This gene encodes a member of the Synaptotagmin (Syt) family of membrane trafficking proteins. Members of this family contain a transmembrane region and a C-terminal-type tandem C2 domain. Unlike related family members, the encoded protein may be involved in membrane trafficking in non-neuronal tissues. Two trancript variants encoding distinct isoforms have been identified for ... See more...

Aliases for SYT15 Gene

Aliases for SYT15 Gene

  • Synaptotagmin 15 2 3 5
  • Synaptotagmin XV 2 3 4
  • Synaptotagmin-15 3 4
  • SytXV 3 4
  • Chr10 Synaptotagmin 3
  • Synaptotagmin XV-A 3
  • CHR10SYT 3
  • Chr10Syt 4

External Ids for SYT15 Gene

Previous GeneCards Identifiers for SYT15 Gene

  • GC10U900263
  • GC10M046339
  • GC10M046378
  • GC10M046955
  • GC10M042810

Summaries for SYT15 Gene

Entrez Gene Summary for SYT15 Gene

  • This gene encodes a member of the Synaptotagmin (Syt) family of membrane trafficking proteins. Members of this family contain a transmembrane region and a C-terminal-type tandem C2 domain. Unlike related family members, the encoded protein may be involved in membrane trafficking in non-neuronal tissues. Two trancript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYT15 Gene

SYT15 (Synaptotagmin 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is LOC102724488.

UniProtKB/Swiss-Prot Summary for SYT15 Gene

  • May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.

Additional gene information for SYT15 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYT15 Gene

Genomics for SYT15 Gene

GeneHancer (GH) Regulatory Elements for SYT15 Gene

Promoters and enhancers for SYT15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J046581 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 506.6 +0.7 662 1.8 GABPA ZBTB26 MCM3 HDAC2 EZH2 SRSF1 PTBP1 YY1 PHF8 GABPB1 SYT15 lnc-GPRIN2-3 WASHC2C PARGP1 SHLD2P1 BMS1P2 piR-48119-001
GH10J046538 Promoter/Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas 11.3 -37.9 -37944 2.6 TCF12 TEAD4 CTCF GABPA HES1 RUNX1 TEAD1 HDAC2 POLR2A KDM1A SYT15 WASHC2C PARGP1 FAM21FP GPRIN2 piR-52294-014 lnc-SYT15-2
GH10J046544 Enhancer 1 Ensembl ENCODE dbSUPER 10.9 -33.1 -33116 1.4 CTCF TCF12 TEAD4 REST ZNF740 SMC3 POLR2A KDM5B SIX5 YY1 piR-30183 piR-42139 piR-52915 SYT15 GPRIN2
GH10J046313 Enhancer 0.8 Ensembl ENCODE 10.5 -261.4 -261416 10 ZNF217 EP300 CTBP1 ZNF316 NFIC TRIM24 ELF1 ZFHX2 TAL1 DPF2 ANXA8L1 LINC00842 SYT15 GDF10 NONHSAG005814.2 piR-32907-001 ANTXRL
GH10J046512 Enhancer 0.7 Ensembl ENCODE 10.5 -65.6 -65573 1.7 NR3C1 MCM3 CTCF FOS FOSL2 SIN3A MAX SUZ12 MNT MYC WASHC2C PARGP1 SYT15 lnc-SYT15-5 lnc-SYT15-6 ENSG00000285402
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYT15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYT15

Top Transcription factor binding sites by QIAGEN in the SYT15 gene promoter:
  • AML1a
  • c-Myb
  • E2F
  • E2F-1
  • En-1
  • GATA-2
  • RFX1
  • STAT3
  • USF-1
  • USF1

Genomic Locations for SYT15 Gene

Genomic Locations for SYT15 Gene
chr10:46,578,217-46,595,194
(GRCh38/hg38)
Size:
16,978 bases
Orientation:
Plus strand
chr10:46,955,444-46,971,400
(GRCh37/hg19)
Size:
15,957 bases
Orientation:
Minus strand

