Aliases for SYT17 Gene

Aliases for SYT17 Gene

  • Synaptotagmin 17 2 3 5
  • Synaptotagmin XVII 2 3 4
  • Synaptotagmin-17 3 4
  • B/K Protein 2 3
  • SytXVII 3 4
  • Syt-17 2 3
  • Protein B/K 4
  • SYT17 5

External Ids for SYT17 Gene

Previous GeneCards Identifiers for SYT17 Gene

  • GC16P019088
  • GC16P017717

Summaries for SYT17 Gene

GeneCards Summary for SYT17 Gene

SYT17 (Synaptotagmin 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT10.

UniProtKB/Swiss-Prot Summary for SYT17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYT17 Gene

Genomics for SYT17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SYT17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J019110 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 611.7 -52.3 -52325 10.1 HNRNPL GATAD2A CTCF PRDM10 ZNF629 TFE3 ZNF512 RFX1 LEF1 IKZF1 SYT17 ENSG00000261427 ITPRIPL2 RPS15A COQ7 RNU4-46P ENSG00000278389 RF00017-1999 piR-57460-248 ENSG00000261759
GH16J019167 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.9 867 2.2 HNRNPL CTCF PRDM10 RFX1 KDM1A ZNF692 BACH1 FOXA1 LARP7 ZNF143 MN297354 SYT17 PKD1P4 NPIPA8 PKD1P5 ENSG00000261427 CLEC19A
GH16J019172 Promoter/Enhancer 0.7 EPDnew Ensembl 600.7 +4.1 4067 1 CREB1 CBX2 SYT17 MN297354 ENSG00000286790 ENSG00000261427 CLEC19A
GH16J019409 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 14 +243.3 243265 2.2 ATF7 PRDM10 KDM1A CTCF ZNF692 ZIC2 PATZ1 REST EZH2 ZNF600 TMC5 ENSG00000260681 lnc-TMC5-2 SYT17 ENSG00000259925 KNOP1 GDE1
GH16J019392 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 14.4 +227.3 227254 5.5 CEBPG RFX1 LEF1 IKZF1 JUND FOXA1 PRDM1 MTA2 MTA1 SP1 TMC5 ENSG00000280265 LOC105371114 SYT17 RNU4-46P COQ7 ENSG00000259925 CLEC19A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYT17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYT17

Top Transcription factor binding sites by QIAGEN in the SYT17 gene promoter:
  • ATF
  • c-Ets-1
  • LCR-F1
  • Lhx3a
  • LHX3b
  • NF-kappaB
  • NF-kappaB1
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SYT17 Gene

Genomic Locations for SYT17 Gene
100,501 bases
Plus strand
100,360 bases
Plus strand

Genomic View for SYT17 Gene

Genes around SYT17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT17 Gene

Proteins for SYT17 Gene

  • Protein details for SYT17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O43330
    • Q9NZ18

    Protein attributes for SYT17 Gene

    474 amino acids
    Molecular mass:
    53849 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SYT17 Gene

neXtProt entry for SYT17 Gene

Post-translational modifications for SYT17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT17 Gene

Domains & Families for SYT17 Gene

Gene Families for SYT17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYT17 Gene

  • C2 domain
  • Synaptotagmin signature

Suggested Antigen Peptide Sequences for SYT17 Gene

GenScript: Design optimal peptide antigens:
  • Synaptotagmin XVII (SYT17_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptotagmin family.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT17: view

Function for SYT17 Gene

Molecular function for SYT17 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Phenotypes From GWAS Catalog for SYT17 Gene

Gene Ontology (GO) - Molecular Function for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA 21873635
GO:0001786 phosphatidylserine binding IBA 21873635
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IPI 16189514
GO:0005544 calcium-dependent phospholipid binding IBA 21873635
genes like me logo Genes that share ontologies with SYT17: view
genes like me logo Genes that share phenotypes with SYT17: view

Animal Models for SYT17 Gene

MGI Knock Outs for SYT17:
  • Syt17 Syt17<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYT17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYT17 Gene

Localization for SYT17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT17 Gene

Membrane. Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT17 gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 3
golgi apparatus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0070382 exocytic vesicle IBA 21873635
genes like me logo Genes that share ontologies with SYT17: view

Pathways & Interactions for SYT17 Gene

PathCards logo

SuperPathways for SYT17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014059 regulation of dopamine secretion IBA 21873635
GO:0016192 vesicle-mediated transport IBA 21873635
GO:0017156 calcium ion regulated exocytosis IBA 21873635
GO:0017158 regulation of calcium ion-dependent exocytosis IBA 21873635
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SYT17: view

