External Ids for SYN3 Gene
Previous GeneCards Identifiers for SYN3 Gene
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]
GeneCards Summary for SYN3 Gene
SYN3 (Synapsin III) is a Protein Coding gene. Diseases associated with SYN3 include Visual Epilepsy and Sorsby Fundus Dystrophy. Among its related pathways are Synaptic vesicle cycle and Neurotransmitter Release Cycle. An important paralog of this gene is SYN2.
UniProtKB/Swiss-Prot Summary for SYN3 Gene
May be involved in the regulation of neurotransmitter release and synaptogenesis.