Genomic View for SYT15 Gene

Genes around SYT15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT15 Gene

Proteins for SYT15 Gene

  • Protein details for SYT15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQS2-SYT15_HUMAN
    Recommended name:
    Synaptotagmin-15
    Protein Accession:
    Q9BQS2
    Secondary Accessions:
    • A5D6W8
    • Q5VY53
    • Q5VY55
    • Q7Z439
    • Q7Z440

    Protein attributes for SYT15 Gene

    Size:
    421 amino acids
    Molecular mass:
    47375 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for SYT15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYT15 Gene

Post-translational modifications for SYT15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT15 Gene

Domains & Families for SYT15 Gene

Gene Families for SYT15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SYT15 Gene

Blocks:
  • C2 domain
  • Cyclic nucleotide-binding domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT15 Gene

GenScript: Design optimal peptide antigens:
  • Synaptotagmin XV (SYT15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BQS2

UniProtKB/Swiss-Prot:

SYT15_HUMAN :
  • Neither C2 domains mediates Ca(2+)-dependent or -independent phospholipid binding.
  • Belongs to the synaptotagmin family.
Domain:
  • Neither C2 domains mediates Ca(2+)-dependent or -independent phospholipid binding.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT15: view

Function for SYT15 Gene

Molecular function for SYT15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.

Phenotypes From GWAS Catalog for SYT15 Gene

Gene Ontology (GO) - Molecular Function for SYT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA 21873635
GO:0001786 phosphatidylserine binding IBA 21873635
GO:0005509 calcium ion binding IBA 21873635
GO:0005544 calcium-dependent phospholipid binding IBA 21873635
GO:0030276 clathrin binding IBA 21873635
genes like me logo Genes that share ontologies with SYT15: view
genes like me logo Genes that share phenotypes with SYT15: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT15 Gene

Localization for SYT15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT15 Gene

[Isoform 1]: Cell membrane; Single-pass type III membrane protein.
[Isoform 2]: Cell membrane; Single-pass type III membrane protein.
[Isoform 4]: Cell membrane; Single-pass type III membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070382 exocytic vesicle IBA 21873635
genes like me logo Genes that share ontologies with SYT15: view

No data available for Subcellular locations from COMPARTMENTS for SYT15 Gene

Pathways & Interactions for SYT15 Gene

PathCards logo

SuperPathways for SYT15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014059 regulation of dopamine secretion IBA 21873635
GO:0016192 vesicle-mediated transport IBA 21873635
GO:0017156 calcium ion regulated exocytosis IBA 21873635
GO:0017158 regulation of calcium ion-dependent exocytosis IBA 21873635
GO:0071277 cellular response to calcium ion IBA 21873635
genes like me logo Genes that share ontologies with SYT15: view

No data available for Pathways by source and SIGNOR curated interactions for SYT15 Gene

Drugs & Compounds for SYT15 Gene

No Compound Related Data Available

Transcripts for SYT15 Gene

mRNA/cDNA for SYT15 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT15 Gene

No ASD Table

Relevant External Links for SYT15 Gene

GeneLoc Exon Structure for
SYT15

Expression for SYT15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYT15 Gene

Protein differential expression in normal tissues from HIPED for SYT15 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SYT15 Gene



Protein tissue co-expression partners for SYT15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYT15

SOURCE GeneReport for Unigene cluster for SYT15 Gene:

Hs.696346

Evidence on tissue expression from TISSUES for SYT15 Gene

  • Nervous system(4.3)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with SYT15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT15 Gene

Orthologs for SYT15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT15 31 30
  • 99.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SYT15 31 30
  • 84.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Syt15 17 31 30
  • 82.93 (n)
rat
(Rattus norvegicus)
Mammalia Syt15 30
  • 81.98 (n)
dog
(Canis familiaris)
Mammalia SYT15 31 30
  • 77.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT15 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYT15 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT15 31 30
  • 64.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT15 31
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496499 30
  • 61.21 (n)
Str.9057 30
zebrafish
(Danio rerio)
Actinopterygii syt15 31 30
  • 57.3 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sytbeta 31
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea snt-6 31
  • 23 (a)
OneToOne
Species where no ortholog for SYT15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT15 Gene

