR_variant
rs1000055417 -- 37,901,757(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000058873 -- 38,012,825(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYTL5 Gene

Variant ID Type Subtype PubMed ID
nsv519012 CNV gain 19592680
nsv518029 CNV gain 19592680
esv3558795 CNV deletion 23714750
esv2752323 CNV gain 17911159
dgv2277e212 CNV loss 25503493

Variation tolerance for SYTL5 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYTL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL5 Gene

Disorders for SYTL5 Gene

Additional Disease Information for SYTL5

No disorders were found for SYTL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYTL5 Gene

Publications for SYTL5 Gene

  1. Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. (PMID: 16630545) Saxena SK … Fukuda M (Biochemical and biophysical research communications 2006) 3 22 58
  2. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. (PMID: 12051743) Kuroda TS … Mikoshiba K (Biochemical and biophysical research communications 2002) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3 58

Products for SYTL5 Gene

Sources for SYTL5 Gene

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