This locus represents naturally occurring read-through transcription from the neighboring SYS1 Golgi-localized integral membrane protein homolog and dysbindin domain containing 2 (DBNDD2) genes. The read-through transcript includes the majority of exons from each individual gene, but it would be subject to nonsense-mediated mRNA decay (NMD) and is therefore predicted to be non-... See more...

Aliases for SYS1-DBNDD2 Gene

Subcategory (RNA class) for SYS1-DBNDD2 Gene

lncRNA

Aliases for SYS1-DBNDD2 Gene

  • SYS1-DBNDD2 Readthrough (NMD Candidate) 2 3 5 13
  • SYS1-DBNDD2 Readthrough (Non-Protein Coding) 2 3
  • C20orf169-DBNDD2 3
  • SYS1-DBNDD2 5

External Ids for SYS1-DBNDD2 Gene

Previous GeneCards Identifiers for SYS1-DBNDD2 Gene

  • GC20U900295
  • GC20P043427
  • GC20P043991

Summaries for SYS1-DBNDD2 Gene

Entrez Gene Summary for SYS1-DBNDD2 Gene

  • This locus represents naturally occurring read-through transcription from the neighboring SYS1 Golgi-localized integral membrane protein homolog and dysbindin domain containing 2 (DBNDD2) genes. The read-through transcript includes the majority of exons from each individual gene, but it would be subject to nonsense-mediated mRNA decay (NMD) and is therefore predicted to be non-coding. [provided by RefSeq, Oct 2010]

GeneCards Summary for SYS1-DBNDD2 Gene

SYS1-DBNDD2 (SYS1-DBNDD2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. An important paralog of this gene is SYS1.

Additional gene information for SYS1-DBNDD2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYS1-DBNDD2 Gene

Genomics for SYS1-DBNDD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SYS1-DBNDD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYS1-DBNDD2 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the SYS1-DBNDD2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • MyoD
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for SYS1-DBNDD2 Gene

Genomic Locations for SYS1-DBNDD2 Gene
chr20:45,363,169-45,410,610
(GRCh38/hg38)
Size:
47,442 bases
Orientation:
Plus strand
chr20:43,991,809-44,039,250
(GRCh37/hg19)
Size:
47,442 bases
Orientation:
Plus strand

Genomic View for SYS1-DBNDD2 Gene

Genes around SYS1-DBNDD2 on UCSC Golden Path with GeneCards custom track
SYS1-DBNDD2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
SYS1-DBNDD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYS1-DBNDD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYS1-DBNDD2 Gene

Proteins for SYS1-DBNDD2 Gene

  • Protein details for SYS1-DBNDD2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F2Z2A3-F2Z2A3_HUMAN
    Recommended name:
    SYS1-DBNDD2 readthrough (NMD candidate)
    Protein Accession:
    F2Z2A3

    Protein attributes for SYS1-DBNDD2 Gene

    Size:
    78 amino acids
    Molecular mass:
    8717 Da
    Quaternary structure:
    No Data Available
  • Protein details for SYS1-DBNDD2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BUS1-H3BUS1_HUMAN
    Recommended name:
    SYS1-DBNDD2 readthrough (NMD candidate)
    Protein Accession:
    H3BUS1

    Protein attributes for SYS1-DBNDD2 Gene

    Size:
    97 amino acids
    Molecular mass:
    11030 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SYS1-DBNDD2 Gene

Post-translational modifications for SYS1-DBNDD2 Gene

No Post-translational modifications

Other Protein References for SYS1-DBNDD2 Gene

No data available for DME Specific Peptides for SYS1-DBNDD2 Gene

Domains & Families for SYS1-DBNDD2 Gene

Protein Domains for SYS1-DBNDD2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SYS1-DBNDD2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SYS1-DBNDD2 Gene

Function for SYS1-DBNDD2 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SYS1-DBNDD2 Gene

Localization for SYS1-DBNDD2 Gene

Gene Ontology (GO) - Cellular Components for SYS1-DBNDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IBA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IBA --
genes like me logo Genes that share ontologies with SYS1-DBNDD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SYS1-DBNDD2 Gene

Pathways & Interactions for SYS1-DBNDD2 Gene

PathCards logo

SuperPathways for SYS1-DBNDD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYS1-DBNDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport IBA --
GO:0034067 protein localization to Golgi apparatus IBA --
GO:0043001 Golgi to plasma membrane protein transport IBA --
genes like me logo Genes that share ontologies with SYS1-DBNDD2: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for SYS1-DBNDD2 Gene

Drugs & Compounds for SYS1-DBNDD2 Gene

No Compound Related Data Available

Transcripts for SYS1-DBNDD2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for SYS1-DBNDD2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D296_9606 lncRNA 1344 1

RefSeq: NR_003189,

SYS1-DBNDD2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for SYS1-DBNDD2 Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYS1-DBNDD2 Gene

No ASD Table

Relevant External Links for SYS1-DBNDD2 Gene

GeneLoc Exon Structure for
SYS1-DBNDD2

Expression for SYS1-DBNDD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYS1-DBNDD2 Gene

Protein differential expression in normal tissues from HIPED for SYS1-DBNDD2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for SYS1-DBNDD2 Gene



Protein tissue co-expression partners for SYS1-DBNDD2 Gene

genes like me logo Genes that share expression patterns with SYS1-DBNDD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYS1-DBNDD2 Gene

Orthologs for SYS1-DBNDD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYS1-DBNDD2 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Gm20458 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 46 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves SYS1 31
  • 36 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii sys1 31
  • 39 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG11753 31
  • 20 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T03F1.12 31
  • 14 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for SYS1-DBNDD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SYS1-DBNDD2 Gene

ENSEMBL:
Gene Tree for SYS1-DBNDD2 (if available)
TreeFam:
Gene Tree for SYS1-DBNDD2 (if available)

Paralogs for SYS1-DBNDD2 Gene

Paralogs for SYS1-DBNDD2 Gene

(1) SIMAP similar genes for SYS1-DBNDD2 Gene using alignment to 2 proteins:

  • F2Z2A3_HUMAN
  • H3BUS1_HUMAN
genes like me logo Genes that share paralogs with SYS1-DBNDD2: view

Variants for SYS1-DBNDD2 Gene

Additional dbSNP identifiers (rs#s) for SYS1-DBNDD2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SYS1-DBNDD2 Gene

Variant ID Type Subtype PubMed ID
dgv4319n100 CNV gain 25217958
nsv1056102 CNV loss 25217958

Additional Variant Information for SYS1-DBNDD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYS1-DBNDD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SYS1-DBNDD2 Gene

Disorders for SYS1-DBNDD2 Gene

Additional Disease Information for SYS1-DBNDD2

No disorders were found for SYS1-DBNDD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYS1-DBNDD2 Gene

Publications for SYS1-DBNDD2 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  3. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 13

Products for SYS1-DBNDD2 Gene

Sources for SYS1-DBNDD2 Gene