This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated wit... See more...

Aliases for SYNCRIP Gene

Aliases for SYNCRIP Gene

  • Synaptotagmin Binding Cytoplasmic RNA Interacting Protein 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein Q 2 3 4
  • GRY-RBP 2 3 4
  • NSAP1 2 3 4
  • Glycine- And Tyrosine-Rich RNA-Binding Protein 3 4
  • NS1-Associated Protein 1 3 4
  • HnRNP-Q 2 3
  • HNRNPQ 2 3
  • HNRPQ1 2 3
  • Synaptotagmin-Binding, Cytoplasmic RNA-Interacting Protein 4
  • DJ3J17.2 2
  • SYNCRIP 5
  • HnRNP Q 4
  • GRYRBP 3
  • HNRPQ 4
  • PP68 3

External Ids for SYNCRIP Gene

Previous GeneCards Identifiers for SYNCRIP Gene

  • GC06M086317
  • GC06M086318
  • GC06M086377
  • GC06M086380
  • GC06M083541
  • GC06M086267

Summaries for SYNCRIP Gene

Entrez Gene Summary for SYNCRIP Gene

  • This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]

GeneCards Summary for SYNCRIP Gene

SYNCRIP (Synaptotagmin Binding Cytoplasmic RNA Interacting Protein) is a Protein Coding gene. Diseases associated with SYNCRIP include Myoblastoma and Spinal Muscular Atrophy. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPR.

UniProtKB/Swiss-Prot Summary for SYNCRIP Gene

  • Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.

Gene Wiki entry for SYNCRIP Gene

Additional gene information for SYNCRIP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYNCRIP Gene

Genomics for SYNCRIP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SYNCRIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J085640 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 621 +1.0 961 6.2 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 TFE3 SYNCRIP lnc-NT5E-9 SNHG5 SNX14 SNORD50A lnc-SYNCRIP-1 lnc-NT5E-1 ENSG00000271793
GH06J085611 Promoter 0.8 UCNEbase EPDnew 612.1 +31.9 31857 0.8 RBM22 POLR2A SYNCRIP SNHG5 ENSG00000271793 lnc-SNX14-3 SNX14
GH06J085612 Promoter 0.4 EPDnew 612.8 +30.9 30934 0.1 POLR2A SYNCRIP SNORD50A SNHG5 ENSG00000271793 lnc-SNX14-3 SNX14
GH06J085674 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 69.2 -33.8 -33763 6.5 ZNF221 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 REST LEF1 SNHG5 LOC107986622 SNORD50A SNORD50B lnc-NT5E-3-002 SYNCRIP SNX14 lnc-NT5E-3-001
GH06J085592 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 21.8 +50.3 50317 3.9 CREB1 GATAD2A HNRNPL PRDM10 ZNF629 TFE3 SIX5 SOX13 KDM1A POLR2A SNX14 SNHG5 SYNCRIP NT5E SNORD50A lnc-SNX14-3 ENSG00000271793 lnc-SYNCRIP-8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYNCRIP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYNCRIP

Top Transcription factor binding sites by QIAGEN in the SYNCRIP gene promoter:
  • AhR
  • Arnt
  • Egr-1
  • Egr-4
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5
  • Sp1
  • SRF
  • SRF (504 AA)

Genomic Locations for SYNCRIP Gene

Genomic Locations for SYNCRIP Gene
chr6:85,607,784-85,643,862
(GRCh38/hg38)
Size:
36,079 bases
Orientation:
Minus strand
chr6:86,317,502-86,353,510
(GRCh37/hg19)
Size:
36,009 bases
Orientation:
Minus strand

Genomic View for SYNCRIP Gene

Genes around SYNCRIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNCRIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNCRIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNCRIP Gene

Proteins for SYNCRIP Gene

  • Protein details for SYNCRIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60506-HNRPQ_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein Q
    Protein Accession:
    O60506
    Secondary Accessions:
    • E1P501
    • E1P502
    • Q53H05
    • Q5TCG2
    • Q5TCG3
    • Q8IW78
    • Q8N599
    • Q96LC1
    • Q96LC2
    • Q9Y583

