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Aliases for SYT16 Gene

Aliases for SYT16 Gene

  • Synaptotagmin 16 2 3 5
  • Synaptotagmin XIV-Related Protein 3 4
  • Synaptotagmin 14-Like Protein 3 4
  • Synaptotagmin XVI 2 3
  • SYT14L 3 4
  • Synaptotagmin XIV-Related 2
  • Synaptotagmin XIV-Like 2
  • Chr14 Synaptotagmin 2
  • Chr14 Synaptotagmin 3
  • Synaptotagmin-16 3
  • CTD-2277K2.1 3
  • CHR14SYT 3
  • Chr14Syt 4
  • Strep14 3
  • STREP14 4
  • Syt14r 3
  • SYT14R 4
  • Yt14r 3

External Ids for SYT16 Gene

Previous HGNC Symbols for SYT16 Gene

  • SYT14L

Previous GeneCards Identifiers for SYT16 Gene

  • GC14P061533
  • GC14P062462
  • GC14P042626
  • GC14P061970

Summaries for SYT16 Gene

GeneCards Summary for SYT16 Gene

SYT16 (Synaptotagmin 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is SYT14.

UniProtKB/Swiss-Prot for SYT16 Gene

  • May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Additional gene information for SYT16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT16 Gene

Genomics for SYT16 Gene

GeneHancer (GH) Regulatory Elements for SYT16 Gene

Promoters and enhancers for SYT16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J061812 Promoter 0.8 Ensembl 650.7 +0.6 627 0.4 MXI1 POLR2A ZBTB8A ZBTB26 EZH2 SYT16 SNAPC1 COX4I1P1 GC14P061748
GH14J061964 Enhancer 0.6 ENCODE 11.7 +153.4 153370 1.7 JUN CEBPB EP300 RFX5 MAFF JUND CEBPA STAT3 FOS TCF7L2 SYT16 GC14P061915 GC14M061941
GH14J061580 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -227.1 -227136 8.3 FOXA2 FEZF1 ZNF2 FOS ATF7 RXRA REST ZNF518A NFIL3 STAT3 HIF1A SYT16 GC14P061590 ENSG00000232774 FLJ22447 LINC01303 ENSG00000258989
GH14J061615 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -195.7 -195677 1.6 JUND POLR2A ZMYM3 KDM1A ENSG00000232774 LINC01303 HIF1A SYT16 GC14P061590 FLJ22447 GC14P061694 ENSG00000258989
GH14J061965 Enhancer 0.2 ENCODE 11.1 +152.1 152124 0.2 SYT16 GC14P061915 GC14M061941
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYT16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYT16 gene promoter:
  • AREB6
  • Nkx2-5
  • Meis-1b
  • Meis-1a
  • Meis-1
  • AML1a
  • Pax-2b
  • Pax-2a
  • Pax-2
  • Nkx6-1

Genomic Locations for SYT16 Gene

Genomic Locations for SYT16 Gene
305,070 bases
Plus strand
114,629 bases
Plus strand

Genomic View for SYT16 Gene

Genes around SYT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT16 Gene

Proteins for SYT16 Gene

  • Protein details for SYT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DZH2
    • B7ZL60
    • C9J8I3
    • Q707N2
    • Q7Z441
    • Q8IUU0
    • Q9BQR8

    Protein attributes for SYT16 Gene

    645 amino acids
    Molecular mass:
    72274 Da
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity).
    • Sequence=CAE85114.1; Type=Erroneous termination; Positions=72; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYT16 Gene


neXtProt entry for SYT16 Gene

Post-translational modifications for SYT16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT16 Gene

Domains & Families for SYT16 Gene

Gene Families for SYT16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SYT16 Gene


Suggested Antigen Peptide Sequences for SYT16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptotagmin family.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT16: view

Function for SYT16 Gene

Molecular function for SYT16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Phenotypes From GWAS Catalog for SYT16 Gene

Gene Ontology (GO) - Molecular Function for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0005543 phospholipid binding IEA --
GO:0005544 NOT calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT16: view
genes like me logo Genes that share phenotypes with SYT16: view

Animal Model Products

miRNA for SYT16 Gene

miRTarBase miRNAs that target SYT16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT16 Gene

Localization for SYT16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT16 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SYT16 Gene

Pathways & Interactions for SYT16 Gene

SuperPathways for SYT16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 NOT calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Pathways by source and SIGNOR curated interactions for SYT16 Gene

Drugs & Compounds for SYT16 Gene

No Compound Related Data Available

Transcripts for SYT16 Gene

mRNA/cDNA for SYT16 Gene

(22) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT16 Gene

Synaptotagmin XVI:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT16 Gene

No ASD Table

Relevant External Links for SYT16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT16 Gene

This gene is overexpressed in Testis (x9.0), Brain - Cortex (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of SYT16 Gene:


SOURCE GeneReport for Unigene cluster for SYT16 Gene:


mRNA Expression by UniProt/SwissProt for SYT16 Gene:

Tissue specificity: Expressed in brain.

Evidence on tissue expression from TISSUES for SYT16 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SYT16: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT16 Gene

Orthologs for SYT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT16 34
  • 99 (a)
(Canis familiaris)
Mammalia SYT16 34 33
  • 90.18 (n)
(Bos Taurus)
Mammalia SYT16 34 33
  • 87.86 (n)
(Mus musculus)
Mammalia Syt16 16 34 33
  • 84.33 (n)
(Rattus norvegicus)
Mammalia Syt16 33
  • 82.71 (n)
(Monodelphis domestica)
Mammalia SYT16 34
  • 67 (a)
(Gallus gallus)
Aves SYT16 34 33
  • 65.05 (n)
(Anolis carolinensis)
Reptilia SYT16 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia syt16 33
  • 67.6 (n)
Str.10061 33
(Danio rerio)
Actinopterygii LOC558725 33
  • 62.93 (n)
syt16 34
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt14 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea D2023.3 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for SYT16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT16 Gene

Gene Tree for SYT16 (if available)
Gene Tree for SYT16 (if available)
Evolutionary constrained regions (ECRs) for SYT16: view image

Paralogs for SYT16 Gene

Paralogs for SYT16 Gene

(2) SIMAP similar genes for SYT16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT16: view

Variants for SYT16 Gene

Sequence variations from dbSNP and Humsavar for SYT16 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000026211 -- 62,071,841(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000028973 -- 62,069,055(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000036723 -- 62,055,916(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000039064 -- 61,907,347(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000041764 -- 61,986,339(+) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYT16 Gene

Variant ID Type Subtype PubMed ID
nsv564887 CNV loss 21841781
nsv456321 CNV loss 19166990
nsv1303 CNV insertion 18451855

Variation tolerance for SYT16 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT16 Gene

Disorders for SYT16 Gene

Additional Disease Information for SYT16

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SYT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT16 Gene

Publications for SYT16 Gene

  1. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M (Genomics 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Synaptotagmin gene content of the sequenced genomes. (PMID: 15238157) Craxton M (BMC genomics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SYT16 Gene

Sources for SYT16 Gene

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