SYK Gene (Protein Coding)

Spleen Associated Tyrosine Kinase

GC09P091171
GIFtS:
50
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell grow... See more...

Aliases for SYK Gene

Aliases for SYK Gene

  • Spleen Associated Tyrosine Kinase 2 3 5
  • Spleen Tyrosine Kinase 2 3 4
  • Tyrosine-Protein Kinase SYK 3 4
  • EC 2.7.10.2 4 51
  • P72-Syk 3 4
  • EC 2.7.10 51
  • SYK 5

External Ids for SYK Gene

Previous GeneCards Identifiers for SYK Gene

  • GC09P084403
  • GC09P085292
  • GC09P086863
  • GC09P088905
  • GC09P090643
  • GC09P092603
  • GC09P093564
  • GC09P063244
  • GC09P090803
  • GC09P091021
  • GC09P091055
  • GC09P091058
  • GC09P091113
  • GC09P090831
  • GC09P090894
  • GC09P090924
  • GC09P090954
  • GC09P090983

Summaries for SYK Gene

Entrez Gene Summary for SYK Gene

  • This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

CIViC Summary for SYK Gene

GeneCards Summary for SYK Gene

SYK (Spleen Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with SYK include Peripheral T-Cell Lymphoma and Hantavirus Pulmonary Syndrome. Among its related pathways are B cell receptor signaling pathway (KEGG) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ZAP70.

UniProtKB/Swiss-Prot Summary for SYK Gene

  • Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity).

Tocris Summary for SYK Gene

  • Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.

Gene Wiki entry for SYK Gene

Additional gene information for SYK Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SYK Gene

Genomics for SYK Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SYK Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J090802 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 645.9 +2.1 2140 5.7 HNRNPL BACH1 ETV6 LARP7 PRDM1 ZIC2 PKNOX1 PATZ1 EZH2 IKZF2 SYK piR-32023-260 AUH
GH09J090825 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 628.2 +27.1 27050 5.8 SP1 CTCF POLR2A TCF12 IKZF2 TRIM22 YY1 PKNOX1 RELA EED SYK piR-32023-260 lnc-DIRAS2-9 AUH
GH09J090801 Enhancer 0.7 ENCODE dbSUPER 600.7 -1.4 -1384 0.2 FOXA1 EED CTCF ZNF316 MAFF MAFK MAFG JUNB EMSY ETV6 SYK piR-30876-109 DIRAS2
GH09J090800 Enhancer 0.4 ENCODE dbSUPER 618.9 -0.9 -906 0.1 SPI1 SYK piR-30876-109 DIRAS2
GH09J090831 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 31.8 +36.2 36200 12 YBX1 JUND PHB2 ZNF776 ZSCAN4 POLR2A ZNF239 TCF12 MNT HES1 SYK ENSG00000229694 lnc-DIRAS2-9 piR-32023-260 AUH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SYK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SYK

Top Transcription factor binding sites by QIAGEN in the SYK gene promoter:
  • AhR
  • AP-1
  • p53
  • STAT1
  • STAT3

Genomic Locations for SYK Gene

Genomic Locations for SYK Gene
chr9:90,801,600-90,898,549
(GRCh38/hg38)
Size:
96,950 bases
Orientation:
Plus strand
chr9:93,564,012-93,660,842
(GRCh37/hg19)
Size:
96,831 bases
Orientation:
Plus strand

Genomic View for SYK Gene

Genes around SYK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYK Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SYK Gene

Proteins for SYK Gene

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  • Protein details for SYK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43405-KSYK_HUMAN
    Recommended name:
    Tyrosine-protein kinase SYK
    Protein Accession:
    P43405

