Aliases for SYDE1 Gene
External Ids for SYDE1 Gene
Previous GeneCards Identifiers for SYDE1 Gene
The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017]
GeneCards Summary for SYDE1 Gene
SYDE1 (Synapse Defective Rho GTPase Homolog 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and protein complex binding. An important paralog of this gene is SYDE2.
UniProtKB/Swiss-Prot for SYDE1 Gene
GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469).