The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010] See more...

Aliases for SYT1 Gene

Aliases for SYT1 Gene

  • Synaptotagmin 1 2 3 5
  • Synaptotagmin I 2 3 4
  • Synaptotagmin-1 3 4
  • SVP65 3 4
  • SytI 3 4
  • P65 3 4
  • SYT 3 4
  • BAGOS 3

External Ids for SYT1 Gene

Previous HGNC Symbols for SYT1 Gene

  • SYT
  • SVP65

Previous GeneCards Identifiers for SYT1 Gene

  • GC12P079232
  • GC12P079621
  • GC12P078113
  • GC12P078076
  • GC12P077760
  • GC12P076312

Summaries for SYT1 Gene

Entrez Gene Summary for SYT1 Gene

  • The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]

GeneCards Summary for SYT1 Gene

SYT1 (Synaptotagmin 1) is a Protein Coding gene. Diseases associated with SYT1 include Baker-Gordon Syndrome and Med13l Haploinsufficiency Syndrome. Among its related pathways are Synaptic vesicle cycle and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include calcium ion binding and transporter activity. An important paralog of this gene is SYT2.

UniProtKB/Swiss-Prot Summary for SYT1 Gene

  • Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Wiki entry for SYT1 Gene

Additional gene information for SYT1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYT1 Gene

Genomics for SYT1 Gene

GeneHancer (GH) Regulatory Elements for SYT1 Gene

Promoters and enhancers for SYT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J078863 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.9 908 3.8 TCF12 REST ZBTB10 NFYB HDAC2 MXI1 POLR2A SMC3 SP2 YY1 SYT1 lnc-NAV3-6 lnc-NAV3-4
GH12J079045 Promoter 1.2 EPDnew Ensembl 506.9 +181.4 181408 1.2 ZNF217 CLOCK CHD1 CTBP1 HCFC1 SIN3A FOXA2 YY1 FOXA1 PKNOX1 SYT1 ENSG00000257191 LOC105369863 lnc-NAV3-6
GH12J078885 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.2 +23.3 23313 4.2 USF1 JUND FOS MEF2C EP300 NFYB FOSL2 CEBPB MEF2B CHD2 SYT1 lnc-NAV3-6 lnc-NAV3-4
GH12J078927 Enhancer 0.8 Ensembl ENCODE 10.8 +64.9 64941 2.1 TCF12 JUND FOS REST FOSL2 CEBPB NR3C1 EP300 PRDM1 POLR2A SYT1 lnc-NAV3-4 lnc-NAV3-6 LOC105369863
GH12J079055 Enhancer 0.9 Ensembl ENCODE 7 +192.7 192708 5.4 ZNF217 TCF12 JUND FOS CUX1 EP300 CTBP1 BCL11A SMARCC1 CEBPG SYT1 ENSG00000257191 piR-38352-128 lnc-NAV3-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYT1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYT1

Top Transcription factor binding sites by QIAGEN in the SYT1 gene promoter:
  • aMEF-2
  • ISGF-3
  • MEF-2A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3

Genomic Locations for SYT1 Gene

Genomic Locations for SYT1 Gene
chr12:78,863,993-79,452,008
(GRCh38/hg38)
Size:
588,016 bases
Orientation:
Plus strand
chr12:79,257,773-79,845,788
(GRCh37/hg19)
Size:
588,016 bases
Orientation:
Plus strand

Genomic View for SYT1 Gene

Genes around SYT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT1 Gene

Proteins for SYT1 Gene

  • Protein details for SYT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21579-SYT1_HUMAN
    Recommended name:
    Synaptotagmin-1
    Protein Accession:
    P21579
    Secondary Accessions:
    • Q6AI31

    Protein attributes for SYT1 Gene

    Size:
    422 amino acids
    Molecular mass:
    47573 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homotetramer (Probable). Interacts with SCAMP5 (PubMed:19234194). Interacts with STON2 (PubMed:11381094). Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity). Interacts with SV2A, SV2B and SV2C (By similarity). Interacts with RIMS1 (By similarity). Interacts with PRRT2 (By similarity). Interacts with DNAJC5 in a phosphorylation-dependent manner (By similarity). Interacts (via N-terminus) with RAB3A (By similarity). Interacts with SYT12 (By similarity). Interacts with calmodulin (By similarity).

