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Aliases for SYT6 Gene

Aliases for SYT6 Gene

  • Synaptotagmin 6 2 3 5
  • Synaptotagmin VI 2 3 4
  • SytVI 3 4
  • Synaptotagmin-6 3

External Ids for SYT6 Gene

Previous GeneCards Identifiers for SYT6 Gene

  • GC01M115046
  • GC01M113515
  • GC01M113733
  • GC01M113931
  • GC01M113922
  • GC01M114346
  • GC01M114433
  • GC01M114631
  • GC01M112489

Summaries for SYT6 Gene

Entrez Gene Summary for SYT6 Gene

  • The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for SYT6 Gene

SYT6 (Synaptotagmin 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is SYT10.

UniProtKB/Swiss-Prot for SYT6 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).

Gene Wiki entry for SYT6 Gene

Additional gene information for SYT6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT6 Gene

Genomics for SYT6 Gene

GeneHancer (GH) Regulatory Elements for SYT6 Gene

Promoters and enhancers for SYT6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I114152 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.2 169 3.4 KLF17 MZF1 SIN3A BMI1 RFX5 ZNF335 GLIS2 ZNF143 FOS SMARCA5 SYT6 GC01M114036
GH01I114112 Enhancer 1.1 FANTOM5 Ensembl ENCODE 29.7 +40.0 40033 2.6 PKNOX1 ZNF189 KLF17 MAFG ZIC2 ZNF316 POLR2A GLIS1 VEZF1 NFE2 SYT6 HIPK1 GC01M114036
GH01I113978 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 +172.0 172027 7.3 MLX ARID4B DMAP1 ZNF48 ARID2 ZNF143 DEK SP5 JUNB REST TRIM33 OLFML3 LRIG2 SIKE1 LOC100421402 SYT6 DCLRE1B RPL13AP10
GH01I114107 Enhancer 0.8 Ensembl ENCODE 21.3 +45.5 45514 2.5 CTCF JUNB CBFA2T3 EBF1 BATF ZIC2 IRF4 ZNF335 FOSL1 MYNN SYT6 OLFML3 GC01M114036
GH01I114088 Enhancer 0.9 ENCODE dbSUPER 18.8 +64.9 64878 1.5 HDAC1 MEIS2 ATF1 TEAD4 TAL1 MAX CEBPG FOSL1 TCF12 GATA3 SYT6 OLFML3 GC01M114036
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYT6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYT6 gene promoter:

Genomic Locations for SYT6 Gene

Genomic Locations for SYT6 Gene
64,629 bases
Minus strand

Genomic View for SYT6 Gene

Genes around SYT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT6 Gene

Proteins for SYT6 Gene

  • Protein details for SYT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B1AMB8
    • B3KPK1

    Protein attributes for SYT6 Gene

    510 amino acids
    Molecular mass:
    57325 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Isoform 1: Homodimer; disulfide-linked via the cysteine motif. Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10. Isoform 1: Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent. Isoform 2: Is not able to form homodimer and heterodimers.

    Alternative splice isoforms for SYT6 Gene


neXtProt entry for SYT6 Gene

Post-translational modifications for SYT6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SYT6 Gene

Domains & Families for SYT6 Gene

Gene Families for SYT6 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SYT6 Gene

Suggested Antigen Peptide Sequences for SYT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • Belongs to the synaptotagmin family.
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT6: view

Function for SYT6 Gene

Molecular function for SYT6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).

Phenotypes From GWAS Catalog for SYT6 Gene

Gene Ontology (GO) - Molecular Function for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IEA --
GO:0005509 calcium ion binding IBA --
GO:0005544 NOT calcium-dependent phospholipid binding IEA,IDA 7791877
GO:0019905 syntaxin binding IDA 7791877
GO:0030276 clathrin binding IDA 7791877
genes like me logo Genes that share ontologies with SYT6: view
genes like me logo Genes that share phenotypes with SYT6: view

Animal Models for SYT6 Gene

MGI Knock Outs for SYT6:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYT6 Gene

Localization for SYT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT6 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
Isoform 1: Membrane; Single-pass membrane protein. Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity). {ECO:0000250 UniProtKB:Q9R0N8}.
Isoform 2: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT6 gene
Compartment Confidence
cytosol 5
plasma membrane 4
endoplasmic reticulum 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane IBA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane ISS --
genes like me logo Genes that share ontologies with SYT6: view

