Aliases for SYT16 Gene

Aliases for SYT16 Gene

  • Synaptotagmin 16 2 3 5
  • Synaptotagmin XIV-Related Protein 3 4
  • Synaptotagmin 14-Like Protein 3 4
  • Synaptotagmin XVI 2 3
  • Synaptotagmin-16 3 4
  • SYT14L 3 4
  • Synaptotagmin XIV-Related 2
  • Synaptotagmin XIV-Like 2
  • Chr14 Synaptotagmin 2
  • Chr14 Synaptotagmin 3
  • CHR14SYT 3
  • Chr14Syt 4
  • Strep14 3
  • STREP14 4
  • Syt14r 3
  • SYT14R 4

External Ids for SYT16 Gene

Previous HGNC Symbols for SYT16 Gene

  • SYT14L

Previous GeneCards Identifiers for SYT16 Gene

  • GC14P061533
  • GC14P062462
  • GC14P042626
  • GC14P061970

Summaries for SYT16 Gene

GeneCards Summary for SYT16 Gene

SYT16 (Synaptotagmin 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is SYT14.

UniProtKB/Swiss-Prot Summary for SYT16 Gene

  • May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Additional gene information for SYT16 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYT16 Gene

Genomics for SYT16 Gene

GeneHancer (GH) Regulatory Elements for SYT16 Gene

Promoters and enhancers for SYT16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J061812 Promoter 1.1 Ensembl CraniofacialAtlas 500.7 +0.8 768 1.3 ZBTB26 HDAC2 EZH2 MXI1 PHF8 ZNF24 RNF2 ZNF202 CTBP2 ZNF449 SYT16 SNAPC1 COX4I1P1
GH14J061964 Enhancer 0.8 Ensembl ENCODE 11.7 +153.4 153370 1.7 FOS EP300 CEBPB JUN STAT3 JUND RFX5 TCF7L2 MAFK BHLHE40 RF00994-330 SYT16 piR-38352-175
GH14J061968 Enhancer 0.3 Ensembl 11.7 +156.6 156627 0.4 TCF12 SYT16 RF00994-330 piR-38352-175
GH14J061580 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 1.9 -227.1 -227136 8.3 ZSCAN5C TCF12 FOS ZNF10 EP300 TEAD1 ATF2 HDAC2 ZNF341 RBM25 NONHSAG015176.2 HIF1A SYT16 LINC01303 FLJ22447 ENSG00000232774 ENSG00000258989
GH14J061614 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -196.0 -195974 3.2 JUND RBM25 POLR2A NR3C1 YY1 ZMYM3 KDM1A ESR1 FOS ENSG00000232774 HIF1A SYT16 RF00951-035 LINC01303 FLJ22447 ENSG00000258989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYT16 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYT16

Top Transcription factor binding sites by QIAGEN in the SYT16 gene promoter:
  • AML1a
  • AREB6
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx2-5
  • Nkx6-1
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for SYT16 Gene

Genomic Locations for SYT16 Gene
305,070 bases
Plus strand
114,629 bases
Plus strand

Genomic View for SYT16 Gene

Genes around SYT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT16 Gene

Proteins for SYT16 Gene

  • Protein details for SYT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DZH2
    • B7ZL60
    • C9J8I3
    • Q707N2
    • Q7Z441
    • Q8IUU0
    • Q9BQR8

    Protein attributes for SYT16 Gene

    645 amino acids
    Molecular mass:
    72274 Da
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity).
    • Sequence=CAE85114.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYT16 Gene


neXtProt entry for SYT16 Gene

Post-translational modifications for SYT16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT16 Gene

Domains & Families for SYT16 Gene

Gene Families for SYT16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SYT16 Gene

  • C2 domain

Suggested Antigen Peptide Sequences for SYT16 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60997, highly similar to Homo sapiens synaptotagmin XVI (SYT16), mRNA (B4DZH2_HUMAN)
  • Synaptotagmin XIV-related protein (SYT16_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptotagmin family.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT16: view

Function for SYT16 Gene

Molecular function for SYT16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Phenotypes From GWAS Catalog for SYT16 Gene

Gene Ontology (GO) - Molecular Function for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005543 phospholipid binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with SYT16: view
genes like me logo Genes that share phenotypes with SYT16: view

Animal Model Products

miRNA for SYT16 Gene

miRTarBase miRNAs that target SYT16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT16 Gene

Localization for SYT16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT16 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SYT16 Gene

Pathways & Interactions for SYT16 Gene

PathCards logo

SuperPathways for SYT16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Pathways by source and SIGNOR curated interactions for SYT16 Gene

Drugs & Compounds for SYT16 Gene

No Compound Related Data Available

Transcripts for SYT16 Gene

mRNA/cDNA for SYT16 Gene

8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT16 Gene

No ASD Table

Relevant External Links for SYT16 Gene

GeneLoc Exon Structure for

Expression for SYT16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT16 Gene

This gene is overexpressed in Testis (x9.0), Brain - Cortex (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYT16

SOURCE GeneReport for Unigene cluster for SYT16 Gene:


mRNA Expression by UniProt/SwissProt for SYT16 Gene:

Tissue specificity: Expressed in brain.

Evidence on tissue expression from TISSUES for SYT16 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SYT16: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT16 Gene

Orthologs for SYT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT16 31
  • 99 (a)
(Canis familiaris)
Mammalia SYT16 31 30
  • 90.18 (n)
(Bos Taurus)
Mammalia SYT16 31 30
  • 87.86 (n)
(Mus musculus)
Mammalia Syt16 17 31 30
  • 84.33 (n)
(Rattus norvegicus)
Mammalia Syt16 30
  • 82.71 (n)
(Monodelphis domestica)
Mammalia SYT16 31
  • 67 (a)
(Gallus gallus)
Aves SYT16 31 30
  • 65.05 (n)
(Anolis carolinensis)
Reptilia SYT16 31
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia syt16 30
  • 67.6 (n)
Str.10061 30
(Danio rerio)
Actinopterygii LOC558725 30
  • 62.93 (n)
syt16 31
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt14 31
  • 29 (a)
(Caenorhabditis elegans)
Secernentea D2023.3 31
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
Species where no ortholog for SYT16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT16 Gene

Gene Tree for SYT16 (if available)
Gene Tree for SYT16 (if available)
Evolutionary constrained regions (ECRs) for SYT16: view image

Paralogs for SYT16 Gene

(2) SIMAP similar genes for SYT16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT16: view

Variants for SYT16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SYT16 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs17099370 - p.Arg131Leu
rs8019076 - p.Val10Ala

Additional dbSNP identifiers (rs#s) for SYT16 Gene

Structural Variations from Database of Genomic Variants (DGV) for SYT16 Gene

Variant ID Type Subtype PubMed ID
nsv1303 CNV insertion 18451855
nsv456321 CNV loss 19166990
nsv564887 CNV loss 21841781

Variation tolerance for SYT16 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT16 Gene

Disorders for SYT16 Gene

Additional Disease Information for SYT16

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SYT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT16 Gene

Publications for SYT16 Gene

  1. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M (Genomics 2001) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Synaptotagmin gene content of the sequenced genomes. (PMID: 15238157) Craxton M (BMC genomics 2004) 3 4 54

Products for SYT16 Gene

Sources for SYT16 Gene