    Three dimensional structures from OCA and Proteopedia for SYT1 Gene

neXtProt entry for SYT1 Gene

Post-translational modifications for SYT1 Gene

Antibody Products

No data available for DME Specific Peptides for SYT1 Gene

Domains & Families for SYT1 Gene

Gene Families for SYT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SYT1 Gene

Blocks:
  • C2 domain
  • Synaptotagmin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT1 Gene

GenScript: Design optimal peptide antigens:
  • SYT protein (Q8TDQ9_HUMAN)
  • p65 (SYT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21579

UniProtKB/Swiss-Prot:

SYT1_HUMAN :
  • The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
  • Belongs to the synaptotagmin family.
Domain:
  • The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
  • The second C2 domain mediates interaction with SV2A and probably with STN2.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT1: view

Function for SYT1 Gene

Molecular function for SYT1 Gene

UniProtKB/Swiss-Prot Function:
Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
GENATLAS Biochemistry:
synaptotagmin 1,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,associating with FGF1 and S100A3 and mediating FGF1 release,involved in exocytosis and endocytosis

Phenotypes From GWAS Catalog for SYT1 Gene

Gene Ontology (GO) - Molecular Function for SYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS --
GO:0001786 phosphatidylserine binding IBA 21873635
GO:0005509 calcium ion binding IBA 21873635
GO:0005515 protein binding IPI 11438518
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with SYT1: view
genes like me logo Genes that share phenotypes with SYT1: view

Human Phenotype Ontology for SYT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SYT1 Gene

MGI Knock Outs for SYT1:
  • Syt1 Syt1<tm1a(EUCOMM)Wtsi>
  • Syt1 Syt1<tm1Sud>

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SYT1 Gene

Localization for SYT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT1 Gene

Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT1 gene
Compartment Confidence
plasma membrane 4
cytosol 4
endoplasmic reticulum 3
golgi apparatus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 24327345
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS,IBA --
GO:0008021 synaptic vesicle IEA,TAS 11438518
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SYT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SYT1 Gene

Pathways & Interactions for SYT1 Gene

genes like me logo Genes that share pathways with SYT1: view

Pathways by source for SYT1 Gene

Gene Ontology (GO) - Biological Process for SYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005513 detection of calcium ion TAS 11438518
GO:0007268 chemical synaptic transmission TAS 1840599
GO:0007269 neurotransmitter secretion TAS,IEA 11438518
GO:0007420 brain development IEA --
GO:0014047 glutamate secretion TAS --
genes like me logo Genes that share ontologies with SYT1: view

No data available for SIGNOR curated interactions for SYT1 Gene

Drugs & Compounds for SYT1 Gene

(15) Drugs for SYT1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884

(14) Additional Compounds for SYT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SYT1: view

Transcripts for SYT1 Gene

mRNA/cDNA for SYT1 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT1 Gene

No ASD Table

Relevant External Links for SYT1 Gene

GeneLoc Exon Structure for
SYT1

Expression for SYT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYT1 Gene

mRNA differential expression in normal tissues according to GTEx for SYT1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.3), Brain - Anterior cingulate cortex (BA24) (x8.7), Brain - Cortex (x6.6), Brain - Cerebellar Hemisphere (x4.6), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for SYT1 Gene

This gene is overexpressed in Brain (32.3), Frontal cortex (21.1), and Retina (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYT1 Gene



Protein tissue co-expression partners for SYT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYT1

SOURCE GeneReport for Unigene cluster for SYT1 Gene:

Hs.310545

mRNA Expression by UniProt/SwissProt for SYT1 Gene:

P21579-SYT1_HUMAN
Tissue specificity: Expressed in melanocytes (PubMed:23999003).

Evidence on tissue expression from TISSUES for SYT1 Gene

  • Nervous system(5)
  • Adrenal gland(2.9)
  • Eye(2)
genes like me logo Genes that share expression patterns with SYT1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT1 Gene

Orthologs for SYT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT1 31 30
  • 99.68 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT1 31
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYT1 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT1 31 30
  • 93.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SYT1 31 30
  • 92.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Syt1 17 31 30
  • 90.18 (n)
rat
(Rattus norvegicus)
Mammalia Syt1 30
  • 89.71 (n)
chicken
(Gallus gallus)
Aves SYT1 31 30
  • 86.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT1 31
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt1 30
  • 80.84 (n)
zebrafish
(Danio rerio)
Actinopterygii syt1a 31
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10446 30
fruit fly
(Drosophila melanogaster)
Insecta syt 32
  • 69 (a)
Syt1 30
  • 63.76 (n)
CG5559 32
  • 37 (a)
CG3020 32
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007942 30
  • 63.09 (n)
worm
(Caenorhabditis elegans)
Secernentea Y75B7AL.3 32
  • 64 (a)
snt-1 32 30
  • 61.67 (n)
F42G9.7 32
  • 52 (a)
C08G5.4 32
  • 40 (a)
R12A1.2 32
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8468 31
  • 67 (a)
OneToMany
Cin.2611 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2611 30
Species where no ortholog for SYT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT1 Gene

