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Aliases for SYT17 Gene

Aliases for SYT17 Gene

  • Synaptotagmin 17 2 3 5
  • Synaptotagmin XVII 2 3 4
  • B/K Protein 2 3
  • SytXVII 3 4
  • Synaptotagmin-17 3
  • Protein B/K 4

External Ids for SYT17 Gene

Previous GeneCards Identifiers for SYT17 Gene

  • GC16P019088
  • GC16P017717

Summaries for SYT17 Gene

GeneCards Summary for SYT17 Gene

SYT17 (Synaptotagmin 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT1.

UniProtKB/Swiss-Prot for SYT17 Gene

  • Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Additional gene information for SYT17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT17 Gene

Genomics for SYT17 Gene

GeneHancer (GH) Regulatory Elements for SYT17 Gene

Promoters and enhancers for SYT17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I019167 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.4 433 1.4 SIN3A GLI4 YY1 GLIS2 ZNF207 ZNF143 SP3 SP5 YY2 REST SYT17 ENSG00000261427 CLEC19A
GH16I019409 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14 +242.9 242910 1.8 SIN3A ZNF2 GTF3C2 ZNF335 ZNF121 GLIS2 SCRT2 ATF7 DEK REST TMC5 ENSG00000260681 SYT17 ENSG00000259925 KNOP1
GH16I019110 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.7 -54.5 -54507 6 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000261427 ENSG00000278389 ITPRIPL2 SYT17 COQ7 RNU4-46P GC16P019109
GH16I019209 Enhancer 1.3 FANTOM5 Ensembl ENCODE 17.3 +43.5 43521 3.2 HDGF CTCF BMI1 BATF RAD21 KLF5 IRF4 RELA POLR2A ZNF207 SYT17 COQ7 RNU4-46P SMG1 CLEC19A
GH16I019116 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11.6 -49.3 -49307 3.8 HDGF PKNOX1 ARNT FEZF1 POLR2B ARID2 FOS RUNX3 RXRA NCOA1 SYT17 COQ7 ENSG00000261427 ENSG00000261759 ITPRIPL2 GC16P019121 GC16P019109
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYT17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYT17 gene promoter:

Genomic Locations for SYT17 Gene

Genomic Locations for SYT17 Gene
100,364 bases
Plus strand

Genomic View for SYT17 Gene

Genes around SYT17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT17 Gene

Proteins for SYT17 Gene

  • Protein details for SYT17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O43330
    • Q9NZ18

    Protein attributes for SYT17 Gene

    474 amino acids
    Molecular mass:
    53849 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SYT17 Gene

neXtProt entry for SYT17 Gene

Post-translational modifications for SYT17 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SYT17 Gene

Domains & Families for SYT17 Gene

Gene Families for SYT17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYT17 Gene

Suggested Antigen Peptide Sequences for SYT17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptotagmin family.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT17: view

Function for SYT17 Gene

Molecular function for SYT17 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Phenotypes From GWAS Catalog for SYT17 Gene

Gene Ontology (GO) - Molecular Function for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 16189514
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT17: view
genes like me logo Genes that share phenotypes with SYT17: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT17 Gene

Localization for SYT17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT17 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT17 gene
Compartment Confidence
cytosol 4
plasma membrane 3
nucleus 3
golgi apparatus 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0045202 synapse IEA --
GO:0098793 presynapse IEA --
genes like me logo Genes that share ontologies with SYT17: view

Pathways & Interactions for SYT17 Gene

SuperPathways for SYT17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006906 vesicle fusion IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0030154 cell differentiation IEA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT17: view

No data available for Pathways by source and SIGNOR curated interactions for SYT17 Gene

Drugs & Compounds for SYT17 Gene

No Compound Related Data Available

Transcripts for SYT17 Gene

Unigene Clusters for SYT17 Gene

Synaptotagmin XVII:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT17 Gene

No ASD Table

Relevant External Links for SYT17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYT17 Gene

mRNA differential expression in normal tissues according to GTEx for SYT17 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.1) and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for SYT17 Gene

This gene is overexpressed in Fetal Brain (47.2) and Frontal cortex (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYT17 Gene

Protein tissue co-expression partners for SYT17 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYT17 Gene:


SOURCE GeneReport for Unigene cluster for SYT17 Gene:


mRNA Expression by UniProt/SwissProt for SYT17 Gene:

Tissue specificity: Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidney and lung (PubMed:16672768). Expressed in melanocytes (PubMed:23999003).

Evidence on tissue expression from TISSUES for SYT17 Gene

  • Lung(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with SYT17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT17 Gene

Orthologs for SYT17 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT17 33 34
  • 97.79 (n)
(Canis familiaris)
Mammalia SYT17 33
  • 91.91 (n)
-- 34
  • 84 (a)
-- 34
  • 72 (a)
(Bos Taurus)
Mammalia SYT17 33 34
  • 90.86 (n)
(Ornithorhynchus anatinus)
Mammalia SYT17 34
  • 90 (a)
(Mus musculus)
Mammalia Syt17 33 16 34
  • 88.13 (n)
(Rattus norvegicus)
Mammalia Syt17 33
  • 87.9 (n)
(Monodelphis domestica)
Mammalia SYT17 34
  • 81 (a)
(Gallus gallus)
Aves SYT17 33 34
  • 74.27 (n)
(Anolis carolinensis)
Reptilia SYT17 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia syt17 33
  • 76.23 (n)
(Danio rerio)
Actinopterygii SYT17 34
  • 73 (a)
LOC100000374 33
  • 70.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sytalpha 34
  • 25 (a)
Species where no ortholog for SYT17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYT17 Gene

Gene Tree for SYT17 (if available)
Gene Tree for SYT17 (if available)

Paralogs for SYT17 Gene

Paralogs for SYT17 Gene

genes like me logo Genes that share paralogs with SYT17: view

Variants for SYT17 Gene

Sequence variations from dbSNP and Humsavar for SYT17 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000039039 -- 19,226,266(+) A/T intron_variant
rs1000126387 -- 19,221,593(+) G/A intron_variant
rs1000164000 -- 19,175,358(+) AA/ intron_variant
rs1000196389 -- 19,268,158(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000198718 -- 19,229,278(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYT17 Gene

Variant ID Type Subtype PubMed ID
dgv1311n106 CNV deletion 24896259
dgv487e214 CNV gain 21293372
esv1661893 CNV deletion 17803354
esv2418352 CNV deletion 18987734
esv2550711 CNV deletion 19546169
esv2714047 CNV deletion 23290073
esv3202679 CNV deletion 24192839
esv3553198 CNV deletion 23714750
esv3570409 CNV gain 25503493
esv3638122 CNV loss 21293372
esv5037 CNV loss 18987735
esv8609 CNV loss 19470904
esv993801 CNV deletion 20482838
esv998101 CNV deletion 20482838
nsv1045019 CNV gain 25217958
nsv1070497 CNV deletion 25765185
nsv436835 CNV insertion 17901297
nsv571579 CNV gain 21841781
nsv571582 CNV gain 21841781
nsv833162 CNV loss 17160897
nsv958199 CNV deletion 24416366

Variation tolerance for SYT17 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT17 Gene

Disorders for SYT17 Gene

Additional Disease Information for SYT17

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SYT17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT17 Gene

Publications for SYT17 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 58
  2. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo JC … Yoon TJ (Journal of dermatological science 2013) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Protein kinase A-dependent phosphorylation of B/K protein. (PMID: 16672768) Chin H … Kwon OJ (Experimental & molecular medicine 2006) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SYT17 Gene

Sources for SYT17 Gene

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