Aliases for SYTL2 Gene
External Ids for SYTL2 Gene
Previous GeneCards Identifiers for SYTL2 Gene
The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
GeneCards Summary for SYTL2 Gene
SYTL2 (Synaptotagmin Like 2) is a Protein Coding gene. Diseases associated with SYTL2 include Griscelli Syndrome, Type 1 and Griscelli Syndrome, Type 2. Among its related pathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer. Gene Ontology (GO) annotations related to this gene include calcium ion binding and Rab GTPase binding. An important paralog of this gene is SYTL1.
UniProtKB/Swiss-Prot Summary for SYTL2 Gene
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.