No data available for Pathways by source and SIGNOR curated interactions for SYT17 Gene

Drugs & Compounds for SYT17 Gene

No Compound Related Data Available

Transcripts for SYT17 Gene

mRNA/cDNA for SYT17 Gene

9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYT17

Alternative Splicing Database (ASD) splice patterns (SP) for SYT17 Gene

No ASD Table

Relevant External Links for SYT17 Gene

GeneLoc Exon Structure for

Expression for SYT17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYT17 Gene

mRNA differential expression in normal tissues according to GTEx for SYT17 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.1) and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for SYT17 Gene

This gene is overexpressed in Fetal Brain (47.2) and Frontal cortex (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYT17 Gene

Protein tissue co-expression partners for SYT17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYT17

SOURCE GeneReport for Unigene cluster for SYT17 Gene:


mRNA Expression by UniProt/SwissProt for SYT17 Gene:

Tissue specificity: Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidney and lung (PubMed:16672768). Expressed in melanocytes (PubMed:23999003).

Evidence on tissue expression from TISSUES for SYT17 Gene

  • Lung(4.3)
  • Nervous system(3.8)
  • Adrenal gland(2.6)
  • Pancreas(2.3)
  • Kidney(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with SYT17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT17 Gene

Orthologs for SYT17 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT17 30 31
  • 97.79 (n)
(Canis familiaris)
Mammalia SYT17 30
  • 91.91 (n)
-- 31
  • 84 (a)
-- 31
  • 72 (a)
(Bos Taurus)
Mammalia SYT17 30 31
  • 90.86 (n)
(Ornithorhynchus anatinus)
Mammalia SYT17 31
  • 90 (a)
(Mus musculus)
Mammalia Syt17 30 17 31
  • 88.13 (n)
(Rattus norvegicus)
Mammalia Syt17 30
  • 87.9 (n)
(Monodelphis domestica)
Mammalia SYT17 31
  • 81 (a)
(Gallus gallus)
Aves SYT17 30 31
  • 74.27 (n)
(Anolis carolinensis)
Reptilia SYT17 31
  • 87 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia syt17 30
  • 76.23 (n)
(Danio rerio)
Actinopterygii SYT17 31
  • 73 (a)
LOC100000374 30
  • 70.76 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Sytalpha 31
  • 25 (a)
Species where no ortholog for SYT17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SYT17 Gene

Gene Tree for SYT17 (if available)
Gene Tree for SYT17 (if available)
Evolutionary constrained regions (ECRs) for SYT17: view image

Paralogs for SYT17 Gene

(13) SIMAP similar genes for SYT17 Gene using alignment to 8 proteins:

  • H3BN78_HUMAN
genes like me logo Genes that share paralogs with SYT17: view

Variants for SYT17 Gene

Additional dbSNP identifiers (rs#s) for SYT17 Gene

Structural Variations from Database of Genomic Variants (DGV) for SYT17 Gene

Variant ID Type Subtype PubMed ID
dgv1311n106 CNV deletion 24896259
dgv487e214 CNV gain 21293372
esv1661893 CNV deletion 17803354
esv2418352 CNV deletion 18987734
esv2550711 CNV deletion 19546169
esv2714047 CNV deletion 23290073
esv3202679 CNV deletion 24192839
esv3553198 CNV deletion 23714750
esv3570409 CNV gain 25503493
esv3638122 CNV loss 21293372
esv5037 CNV loss 18987735
esv8609 CNV loss 19470904
esv993801 CNV deletion 20482838
esv998101 CNV deletion 20482838
nsv1045019 CNV gain 25217958
nsv1070497 CNV deletion 25765185
nsv436835 CNV insertion 17901297
nsv571579 CNV gain 21841781
nsv571582 CNV gain 21841781
nsv833162 CNV loss 17160897
nsv958199 CNV deletion 24416366

Variation tolerance for SYT17 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SYT17 Gene

Disorders for SYT17 Gene

Additional Disease Information for SYT17

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for SYT17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT17 Gene

Publications for SYT17 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4
  2. Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways. (PMID: 31387992) Ruhl DA … Chapman ER (Nature communications 2019) 2 3
  3. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo JC … Yoon TJ (Journal of dermatological science 2013) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Protein kinase A-dependent phosphorylation of B/K protein. (PMID: 16672768) Chin H … Kwon OJ (Experimental & molecular medicine 2006) 3 4

Products for SYT17 Gene

  • Signalway ELISA kits for SYT17
  • Signalway Proteins for SYT17

Sources for SYT17 Gene