    Protein attributes for SYK Gene

    Size:
    635 amino acids
    Molecular mass:
    72066 Da
    Quaternary structure:
    • Interacts with LYN; phosphorylates SYK (By similarity). Interacts with RHOH (phosphorylated); regulates mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling (By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation (By similarity). Interacts with FCRL3 (PubMed:19843936, PubMed:11162587). Interacts (via SH2 domains) with FCER1G (via ITAM domain); activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interaction with FCER1G in basophils triggers IL3-induced IL4 production (By similarity). Interacts with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation by ITGB3 promotes platelet adhesion. Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates the selectin-dependent activation of SYK by SELPLG. Interacts with BLNK (via SH2 domain). Interacts (via the second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels. Interacts (via SH2 domains) with CLEC1B (dimer). Interacts with CLEC7A; participates in leukocyte activation in presence of fungal pathogens. Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment. Interacts with YWHAG; attenuates BCR-induced membrane translocation and activation of SYK. Interacts (via SH2 domains) with GCSAM; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity. Interacts with TNS2; leading to the phosphorylation of SYK (PubMed:22019427). Interacts with FLNA (via filamin repeat 5); docks SYK to the plasma membrane (PubMed:20713593). Interacts with CEACAM1; lipopolysaccharide activated neutrophils induce phosphorylation of SYK resulting in the formation of a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, leading to a reduction of the inflammasome activity (By similarity). Interacts (via SH2 domains) with CEACAM20 (phosphorylated form); the interaction further enhances CEACAM20 phosphorylation (By similarity). Interacts with IL15RA (PubMed:15123770).
    • (Microbial infection) Interacts with Epstein-Barr virus LMP2A.

    Three dimensional structures from OCA and Proteopedia for SYK Gene

    Alternative splice isoforms for SYK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYK Gene

Protein Expression for SYK Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for SYK Gene

P43405:
  • LCHYHSQE
  • SSKSDVWSFGVLMWE
  • RDLAARN
  • EKLIATTAHE
  • RKAHHYTIERELNGTYAI
  • QLDNPYIVR
  • SYGQKPY
  • SDVWSFGVLMWE
  • LCWTYDVENRPGF
  • MGMKYLEE
  • AARNVLL
  • DGLLRVLTVPCQKIG
  • KSDVWSFG
  • KWYAPECIN
  • ALEQAIISQ
  • FDTLWQLVEHYSYK
  • HYAKISDFGLSKAL
  • FVHRDLA
  • NFVHRDLAARNVL

Post-translational modifications for SYK Gene

  • Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation.
  • Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on Tyr-323 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. Phosphorylation at Tyr-348 creates a binding site for VAV1. Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylated on tyrosine residues in response to IL15 (PubMed:15123770). Phosphorylation on Ser-297 is very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG. Phosphorylation at Tyr-630 creates a binding site for BLNK. Dephosphorylated by PTPN6.
  • Ubiquitination at Lys517
  • Modification sites at PhosphoSitePlus

Other Protein References for SYK Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SYK

Domains & Families for SYK Gene

Gene Families for SYK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SYK Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Tyrosine protein kinase, active site
ProtoNet:

Suggested Antigen Peptide Sequences for SYK Gene

GenScript: Design optimal peptide antigens:
  • Spleen tyrosine kinase (C3W980_HUMAN)
  • Spleen tyrosine kinase (C3W981_HUMAN)
  • Spleen tyrosine kinase (KSYK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P43405

UniProtKB/Swiss-Prot:

KSYK_HUMAN :
  • The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
Domain:
  • The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
genes like me logo Genes that share domains with SYK: view

Function for SYK Gene

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Molecular function for SYK Gene

UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement. May also be negatively regulated by PTPN6 through dephosphorylation. Downstream signaling adapters and intermediates like BLNK or RHOH may mediate positive and/or negative feedback regulation. Negatively regulated by CBL and CBLB through ubiquitination and probable degradation. Phosphorylates SH3BP2 which in turn may regulate SYK through LYN (By similarity).
GENATLAS Biochemistry:
spleen tyrosine kinase,non SRC family,expressed in B,T and myeloid cells

