Aliases for SYNPO2L Gene

Aliases for SYNPO2L Gene

  • Synaptopodin 2 Like 2 3 5
  • Synaptopodin 2-Like Protein 3 4
  • Synaptopodin 2-Like 2

External Ids for SYNPO2L Gene

Previous GeneCards Identifiers for SYNPO2L Gene

  • GC10M074749
  • GC10M075076
  • GC10M075404
  • GC10M069398

Summaries for SYNPO2L Gene

GeneCards Summary for SYNPO2L Gene

SYNPO2L (Synaptopodin 2 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is SYNPO2.

UniProtKB/Swiss-Prot Summary for SYNPO2L Gene

  • Actin-associated protein that may play a role in modulating actin-based shape.

Additional gene information for SYNPO2L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYNPO2L Gene

Genomics for SYNPO2L Gene

GeneHancer (GH) Regulatory Elements for SYNPO2L Gene

Promoters and enhancers for SYNPO2L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYNPO2L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYNPO2L

Top Transcription factor binding sites by QIAGEN in the SYNPO2L gene promoter:
  • Ik-3
  • ISGF-3
  • SRF
  • SRF (504 AA)
  • Zic3

Genomic Locations for SYNPO2L Gene

Genomic Locations for SYNPO2L Gene
chr10:73,644,881-73,663,803
(GRCh38/hg38)
Size:
18,923 bases
Orientation:
Minus strand
chr10:75,404,639-75,423,561
(GRCh37/hg19)
Size:
18,923 bases
Orientation:
Minus strand

Genomic View for SYNPO2L Gene

Genes around SYNPO2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNPO2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNPO2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNPO2L Gene

Proteins for SYNPO2L Gene

  • Protein details for SYNPO2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H987-SYP2L_HUMAN
    Recommended name:
    Synaptopodin 2-like protein
    Protein Accession:
    Q9H987
    Secondary Accessions:
    • A5PKV9
    • Q68A20

    Protein attributes for SYNPO2L Gene

    Size:
    977 amino acids
    Molecular mass:
    102481 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYNPO2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYNPO2L Gene

Post-translational modifications for SYNPO2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYNPO2L Gene

No data available for DME Specific Peptides for SYNPO2L Gene

Domains & Families for SYNPO2L Gene

Gene Families for SYNPO2L Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SYNPO2L Gene

Blocks:
  • PDZ/DHR/GLGF domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNPO2L Gene

GenScript: Design optimal peptide antigens:
  • SYNPO2L protein (A3KMG7_HUMAN)
  • Synaptopodin 2-like protein (SYP2L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H987

UniProtKB/Swiss-Prot:

SYP2L_HUMAN :
  • Belongs to the synaptopodin family.
Family:
  • Belongs to the synaptopodin family.
genes like me logo Genes that share domains with SYNPO2L: view

Function for SYNPO2L Gene

Molecular function for SYNPO2L Gene

UniProtKB/Swiss-Prot Function:
Actin-associated protein that may play a role in modulating actin-based shape.

Phenotypes From GWAS Catalog for SYNPO2L Gene

Gene Ontology (GO) - Molecular Function for SYNPO2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with SYNPO2L: view
genes like me logo Genes that share phenotypes with SYNPO2L: view

miRNA for SYNPO2L Gene

miRTarBase miRNAs that target SYNPO2L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNPO2L Gene

Localization for SYNPO2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNPO2L Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYNPO2L gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear speckles (4)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYNPO2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SYNPO2L: view

Pathways & Interactions for SYNPO2L Gene

PathCards logo

SuperPathways for SYNPO2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNPO2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003007 heart morphogenesis ISS 29206857
GO:0032233 positive regulation of actin filament bundle assembly IBA 21873635
GO:0035025 positive regulation of Rho protein signal transduction ISS 29206857
GO:0045214 sarcomere organization ISS 29206857
GO:0051496 positive regulation of stress fiber assembly ISS 29206857
genes like me logo Genes that share ontologies with SYNPO2L: view

No data available for Pathways by source and SIGNOR curated interactions for SYNPO2L Gene

Drugs & Compounds for SYNPO2L Gene

No Compound Related Data Available

Transcripts for SYNPO2L Gene

mRNA/cDNA for SYNPO2L Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNPO2L Gene

No ASD Table

Relevant External Links for SYNPO2L Gene

GeneLoc Exon Structure for
SYNPO2L

Expression for SYNPO2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYNPO2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNPO2L Gene

This gene is overexpressed in Heart - Left Ventricle (x20.8), Muscle - Skeletal (x15.7), and Heart - Atrial Appendage (x13.5).

Protein differential expression in normal tissues from HIPED for SYNPO2L Gene

This gene is overexpressed in Heart (43.3) and Fetal heart (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYNPO2L Gene



Protein tissue co-expression partners for SYNPO2L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYNPO2L

SOURCE GeneReport for Unigene cluster for SYNPO2L Gene:

Hs.645273

Evidence on tissue expression from TISSUES for SYNPO2L Gene

  • Heart(4.7)
  • Muscle(3.5)
genes like me logo Genes that share expression patterns with SYNPO2L: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYNPO2L Gene

Orthologs for SYNPO2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNPO2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYNPO2L 31 30
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SYNPO2L 31 30
  • 88.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SYNPO2L 31 30
  • 87.85 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Synpo2l 30
  • 84.67 (n)
mouse
(Mus musculus)
Mammalia Synpo2l 17 31 30
  • 84.33 (n)
oppossum
(Monodelphis domestica)
Mammalia SYNPO2L 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNPO2L 31 30
  • 62.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNPO2L 31
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia synpo2l 30
  • 56.54 (n)
zebrafish
(Danio rerio)
Actinopterygii synpo2lb 31 30
  • 60.22 (n)
OneToMany
SYNPO2L (1 of 2) 31
  • 40 (a)
OneToMany
Species where no ortholog for SYNPO2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNPO2L Gene

ENSEMBL:
Gene Tree for SYNPO2L (if available)
TreeFam:
Gene Tree for SYNPO2L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SYNPO2L: view image

Paralogs for SYNPO2L Gene

Paralogs for SYNPO2L Gene

(1) SIMAP similar genes for SYNPO2L Gene using alignment to 3 proteins:

  • SYP2L_HUMAN
  • A3KMG7_HUMAN
  • U3KQD0_HUMAN
genes like me logo Genes that share paralogs with SYNPO2L: view

Variants for SYNPO2L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SYNPO2L Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs34163229 - p.Ser833Tyr
rs3812629 - p.Pro707Leu
rs57006992 - p.Pro508His

Additional dbSNP identifiers (rs#s) for SYNPO2L Gene

Structural Variations from Database of Genomic Variants (DGV) for SYNPO2L Gene

Variant ID Type Subtype PubMed ID
nsv831912 CNV gain 17160897

Variation tolerance for SYNPO2L Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.28; 96.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYNPO2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYNPO2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNPO2L Gene

Disorders for SYNPO2L Gene

Additional Disease Information for SYNPO2L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SYNPO2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNPO2L Gene

Publications for SYNPO2L Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  4. Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart. (PMID: 29206857) van Eldik W … Beqqali A (PloS one 2017) 3 54
  5. Whole Exome Sequencing in Atrial Fibrillation. (PMID: 27589061) Lubitz SA … Lin H (PLoS genetics 2016) 3 54

Products for SYNPO2L Gene

Sources for SYNPO2L Gene