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This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
SYT13 (Synaptotagmin 13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is SYT9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000149 | SNARE binding | IBA | 21873635 |
GO:0001786 | phosphatidylserine binding | IBA | 21873635 |
GO:0005509 | calcium ion binding | IBA | 21873635 |
GO:0005544 | calcium-dependent phospholipid binding | IBA | 21873635 |
GO:0030276 | clathrin binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0005887 | integral component of plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030133 | transport vesicle | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006906 | vesicle fusion | IBA | 21873635 |
GO:0014059 | regulation of dopamine secretion | IBA | 21873635 |
GO:0016192 | vesicle-mediated transport | IEA,IBA | 21873635 |
GO:0017156 | calcium ion regulated exocytosis | IBA | 21873635 |
GO:0017158 | regulation of calcium ion-dependent exocytosis | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SYT13 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SYT13 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SYT13 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Syt13 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Syt13 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SYT13 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SYT13 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SYT13 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SYT13 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | syt13 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | syt13 30 31 |
|
OneToOne | |
Dr.17253 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3388585 | CNV | insertion | 20981092 |
nsv305 | CNV | insertion | 18451855 |
No disorders were found for SYT13 Gene.