Enzyme Numbers (IUBMB) for SYK Gene

Phenotypes From GWAS Catalog for SYK Gene

Gene Ontology (GO) - Molecular Function for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001784 phosphotyrosine residue binding IPI 12051764
GO:0004672 protein kinase activity IDA,NAS 12885943
GO:0004674 protein serine/threonine kinase activity IDA 23071339
GO:0004713 protein tyrosine kinase activity NAS,TAS --
genes like me logo Genes that share ontologies with SYK: view
genes like me logo Genes that share phenotypes with SYK: view

Animal Models for SYK Gene

MGI Knock Outs for SYK:
  • Syk Syk<tm1Paw>
  • Syk Syk<tm1Tyb>
  • Syk Syk<tm1.1Tara>
  • Syk Syk<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYK

Clone Products

  • Addgene plasmids for SYK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYK Gene

Localization for SYK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYK Gene

Cell membrane. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYK gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 3
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23071339
GO:0005737 cytoplasm IDA 23071339
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SYK: view

Pathways & Interactions for SYK Gene

PathCards logo

SuperPathways for SYK Gene

SuperPathway Contained pathways
1 RET signaling
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
DAP12 signaling
.92
FCERI mediated MAPK activation
.90
DAP12 interactions
.89
Fc epsilon receptor (FCERI) signaling
.79
2 Immune response Fc epsilon RI pathway
Immune response BCR pathway
.44
Immune response Fc epsilon RI pathway
.44
Fc epsilon RI signaling pathway
.41
Fc-epsilon receptor I signaling in mast cells
.34
3 B cell receptor signaling pathway (KEGG)
B cell receptor signaling pathway
.38
BCR signaling pathway
.38
B Cell Receptor Signaling Pathway
.32
4 Immune response Role of DAP12 receptors in NK cells
Immune response CD16 signaling in NK cells
.32
Immune response Role of DAP12 receptors in NK cells
.32
Natural killer cell mediated cytotoxicity
.31
5 IL-2 Pathway
IL-2 Pathway
.48
TREM1 Pathway
.43
PI3K Signaling in B-Lymphocyte
.35
genes like me logo Genes that share pathways with SYK: view

Pathways by source for SYK Gene

8 GeneGo (Thomson Reuters) pathways for SYK Gene
  • Development EPO-induced MAPK pathway
  • Immune response BCR pathway
  • Immune response CD16 signaling in NK cells
  • Immune response Fc epsilon RI pathway
  • Immune response IL-2 activation and signaling pathway
15 Qiagen pathways for SYK Gene
  • Akt Signaling
  • CD28 Signaling in T-Helper Cell
  • CTLA4 Signaling
  • Fc-EpsilonRI Pathway
  • Fc-GammaR Pathway
2 Cell Signaling Technology pathways for SYK Gene

SIGNOR curated interactions for SYK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001525 angiogenesis IEA --
GO:0001820 serotonin secretion IEA --
GO:0001945 lymph vessel development ISS --
GO:0002092 positive regulation of receptor internalization IEA --
genes like me logo Genes that share ontologies with SYK: view

Drugs & Compounds for SYK Gene

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(60) Drugs for SYK Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Nilvadipine Approved, Investigational Pharma Syk kinase inhibitor; inhibits Abeta production 1
Tamatinib Experimental, Investigational Pharma Target 0
Piceatannol Experimental Pharma p56lck/Syk inhibitor 0
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Experimental Pharma Target 0

(39) Additional Compounds for SYK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) Tocris Compounds for SYK Gene

Compound Action Cas Number
ER 27319 maleate Selective Syk kinase inhibitor 1204480-26-1
Nilvadipine Syk kinase inhibitor; inhibits Abeta production 75530-68-6

