External Ids for SYN2 Gene
Previous GeneCards Identifiers for SYN2 Gene
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014]
GeneCards Summary for SYN2 Gene
SYN2 (Synapsin II) is a Protein Coding gene. Diseases associated with SYN2 include Schizophrenia and Bipolar Disorder. Among its related pathways are Synaptic vesicle cycle and Neurotransmitter Release Cycle. An important paralog of this gene is SYN1.
UniProtKB/Swiss-Prot Summary for SYN2 Gene
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).