    Protein attributes for SYNCRIP Gene

    Size:
    623 amino acids
    Molecular mass:
    69603 Da
    Quaternary structure:
    • Isoform 1 is a component of the APOB mRNA editosome complex and interacts with APOBEC1 and A1CF (APOBEC1 complementation factor). Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR, HNRPD and SYNCRIP. Isoform 3 interacts with HNRPR. Interacts with POLR2A hyperphosphorylated C-terminal domain. Isoform 1, isoform 2 and isoform 3 interact with SMN. Isoform 3 interacts through its C-terminal domain with SYT7, SYT8 and SYT9 (By similarity). The non-phosphorylated and phosphorylated forms are colocalized with PAIP1 in polysomes (By similarity). Interacts with HABP4 (PubMed:19523114). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Identified in the spliceosome C complex. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with GTPBP1. Component of the GAIT complex; in humans the complex assembly seems to be a two-step process in which EPRS1 first associates with SYNCRIP to form a pre-GAIT complex which is deficient in GAIT element binding.
    • (Microbial infection) Interacts with minute virus of mice (MVM) NS1 protein.
    SequenceCaution:
    • Sequence=AAH15575.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 413.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be due to a competing donor splice site.
    • [Isoform 3]: May be due to a competing donor splice site and to an exon inclusion.
    • [Isoform 4]: May be due to a competing donor splice site and to an exon inclusion.
    • [Isoform 5]: May be due to a competing donor splice site and to an exon inclusion.

    Three dimensional structures from OCA and Proteopedia for SYNCRIP Gene

    Alternative splice isoforms for SYNCRIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYNCRIP Gene

Post-translational modifications for SYNCRIP Gene

  • Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity).
  • Ubiquitination at Lys221, Lys356, Lys363, and Lys371
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SYNCRIP Gene

Domains & Families for SYNCRIP Gene

Gene Families for SYNCRIP Gene

Suggested Antigen Peptide Sequences for SYNCRIP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50849, highly similar to Heterogeneous nuclear ribonucleoprotein Q (B7Z645_HUMAN)
  • Synaptotagmin-binding, cytoplasmic RNA-interacting protein (HNRPQ_HUMAN)
  • SYNCRIP protein (Q05CK9_HUMAN)
  • Synaptotagmin binding, cytoplasmic RNA interacting protein (Q5TCG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60506

UniProtKB/Swiss-Prot:

HNRPQ_HUMAN :
  • The domain containing eight Arg-Gly-Gly repeats (RGG/RXR-box) may be involved in RNA-binding and protein-protein interactions. It is methylated by PRMT1, and essential for nuclear localization.
Domain:
  • The domain containing eight Arg-Gly-Gly repeats (RGG/RXR-box) may be involved in RNA-binding and protein-protein interactions. It is methylated by PRMT1, and essential for nuclear localization.
genes like me logo Genes that share domains with SYNCRIP: view

Function for SYNCRIP Gene

Molecular function for SYNCRIP Gene

UniProtKB/Swiss-Prot Function:
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.

Phenotypes From GWAS Catalog for SYNCRIP Gene

Gene Ontology (GO) - Molecular Function for SYNCRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IBA 21873635
GO:0003729 mRNA binding IBA 21873635
GO:0005515 protein binding IPI 12674497
GO:0008143 poly(A) binding IEA --
genes like me logo Genes that share ontologies with SYNCRIP: view
genes like me logo Genes that share phenotypes with SYNCRIP: view

Animal Model Products

CRISPR Products

miRNA for SYNCRIP Gene

miRTarBase miRNAs that target SYNCRIP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYNCRIP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNCRIP Gene

Localization for SYNCRIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNCRIP Gene

Cytoplasm. Microsome. Endoplasmic reticulum. Nucleus. Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). {ECO:0000250 UniProtKB:O43390, ECO:0000250 UniProtKB:Q7TMK9}.
[Isoform 1]: Nucleus, nucleoplasm. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250 UniProtKB:Q7TMK9}.
[Isoform 2]: Nucleus, nucleoplasm. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250 UniProtKB:Q7TMK9}.
[Isoform 3]: Nucleus, nucleoplasm. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250 UniProtKB:Q7TMK9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYNCRIP gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 4
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYNCRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IBA 21873635
GO:0005654 nucleoplasm IEA --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with SYNCRIP: view

Pathways & Interactions for SYNCRIP Gene

PathCards logo

SuperPathways for SYNCRIP Gene

SuperPathway Contained pathways
1 Translational Control
genes like me logo Genes that share pathways with SYNCRIP: view

Pathways by source for SYNCRIP Gene

1 Cell Signaling Technology pathway for SYNCRIP Gene

SIGNOR curated interactions for SYNCRIP Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for SYNCRIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0001649 osteoblast differentiation HDA 16210410
GO:0006396 RNA processing TAS 9847309
GO:0006397 mRNA processing IEA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with SYNCRIP: view

