Aliases for SYCP2 Gene
External Ids for SYCP2 Gene
Previous GeneCards Identifiers for SYCP2 Gene
The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for SYCP2 Gene
SYCP2 (Synaptonemal Complex Protein 2) is a Protein Coding gene. Diseases associated with SYCP2 include Spermatogenic Failure 1 and Tonsil Squamous Cell Carcinoma. Among its related pathways are Meiosis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SYCP2L.
UniProtKB/Swiss-Prot Summary for SYCP2 Gene
Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.