(11) ApexBio Compounds for SYK Gene

Compound Action Cas Number
BAY 61-3606 Syk Inhibitor 732983-37-8
BAY 61-3606 dihydrochloride Syk tyrosine kinase inhibitor 648903-57-5
Cerdulatinib Syk/JAK inhibitor 1198300-79-6
Fostamatinib (R788) Spleen tyrosine kinase (Syk) inhibitor 901119-35-5
GS-9973 1229208-44-9
MNS Inhibitor of Src/Syk tyrosine kinases 1485-00-3
Piceatannol p56lck/Syk inhibitor 10083-24-6
PRT062607 Hydrochloride SYK inhibitor,potent and selective 1370261-97-4
R406 SYK inhibitor,potent and ATP-competitive 841290-81-1
R406 (free base) Syk inhibitor 841290-80-0
R788 Syk inhibitor,ATP competitive and potent 1025687-58-4
genes like me logo Genes that share compounds with SYK: view

Drug Products

Transcripts for SYK Gene

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mRNA/cDNA for SYK Gene

4 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SYK

Clone Products

  • Addgene plasmids for SYK

Alternative Splicing Database (ASD) splice patterns (SP) for SYK Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6:
SP7: - - -
SP8: -
SP9: -
SP10: - -

ExUns: 17b · 17c ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for SYK Gene

GeneLoc Exon Structure for
SYK

Expression for SYK Gene

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  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYK Gene

mRNA expression in normal human tissues for SYK Gene
mRNA expression by BioGPS for SYK GenemRNA expression by GTEx for SYK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYK Gene

This gene is overexpressed in Whole Blood (x16.4) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for SYK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.0), Lymph node (14.1), Platelet (7.4), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYK Gene



Protein tissue co-expression partners for SYK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SYK

SOURCE GeneReport for Unigene cluster for SYK Gene:

Hs.371720

mRNA Expression by UniProt/SwissProt for SYK Gene:

P43405-KSYK_HUMAN
Tissue specificity: Widely expressed in hematopoietic cells (at protein level) (PubMed:8163536). Expressed in neutrophils (at protein level) (PubMed:15123770). Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells (PubMed:8163536).

Evidence on tissue expression from TISSUES for SYK Gene

  • Blood(4.8)
  • Eye(4.4)
  • Lymph node(3.6)
  • Spleen(3.5)
  • Bone marrow(3.4)
  • Lung(3.4)
  • Intestine(3)
  • Kidney(2.9)
  • Nervous system(2.8)
  • Skin(2.8)
  • Liver(2.6)
  • Heart(2.6)
  • Stomach(2.4)
  • Bone(2.3)
  • Thyroid gland(2.2)
  • Muscle(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with SYK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SYK Gene

Orthologs for SYK Gene

This gene was present in the common ancestor of animals.

Orthologs for SYK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SYK 30 31
  • 95.66 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SYK 30 31
  • 88.19 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SYK 30 31
  • 86.45 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Syk 30 17 31
  • 85.43 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Syk 30
  • 84.72 (n)
Oppossum
(Monodelphis domestica)
 Mammalia SYK 31
  • 82 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SYK 30 31
  • 72.71 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SYK 31
  • 75 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia syk 30
  • 67.74 (n)
African clawed frog
(Xenopus laevis)
 Amphibia MGC68754 30
Zebrafish
(Danio rerio)
 Actinopterygii syk 30 31
  • 67.3 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.10821 30
Fruit Fly
(Drosophila melanogaster)
 Insecta shark 31
  • 21 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea ark-1 31
  • 11 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.2657 31
  • 27 (a)
 OneToMany
Species where no ortholog for SYK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SYK Gene

ENSEMBL:
Gene Tree for SYK (if available)
TreeFam:
Gene Tree for SYK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SYK: view image

Paralogs for SYK Gene

Paralogs for SYK Gene

(4) SIMAP similar genes for SYK Gene using alignment to 3 proteins:

  • KSYK_HUMAN
  • C3W980_HUMAN
  • C3W981_HUMAN
genes like me logo Genes that share paralogs with SYK: view

Variants for SYK Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SYK Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
776431 Benign: not provided 90,864,655(+) A/C MISSENSE_VARIANT
776432 Benign: not provided 90,877,564(+) C/A INTRON_VARIANT
rs796052158 Likely Benign: Long QT syndrome 90,844,052(+) G/T MISSENSE_VARIANT
rs16906862 - p.Arg45His

Additional dbSNP identifiers (rs#s) for SYK Gene

Structural Variations from Database of Genomic Variants (DGV) for SYK Gene

Variant ID Type Subtype PubMed ID
dgv265n6 CNV deletion 16902084
dgv4479e59 CNV duplication 20981092
dgv7687n100 CNV gain 25217958
esv1404670 CNV insertion 17803354
esv24177 CNV loss 19812545
esv2664340 CNV deletion 23128226
esv2669899 CNV deletion 23128226
esv2738748 CNV deletion 23290073
esv2738749 CNV deletion 23290073
esv2738750 CNV deletion 23290073
esv2738752 CNV deletion 23290073
esv2738753 CNV deletion 23290073
esv2738754 CNV deletion 23290073
esv275555 CNV gain+loss 21479260
esv3545114 CNV deletion 23714750
esv3573290 CNV loss 25503493
esv3576680 CNV gain 25503493
esv3621048 CNV gain 21293372
esv3621051 CNV gain 21293372
esv3621052 CNV gain 21293372
esv3621053 CNV gain 21293372
esv3621054 CNV gain 21293372
esv7686 CNV gain 19470904
nsv1038685 CNV gain 25217958
nsv1046989 CNV gain 25217958
nsv1075661 CNV deletion 25765185
nsv1077561 CNV duplication 25765185
nsv1124447 CNV deletion 24896259
nsv1125970 CNV tandem duplication 24896259
nsv1129054 CNV duplication 24896259
nsv1130179 CNV deletion 24896259
nsv1130609 CNV deletion 24896259
nsv1134926 CNV tandem duplication 24896259
nsv1146213 CNV duplication 26484159
nsv1147832 CNV insertion 26484159
nsv614855 CNV gain 21841781
nsv614856 CNV gain 21841781
nsv831652 CNV gain 17160897
nsv950888 CNV duplication 24416366

Variation tolerance for SYK Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYK Gene

Human Gene Mutation Database (HGMD)
SYK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYK Gene

Disorders for SYK Gene

MalaCards: The human disease database

(44) MalaCards diseases for SYK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
peripheral t-cell lymphoma
  • peripheral t cell lymphoma
hantavirus pulmonary syndrome
  • four corners hantavirus
rapidly progressive glomerulonephritis
  • glomerulonephritis rapidly progressive
macroglobulinemia
  • waldenstrom macroglobulinemia
epidermolysis bullosa acquisita
  • acquired epidermolysis bullosa
- elite association - COSMIC cancer census association via MalaCards
Search SYK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SYK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SYK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYK Gene

Publications for SYK Gene

  1. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. (PMID: 18369315) Kulathu Y … Reth M (The EMBO journal 2008) 3 4 23
  2. Molecular mechanism of the Syk activation switch. (PMID: 18818202) Tsang E … Bradshaw JM (The Journal of biological chemistry 2008) 3 4 23
  3. Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. (PMID: 15123770) Ratthé C … Girard D (Journal of leukocyte biology 2004) 3 4 23
  4. Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. (PMID: 15388330) Shim EK … Lee JR (FEBS letters 2004) 3 4 23
  5. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. (PMID: 11940607) Obergfell A … Shattil SJ (The Journal of cell biology 2002) 3 4 23

ExternalLinks

View latest publications for SYK gene in Mastermind

Products for SYK Gene

  • Addgene plasmids for SYK

Sources for SYK Gene