External Ids for SYNPO Gene
Previous GeneCards Identifiers for SYNPO Gene
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SYNPO Gene
SYNPO (Synaptopodin) is a Protein Coding gene. Diseases associated with SYNPO include Focal Segmental Glomerulosclerosis and Crescentic Glomerulonephritis. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and Tight junction. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is SYNPO2.
UniProtKB/Swiss-Prot Summary for SYNPO Gene
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).