Drugs & Compounds for SYNCRIP Gene

No Compound Related Data Available

Transcripts for SYNCRIP Gene

mRNA/cDNA for SYNCRIP Gene

7 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYNCRIP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNCRIP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^
SP1:
SP2: -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - - - -
SP8: -
SP9: - - -
SP10:
SP11:
SP12:

ExUns: 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:

Relevant External Links for SYNCRIP Gene

GeneLoc Exon Structure for
SYNCRIP

Expression for SYNCRIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYNCRIP Gene

Protein differential expression in normal tissues from HIPED for SYNCRIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYNCRIP Gene



Protein tissue co-expression partners for SYNCRIP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYNCRIP

SOURCE GeneReport for Unigene cluster for SYNCRIP Gene:

Hs.571177

mRNA Expression by UniProt/SwissProt for SYNCRIP Gene:

O60506-HNRPQ_HUMAN
Tissue specificity: Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.

Evidence on tissue expression from TISSUES for SYNCRIP Gene

  • Nervous system(4.8)
  • Lung(4.6)
  • Liver(4.5)
  • Kidney(4.5)
  • Eye(4.4)
  • Intestine(2.8)
  • Skin(2.7)
  • Muscle(2.6)
  • Spleen(2.4)
  • Heart(2.4)
  • Blood(2.2)
  • Pancreas(2.1)
  • Lymph node(2.1)
  • Bone marrow(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with SYNCRIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYNCRIP Gene

Orthologs for SYNCRIP Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNCRIP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SYNCRIP 30 31
  • 99.94 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SYNCRIP 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SYNCRIP 30 31
  • 98.13 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 98 (a)
OneToMany
-- 31
  • 98 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia SYNCRIP 30 31
  • 97.32 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Syncrip 30 17 31
  • 96.74 (n)
OneToOne
Chicken
(Gallus gallus)
Aves SYNCRIP 31
  • 97 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SYNCRIP 31
  • 94 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia syncrip 30
  • 87.53 (n)
Str.8724 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.25249 30
Zebrafish
(Danio rerio)
Actinopterygii syncripl 31
  • 84 (a)
OneToMany
syncrip 30 31
  • 76.94 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG17838 31
  • 46 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea hrp-2 31
  • 40 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
OneToMany
Species where no ortholog for SYNCRIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SYNCRIP Gene

ENSEMBL:
Gene Tree for SYNCRIP (if available)
TreeFam:
Gene Tree for SYNCRIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SYNCRIP: view image

Paralogs for SYNCRIP Gene

(8) SIMAP similar genes for SYNCRIP Gene using alignment to 4 proteins:

  • HNRPQ_HUMAN
  • B7Z645_HUMAN
  • F6UXX1_HUMAN
  • Q05CK9_HUMAN

Pseudogenes.org Pseudogenes for SYNCRIP Gene

genes like me logo Genes that share paralogs with SYNCRIP: view

Variants for SYNCRIP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SYNCRIP Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
872610 Uncertain Significance: not provided 85,622,635(-) G/GT FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for SYNCRIP Gene

Structural Variations from Database of Genomic Variants (DGV) for SYNCRIP Gene

Variant ID Type Subtype PubMed ID
nsv5383 CNV deletion 18451855

Variation tolerance for SYNCRIP Gene

Residual Variation Intolerance Score: 7.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYNCRIP Gene

Human Gene Mutation Database (HGMD)
SYNCRIP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYNCRIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNCRIP Gene

Disorders for SYNCRIP Gene

MalaCards: The human disease database

(3) MalaCards diseases for SYNCRIP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myoblastoma
  • benign granular cell tumor
spinal muscular atrophy
  • progressive muscular atrophy
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SYNCRIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYNCRIP Gene

Publications for SYNCRIP Gene

  1. Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. (PMID: 11352648) Lau PP … Chan L (Biochemical and biophysical research communications 2001) 2 3 4 23
  2. A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice. (PMID: 9847309) Harris CE … Astell CR (Journal of virology 1999) 2 3 4 23
  3. SMN interacts with a novel family of hnRNP and spliceosomal proteins. (PMID: 11574476) Mourelatos Z … Dreyfuss G (The EMBO journal 2001) 3 4 23
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 4
  5. Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. (PMID: 23071094) Arif A … Fox PL (Molecular and cellular biology 2012) 3 4

Products for SYNCRIP Gene

  • Signalway ELISA kits for SYNCRIP
  • Signalway Proteins for SYNCRIP

Sources for SYNCRIP Gene