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Aliases for SYS1 Gene

Aliases for SYS1 Gene

  • SYS1, Golgi Trafficking Protein 2 3 5
  • Sys1 Golgi Trafficking Protein 2 3
  • C20orf169 3 4
  • SYS1 Golgi-Localized Integral Membrane Protein Homolog (S. Cerevisiae) 2
  • SYS1 Golgi-Localized Integral Membrane Protein Homolog 3
  • Chromosome 20 Open Reading Frame 169 2
  • Protein SYS1 Homolog 3
  • DJ453C12.4.1 3
  • DJ453C12.4 3

External Ids for SYS1 Gene

Previous HGNC Symbols for SYS1 Gene

  • C20orf169

Previous GeneCards Identifiers for SYS1 Gene

  • GC20P043424
  • GC20P043990
  • GC20P040733

Summaries for SYS1 Gene

Entrez Gene Summary for SYS1 Gene

  • SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al., 2004 [PubMed 15077113]).[supplied by OMIM, Aug 2009]

GeneCards Summary for SYS1 Gene

SYS1 (SYS1, Golgi Trafficking Protein) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. An important paralog of this gene is SYS1-DBNDD2.

UniProtKB/Swiss-Prot for SYS1 Gene

  • Involved in protein trafficking. May serve as a receptor for ARFRP1.

Additional gene information for SYS1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYS1 Gene

Genomics for SYS1 Gene

GeneHancer (GH) Regulatory Elements for SYS1 Gene

Promoters and enhancers for SYS1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045362 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.1 +1.5 1516 1.9 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SYS1 SYS1-DBNDD2 NCOA5 ZNF335 TP53TG5 PCIF1 ZSWIM1 CD40 ENSG00000271984 NDUFB4P10
GH20I045361 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 0.0 -41 0.2 ELF3 SOX13 FOXA2 SAP130 ZNF644 RARA GATA3 HOMEZ THAP11 MIXL1 SYS1 SYS1-DBNDD2 SDC4
GH20I045363 Enhancer 0.7 ENCODE 550.8 +0.2 159 0.2 ELF3 SOX13 FOXA2 SAP130 ZNF644 RARA YY1 GATA3 HOMEZ THAP11 SYS1 SYS1-DBNDD2
GH20I045967 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 19 +608.9 608937 5.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF335 NCOA5 SLC35C2 TP53RK ZNF334 PCIF1 ZNF663P CD40 ENSG00000271984 SPATA25
GH20I044475 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19 -885.6 -885600 2.5 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TTPAL SYS1 PIGT PKIG GC20P044473 PIR42438
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYS1 gene promoter:

Genomic Locations for SYS1 Gene

Genomic Locations for SYS1 Gene
14,866 bases
Plus strand

Genomic View for SYS1 Gene

Genes around SYS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYS1 Gene

Proteins for SYS1 Gene

  • Protein details for SYS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SYS1 homolog
    Protein Accession:
    Secondary Accessions:
    • C9JFB3
    • E1P620
    • Q5QPU7
    • Q96SD8
    • Q9BQZ2
    • Q9BQZ4
    • Q9H1F7

    Protein attributes for SYS1 Gene

    156 amino acids
    Molecular mass:
    17615 Da
    Quaternary structure:
    • Interacts with ARFRP1.
    • Sequence=CAC39448.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SYS1 Gene


neXtProt entry for SYS1 Gene

Post-translational modifications for SYS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYS1 Gene

Domains & Families for SYS1 Gene

Gene Families for SYS1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SYS1 Gene

Suggested Antigen Peptide Sequences for SYS1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SYS1 family.
  • Belongs to the SYS1 family.
genes like me logo Genes that share domains with SYS1: view

Function for SYS1 Gene

Molecular function for SYS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in protein trafficking. May serve as a receptor for ARFRP1.

Phenotypes From GWAS Catalog for SYS1 Gene

genes like me logo Genes that share phenotypes with SYS1: view

miRNA for SYS1 Gene

miRTarBase miRNAs that target SYS1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYS1 Gene

Localization for SYS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYS1 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYS1 gene
Compartment Confidence
golgi apparatus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SYS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IBA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SYS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SYS1 Gene

Pathways & Interactions for SYS1 Gene

genes like me logo Genes that share pathways with SYS1: view

Gene Ontology (GO) - Biological Process for SYS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IBA --
GO:0006810 transport IEA --
GO:0006895 Golgi to endosome transport IBA --
GO:0015031 protein transport IEA --
GO:0043001 Golgi to plasma membrane protein transport IBA --
genes like me logo Genes that share ontologies with SYS1: view

No data available for SIGNOR curated interactions for SYS1 Gene

Drugs & Compounds for SYS1 Gene

No Compound Related Data Available

Transcripts for SYS1 Gene

mRNA/cDNA for SYS1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYS1 Gene

SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYS1 Gene

No ASD Table

Relevant External Links for SYS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYS1 Gene

Protein differential expression in normal tissues from HIPED for SYS1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYS1 Gene

Protein tissue co-expression partners for SYS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYS1 Gene:


SOURCE GeneReport for Unigene cluster for SYS1 Gene:


Evidence on tissue expression from TISSUES for SYS1 Gene

  • Blood(4.2)
  • Thyroid gland(4)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with SYS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYS1 Gene

Orthologs for SYS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SYS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYS1 33 34
  • 99.79 (n)
(Canis familiaris)
Mammalia SYS1 33 34
  • 96.15 (n)
(Bos Taurus)
Mammalia SYS1 33 34
  • 95.3 (n)
(Mus musculus)
Mammalia Sys1 33 16 34
  • 94.23 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
-- 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Sys1 33
  • 93.8 (n)
(Gallus gallus)
Aves SYS1 33 34
  • 77.99 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sys1 33
  • 68.16 (n)
(Danio rerio)
Actinopterygii sys1 33 34
  • 69.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001975 33
  • 57.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11753 33 34
  • 52.26 (n)
(Caenorhabditis elegans)
Secernentea T03F1.12 33 34
  • 44.92 (n)
(Oryza sativa)
Liliopsida Os01g0593600 33
  • 54.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for SYS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYS1 Gene

Gene Tree for SYS1 (if available)
Gene Tree for SYS1 (if available)

Paralogs for SYS1 Gene

Paralogs for SYS1 Gene

(1) SIMAP similar genes for SYS1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYS1: view

Variants for SYS1 Gene

Sequence variations from dbSNP and Humsavar for SYS1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000069498 -- 45,364,925(+) A/T intron_variant
rs1000252888 -- 45,372,757(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000369573 -- 45,372,279(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000533386 -- 45,370,770(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000574315 -- 45,360,675(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SYS1 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for SYS1 Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYS1 Gene

Disorders for SYS1 Gene

Additional Disease Information for SYS1

No disorders were found for SYS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYS1 Gene

Publications for SYS1 Gene

  1. Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. (PMID: 15077113) Behnia R … Munro S (Nature cell biology 2004) 2 3 4 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for SYS1 Gene

Sources for SYS1 Gene

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