ENSEMBL:
Gene Tree for SYT15 (if available)
TreeFam:
Gene Tree for SYT15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SYT15: view image

Paralogs for SYT15 Gene

(13) SIMAP similar genes for SYT15 Gene using alignment to 3 proteins:

  • SYT15_HUMAN
  • D6RF99_HUMAN
  • H3BLX3_HUMAN

Pseudogenes.org Pseudogenes for SYT15 Gene

genes like me logo Genes that share paralogs with SYT15: view

Variants for SYT15 Gene

Additional dbSNP identifiers (rs#s) for SYT15 Gene

Structural Variations from Database of Genomic Variants (DGV) for SYT15 Gene

Variant ID Type Subtype PubMed ID
dgv147n67 CNV gain 20364138
dgv216e212 CNV loss 25503493
dgv218e212 CNV loss 25503493
dgv219e212 CNV gain 25503493
dgv22e55 CNV gain 17911159
dgv409e59 CNV duplication 20981092
dgv410e59 CNV duplication 20981092
dgv440n106 CNV duplication 24896259
dgv734n100 CNV gain 25217958
dgv737n100 CNV loss 25217958
dgv738n100 CNV loss 25217958
dgv739n100 CNV gain 25217958
dgv740n100 CNV gain+loss 25217958
dgv742n100 CNV loss 25217958
dgv743n100 CNV gain 25217958
dgv746n100 CNV gain 25217958
dgv747n100 CNV gain+loss 25217958
dgv748n100 CNV gain 25217958
dgv749n100 CNV gain+loss 25217958
dgv750n100 CNV loss 25217958
dgv751n100 CNV gain 25217958
dgv752n100 CNV loss 25217958
dgv753n100 CNV gain 25217958
dgv759n100 CNV loss 25217958
dgv760n100 CNV gain 25217958
dgv763n100 CNV gain 25217958
dgv764n100 CNV loss 25217958
dgv765n100 CNV loss 25217958
dgv767n100 CNV gain 25217958
dgv768n100 CNV loss 25217958
dgv771n100 CNV loss 25217958
dgv8n68 CNV gain 17160897
esv2632472 CNV gain 19546169
esv2736152 CNV deletion 23290073
esv2854902 CNV duplication 24192839
esv3347159 CNV duplication 20981092
esv3367058 CNV duplication 20981092
esv3385822 CNV duplication 20981092
esv3417603 CNV duplication 20981092
esv3584617 CNV loss 24956385
esv3891799 CNV gain 25118596
nsv1037583 CNV loss 25217958
nsv1040552 CNV gain+loss 25217958
nsv1041409 CNV loss 25217958
nsv1042820 CNV gain+loss 25217958
nsv1047223 CNV loss 25217958
nsv1047376 CNV loss 25217958
nsv1047710 CNV gain+loss 25217958
nsv1049394 CNV loss 25217958
nsv1050225 CNV gain+loss 25217958
nsv1050530 CNV loss 25217958
nsv1050696 CNV gain 25217958
nsv1075818 CNV duplication 25765185
nsv1152446 CNV duplication 26484159
nsv438171 CNV loss 16468122
nsv482144 CNV gain 20164927
nsv550722 CNV gain 21841781
nsv820817 CNV duplication 20802225
nsv947928 CNV duplication 23825009
nsv951576 CNV duplication 24416366

Variation tolerance for SYT15 Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYT15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SYT15 Gene

Disorders for SYT15 Gene

Additional Disease Information for SYT15

No disorders were found for SYT15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT15 Gene

Publications for SYT15 Gene

  1. Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV. (PMID: 12788067) Fukuda M (Biochemical and biophysical research communications 2003) 3 4 23 54
  2. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M (Genomics 2001) 2 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation. (PMID: 29969578) Xiao N … Yao M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for SYT15 Gene

Sources for SYT15 Gene