ENSEMBL:
Gene Tree for SYT1 (if available)
TreeFam:
Gene Tree for SYT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SYT1: view image

Paralogs for SYT1 Gene

(26) SIMAP similar genes for SYT1 Gene using alignment to 9 proteins:

  • SYT1_HUMAN
  • C9JX50_HUMAN
  • F8VP93_HUMAN
  • F8VXH0_HUMAN
  • F8VYH8_HUMAN
  • F8VZY3_HUMAN
  • F8W1U9_HUMAN
  • H0YIH4_HUMAN
  • J3KQA0_HUMAN
genes like me logo Genes that share paralogs with SYT1: view

Variants for SYT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SYT1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
722025 Likely Benign: not provided 79,448,968(+) C/T SYNONYMOUS_VARIANT
763283 Likely Benign: not provided 79,449,112(+) C/T SYNONYMOUS_VARIANT
778644 Benign: not provided 79,449,013(+) G/A SYNONYMOUS_VARIANT
790668 Benign: not provided 79,292,034(+) T/C SYNONYMOUS_VARIANT
rs1135402761 Pathogenic/Likely Pathogenic: SYT1-associated neurodevelopmental disorder; BAKER-GORDON SYNDROME; not provided. Baker-Gordon syndrome (BAGOS) [MIM:618218] 79,448,958(+) T/Cp.Ile368Thr MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SYT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SYT1 Gene

Variant ID Type Subtype PubMed ID
esv1006890 CNV insertion 20482838
esv1290661 CNV insertion 17803354
esv2660779 CNV deletion 23128226
esv2672330 CNV deletion 23128226
esv2746111 CNV deletion 23290073
esv3305268 CNV mobile element insertion 20981092
esv3399689 CNV insertion 20981092
esv3437362 CNV insertion 20981092
esv3549458 CNV deletion 23714750
esv3549460 CNV deletion 23714750
esv3580339 CNV loss 25503493
esv3630065 CNV gain 21293372
esv3630067 CNV loss 21293372
esv3630068 CNV gain 21293372
esv3630071 CNV loss 21293372
esv3630074 CNV loss 21293372
esv3630075 CNV gain 21293372
esv3892228 CNV gain 25118596
nsv1045957 CNV loss 25217958
nsv1054360 CNV loss 25217958
nsv1116705 CNV tandem duplication 24896259
nsv1125555 CNV tandem duplication 24896259
nsv1129535 CNV tandem duplication 24896259
nsv1152109 CNV duplication 26484159
nsv477376 CNV novel sequence insertion 20440878
nsv507657 OTHER sequence alteration 20534489
nsv507658 OTHER sequence alteration 20534489
nsv52925 CNV deletion 16902084
nsv559438 CNV gain 21841781
nsv832466 CNV loss 17160897
nsv832467 CNV loss 17160897
nsv957908 CNV insertion 24416366
nsv976643 CNV duplication 23825009

Variation tolerance for SYT1 Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT1 Gene

Human Gene Mutation Database (HGMD)
SYT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT1 Gene

Disorders for SYT1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for SYT1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
baker-gordon syndrome
  • bagos
med13l haploinsufficiency syndrome
  • mrfacd
foodborne botulism
  • wound botulism
infantile hypotonia
mast-cell leukemia
  • mast cell leukemia
- elite association - COSMIC cancer census association via MalaCards
Search SYT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYT1_HUMAN
  • Baker-Gordon syndrome (BAGOS) [MIM:618218]: An autosomal dominant neurodevelopmental disorder characterized by infantile hypotonia, congenital ophthalmic abnormalities, involuntary and hyperkinetic movements, stereotypic behavior, poor or absent speech, EEG abnormalities, and global developmental delay varying in severity from moderate to profound. Behavioral characteristics include sleep disturbance and episodic agitation. {ECO:0000269 PubMed:25705886, ECO:0000269 PubMed:25712080, ECO:0000269 PubMed:30107533}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SYT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SYT1: view

No data available for Genatlas for SYT1 Gene

Publications for SYT1 Gene

  1. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans. (PMID: 1840599) Perin MS … Südhof TC (The Journal of biological chemistry 1991) 2 3 4 23 54
  2. A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. (PMID: 20222955) Pattaro C … EUROSPAN consortium (BMC medical genetics 2010) 3 23 41 54
  3. Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling. (PMID: 25705886) Baker K … Raymond FL (The Journal of clinical investigation 2015) 3 4 54
  4. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo JC … Yoon TJ (Journal of dermatological science 2013) 3 4 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for SYT1 Gene

  • Signalway ELISA kits for SYT1
  • Signalway Proteins for SYT1

Sources for SYT1 Gene