Pathways & Interactions for SYT6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0007340 acrosome reaction IEA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
GO:0060478 acrosomal vesicle exocytosis IMP 11437455
genes like me logo Genes that share ontologies with SYT6: view

No data available for Pathways by source and SIGNOR curated interactions for SYT6 Gene

Drugs & Compounds for SYT6 Gene

(1) Drugs for SYT6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with SYT6: view

Transcripts for SYT6 Gene

Unigene Clusters for SYT6 Gene

Synaptotagmin VI:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: -
SP3: -
SP4: -
SP5: - -

Relevant External Links for SYT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYT6 Gene

mRNA differential expression in normal tissues according to GTEx for SYT6 Gene

This gene is overexpressed in Brain - Hypothalamus (x13.8), Brain - Nucleus accumbens (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.4), Brain - Putamen (basal ganglia) (x4.8), and Brain - Spinal cord (cervical c-1) (x4.0).

Protein differential expression in normal tissues from HIPED for SYT6 Gene

This gene is overexpressed in Plasma (36.0), Fetal Brain (18.8), and Heart (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SYT6 Gene

Protein tissue co-expression partners for SYT6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYT6 Gene:


SOURCE GeneReport for Unigene cluster for SYT6 Gene:


Evidence on tissue expression from TISSUES for SYT6 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SYT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT6 Gene

Orthologs for SYT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT6 33
  • 99.53 (n)
(Bos Taurus)
Mammalia SYT6 33 34
  • 90.78 (n)
(Mus musculus)
Mammalia Syt6 33 16 34
  • 90.35 (n)
(Rattus norvegicus)
Mammalia Syt6 33
  • 90.12 (n)
(Canis familiaris)
Mammalia SYT6 33 34
  • 89.78 (n)
(Monodelphis domestica)
Mammalia SYT6 34
  • 78 (a)
(Gallus gallus)
Aves SYT6 33 34
  • 78.63 (n)
(Anolis carolinensis)
Reptilia SYT6 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia syt6 33
  • 73.49 (n)
Str.5667 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18838 33
(Danio rerio)
Actinopterygii syt6a 33 34
  • 72.58 (n)
SYT6 (1 of 2) 34
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5559 35
  • 43 (a)
CG3020 35
  • 35 (a)
Syt1 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea snt-3 34
  • 46 (a)
R12A1.2 35
  • 40 (a)
C08G5.4 35
  • 39 (a)
snt-2 34
  • 36 (a)
snt-1 34
  • 35 (a)
Species where no ortholog for SYT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT6 Gene

Gene Tree for SYT6 (if available)
Gene Tree for SYT6 (if available)

Paralogs for SYT6 Gene

Paralogs for SYT6 Gene

genes like me logo Genes that share paralogs with SYT6: view

Variants for SYT6 Gene

Sequence variations from dbSNP and Humsavar for SYT6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs142164979 uncertain-significance, Ductal breast carcinoma 114,097,771(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000003805 -- 114,121,160(-) T/C intron_variant
rs1000038834 -- 114,102,641(-) T/C intron_variant
rs1000044549 -- 114,107,137(-) G/C intron_variant
rs1000077167 -- 114,144,034(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYT6 Gene

Variant ID Type Subtype PubMed ID
nsv528503 CNV loss 19592680
nsv517962 CNV loss 19592680
nsv2476 CNV insertion 18451855
nsv1110877 OTHER inversion 24896259
nsv1000894 CNV gain 25217958
esv3587256 CNV loss 21293372
esv3587254 CNV loss 21293372
esv3587240 CNV loss 21293372
esv3326355 OTHER inversion 20981092
esv2866347 CNV insertion 24192839
esv23869 CNV loss 19812545

Variation tolerance for SYT6 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.03; 84.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT6 Gene

Disorders for SYT6 Gene

Additional Disease Information for SYT6

No disorders were found for SYT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT6 Gene

Publications for SYT6 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis. (PMID: 16111671) Roggero CM … Mayorga LS (Developmental biology 2005) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M (Genomics 2001) 2 3 58
  5. Synaptotagmin VI participates in the acrosome reaction of human spermatozoa. (PMID: 11437455) Michaut M … Mayorga LS (Developmental biology 2001) 3 22 58

Products for SYT6 Gene

Sources for SYT6 Gene

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